May 10, 2022 Volume 55 Issue 5 p735-924
Inducing broad-based immunity against viruses with pandemic potential
Alessandro Sette, Erica Ollmann Saphire
Saphire and Sette discuss potential approaches for vaccine development against the broad array of SARS-CoV-2 variants and other viruses of pandemic potential. Approaches that elicit both humoral and cellular responses are considered and are expected to be synergistic with each other, providing humanity with the best chance to defend against the next pandemic.