Apollo Therapeutics: Consortium of World-Leading UK Universities and Global Pharmaceutical Companies Launch £40 Million Fund to Drive Therapeutic Innovation

Apollo Therapeutics: Consortium of World-Leading UK Universities and Global Pharmaceutical Companies Launch £40 Million Fund to Drive Therapeutic Innovation
:: Unique collaboration between AstraZeneca, GlaxoSmithKline, Johnson & Johnson Innovation and the technology transfer offices of Imperial College London, UCL (University College London) and the University of Cambridge, to drive forward therapeutic innovation
:: £40 million Apollo Therapeutics Fund aims to significantly improve the speed and potential of university research being translated into novel medicines
:: First time global pharmaceutical companies and world-leading universities* have created this type of fund
January 25, 2016
LONDON–(BUSINESS WIRE)–Three global pharmaceutical companies (AstraZeneca, GlaxoSmithKline, Johnson & Johnson Innovation) and the technology transfer offices of three world-leading universities (Imperial College London, University College London and the University of Cambridge) have joined forces with a combined £40 million to create the Apollo Therapeutics Fund (‘Apollo’). This pioneering new joint venture will support the translation of ground-breaking academic science from within these universities into innovative new medicines for a broad range of diseases.

“Collaboration is one of our most powerful tools in the pursuit of new medicines. Working with experts outside our own laboratories exposes us to differing expertise and innovation and means we can jointly shoulder risk – which in turn enables us to pursue some really exciting, ambitious science.”

Each of the three industry partner companies (AstraZeneca UK Limited, Glaxo Group Limited and Johnson & Johnson Innovation-JJDC, Inc.) will contribute £10 million over 6 years to the venture. The technology transfer offices (TTOs) of the three university partners – Imperial Innovations Group plc, Cambridge Enterprise Ltd Limited and UCL Business PLC – will each contribute a further £3.3 million. The aim of Apollo is to advance academic preclinical research from these universities to a stage at which it can either be taken forward by one of the industry partners following an internal bidding process or be out-licensed. The three industry partners will also provide R&D expertise and additional resources to assist with the commercial evaluation and development of projects.

Drug development is extremely complex, costly and lengthy; currently only around 10 percent of therapies entering clinical trials reach patients as medicines. By combining funding for promising early-stage therapeutics from leading UK universities with a breadth of industry expertise, Apollo aims to share the risk and accelerate the development of important new treatments, while also reducing the cost.

Dr Ian Tomlinson, former Senior Vice President, Worldwide Business Development and Biopharmaceuticals R&D, for GSK and founder & Chief Scientific Officer of Domantis Limited has been appointed Chairman of the Apollo Therapeutics Investment Committee (AIC). Comprising representatives from the six partners, the AIC will make all investment decisions.

The AIC will be advised by an independent Drug Discovery Team (DDT) of ex-industry scientists who will be employed by Apollo to work with the universities and their TTOs to identify and shape projects to bring forward for development. All therapy areas and modalities, including small molecules, peptides, proteins, antibodies, cell and gene therapies will be considered.

Apollo will be based at Stevenage Bioscience Catalyst. Once funded, projects will be progressed by the DDT alongside the university investigators, with other external resources and also in-kind resources from the industry partners as appropriate. For successful projects, the originating university and TTO will receive a percentage of future commercial revenues or out-licensing fees and the remainder will be divided amongst all the Apollo partners.

Dr Ian Tomlinson, Chairman of the Apollo Therapeutics Investment Committee commented:
“This is the first time that three global pharmaceutical companies and the TTOs of three of the world’s top ten universities have come together to form a joint enterprise of this nature, making the Apollo Therapeutics Fund a truly innovative venture.

Apollo provides an additional source of early stage funding that will allow more therapeutics projects within the three universities to realise their full potential. The active participation of the industry partners will also mean that projects will be shaped at a very early stage to optimise their suitability for further development…

MSF/Médecins Sans Frontières [to 30 January 2016]

MSF/Médecins Sans Frontières [to 30 January 2016]
http://www.doctorswithoutborders.org/news-stories/press/press-releases

.
Press Releases
MSF Alert: Five Epidemics to Watch
January 25, 2016
GENEVA/NEW YORK—Five diseases with the potential to become epidemics in 2016 are being highlighted by the international medical humanitarian organization Doctors Without Borders/Médecins Sans Frontières (MSF), as the World Health Organization’s executive board meets in Geneva this week.

Without proper investment in preventing and responding to outbreaks of cholera, malaria, measles, meningitis and a group of often-overlooked diseases spread by viruses and parasites, they are likely to pose an ever greater threat to people’s health in the year ahead.

“We know that thousands of lives will be at risk in the year to come, although the means exist to prevent these deaths,” said Monica Rull, operational health advisor for MSF. “Epidemics of cholera, malaria, measles and meningitis take place every year, incapacitating and killing many—and this needs to stop. At the same time, the threat posed by emerging and re-emerging virus and parasite-spread diseases—such as dengue fever, Zika, Ebola and Kala Azar—needs to be faced.”…

Partners In Health [to 30 January 2016]

Partners In Health [to 30 January 2016]
http://www.pih.org/blog

.
Jan 29, 2016
Cervical Cancer Program Expands in Haiti
Cervical cancer is the most common cancer in women in Haiti, and the second leading cause of cancer deaths among the same group, according to the ICO Information Centre on HPV and Cancer, a data clearinghouse.

This is true in a day and age when cervical cancer can largely be prevented and treated through timely vaccinations and regular gynecological exams. There is no reason that can’t be true in Haiti.

In November, Zanmi Lasante, as Partners In Health is known in Haiti, launched a two-year program that will dramatically increase its capacity to vaccinate young girls and screen and treat women for cervical cancer. Over the next 24 months, staff will vaccinate 20,000 girls in St. Marc, Mirebalais, and Belladère against human papillomavirus (HPV), a disease that causes virtually all cervical cancer. They will also screen 20,000 more women for cervical cancer in St. Marc and the surrounding area, while boosting efforts to screen and treat women in Mirebalais and Belladère.

Additional staff will be hired and equipment and materials will be purchased to meet increased demand for these gynecological services, most of which will be provided at St. Nicholas Hospital in St. Marc. Pap smears, biopsies, and colposcopy—a procedure used to closely examine the cervix—will also be available for women whose initial tests indicate they may have cancer…

.

Jan 28, 2016
Need to Know: Zika Virus
The Zika virus has been reported in 23 countries and territories so far, including Haiti and Mexico, where Partners In Health has thousands of staff and serves thousands more patients on a daily basis. Dr. Joia Mukherjee, PIH’s chief medical officer and an infectious disease expert, answers key questions about the virus. .

.

Jan 27, 2016
Study Finds Poverty Spread Ebola
A study quantifies how poor areas of Monrovia increased transmission of Ebola in 2014.

Global Fund [to 30 January 2016]

Global Fund [to 30 January 2016]
http://www.theglobalfund.org/en/news/

.
News
Dutch Postcode Lottery Supports TB Programs for Syrian Refugees
28 January 2016
AMSTERDAM – The Dutch Postcode Lottery announced a contribution of €2.5 million to the Global Fund to support the fight against tuberculosis among Syrian refugees in Lebanon, Jordan and Iraq.

The Bill & Melinda Gates Foundation will match the contribution from the Dutch Postcode Lottery.

“Partnerships like this allow us to better focus on leaving no one behind, regardless of their status, circumstance, or ethnic and religious background,” said Mark Dybul, Executive Director of the Global Fund. “TB is a serious challenge, and collective efforts to reduce it are ultimately connected with achieving quality access to health care by all.”

Marieke van Schaik, Managing Director of the Dutch Postcode Lottery, said: “We are honored to grant this award to the Global Fund to support the work that the organization is doing in emergency situations.”

The Global Fund partnership, through the Emergency Fund special initiative, provides access to funds in emergency situations connected with HIV, TB or malaria. The Emergency Fund currently supports the provision and continuity of essential TB prevention, diagnosis and treatment services in Lebanon and Jordan, and will be expanded to Iraq.

.

News
Global Fund Hails New Malaria Investment
25 January 2016
GENEVA – The Global Fund welcomes a significant new investment against malaria by the United Kingdom and the Bill & Melinda Gates Foundation.

Announced today in Liverpool by George Osborne, Chancellor of the Exchequer, and Bill Gates, co-chair of the Bill & Melinda Gates Foundation, the funding of £3 billion over the next five years will support research and other efforts to eliminate malaria.

The new fund will accelerate gains made against the mosquito-borne disease. Global efforts have already achieved a 60 percent decline in deaths since 2000, when malaria killed one million people, mostly young children. Yet today’s announcement underscored the need to expand efforts to eliminate this preventable disease.

The fund will receive £500 million a year from Britain’s overseas aid budget for the next five years, as well as US$200 million a year from the Gates Foundation to support research and development and accelerate malaria elimination efforts…

Cost effectiveness analysis of Year 2 of an elementary school-located influenza vaccination program–Results from a randomized controlled trial

BMC Health Services Research

(Accessed 30 January 2016)

