COVID-19 in 2021—Continuing Uncertainty

April 13, 2021, Vol 325, No. 14, Pages 1369-1480


COVID-19 in 2021—Continuing Uncertainty
Carlos del Rio, MD; Preeti Malani, MD, MSJ
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JAMA. 2021;325(14):1389-1390. doi:10.1001/jama.2021.3760
This Viewpoint summarizes the current best evidence about COVID-19 vaccines, immunity, and whether SARS-CoV-2 will become an endemic or seasonal virus.
The world has transformed in the past year and some aspects of life may remain changed forever. COVID-19 may reoccur seasonally, like other respiratory viruses, most notably influenza. In addition, a substantial number of patients with post-COVID syndromes will experience various degrees of disabilities and symptoms for years. Infection risk aside, it will be essential for public health agencies and society to develop ways to safely continue essential activities, including in-person learning in the K-12 and higher education space. Social gatherings, sporting events, and other community activities will undoubtedly resume but some restrictions will continue depending on evidence of community spread, the proportion of individuals vaccinated, and other factors that will need to be monitored regularly as individuals, institutions, and governments all perform calculations to balance competing risks.