December 8, 2020, Vol 324, No. 22, Pages 2238-2334
A Proposed Framework and Timeline of the Spectrum of Disease Due to SARS-CoV-2 InfectionIllness Beyond Acute Infection and Public Health Implications
S. Deblina Datta, MD; Amish Talwar, MD, MPH; James T. Lee, MD, MSc
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JAMA. 2020;324(22):2251-2252. doi:10.1001/jama.2020.22717
This Viewpoint uses clinical observations of the natural course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to propose 3 phases of illness: acute infection (what people commonly refer to with the COVID-19 designation); postacute hyperinflammatory illness (referred to clinically as multisystem inflammatory syndrome); and late inflammatory sequelae, manifest as enduring cardiac, neurological, and psychological symptoms.