.
Research article
Cost effectiveness analysis of Year 2 of an elementary school-located influenza vaccination program–Results from a randomized controlled trial
Byung-Kwang Yoo, Sharon G. Humiston, Peter G. Szilagyi, Stanley J. Schaffer, Christine Long and Maureen Kolasa
BMC Health Services Research201515:511
DOI: 10.1186/s12913-015-1169-5
Abstract
Background
School-located vaccination against influenza (SLV-I) has the potential to improve current suboptimal influenza immunization coverage for U.S. school-aged children. However, little is known about SLV-I’s cost-effectiveness. The objective of this study is to establish the cost-effectiveness of SLV-I based on a two-year community-based randomized controlled trial (Year 1: 2009–2010 vaccination season, an unusual H1N1 pandemic influenza season, and Year 2: 2010–2011, a more typical influenza season).
Methods
We performed a cost-effectiveness analysis on a two-year randomized controlled trial of a Western New York SLV-I program. SLV-I clinics were offered in 21 intervention elementary schools (Year 1 n = 9,027; Year 2 n = 9,145 children) with standard-of-care (no SLV-I) in control schools (Year 1 n = 4,534 (10 schools); Year 2 n  = 4,796 children (11 schools)). We estimated the cost-per-vaccinated child, by dividing the incremental cost of the intervention by the incremental effectiveness (i.e., the number of additionally vaccinated students in intervention schools compared to control schools).
Results
In Years 1 and 2, respectively, the effectiveness measure (proportion of children vaccinated) was 11.2 and 12.0 percentage points higher in intervention (40.7 % and 40.4 %) than control schools. In year 2, the cost-per-vaccinated child excluding vaccine purchase ($59.88 in 2010 US $) consisted of three component costs: (A) the school costs ($8.25); (B) the project coordination costs ($32.33); and (C) the vendor costs excluding vaccine purchase ($16.68), summed through Monte Carlo simulation. Compared to Year 1, the two component costs (A) and (C) decreased, while the component cost (B) increased in Year 2. The cost-per-vaccinated child, excluding vaccine purchase, was $59.73 (Year 1) and $59.88 (Year 2, statistically indistinguishable from Year 1), higher than the published cost of providing influenza vaccination in medical practices ($39.54). However, taking indirect costs (e.g., averted parental costs to visit medical practices) into account, vaccination was less costly in SLV-I ($23.96 in Year 1, $24.07 in Year 2) than in medical practices.
Conclusions
Our two-year trial’s findings reinforced the evidence to support SLV-I as a potentially favorable system to increase childhood influenza vaccination rates in a cost-efficient way. Increased efficiencies in SLV-I are needed for a sustainable and scalable SLV-I program

Adult pertussis is unrecognized public health problem in Thailand

BMC Infectious Diseases
http://www.biomedcentral.com/bmcinfectdis/content
(Accessed 30 January 2016)

.
Research article
Adult pertussis is unrecognized public health problem in Thailand
Nirada Siriyakorn, Pornvimol Leethong, Terapong Tantawichien, Saowalak Sripakdee, Anusak Kerdsin, Surang Dejsirilert and Leilani Paitoonpong
BMC Infectious Diseases 2016 16:25
Published on: 25 January 2016
Abstract
Background
Although pertussis has been considered a disease of childhood, it is also recognized as an important respiratory tract infection in adolescents and adults. However, in countries with routine vaccination against pertussis with high coverage, pertussis is not usually taken into consideration for the etiology of prolonged cough in adults. Previous studies in a variety of populations in developed countries have documented that pertussis is quite common, ranging from 2.9 to 32 % of adolescents and adults with prolonged cough. The anticipation and early recognition of this change in the epidemiology is important because the affected adolescents and adults act as reservoirs of the disease and source of infection to the vulnerable population of infants, for whom the disease can be life threatening. We conducted a prospective study to determine the prevalence of pertussis in Thai adults with prolonged cough.
Methods
Seventy-six adult patients with a cough lasting for more than 2 weeks (range, 14–180 days) were included in the present study. The data regarding medical history and physical examination were carefully analyzed. Nasopharyngeal swabs from all patients were obtained for the detection of deoxyribonucleic acid of Bordetella pertussis by the polymerase chain reaction (PCR) method. Paired serum samples were collected and tested for IgG antibody against pertussis toxin by using an ELISA method.
Results
Of 76 adult patients, 14 patients (18.4 %) with the mean age of 59 (range, 28–85) years and the mean duration of cough of 34 (range, 14–120) days had laboratory evidence of acute pertussis infection. One patient was diagnosed by the PCR method, while the rest had serological diagnosis. Whooping cough is a significantly associated symptom of patients with chronic cough who had laboratory evidence of pertussis. (p < .05, odds ratio 3.75, 95 % confidence interval: 1.00,14.06)
Conclusion
Pertussis is being increasingly recognized as a cause of prolonged, distressing cough among adults in Thailand. This result addresses the need of pertussis vaccination in Thai adults for preventing transmission to a high risk group such as newborn infants.

Economic evaluations of interventions to reduce neonatal morbidity and mortality: a review of the evidence in LMICs and its implications for South Africa

Cost Effectiveness and Resource Allocation
http://www.resource-allocation.com/
(Accessed 30 January 2016)

.
Review
Economic evaluations of interventions to reduce neonatal morbidity and mortality: a review of the evidence in LMICs and its implications for South Africa
Mandy Maredza, Lumbwe Chola and Karen Hofman
Abstract
Background
Newborn mortality, comprising a third of all under-5 deaths, has hardly changed in low and middle income countries (LMICs) including South Africa over the past decade. To attain the MDG 4 target, greater emphasis must be placed on wide-scale implementation of proven, cost-effective interventions. This paper reviews economic evidence on effective neonatal health interventions in LMICs from 2000–2013; documents lessons for South African policy on neonatal health; and identifies gaps and areas for future research.
Methods
A narrative review was performed in leading public health databases for full economic evaluations conducted between 2000 and 2013. Data extraction from the articles included in the review was guided by the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist, and the quality of the included economic evaluations was assessed using the Quality of Health Economics Studies Instrument (QHES).
Results
Twenty-seven economic evaluations were identified, from South East Asia and sub-Saharan Africa, with those from sub-Saharan Africa primarily focused on HIV/AIDS. Packages of care to prevent neonatal mortality were more cost-effective than vertical interventions. A wide variability in methodological approaches challenges the comparability of study results between countries. In South Africa, there is limited cost-effectiveness evidence for the interventions proposed by the National Perinatal Morbidity and Mortality Committee.
Conclusions
Neonatal strategies have a strong health system focus but this review suggests that strengthening community care could be an additional component for averting neonatal deaths. While some evidence exists, having a more complete understanding of how to most effectively deploy scarce resources for neonatal health in South Africa in the post-2015 era is essential.

Systematic review on tuberculosis transmission on aircraft…

Eurosurveillance
Volume 21, Issue 4, 28 January 2016
http://www.eurosurveillance.org/Public/Articles/Archives.aspx?PublicationId=11678

.
Review articles
Systematic review on tuberculosis transmission on aircraft and update of the European Centre for Disease Prevention and Control risk assessment guidelines for tuberculosis transmitted on aircraft (RAGIDA-TB)
by S Kotila, L Payne Hallström, N Jansen, P Helbling, I Abubakar
Abstract
As a setting for potential tuberculosis (TB) transmission and contact tracing, aircraft pose specific challenges. Evidence-based guidelines are needed to support the related-risk assessment and contact-tracing efforts. In this study evidence of TB transmission on aircraft was identified to update the Risk Assessment Guidelines for TB Transmitted on Aircraft (RAGIDA-TB) of the European Centre for Disease Prevention and Control (ECDC). Electronic searches were undertaken from Medline (Pubmed), Embase and Cochrane Library until 19 July 2013. Eligible records were identified by a two-stage screening process and data on flight and index case characteristics as well as contact tracing strategies extracted. The systematic literature review retrieved 21 records. Ten of these records were available only after the previous version of the RAGIDA guidelines (2009) and World Health Organization guidelines on TB and air travel (2008) were published. Seven of the 21 records presented some evidence of possible in-flight transmission, but only one record provided substantial evidence of TB transmission on an aircraft. The data indicate that overall risk of TB transmission on aircraft is very low. The updated ECDC guidelines for TB transmission on aircraft have global implications due to inevitable need for international collaboration in contract tracing and risk assessment.

Global Public Health – Volume 11, Issue 3, 2016

Global Public Health
Volume 11, Issue 3, 2016
http://www.tandfonline.com/toc/rgph20/current

.
Articles
Developing collaborative approaches to international research: Perspectives of new global health researchers
Paula Godoy-Ruiz, Donald C. Cole, Lindsey Lenters & Kwame McKenzie
pages 253-275
Open access
DOI:10.1080/17441692.2014.999814
Abstract
Within a global context of growing health inequities, the fostering of partnerships and collaborative research have been promoted as playing a critical role in tackling health inequities and health system problems worldwide. Since 2004, the Canadian Coalition for Global Health Research (CCGHR) has facilitated annual Summer Institutes for new global health researchers aimed at strengthening global health research competencies and partnerships among participants. We sought to explore CCGHR Summer Institute alumni perspectives on the Summer Institute experience, particularly on the individual research pairings of Canadian and low- and middle-income countries researchers that have characterised the program. The results reveal that the Summer Institute offered an enriching learning opportunity for participants and worked to further their collaborative projects through providing dedicated one-on-one time with their international research partner, feedback from colleagues from around the world and mentorship by more senior researchers. Positive individual relationships among researchers, as well as the existence of institutional collaborations, employer and funding support, and agendas of local and national politicians were factors that have influenced the ongoing collaboration of partners. There is a need to more fully examine the interplay between individual and institutional-level collaborations, as well as their social and political contexts.

.

Articles
Alternative accounting in maternal and infant global health
Vincanne Adams, Sienna R. Craig & Arlene Samen
DOI:10.1080/17441692.2015.1021364
pages 276-294
Abstract
Efforts to augment accountability through the use of metrics, and especially randomised controlled trial or other statistical methods place an increased burden on small nongovernmental organisations (NGOs) doing global health. In this paper, we explore how one small NGO works to generate forms of accountability and evidence that may not conform to new metrics trends but nevertheless deserve attention and scrutiny for being effective, practical and reliable in the area of maternal and infant health. Through an analysis of one NGO and, in particular, its organisational and ethical principles for creating a network of safety for maternal and child health, we argue that alternative forms of (ac)counting like these might provide useful evidence of another kind of successful global health work

.

Vaccine procurement during an influenza pandemic and the role of Advance Purchase Agreements: Lessons from 2009-H1N1
Mark Turner
pages 322-335
DOI:10.1080/17441692.2015.1043743
Abstract
Vaccines are hugely important tools in minimising the effect pandemic influenza could have on a population. The reforms introduced by the Pandemic Influenza Preparedness Framework are ill-suited to providing sufficient levels of access to vaccines to meet the needs of developing states, and as such developing states will continue to be reliant upon the traditional methods of vaccine procurement to procure the majority of the vaccines they required. Using procurement during 2009-H1N1 as a case study, this paper examines the methods of procurement utilised by states in order to determine if the procurement tools available to developing states are sufficient to procure adequate levels of pandemic influenza vaccines. Particular focus is given to the role Advance Purchase Agreements (APAs) play in the procurement process. By exploring this case study it is possible to argue that these procurement methods are ineffective for developing states, and when the next influenza pandemic occurs, demand will once again outstrip supply globally, due to supply of vaccines being dominated by the developed states with APAs in place.

