Nature Reviews Drug Discovery
Volume 21 Issue 5, May 2022
Review Article | 16 March 2022
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
Natural products derived from bacteria are an important source of potential new drug compounds, such as antibiotics and anticancer agents, but how to efficiently mine this resource remains a challenge. In their Review, Hemmerling and Piel discuss newly developed computational tools and strategies to access biosynthetic novelty in bacterial genomes. They consider the opportunities and challenges associated with different bacterial sources, including cultivated, ecology-based and previously untapped bacterial ‘dark matter’.
Franziska Hemmerling, Jörn Piel