Immunological defense of CNS barriers against infections

May 10, 2022 Volume 55 Issue 5 p735-924


Immunological defense of CNS barriers against infections
Leonel Ampie, Dorian B. McGavern
Neuroanatomical barriers are defended by the immune system to safeguard the CNS parenchyma from pathogens. Ampie and McGavern review the anatomy and development of CNS barriers as well as their immunological composition during steady state and in response to infections. They also explore how to protect these barriers via vaccination and then discuss the immunology and neuropathogenesis of a contemporary CNS challenge (i.e., SARS-CoV-2).