Journal of Virology
Volume 95 Number 19 September 2021
Articles of Significant Interest in This Issue
Human papillomavirus (HPV) genomes replicate as extrachromosomal minichromosomes in persistently infected cells. Coursey at al. (e00686-21) defined elements in the HPV18 enhancer element that promote stable replication of viral DNA in dividing keratinocytes. They concluded that multiple elements within the enhancer contribute to stable replication and proposed that cellular pioneer factors create a favorable chromatin environment that supports and enhances the maintenance of the extrachromosomal minichromosomes.