Annals of Internal Medicine
August 2021 Volume 174, Issue 8
Research and Reporting Methods
A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated
Dean Follmann, PhD, Jonathan Fintzi, PhD, Michael P. Fay, PhD, Holly E. Janes, PhD,
… et al. Pages:1118–1125
This study discusses how continued follow-up of participants in COVID-19 vaccine trials after vaccination of the placebo group permits determination of vaccine durability and allows the incorporation of a booster trial if waning vaccine efficacy is observed while ensuring ethical treatment of participants.