Nature Reviews Genetics
Volume 23 Issue 4, April 2022
Review Article | 02 December 2021
The potential of mitochondrial genome engineering
The authors review the field of mammalian mitochondrial genome engineering, culminating in the recent development of mitochondrially targeted programmable nucleases and base editors. They describe research that led to the development of animal models of mitochondrial disease, as well as the potential for translating these approaches to the clinic.
Pedro Silva-Pinheiro, Michal Minczuk