HPV Vaccine Awareness, Barriers, Intentions, and Uptake in Latina Women

Journal of Immigrant and Minority Health
Volume 18, Issue 1, February 2016
http://link.springer.com/journal/10903/18/1/page/1

.
Original paper
HPV Vaccine Awareness, Barriers, Intentions, and Uptake in Latina Women
Julia Lechuga, Lina Vera-Cala…
Abstract
Latina women are at heightened risk of cervical cancer incidence and mortality. The human papillomavirus (HPV) is the principal cause of the majority of cervical cancer cases. A vaccine that protects against HPV was licensed in 2006. Eight years post-licensure, mixed research findings exist regarding the factors that predict vaccine uptake in Latinas. We conducted a population-based phone survey with a random sample of 296 Latinas living in a Midwestern U.S. City. Intention to vaccinate was significantly associated with health care provider recommendations, worry about side effects, knowing other parents have vaccinated, perceived severity of HPV, and worry that daughter may become sexually active following vaccination. Worry that daughter may become sexually active was the only factor related to vaccine uptake. Findings suggest that training providers to discuss the low risk of severe side effects, consequences of persistent HPV, and sexuality related concerns with Latino women may encourage vaccination.

Journal of the Royal Society – Interface :: 01 January 2016

Journal of the Royal Society – Interface
01 January 2016; volume 13, issue 114
.
Research Articles
Self-enforcing regional vaccination agreements
Petra Klepac, Itamar Megiddo, Bryan T. Grenfell, Ramanan Laxminarayan
J. R. Soc. Interface 2016 13 20150907; DOI: 10.1098/rsif.2015.0907. Published 20 January 2016
Abstract
In a highly interconnected world, immunizing infections are a transboundary problem, and their control and elimination require international cooperation and coordination. In the absence of a global or regional body that can impose a universal vaccination strategy, each individual country sets its own strategy. Mobility of populations across borders can promote free-riding, because a country can benefit from the vaccination efforts of its neighbours, which can result in vaccination coverage lower than the global optimum. Here we explore whether voluntary coalitions that reward countries that join by cooperatively increasing vaccination coverage can solve this problem. We use dynamic epidemiological models embedded in a game-theoretic framework in order to identify conditions in which coalitions are self-enforcing and therefore stable, and thus successful at promoting a cooperative vaccination strategy. We find that countries can achieve significantly greater vaccination coverage at a lower cost by forming coalitions than when acting independently, provided a coalition has the tools to deter free-riding. Furthermore, when economically or epidemiologically asymmetric countries form coalitions, realized coverage is regionally more consistent than in the absence of coalitions.

.

Research Articles
Role of vaccination-induced immunity and antigenic distance in the transmission dynamics of highly pathogenic avian influenza H5N1
Ioannis Sitaras, Xanthoula Rousou, Donata Kalthoff, Martin Beer, Ben Peeters, Mart C. M. de Jong
J. R. Soc. Interface 2016 13 20150976; DOI: 10.1098/rsif.2015.0976. Published 13 January 2016
Abstract
Highly pathogenic avian influenza (HPAI) H5N1 epidemics in poultry cause huge economic losses as well as sporadic human morbidity and mortality. Vaccination in poultry has often been reported as being ineffective in preventing transmission and as a potential driving force in the selection of immune escape mutants. We conducted transmission experiments to evaluate the transmission dynamics of HPAI H5N1 strains in chickens vaccinated with high and low doses of immune escape mutants we have previously selected, and analysed the data using mathematical models. Remarkably, we demonstrate that the effect of antigenic distances between the vaccine and challenge strains used in this study is too small to influence the transmission dynamics of the strains used. This is because the effect of a sufficient vaccine dose on antibody levels against the challenge viruses is large enough to compensate for any decrease in antibody titres due to antigenic differences between vaccine and challenge strains. Our results show that at least under experimental conditions, vaccination will remain effective even after antigenic changes as may be caused by the initial selection in vaccinated birds.

The Lancet – Jan 30, 2016

The Lancet
Jan 30, 2016 Volume 387 Number 10017 p403-504
http://www.thelancet.com/journals/lancet/issue/current

.
Editorial
Ebola’s legacy: UK deficits and their global lessons
The Lancet
Summary
A devastating report on the UK’s lessons from Ebola was published this week by the House of Commons Science and Technology Committee. Much of the blame for the world’s lacklustre response to Ebola has been laid at the door of WHO. But the committee also found surprising weaknesses in the UK’s application of science to global health emergencies. It makes important recommendations for corrective action. Although targeted towards the UK, the committee’s findings will also likely apply to other high-income countries involved in the response to Ebola.

.

Articles
Global, regional, and national levels and trends in maternal mortality between 1990 and 2015, with scenario-based projections to 2030: a systematic analysis by the UN Maternal Mortality Estimation Inter-Agency Group
Leontine Alkema, Doris Chou, Daniel Hogan, Sanqian Zhang, Ann-Beth Moller, Alison Gemmill, Doris Ma Fat, Ties Boerma, Marleen Temmerman, Colin Mathers, Lale Say, United Nations Maternal Mortality Estimation Inter-Agency Group collaborators, technical advisory group
Summary
Background
Millennium Development Goal 5 calls for a 75% reduction in the maternal mortality ratio (MMR) between 1990 and 2015. We estimated levels and trends in maternal mortality for 183 countries to assess progress made. Based on MMR estimates for 2015, we constructed projections to show the requirements for the Sustainable Development Goal (SDG) of less than 70 maternal deaths per 100 000 livebirths globally by 2030.
Methods
We updated the UN Maternal Mortality Estimation Inter-Agency Group (MMEIG) database with more than 200 additional records (vital statistics from civil registration systems, surveys, studies, or reports). We generated estimates of maternal mortality and related indicators with 80% uncertainty intervals (UIs) using a Bayesian model. The model combines the rate of change implied by a multilevel regression model with a time-series model to capture data-driven changes in country-specific MMRs, and includes a data model to adjust for systematic and random errors associated with different data sources.
Results
We had data for 171 of 183 countries. The global MMR fell from 385 deaths per 100 000 livebirths (80% UI 359–427) in 1990, to 216 (207–249) in 2015, corresponding to a relative decline of 43·9% (34·0–48·7), with 303 000 (291 000–349 000) maternal deaths worldwide in 2015. Regional progress in reducing the MMR since 1990 ranged from an annual rate of reduction of 1·8% (0·0–3·1) in the Caribbean to 5·0% (4·0–6·0) in eastern Asia. Regional MMRs for 2015 ranged from 12 deaths per 100 000 livebirths (11–14) for high-income regions to 546 (511–652) for sub-Saharan Africa. Accelerated progress will be needed to achieve the SDG goal; countries will need to reduce their MMRs at an annual rate of reduction of at least 7·5%.
Interpretation
Despite global progress in reducing maternal mortality, immediate action is needed to meet the ambitious SDG 2030 target, and ultimately eliminate preventable maternal mortality. Although the rates of reduction that are needed to achieve country-specific SDG targets are ambitious for most high mortality countries, countries that made a concerted effort to reduce maternal mortality between 2000 and 2010 provide inspiration and guidance on how to accomplish the acceleration necessary to substantially reduce preventable maternal deaths.
Funding
National University of Singapore, National Institute of Child Health and Human Development, USAID, and the UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction.

.

Series
Breastfeeding
Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect
Cesar G Victora, Rajiv Bahl, Aluísio J D Barros, Giovanny V A França, Susan Horton, Julia Krasevec, Simon Murch, Mari Jeeva Sankar, Neff Walker, Nigel C Rollins, The Lancet Breastfeeding Series Group

Breastfeeding
Why invest, and what it will take to improve breastfeeding practices?
Nigel C Rollins, Nita Bhandari, Nemat Hajeebhoy, Susan Horton, Chessa K Lutter, Jose C Martines, Ellen G Piwoz, Linda M Richter, Cesar G Victora, The Lancet Breastfeeding Series Group

Sharing Clinical Trial Data — A Proposal from the International Committee of Medical Journal Editors

New England Journal of Medicine
January 28, 2016 Vol. 374 No. 4
http://www.nejm.org/toc/nejm/medical-journal

.
Editorial
Sharing Clinical Trial Data — A Proposal from the International Committee of Medical Journal Editors
Darren B. Taichman, M.D., Ph.D., Joyce Backus, M.S.L.S., Christopher Baethge, M.D., Howard Bauchner, M.D., Peter W. de Leeuw, M.D., Jeffrey M. Drazen, M.D., John Fletcher, M.B., B.Chir., M.P.H., Frank A. Frizelle, M.B., Ch.B., F.R.A.C.S., Trish Groves, M.B., B.S., M.R.C.Psych., Abraham Haileamlak, M.D., Astrid James, M.B., B.S., Christine Laine, M.D., M.P.H., Larry Peiperl, M.D., Anja Pinborg, M.D., Peush Sahni, M.B., B.S., M.S., Ph.D., and Sinan Wu, M.D.
N Engl J Med 2016; 374:384-386
January 28, 2016
DOI: 10.1056/NEJMe1515172

The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk. In a growing consensus, many funders around the world — foundations, government agencies, and industry — now mandate data sharing. Here we outline the ICMJE’s proposed requirements to help meet this obligation. We encourage feedback on the proposed requirements. Anyone can provide feedback at http://www.icmje.org by 18 April 2016.

The ICMJE defines a clinical trial as any research project that prospectively assigns people or a group of people to an intervention, with or without concurrent comparison or control groups, to study the cause-and-effect relationship between a health-related intervention and a health outcome. Further details may be found in the Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals at http://www.icmje.org.

As a condition of consideration for publication of a clinical trial report in our member journals, the ICMJE proposes to require authors to share with others the deidentified individual-patient data (IPD) underlying the results presented in the article (including tables, figures, and appendices or supplementary material) no later than 6 months after publication. The data underlying the results are defined as the IPD required to reproduce the article’s findings, including necessary metadata. This requirement will go into effect for clinical trials that begin to enroll participants beginning 1 year after the ICMJE adopts its data-sharing requirements. (The ICMJE plans to adopt data-sharing requirements after considering feedback received to the proposals made here.)

Enabling responsible data sharing is a major endeavor that will affect the fabric of how clinical trials are planned and conducted and how their data are used. By changing the requirements of the manuscripts we will consider for publication in our journals, editors can help foster this endeavor. As editors, our direct influence is logically, and practically, limited to those data underpinning the results and analyses we publish in our journals.

