Annals of Internal Medicine
20 October 2020 Volume 173, Issue 8
Research and Reporting Methods
How to Quantify and Interpret Treatment Effects in Comparative Clinical Studies of COVID-19
Zachary R. McCaw, PhD, Lu Tian, ScD, Jason L. Vassy, MD, MPH, Christine Seel Ritchie, MD, MSPH, … et al.
Trials evaluating treatments for COVID-19 often use the time to a positive outcome as a key end point. In the presence of death as a competing risk, commonly used survival analysis techniques may not be appropriate. This article discusses issues with the current practice and presents alternative, more clinically interpretable approaches.