Dec 14, 2021 Volume 54 Issue 12 p2671-2922
From mRNA sensing to vaccines
Anthony S. Fauci, et al.
The 2005 Immunity paper by Karikó et al. has been hailed as a cornerstone insight that directly led to the design and delivery of the mRNA vaccines against COVID-19. We asked experts in pathogen sensing, vaccine development, and public health to provide their perspective on the study and its implications.