The ICMJE also proposes to require that authors include a plan for data sharing as a component of clinical trial registration. This plan must include where the researchers will house the data and, if not in a public repository, the mechanism by which they will provide others access to the data, as well as other data-sharing plan elements outlined in the 2015 Institute of Medicine Report (e.g., whether data will be freely available to anyone upon request or only after application to and approval by a learned intermediary, whether a data use agreement will be required).1 ClinicalTrials.gov has added an element to its registration platform to collect data-sharing plans. We encourage other trial registries to similarly incorporate mechanisms for the registration of data-sharing plans. Trialists who want to publish in ICMJE member journals (or nonmember journals that choose to follow these recommendations) should choose a registry that includes a data-sharing plan element as a specified registry item or allows for its entry as a free-text statement in a miscellaneous registry field. As a condition of consideration for publication in our member journals, authors will be required to include a description of the data-sharing plan in the submitted manuscript. Authors may choose to share the deidentified IPD underlying the results presented in the article under less restrictive, but not more restrictive, conditions than were indicated in the registered data-sharing plan.

The ICMJE already requires the prospective registration of all clinical trials prior to enrollment of the first participant. This requirement aims, in part, to prevent selective publication and selective reporting of research outcomes, and to prevent unnecessary duplication of research effort. Including a commitment to a data-sharing plan is a logical addition to trial registration that will further each of these goals. Prospective trial registration currently includes documenting the planned primary and major secondary end points to be assessed, which enables identification of incomplete reporting as well as post hoc analyses. Declaring the plan for sharing data prior to their collection will further enhance transparency in the conduct and reporting of clinical trials by exposing when data availability following trial completion differs from prior commitments.

Sharing clinical trial data, including deidentified IPD, requires planning to ensure appropriate ethics committee or institutional review board approval and the informed consent of study participants. Accordingly, we will defer these requirements for 1 year to allow investigators, trial sponsors, and regulatory bodies time to plan for their implementation.

Just as the confidentiality of trial participants must be protected (through the deidentification of IPD), and the needs of those reasonably requesting data met (through the provision of useable data), the reasonable rights of investigators and trial sponsors must also be protected. The ICMJE proposes the following to safeguard these rights. First, ICMJE editors will not consider the deposition of data in a registry to constitute prior publication. Second, authors of secondary analyses using these shared data must attest that their use was in accordance with the terms (if any) agreed to upon their receipt. Third, they must reference the source of the data using a unique identifier of a clinical trial’s data set to provide appropriate credit to those who generated it and allow searching for the studies it has supported. Fourth, authors of secondary analyses must explain completely how theirs differ from previous analyses. In addition, those who generate and then share clinical trial data sets deserve substantial credit for their efforts. Those using data collected by others should seek collaboration with those who collected the data. However, because collaboration will not always be possible, practical, or desired, an alternative means of providing appropriate credit needs to be developed and recognized in the academic community. We welcome ideas about how to provide such credit.

Data sharing is a shared responsibility. Editors of individual journals can help foster data sharing by changing the requirements of the manuscripts they will consider for publication in their journals. Funders and sponsors of clinical trials are in a position to support and ensure adherence to IPD-sharing obligations. If journal editors become aware that IPD-sharing obligations are not being met, they may choose to request additional information; to publish an expression of concern; to notify the sponsors, funders, or institutions; or in certain cases, to retract the publication.

In the rare situation in which compliance with these requirements is impossible, editors may consider authors’ requests for exceptions. If an exception is made, the reason(s) must be explained in the publication.

Sharing data will increase confidence and trust in the conclusions drawn from clinical trials. It will enable the independent confirmation of results, an essential tenet of the scientific process. It will foster the development and testing of new hypotheses. Done well, sharing clinical trial data should also make progress more efficient by making the most of what may be learned from each trial and by avoiding unwarranted repetition. It will help to fulfill our moral obligation to study participants, and we believe it will benefit patients, investigators, sponsors, and society.

Historical Parallels, Ebola Virus Disease and Cholera: Understanding Community Distrust and Social Violence with Epidemics

PLoS Currents: Outbreaks
http://currents.plos.org/outbreaks/
(Accessed 30 January 2016)

.
Historical Parallels, Ebola Virus Disease and Cholera: Understanding Community Distrust and Social Violence with Epidemics
January 26, 2016 · Discussion
In the three West African countries most affected by the recent Ebola virus disease (EVD) outbreak, resistance to public health measures contributed to the startling speed and persistence of this epidemic in the region. But how do we explain this resistance, and how have people in these communities understood their actions? By comparing these recent events to historical precedents during Cholera outbreaks in Europe in the 19th century we show that these events have not been new to history or unique to Africa. Community resistance must be analysed in context and go beyond simple single-variable determinants. Knowledge and respect of the cultures and beliefs of the afflicted is essential for dealing with threatening disease outbreaks and their potential social violence.

Strategies to Prevent Cholera Introduction during International Personnel Deployments: A Computational Modeling Analysis Based on the 2010 Haiti Outbreak

PLoS Medicine
http://www.plosmedicine.org/
(Accessed 30 January 2016)

.
Editorial
Can Data Sharing Become the Path of Least Resistance?
The PLOS Medicine Editors
Published: January 26, 2016
DOI: 10.1371/journal.pmed.1001949
Initial text
The year 2016 could be the year when medical research converges on data sharing as a universal standard, if recent events, reflected in several PLOS Medicine articles this month, are a good indication. Attaining that standard, however, may take a little longer…

.

Strategies to Prevent Cholera Introduction during International Personnel Deployments: A Computational Modeling Analysis Based on the 2010 Haiti Outbreak
Joseph A. Lewnard, Marina Antillón, Gregg Gonsalves, Alice M. Miller, Albert I. Ko, Virginia E. Pitzer
Research Article | published 26 Jan 2016 | PLOS Medicine
10.1371/journal.pmed.1001947
Abstract
Background
Introduction of Vibrio cholerae to Haiti during the deployment of United Nations (UN) peacekeepers in 2010 resulted in one of the largest cholera epidemics of the modern era. Following the outbreak, a UN-commissioned independent panel recommended three pre-deployment intervention strategies to minimize the risk of cholera introduction in future peacekeeping operations: screening for V. cholerae carriage, administering prophylactic antimicrobial chemotherapies, or immunizing with oral cholera vaccines. However, uncertainty regarding the effectiveness of these approaches has forestalled their implementation by the UN. We assessed how the interventions would have impacted the likelihood of the Haiti cholera epidemic.
Methods and Findings
We developed a stochastic model for cholera importation and transmission, fitted to reported cases during the first weeks of the 2010 outbreak in Haiti. Using this model, we estimated that diagnostic screening reduces the probability of cases occurring by 82% (95% credible interval: 75%, 85%); however, false-positive test outcomes may hamper this approach. Antimicrobial chemoprophylaxis at time of departure and oral cholera vaccination reduce the probability of cases by 50% (41%, 57%) and by up to 61% (58%, 63%), respectively. Chemoprophylaxis beginning 1 wk before departure confers a 91% (78%, 96%) reduction independently, and up to a 98% reduction (94%, 99%) if coupled with vaccination. These results are not sensitive to assumptions about the background cholera incidence rate in the endemic troop-sending country. Further research is needed to (1) validate the sensitivity and specificity of rapid test approaches for detecting asymptomatic carriage, (2) compare prophylactic efficacy across antimicrobial regimens, and (3) quantify the impact of oral cholera vaccine on transmission from asymptomatic carriers.
Conclusions
Screening, chemoprophylaxis, and vaccination are all effective strategies to prevent cholera introduction during large-scale personnel deployments such as that precipitating the 2010 Haiti outbreak. Antimicrobial chemoprophylaxis was estimated to provide the greatest protection at the lowest cost among the approaches recently evaluated by the UN.

Assessing Progress towards Public Health, Human Rights, and International Development Goals Using Frontier Analysi

PLoS One
http://www.plosone.org/
[Accessed 30 January 2016]

.

Assessing Progress towards Public Health, Human Rights, and International Development Goals Using Frontier Analysis
Jeanne Luh, Ryan Cronk, Jamie Bartram
Research Article | published 26 Jan 2016 | PLOS ONE
10.1371/journal.pone.0147663
71/journal.pone.0145548
Abstract
Indicators to measure progress towards achieving public health, human rights, and international development targets, such as 100% access to improved drinking water or zero maternal mortality ratio, generally focus on status (i.e., level of attainment or coverage) or trends in status (i.e., rates of change). However, these indicators do not account for different levels of development that countries experience, thus making it difficult to compare progress between countries. We describe a recently developed new use of frontier analysis and apply this method to calculate country performance indices in three areas: maternal mortality ratio, poverty headcount ratio, and primary school completion rate. Frontier analysis is used to identify the maximum achievable rates of change, defined by the historically best-performing countries, as a function of coverage level. Performance indices are calculated by comparing a country’s rate of change against the maximum achievable rate at the same coverage level. A country’s performance can be positive or negative, corresponding to progression or regression, respectively. The calculated performance indices allow countries to be compared against each other regardless of whether they have only begun to make progress or whether they have almost achieved the target. This paper is the first to use frontier analysis to determine the maximum achievable rates as a function of coverage level and to calculate performance indices for public health, human rights, and international development indicators. The method can be applied to multiple fields and settings, for example health targets such as cessation in smoking or specific vaccine immunizations, and offers both a new approach to analyze existing data and a new data source for consideration when assessing progress achieved.

