Genetics meets proteomics: perspectives for large population-based studies

Nature Reviews Genetics
Volume 22 Issue 1, January 2021
https://www.nature.com/nrg/volumes/22/issues/1

 

Review Article | 28 August 2020
Genetics meets proteomics: perspectives for large population-based studies
In this Review, Suhre, McCarthy and Schwenk describe how combining genetics with plasma proteomics is providing notable insights into human disease. As changes in the circulating proteome are often an intermediate molecular readout between a genetic variant and its organismal effect, proteomics can enable a deeper understanding of disease mechanisms, clinical biomarkers and therapeutic opportunities.
Karsten Suhre , Mark I. McCarthy  & Jochen M. Schwenk