Inherited causes of clonal haematopoiesis in 97,691 whole genomes

Nature
Volume 586 Issue 7831, 29 October 2020
http://www.nature.com/nature/current_issue.html

 

Article | 14 October 2020
Inherited causes of clonal haematopoiesis in 97,691 whole genomes
Analysis of 97,691 high-coverage human blood DNA-derived whole-genome sequences enabled simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells, indicating that both inherited and acquired mutations are linked to age-related cancers and coronary heart disease.
Alexander G. Bick, Joshua S. Weinstock[…] & Pradeep Natarajan