April 6, 2021, Vol 325, No. 13, Pages 1239-1356
Approaches for Optimal Use of Different COVID-19 VaccinesIssues of Viral Variants and Vaccine Efficacy
John P. Moore, PhD
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JAMA. 2021;325(13):1251-1252. doi:10.1001/jama.2021.3465
This Viewpoint proposes ways to maximize vaccine efficacy and allocation given the rise of coronavirus variants and authorization of a Johnson & Johnson vaccine, including reserving the latter for younger healthier populations, boosting it with a single-dose messenger RNA (mRNA) vaccination, and single mRNA immunization of people with prior documented SARS-CoV-2 infection.