A synthetic antibiotic class overcoming bacterial multidrug resistance

Nature
Volume 599 Issue 7885, 18 November 2021
https://www.nature.com/nature/volumes/599/issues/7885

 

Article | 27 October 2021
A synthetic antibiotic class overcoming bacterial multidrug resistance
Structure-guided design and component-based synthesis are used to produce iboxamycin, a novel ribosome-binding antibiotic with potent activity against Gram-positive and Gram-negative bacteria.
Matthew J. Mitcheltree, Amarnath Pisipati, Andrew G. Myers