Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans

Science Translational Medicine
09 December 2020 Vol 12, Issue 573
https://stm.sciencemag.org/

 

Research Articles
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans
By Haley L. Dugan, Jenna J. Guthmiller, Philip Arevalo, Min Huang, Yao-Qing Chen, Karlynn E. Neu, Carole Henry, Nai-Ying Zheng, Linda Yu-Ling Lan, Micah E. Tepora, Olivia Stovicek, Dalia Bitar, Anna-Karin E. Palm, Christopher T. Stamper, Siriruk Changrob, Henry A. Utset, Lynda Coughlan, Florian Krammer, Sarah Cobey, Patrick C. Wilson
Science Translational Medicine09 Dec 2020 Full Access
Antibody immunodominance to conserved influenza virus epitopes is affected by both preexisting B cell memory and route of exposure