Cervical Cancer Screening in Partly HPV Vaccinated Cohorts – A Cost-Effectiveness Analysis

PLoS One
http://www.plosone.org/
[Accessed 30 January 2016]

.
Cervical Cancer Screening in Partly HPV Vaccinated Cohorts – A Cost-Effectiveness Analysis
Steffie K. Naber, Suzette M. Matthijsse, Kirsten Rozemeijer, Corine Penning, Inge M. C. M. de Kok, Marjolein van Ballegooijen
Research Article | published 29 Jan 2016 | PLOS ONE
10.13
Abstract
Background
Vaccination against the oncogenic human papillomavirus (HPV) types 16 and 18 will reduce the prevalence of these types, thereby also reducing cervical cancer risk in unvaccinated women. This (measurable) herd effect will be limited at first, but is expected to increase over time. At a certain herd immunity level, tailoring screening to vaccination status may no longer be worth the additional effort. Moreover, uniform screening may be the only viable option. We therefore investigated at what level of herd immunity it is cost-effective to also reduce screening intensity in unvaccinated women.
Methods
We used the MISCAN-Cervix model to determine the optimal screening strategy for a pre-vaccination population and for vaccinated women (~80% decreased risk), assuming a willingness-to-pay of €50,000 per quality-adjusted life year gained. We considered HPV testing, cytology testing and co-testing and varied the start age of screening, the screening interval and the number of lifetime screens. We then calculated the incremental cost-effectiveness ratio (ICER) of screening unvaccinated women with the strategy optimized to the pre-vaccination population as compared to with the strategy optimized to vaccinated women, assuming different herd immunity levels.
Results
Primary HPV screening with cytology triage was the optimal strategy, with 8 lifetime screens for the pre-vaccination population and 3 for vaccinated women. The ICER of screening unvaccinated women 8 times instead of 3 was €28,085 in the absence of herd immunity. At around 50% herd immunity, the ICER reached €50,000.
Conclusion
From a herd immunity level of 50% onwards, screening intensity based on the pre-vaccination risk level becomes cost-ineffective for unvaccinated women. Reducing the screening intensity of uniform screening may then be considered.

.

Science – 29 January 2016

Science
29 January 2016 Vol 351, Issue 6272
http://www.sciencemag.org/current.dtl

.
EDITORIAL
Global science engagement
Geraldine Richmond
Summary
In rural Laos, more than 50% of newborns will be stunted by age 2 due to chronic malnourishment. Worldwide, 161 million children under the age of 5, many of them in Africa and Asia, suffered irreversible stunting as of 2013. The developed world is not immune. As recently as 2010, stunting affected 8 to 9% of babies enrolled in U.S. federal food-subsidy programs. Next week in Washington, DC, the American Association for the Advancement of Science (AAAS is the publisher of Science) will convene its annual meeting (11 to 15 February), where world leaders will discuss food security and other major challenges that lie ahead in both the science and international policy arenas.

WHO Director-General addresses the Executive Board

WHO Director-General addresses the Executive Board
Report by the Director-General to the Executive Board at its 138th Session
Geneva, Switzerland
25 January 2016
Madam Chair, distinguished members of the Executive Board, Excellencies, colleagues in the UN system, ladies and gentlemen,
Fifteen months ago, Guinea, Liberia, and Sierra Leone were together reporting more than 950 cases of Ebola every week. Today, the three countries have interrupted all chains of transmission from the original outbreak that began more than two years ago.
This is a monumental achievement that needs to be acknowledged. Please join me in honouring the leadership of the three governments, the heroic sacrifices of health care workers and communities, and the unwavering support from a host of partners.
However, WHO has not yet declared the outbreak in West Africa over. As we now know, the virus can hide in the bodies of fully recovered survivors for as long as a year.
Since March of last year, WHO has documented 11 small flare-ups of infection following reintroduction of the virus from survivors. All were rapidly detected and quickly contained.
On 14 January, WHO declared that the outbreak in Liberia, the last country reporting cases, was over, but warned that the risk of further flare-ups would persist. The warning was well-founded. The next day, Sierra Leone confirmed its first new case since September of last year.

Let me put this setback in perspective.
First, these countries promptly report new cases. Vigilance is intense. Our view of the situation is sharp and transparent.
Second, these countries have the world’s largest pool of expertise in responding to Ebola. They know exactly what to do.
Third, I still have more than 1000 staff in West Africa to assist in detecting and responding to flare-ups like this one. I thank them for their skill and dedication.
Finally, thanks to a WHO-led clinical trial, we have a vaccine that can be used to confer a back-up ring of protection.
The Ebola virus is stubborn. I have no doubt that further flare-ups will occur. I have no doubt that all will be quickly contained.
The outbreak lingers in a second sense as well. Well over 10,000 survivors face persistent health problems together with continuing stigmatization. They need care.
Ebola delivered an extremely severe and shattering blow to societies and economies. Recovery will take some time.
While the job is by no means finished, no one anticipates that the situation will return to what we were seeing 15 months ago.
The determination is fierce. International solidarity has been extraordinary. The many steps taken at national and international levels have had a decisive impact.
No one will let this virus take off and run away again….

In the wake of Ebola, health officials are more alert to alarming signals coming from the microbial world.
Last year’s MERS outbreak in the Republic of Korea showed the devastation a new disease can cause, even in a country with an advanced health system.
The explosive spread of Zika virus to new geographical areas, with little population immunity, is another cause for concern, especially given the possible link between infection during pregnancy and babies born with small heads.
Although a causal link between Zika infection in pregnancy and microcephaly has not been established, the circumstantial evidence is suggestive and extremely worrisome. An increased occurrence of neurological syndromes, noted in some countries coincident with arrival of the virus, adds to the concern.
I thank all newly affected countries for detecting the virus quickly, and promptly and transparently notifying WHO in line with the International Health Regulations.
I have asked Dr Carissa Etienne to brief the Board later this week on the current Zika situation and our response.

Yet another alarming signal was China’s detection last year, in animal and human samples, of a mechanism of drug resistance, involving the mcr-1 gene, that is easily transferred from one bacterial strain to others, including some with epidemic potential.
That finding, which raised the spectre of bacteria that are resistant to nearly all antibiotics, has since been replicated in several other countries.

Ladies and gentlemen,
In my address to last year’s Health Assembly, I announced my intention to create a new programme for responding to outbreaks and humanitarian emergencies.
I expressed my desire to design the programme for effectiveness, speed, flexibility, and rapid impact, with administrative procedures and business processes fit to support its operational platform.
In July, I appointed a group of very senior experts to advise me on the programme’s functions, structure, administration, and lines of managerial accountability. The advisory group provided this guidance with great diligence, and in great detail. The group was frank, critical, and thorough.
The experts looked at all independent assessments of the Ebola response issued to date and analysed the experiences of some effective emergency operations, like those run by the World Food Programme and UNICEF.
The group held eight meetings, beginning in July, and delivered its final report to me last week.
The experts in the advisory group called for profound transformational changes in the way we respond to outbreaks and emergencies.
This is what was needed. This is what I wanted. This is what is widely regarded as the right direction to take.
Let me reassure you, our Member States that the Regional Directors and I are determined to change the way we respond to outbreaks and emergencies. The lessons from Ebola must be applied.
We are committed to implementing a single programme, with a single line of accountability, a single budget, a single set of business processes, a single cadre of staff, and a single set of performance benchmarks that cut across all three levels of WHO.
These changes will make WHO much stronger, at all levels, in supporting countries and building national and global capacity to prevent, detect, and respond to emergencies with health consequences.
The new programme for health emergency management will have an operational arm, complementing WHO’s established functions in setting norms and standards.

As with outbreaks, the complexity of humanitarian emergencies underscores the need for transformational changes in our response capacity.
Ongoing armed conflicts and protracted crises have left an unprecedented 77 million people in urgent need of essential health care. Some 60 million of these people have been uprooted from their homes, the largest number since the Second World War.
Their health expectations are not high. They just want to survive.
I join others in deploring the attacks on health care workers and facilities that are becoming almost routine in the Middle East, including the recent bombing of a polio vaccination centre in Pakistan.
I join others, including the UN Secretary-General, in deploring the use of siege tactics as a method of warfare. Such tactics target civilians and violate international humanitarian law.
Has the world lost its moral compass? Even wars have laws. Forcing civilians to starve to death breaks those laws.
On the positive side, the world showed its solidarity before a shared threat last December in Paris, when 195 countries adopted a climate treaty. But more needs to be done to address the root causes of other crises that profoundly threaten health.
It is easier to deliver humanitarian assistance than to work out political solutions to the root causes of protracted conflict, violent extremism, terrorism, and the forced displacement of millions.
The world has rallied in support, delivering unprecedented levels of humanitarian assistance. But the costs of doing so are unsustainable.

Ebola taught the world that an outbreak in any part of the world can have global repercussions. The refugee crisis in Europe taught the world that wars in faraway places will not stay remote.
In a profoundly interconnected world, there is no such thing as a local outbreak. There is no such thing as a faraway war. As some assessments of the Ebola response have concluded, having strong public health infrastructures and capabilities in place in vulnerable countries is the first line of defence against the infectious disease threat.

Universal health coverage, based on the principles of primary health care, is an instrument for improving the resilience of health systems and the resilience of communities. It tackles the root causes of conditions that let outbreaks hide undetected for months and run out of control.
Universal health coverage is also the most efficient way to respond to the rise of noncommunicable diseases. It is a pillar of sustainable development that supports multiple goals and targets in the 2030 development agenda.
Development that is inclusive and sustainable is by far the best way to build resilience to the shocks our world keeps delivering with ever-greater force.

Ladies and gentlemen,
The Sustainable Development Goals, the SDGs, respect the way that all dimensions of life on this planet shape human health. The agenda is unprecedented in its scope and breath-taking in its ambition.
Health is the focus of goal three, but multiple other goals and targets address the social, economic, and environmental determinants of health.
The thirteen targets under the health goal continue the unfinished business of the Millennium Development Goals and respond to some additional health threats, namely NCDs and mental health, substance abuse, road traffic crashes, and hazardous environmental chemicals.
The inclusion of universal health coverage is the target that underpins all others and is key to their achievement. Health benefits greatly from the agenda’s broad and integrated approach, especially when it comes to the target set for NCDs.
The SDGs easily accommodate recent global strategies and plans of action approved by our Member States. In fact, all 13 health targets are reflected in your agenda for this EB session.
However, the new agenda has profound implications for the way WHO operates, not supplying health services but delivering what countries and their people need and expect.
The SDGs call for stronger country offices, a firm emphasis on innovation, and greater collaboration with partners and multiple sectors of government.
Our programmes that contributed so much to the MDGs for reducing maternal and child mortality, and turning around the epidemics of HIV, tuberculosis, malaria, and the neglected tropical diseases are mature.
They are well-placed to support even more ambitious targets, aligned with the SDG principles of integrated and inclusive approaches that deliver country-level results.
The culture of measurement and accountability, introduced during the MDG era, will continue. Determination to address the health needs of women and adolescents is strong.
Initiatives for the eradication of polio and guinea worm disease have moved forward greatly over the past year. These efforts must continue.

