Immunity [NEW JOURNAL ADDED]
Sep 14, 2021 Volume 54 Issue 9 p1903-2168
A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants
Aaron J. Schmitz, et al.
SARS-CoV-2 variants with increased transmissibility are a public health threat. Schmitz et al. characterize 2C08, a human monoclonal antibody derived from a SARS-CoV-2 vaccine-induced germinal center B cell. 2C08 possesses a broad and potent neutralization capacity and protects hamsters against challenge with D614G, B.1.351, or B.1.617.2 strains. Public 2C08-like clones can be elicited by both SARS-CoV-2 infection and vaccination.