Mar 18, 2021 Volume 184 Issue 6 p1395-1650
Heritable human genome editing: Research progress, ethical considerations, and hurdles to clinical practice
Jenna Turocy, Eli Y. Adashi, Dieter Egli
Our genomes at conception contribute substantially to our overall health, and heritable genome editing could provide many benefits by preventing disease from the beginning of life. Egli and colleagues review the scientific contributions to the field, the ethical challenges that cannot be overlooked, and the hurdles to be overcome prior to clinical practice.