Ladies and gentlemen,
The future is clouded by some major threats to health that encircle the globe. They define some top priorities for urgent and collaborative action in the months ahead.
The volatile microbial world is an ever-present threat. As underscored during last year’s Health Assembly, too many countries lack the core capacities needed to implement the International Health Regulations.
This must change. These countries must be supported to build IHR core capacities to prevent, detect, and respond to outbreaks.
The Global Policy Group has endorsed the Joint External Evaluation tool for the assessment of gaps so that technical support to the countries, from WHO and partners, can be provided.
Noncommunicable diseases are a growing threat with major risk factors that can be modified.

Later today, the Commission on Ending Childhood Obesity will present its final report to me.
The report uses the latest cutting-edge science to deliver a series of policy recommendations with teeth. Implementing the recommendations will take political will, and courage, as some go against the interests of powerful economic operators.
Antimicrobial resistance is a danger of the utmost urgency. This year will be a pivotal one, culminating in a UN high level meeting on AMR later this year. We have a global action plan. What we need now is the action.
A top priority is to fully engage ministers responsible for agriculture and food. We will explore ways to do so during next month’s European Union ministerial conference on antimicrobial resistance in Amsterdam.
Climate change is another defining issue for health. While the Paris climate accord is a most welcome step forward, it will not prevent a number of immediate and severe health consequences.
We need to sharpen our programmes for dealing with these consequences, like outbreaks of cholera and dengue, the disruptions in food security that follow droughts and floods, the ill health linked to indoor and outdoor pollution, and the need for emergency assistance following extreme weather events.
The priority dearest to my heart is, of course, universal health coverage. Packed into that commitment are a host of issues that are important for you and all Member States: like access to safe and effective medicines, an adequate health workforce, finding ways to make health products more affordable, and the challenge of caring for ageing populations, especially people with dementia.
By stressing people instead of diseases, universal health coverage provides a much needed, compassionate, and more responsive platform for delivering coherent and integrated health services. By honouring the human right to health, and providing protection against financial ruin, it helps alleviate the root cause of significant human misery.
It embodies that commitment to fairness that I believe is at the heart of what WHO does best.
We must always remember the people. People seeing their families and communities devastated by an outbreak. Children trapped in obesogenic environments.
People with a common infection whose doctors say, “Sorry, there is nothing I can do.” People forced to leave their homes by war or weather.
People driven into poverty by the costs of a disease like cancer or a car crash.
These are the people, and their needs, that must drive our commitment.
Thank you.

Vaccines and Global Health: The Week in Review 23 January 2016

Vaccines and Global Health: The Week in Review is a weekly digest  summarizing news, events, announcements, peer-reviewed articles and research in the global vaccine ethics and policy space. Content is aggregated from key governmental, NGO, international organization and industry sources, key peer-reviewed journals, and other media channels. This summary proceeds from the broad base of themes and issues monitored by the Center for Vaccine Ethics & Policy in its work: it is not intended to be exhaustive in its coverage. You are viewing the blog version of our weekly digest, typically comprised of between 30 and 40 posts below all dated with the current issue date

.Request an Email Summary: Vaccines and Global Health : The Week in Review is published as a single email summary, scheduled for release each Saturday evening before midnight (EDT in the U.S.). If you would like to receive the email version, please send your request to david.r.curry@centerforvaccineethicsandpolicy.org.

pdf version A pdf of the current issue is available here:  Vaccines and Global Health_The Week in Review_23 January 2016

blog edition: comprised of the approx. 35+ entries posted below on 24January 2016.

Twitter:  Readers can also follow developments on twitter: @vaxethicspolicy.
.
Links:  We endeavor to test each link as we incorporate it into any post, but recognize that some links may become “stale” as publications and websites reorganize content over time. We apologize in advance for any links that may not be operative. We believe the contextual information in a given post should allow retrieval, but please contact us as above for assistance if necessary.

.
David R. Curry, MS
Executive Director
Center for Vaccine Ethics and Policy
a program of the
– Division of Medical Ethics, NYU Medical School
– Children’s Hospital of Philadelphia Vaccine Education Center
Associate Faculty, Division of Medical Ethics, NYU Medical School

EBOLA/EVD [to 23 January 2016]

EBOLA/EVD [to 23 January 2016]
Public Health Emergency of International Concern (PHEIC); “Threat to international peace and security” (UN Security Council)

.

Ebola Situation Report – 20 January 2016
SUMMARY [Excerpts]
:: Human-to-human transmission directly linked to the 2014 Ebola virus disease (EVD) outbreak in West Africa was declared to have ended in Sierra Leone on 7 November 2015. The country then entered a 90-day period of enhanced surveillance to ensure the rapid detection of any further cases that might arise as a result a missed transmission chain, reintroduction from an animal reservoir, importation from an area of active transmission, or re-emergence of virus that had persisted in a survivor. On 14 January, 68 days into the 90-day surveillance period, a new confirmed cases of EVD was reported in Sierra Leone after a post-mortem swab collected from a deceased 22-year-old woman tested positive for Ebola virus. The woman died on 12 January at her family home in the town of Magburaka, Tonkolili district, and received an unsafe burial. In the preceding 2 weeks the woman travelled from Port Loko, where she was a student, via the districts of Kambia and Bombali before arriving in Magburaka on 7 January. Reports indicate that her symptoms during travel included vomiting and diarrhoea. The Sierra Leone Ministry of Health and Sanitation (MoHS), with the support of WHO and other partners, responded rapidly to the new case, identifying approximately 150 contacts of whom approximately 50 are deemed to be at high risk. Vaccination of contacts and contacts of contacts is underway under the authority and coordination of the Sierra Leone MoHS. However, the woman’s extensive travel history in the 2 weeks prior to her death, her presentation to and subsequent discharge from a health care facility at which health workers did not use personal protective equipment (PPE), her period of close contact with family whilst ill, and her unsafe burial indicate a significant risk of further transmission. One contact in Tonkolili remains to be traced. The origin of infection is under investigation.

:: Human-to-human transmission linked to the most recent cluster of cases in Liberia was declared to have ended on 14 January 2016. Guinea was declared free of Ebola transmission on 29 December 2015, and has now entered a 90-day period of enhanced surveillance that is due to end on 27 March 2016.

:: With guidance from WHO and other partners, ministries of health in Guinea, Liberia and Sierra Leone have plans to deliver a package of essential services to safeguard the health of the estimated more than 10,000 survivors of EVD, and enable those individuals to take any necessary precautions to prevent infection of their close contacts. Over 300 male survivors in Liberia had accessed semen screening and counselling services by 17 January 2016…

.
Ebola vaccine purchasing commitment from Gavi to prepare for future outbreaks
20 January 2016
Agreement will help push vaccine towards regulatory approval.
Davos, 20 January 2016 – Gavi, the Vaccine Alliance and Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. (known as MSD outside the U.S. and Canada) have signed an agreement to support the provision of a vaccine to protect against future deadly Ebola outbreaks. The agreement, announced today at the World Economic Forum in Davos, will help Merck take the vaccine through licensure and WHO prequalification.

Under the Advance Purchase Commitment, Gavi has provided US$ 5 million towards the development of Merck’s rVSV∆G-ZEBOV-GP live attenuated Ebola Zaire vaccine, on the understanding that it will be submitted for licensure by the end of 2017. If approved, it would become one of the world’s first licensed Ebola vaccines and Gavi would be able to begin purchasing the vaccine to create a stockpile for future outbreaks.

Additionally, Merck will ensure that 300,000 doses of the vaccine are available from May 2016 for use in expanded use clinical trials and/or for emergency use as needed while vaccine development continues. Merck has already submitted an application through WHO’s Emergency Use Assessment and Listing (EUAL) procedure. If the EUAL is approved, this will provide an opportunity for the investigational vaccine to be used if another public health emergency with Ebola occurs before the vaccine is licensed.

“The suffering caused by the Ebola crisis was a wake-up call to many in the global health community,” said Gavi CEO Dr Seth Berkley. “New threats require smart solutions and our innovative financing agreement with Merck will ensure that we are ahead of the curve for future Ebola outbreaks.”

“We are very pleased to join with Gavi in announcing this Advance Purchase Commitment agreement to support the provision of MSD’s investigational monovalent Ebola Zaire vaccine – in case of a resurgence of the Ebola outbreak or a new outbreak,” said Dr Julie Gerberding, executive vice president, Strategic Communications, Global Public Policy and Population Health for Merck. “We applaud Gavi for this bold step to be a part of the solution to address a disease that has impacted so many lives.”…

.
Guinea Revives Border Health Screening to Mitigate Risk of Spread of Ebola
01/22/16 – IOM / International Organization for Migration
Guinea – Following the confirmation of a new Ebola case in Sierra Leone on January 12 – and confirmation of another case on January 20th – IOM and its partners are reactivating cross-border health screening at Guinea’s borders with Sierra Leone and reinforcing their surveillance capacity in Forecariah Prefecture, the border area closest to the outbreak.

.
WHO: Clinical care for survivors of Ebola virus disease
22 January 2016 — Today, there are over 10 000 survivors of Ebola virus disease. A number of medical problems have been reported in survivors, including mental health issues. Ebola virus may persist in some body fluids, including semen. Ebola survivors need comprehensive support for the medical and psychosocial challenges they face and also to minimize the risk of continued Ebola virus transmission. WHO has developed this document to guide health services on how to provide quality care to survivors of Ebola virus disease.
Read the guidance for survivors

POLIO [to 23 January 2016]

POLIO [to 23 January 2016]
Public Health Emergency of International Concern (PHEIC)

.

Polio this week as of 20 January 2016
:: There are three months to go until the globally synchronized switch from the trivalent to bivalent oral polio vaccine, an important milestone in achieving a polio-free world. Read more here.
:: A sample from environmental surveillance in Kabul, Afghanistan has tested positive for wild poliovirus type 1. A vaccination response is being planned for the immediate vicinity.

