January 5, 2021, Vol 325, No. 1, Pages 9-96
Effect of High-Dose Trivalent vs Standard-Dose Quadrivalent Influenza Vaccine on Mortality or Cardiopulmonary Hospitalization in Patients With High-risk Cardiovascular DiseaseA Randomized Clinical Trial
Orly Vardeny, PharmD, MS; KyungMann Kim, PhD; Jacob A. Udell, MD, MPH; et al.
JAMA. 2021;325(1):39-49. doi:10.1001/jama.2020.23649
This randomized clinical trial compares the effect of high-dose vs standard-dose influenza vaccine on all-cause mortality and hospitalizations due to cardiovascular or pulmonary causes in patients with high-risk cardiovascular disease.