The PROTACtable genome

Nature Reviews Drug Discovery
Volume 20 Issue 10, October 2021


Perspective | 20 July 2021
The PROTACtable genome
Targeted protein degradation by proteolysis-targeting chimeras (PROTACs) is attracting substantial interest as a therapeutic modality that could circumvent some limitations of traditional small-molecule drugs. This article presents a systematic approach to assessing the PROTAC tractability (PROTACtability) of protein targets, which could support decision-making on whether a particular target may be amenable to modulation using a PROTAC.
Melanie Schneider, Chris J. Radoux, Andrew R. Leach