Selected content from country-level reports
Afghanistan
:: Two new WPV1 environmental positive samples were reported in the past week – one in Jalalabad in Nangarhar province, and the second Kabul city. Both samples were collected on 27 December 2015.
:: Subnational Immunization Days (SNIDs) were carried out in the south on 12 to 15 January using bOPV. Further SNIDs are planned from 16 to 19 February, also using bOPV and National Immunization Days (NIDs) are planned from 15 to 18 March using tOPV, prior to the switch. Read more about the switch here.
Pakistan
:: One new wild poliovirus type 1 (WPV1) case was reported in the past week, with onset of paralysis on 22 December 2015 in Peshawar. The total number of WPV1 cases for 2015 is now 53, compared to 303 reported for 2014 by this time last year. A total of 306 cases occurred in Pakistan in 2014.
:: Two new WPV1 environmental positive samples were detected in Karachi’s Gadap Town in Sindh province and Quetta, Balochistan with collection dates of 11 December 2015 and 14 December 2015 respectively
Lao People’s Democratic Republic
:: One new case of circulating vaccine-derived poliovirus type 1 (cVDPV1) was reported in the past week, in Longxan district of Xaysomboune province with onset of paralysis on 18 November 2015. The total number of cVDPV1 cases in 2015 is now seven.
:: Outbreaks of cVDPVs can arise in areas with low population immunity, emphasizing the importance of maintaining strong vaccination coverage. Learn more about VDPVs.
:: An emergency outbreak response is continuing in the country, with particular focus on three high-risk provinces.

.
ECHO [to 23 January 2016]
http://ec.europa.eu/echo/en/news
22/01/2016
EU supports vaccination campaign to combat polio in Ukraine
The European Commission is providing €1.2 million to support a third round of polio vaccinations in Ukraine following the start of an outbreak in August last year.

The vaccination campaign is carried out with the cooperation of relevant Ukrainian government ministries, UNICEF and the World Health Organisation (WHO).

Speaking at a press conference in Kiev today launching the latest vaccination drive, Director of Operations of the European Commission’s Humanitarian Aid and Civil Protection department (ECHO), Jean-Louis de Brouwer, stated: “I laud the combined efforts of the Ministries of Health and Education who, together with our partners UNICEF and WHO, have made tremendous strides in vaccinating thousands of children against this dreaded disease”.

The first two rounds of polio vaccinations took place in November 2015, after an outbreak was confirmed by WHO. The third round of vaccinations will target 4.75 million children aged 0-10.
The funding is being made available through the European Commission’s Humanitarian Aid and Civil Protection department (ECHO). The vaccines were flown in the first week of January in preparation for the latest vaccination drive…

WHO & Regionals [to 23 January 2016]

WHO & Regionals [to 23 January 2016]

El Niño threatens at least 60 million people
22 January 2016 — WHO and partners predict a major global increase in health-related emergencies this year due to El Niño. According to a new WHO report, severe drought, flooding, rains and temperature rises are all known effects of El Niño that can lead to food insecurity, malnutrition, disease outbreaks, acute water shortages and disruption of health services.
Read the story on El Niño and health

.

Weekly Epidemiological Record (WER) 22 January 2016, vol. 91, 3 (pp. 21–32)
Contents
21 Global Advisory Committee on Vaccine Safety, 2–3 December 2015
31 Monthly report on dracunculiasis cases, January– November 2015

.

Disease Outbreak News (DONs)
:: 21 January 2016 – Zika virus infection – France – Saint Martin and Guadeloupe
:: 21 January 2016 – Guillain-Barré syndrome – El Salvador
:: 21 January 2016 – Zika virus infection – Haiti
:: 20 January 2016 – Zika virus infection – Bolivia
:: 20 January 2016 – Zika virus infection – Guyana, Barbados and Ecuador
:: 19 January 2016 – Human infection with avian influenza A(H7N9) virus – China
Call for nomination of experts to serve on the Strategic Advisory Group of Experts on immunization (SAGE) Working Group on Typhoid Vaccines
20 January 2016
.

:: WHO Regional Offices
WHO African Region AFRO
No new digest content identified.

WHO Region of the Americas PAHO
:: As the Zika virus spreads, PAHO advises countries to monitor and report birth anomalies and other suspected complications of the virus (01/18/2016)
:: PAHO helps countries in the Americas prepare for spread of Zika (01/16/2016)

WHO South-East Asia Region SEARO
No new digest content identified.

WHO European Region EURO
:: Collaboration on refugee and migrant health 21-01-2016
Countries in the WHO European Region have agreed to prepare a common framework for coordinated collaboration and action on refugee and migrant health, based on solidarity and mutual assistance and in the spirit of the 2030 Sustainable Development agenda, whereby “no one should be left behind”
…The document states, among other issues:
:: Migrants and refugees do not pose an additional threat to health security in host communities.
:: Screening can be an effective public health instrument but should be non-discriminatory and non-stigmatizing and should benefit both the individual and the public.
:: Special attention should be paid to the most vulnerable groups, such as children, pregnant women, the elderly, people with disabilities and victims of torture.
:: Health records and health cards must be made portable as a priority…

WHO Eastern Mediterranean Region EMRO
:: New delivery rooms in camps for the internally displaced in Iraq save the lives of mothers and babies
20 January 2016

WHO Western Pacific Region
No new digest content identified.

CDC/ACIP [to 23 January 2016]

CDC/ACIP [to 23 January 2016]
http://www.cdc.gov/media/index.html

.

CDC adds countries to interim travel guidance related to Zika virus
FRIDAY, JANUARY 22, 2016
CDC is working with other public health officials to monitor for ongoing Zika virus‎ transmission. Today, CDC added the following destinations to the Zika virus travel alerts: Barbados, Bolivia, Ecuador, Guadeloupe, Saint Martin, Guyana, Cape Verde, and Samoa. On January 15, CDC issued a travel alert (Level 2-Practice Enhanced Precautions) for people traveling to regions and certain countries where Zika virus transmission is ongoing: the Commonwealth of Puerto Rico, a U.S. territory; Brazil; Colombia; El Salvador; French Guiana; Guatemala; Haiti; Honduras; Martinique; Mexico; Panama; Paraguay; Suriname; and Venezuela. Specific areas where Zika virus transmission is ongoing are often difficult to determine and are likely to continue to change over time…

.

MMWR Weekly – January 22, 2016 / Vol. 65 / No. 2
http://www.cdc.gov/mmwr/index2015.html
:: Inadequate Diagnosis and Treatment of Malaria Among Travelers Returning from Africa During the Ebola Epidemic — United States, 2014–2015
:: Interim Guidelines for Pregnant Women During a Zika Virus Outbreak — United States, 2016
:: Notes from the Field: Outbreak of Locally Acquired Cases of Dengue Fever — Hawaii, 2015

Gavi launches ‘INFUSE’ initiative to overcome barriers to immunisation

Gavi [to 23 January 2016]
http://www.gavialliance.org/library/news/press-releases/

.
22 January 2016
Gavi launches ‘INFUSE’ initiative to overcome barriers to immunisation
Call to entrepreneurs, corporations and implementers to innovate and improve vaccine delivery.
Davos, 22 January 2016 – Gavi, the Vaccine Alliance today called for proven-concept innovations from entrepreneurs and companies that could drive improvements in immunisation in developing countries. The Geneva-based public-private partnership will identify the most promising concepts and technologies and connect them with influential public and private sector leaders.

At the World Economic Forum’s annual meeting, Gavi hosted global business leaders, government officials and high-tech innovators to introduce Innovation for Uptake, Scale and Equity in immunisation (INFUSE) – an initiative focused on overcoming the obstacles that lead to almost 19 million children per year not receiving a full course of the most basic vaccines. Gavi CEO Dr Seth Berkley highlighted the importance of harnessing new thinking, potentially from innovators outside the immunisation and global health fields, to reach more children with vaccines.

The INFUSE topic for 2016 is immunisation data availability, quality, and use – a fundamental step to building an efficient and sustainable immunisation systems in developing countries. Gavi will welcome data-related proposals of projects that are either already operating or have completed their pilot phase. Gavi will encourage new partnerships to enable a small number of successful projects to help bridge the gap between pilot phase, small-scale implementation and regional or global scale- up.

“I am excited that Gavi is ready to embrace new and diverse thinking to solve the challenges that are preventing us from reaching children with vaccines,” said Dr Berkley. “Data is absolutely critical to health as it enables us to track both people and diseases. We are looking forward to exploring new possibilities for capturing and using data in the countries we work with.”

INFUSE is open to local and global entrepreneurs, corporations, and implementers with a proven-to-work technology or implementation innovation enhancing data availability, quality, or use, that could be adapted to the broad developing country context. These could include solutions ranging from better tools and training resources for local health workers to track vaccinated children at the point of care, to the application of emerging “deep data” concepts to identify resource gaps and areas for improving health and immunisation systems.

By connecting innovators with influential public and private sector figures, Gavi hopes to accelerate the use of proven-concept innovations to modernise immunisation delivery. Those interested in joining INFUSE can apply online at infuse.gavi.org

Nigerian Governors Partner with Dangote Foundation, Gates Foundation, and USAID to Bring Life-saving Vaccines to Children

BMGF – Gates Foundation [to 23 January 2016]
http://www.gatesfoundation.org/Media-Center/Press-Releases

.
JANUARY 19, 2016
Nigerian Governors Partner with Dangote Foundation, Gates Foundation, and USAID to Bring Life-saving Vaccines to Children
Four northern Nigerian governors, Alhaji Aliko Dangote, Bill Gates, and U.S. Ambassador James Entwistle agree to Memorandum of Understanding to improve routine immunization and strengthen primary health care.

KADUNA (January 20, 2016) – In a ceremony at the Kaduna State Government House, Alhaji Aliko Dangote, chair of the Dangote Foundation; Bill Gates, co-chair of the Bill & Melinda Gates Foundation; and U.S. Ambassador to Nigeria, James Entwistle, joined governors from Kaduna, Sokoto, Yobe, and Borno to launch an ambitious new partnership committing political and financial resources to strengthen and sustain routine immunization programs that will save more lives and keep Nigeria polio-free.

The witnessing of new Memorandums of Understanding (MOUs) served as an opportunity to review successes and lessons learned from existing programs in Kano and Bauchi states. To extend these efforts, the executive governor of Kano State signed a fourth-year extension to the state’s existing MOU.

Professor I.F Adewole, Nigeria’s health minister, congratulated the states and partners for making a significant investment in immunization. “These are tough financial times in Nigeria, but the health of children cannot wait. The country has an ambitious plan to introduce new life-saving vaccines over the next several years, and today’s commitments will ensure we can get those vaccines to the children who need them most.”

