Aug 19, 2021 Volume 184 Issue 17 p4373-4596
Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses
Anusha Nathan, ET AL.
Structure-based network analyses identify regions in the SARS-CoV-2 proteome that are mutationally constrained and bear CD8+ T cell epitopes that are also conserved in emerging variants as well as other sarbecoviruses. These epitopes elicit stronger CD8+ T cell responses in convalescent individuals over mRNA vaccine recipients and provide a framework for a broad T-cell-based vaccine against coronaviruses.