American Journal of Infection Control
December 2020 Volume 48Issue 12p1415-1570
Impact of repeated yearly vaccination on immune responses to influenza vaccine in an elderly population
Satoko Kitamura, MD et al
:: One hundred and 11 volunteers aged >61 years were vaccinated with inactivated influenza vaccine over 5 consecutive years.
:: Hemagglutination inhibition antibody titers were determined in each of 5 consecutive years.
:: Annual vaccination is necessary to maintain humoral immunity.
:: Annual seasonal vaccination was not associated with reduced vaccine effectiveness.
:: Vaccine strain changes were associated with specific immune responses among those undergoing yearly vaccination.