Through the MOUs, the governors commit to effective governance, leadership, and financial accountability to reduce child illness and death from diseases such as measles, pertussis, and hepatitis through increased routine immunization in their respective states. The other partners will bring the financial and technical support needed to operationalize the program. All signatories pledged to improve routine immunization coverage in northern Nigeria systematically and sustainably, where vaccine coverage rates are low.

“These agreements strengthen our partnerships with Nigerian states working to provide health services to all their citizens,” said Dangote. “Building on their recent success in eliminating polio from the region, Nigerian governors have and will continue to play a vital role in establishing a legacy of sustained commitment to routine immunization.”

The objective of the MOUs is to reach 80 percent of the target population in the signing states with the necessary life-saving vaccines by December 2018 to prevent common childhood diseases and ensure a polio-free environment. To achieve this, key components of the program include the operationalization of the ‘Primary Health Care Under One Roof’ policy that will see a single management body oversee the program. The implementation of regular audits and reports will ensure transparent funding and financial discipline is paramount during implementation. Contributions towards the costs of the program by the Bill & Melinda Gates Foundation, Dangote Foundation, and state governments will be staggered across three years: 30 percent in year one, 50 percent in year two, and 70 percent in year three with the states taking progressive responsibility for financing immunization services.

“These commitments will improve immunization coverage and help provide reliable health services in Nigeria. The States will be able to reap the full return on their investment through the number of lives improved and saved, and communities will remain protected from vaccine-preventable diseases for years to come,” said Gates. “Nigeria’s governors have the opportunity to build health systems strong enough to stop future outbreaks.” “These MOUs offer the model platform to capitalize on the prospects of evidence-based approaches. Results will include stronger systems for immunizations, equal access to routine immunization services, and building capacity for Nigerian states to lead in developing solutions for its people,” said Ambassador Entwistle.

Fondation Merieux [to 23 January 2016]

Fondation Merieux [to 23 January 2016]
Mission: Contribute to global health by strengthening local capacities of developing countries to reduce the impact of infectious diseases on vulnerable populations.
http://www.fondation-merieux.org/news

.
19 January 2016, Lyon (France)
World’s first dengue vaccine authorized for use in 3 endemic countries
A long awaited tool for dengue prevention and control has finally become available in three endemic countries. During the month of December, health authorities in Mexico, the Philippines and Brazil granted marketing authorization for the first dengue vaccine.

The Partnership for Dengue Control (PDC), hosted by Fondation Mérieux, considers a dengue vaccine to be an essential part of the integrated approach needed to lower the burden of dengue fever globally, which the WHO estimates at nearly 400 million infections each year…

IVI [to 23 January 2016]

IVI [to 23 January 2016]
http://www.ivi.org/web/www/home

.
2016.01.21
First Joint Symposium between IVI and Shanghai Public Health Clinical Center, Jan. 22-23, 2016
IVI and Shanghai Public Health Clinical Center (SPCC), an affiliate of Fudan University, are hosting a vaccine symposium that will take place at IVI on Jan. 22-23. The symposium will be the first meeting of its kind between IVI and SPCC. The multidisciplinary symposium will provide a platform for Korean and Chinese scientists to share data and to discuss international research collaborations across cross-cutting themes such as: a) Emerging and re-emerging infectious diseases; b) Viral infection and immunity; and c) Development of vaccines and protective antibodies. The symposium is sponsored by the National Natural Science Foundation of China and the National Research Foundation of Korea.

Global Fund [to 23 January 2016]

Global Fund [to 23 January 2016]
http://www.theglobalfund.org/en/news/

.
22 January 2016
(RED) Marks 10 Years of Contributions to Fight AIDS
DAVOS, Switzerland – The Global Fund congratulates (RED) on 10 years of spectacular private sector engagement in the fight against AIDS, as (RED) celebrates its anniversary today at the World Economic Forum in Davos and announces that it has generated contributions of more than US$350 million

.

Deal on Mosquito Nets to Yield $93 million in Savings
18 January 2016
GENEVA – As part of a new framework for procuring health products in the most cost-effective and sustainable way, the Global Fund has reached an agreement to purchase insecticide-treated mosquito nets that prevent malaria with projected savings of US$93 million over two years.

By achieving sharply lower prices for nets – a 38 percent reduction from 2013 – the agreement serves the Global Fund’s goal of accelerating progress against malaria, a preventable disease that most seriously affects young children and pregnant women. Building on the Global Fund’s large-scale purchasing power, the framework improves the supply of an important tool to fight the epidemic.

The Global Fund projects US$350 million in mosquito net purchases over the next two years through its Pooled Procurement Mechanism. A tender process has selected 10 suppliers and includes volume commitments from the Global Fund and performance contracts from the suppliers.

The agreement creates a level of certainty for suppliers, allowing them greater visibility and planning time to manufacture and deliver nets. That facilitates lower prices, and yields significant savings for the Global Fund partnership. The US$93 million in projected savings is equivalent to about 40 million additional nets…

Preparing for the Next Pandemic: Fear Cannot be our Motivation

Preparing for the Next Pandemic: Fear Cannot be our Motivation
46th Annual Meeting of the World Economic Forum to Focus on Fourth Industrial Revolution
· WHO’s Chan: national and local capacity must be built to prevent economic, growth and stability issues that arise from health crises
· William H. Gates III: Surveillance and primary care are critical to building resiliency
· World Economic Forum is launching a two-year initiative to manage the risk and impact of future epidemics through optimized public-private cooperation under its newly formed Global Challenge Initiative on the Future of Health

Davos-Klosters, Switzerland, 22 January 2016 – The recent Ebola epidemic challenged leaders of all nations and sectors and brought to light the need for resiliency and infrastructure to prevent and mitigate risks of future outbreaks.

“Dealing with epidemics presents growth, economic and stability issues,” said Margaret Chan, Director-General, World Health Organization (WHO), Geneva. “The world is ill prepared. We need national and local capacity,” she added.

Strengthening surveillance and primary care are critical to building resiliency, said William H. Gates III, Co-Chair, Bill & Melinda Gates Foundation, USA. He pointed to the insights that technology can provide: “If we are serious about dealing with future epidemics, we must do simulations. Primary healthcare will be digitized in the next 10 years. This will be a huge benefit.”

There is shared recognition that slow action will not be an option moving forward. “The Ebola epidemic was difficult and complicated, but it was slow moving,” said Jim Yong Kim, President of The World Bank, Washington DC. “It is much more difficult to deal with fast-moving epidemics.”

“The motivation of fear that brought us together should not be our motivation in the future,” said Ertharin Cousin, Executive Director, United Nations World Food Programme (WFP), Rome.

Addressing these issues will stretch beyond these discussions at the Annual Meeting 2016. The World Economic Forum is launching a two-year initiative to manage the risk and impact of future epidemics through optimized public-private cooperation under its newly formed Global Challenge Initiative on the Future of Health.

The initiative’s efforts will harness the capabilities of the healthcare, mining, telecommunications and mobility industries, among others, to work with national governments, international organizations and civil society to create solid, preventative action plans for emerging outbreaks.

“The Forum’s new Global Challenge Initiative on the Future of Health seeks to drive forward a critical transformation, putting health at the centre before healthcare is needed, with two pillars focused on health promotion and disease prevention. It’s imperative that across all sectors, stakeholders and nations, we find ways to allow healthy lives and health security for all,” said Arnaud Bernaert, Head of Global Health and Healthcare Industries at the World Economic Forum.

BMC Medicine (Accessed 23 January 2016)

BMC Medicine
http://www.biomedcentral.com/bmcmed/content
(Accessed 23 January 2016)

.
Research article
Wasted research when systematic reviews fail to provide a complete and up-to-date evidence synthesis: the example of lung cancer
Perrine Créquit, Ludovic Trinquart, Amélie Yavchitz and Philippe Ravaud
Published on: 20 January 2016

.

Debate
The need for pragmatic clinical trials in low and middle income settings – taking essential neonatal interventions delivered as part of inpatient care as an illustrative example
Mike English, Jamlick Karumbi, Michuki Maina, Jalemba Aluvaala, Archna Gupta, Merrick Zwarenstein and Newton Opiyo
Published on: 18 January 2016

eRegistries: Electronic registries for maternal and child health

BMC Pregnancy and Childbirth
http://www.biomedcentral.com/bmcpregnancychildbirth/content
(Accessed 23 January 2016)

.
Research article
eRegistries: Electronic registries for maternal and child health
The Global Roadmap for Health Measurement and Accountability sees integrated systems for health information as key to obtaining seamless, sustainable, and secure information exchanges at all levels of health…
J. Frederik Frøen, Sonja L. Myhre, Michael J. Frost, Doris Chou, Garrett Mehl, Lale Say, Socheat Cheng, Ingvild Fjeldheim, Ingrid K. Friberg, Steve French, Jagrati V. Jani, Jane Kaye, John Lewis, Ane Lunde, Kjersti Mørkrid, Victoria Nankabirwa…
BMC Pregnancy and Childbirth 2016 16:11
Published on: 19 January 2016

Cost- effectiveness of HPV vaccination regime: comparing twice versus thrice vaccinations dose regime among adolescent girls in Malaysia

BMC Public Health
http://bmcpublichealth.biomed

.
Research article
Cost- effectiveness of HPV vaccination regime: comparing twice versus thrice vaccinations dose regime among adolescent girls in Malaysia
The HPV vaccine was introduced to Malaysian national immunization programme in 2010.
Syed Aljunid, Namaitijiang Maimaiti, Amrizal M Nur, Mohd Rushdan Md Noor and Sharifa Ezat Wan Puteh

International Health – Volume 8 Issue 1 – January 2016

International Health
Volume 8 Issue 1 January 2016
http://inthealth.oxfordjournals.org/content/current

.
EDITORIAL
Violence against children and education
Karen Devries
Int. Health (2016) 8 (1): 1-2 doi:10.1093/inthealth/ihv076
Extract
In most countries around the world, children and adolescents spend more time in school than any other single location besides the family home. Whether or not children and adolescents are able to attend school, whether they are safe in school and whether they leave school with necessary learning and skills, are affected by their experiences of violence—at home, at school and in the community.
Before children get to school, they are often exposed to violence at home. Analysis of the Multiple Indicator Cluster Surveys data from 28 countries shows that 43% of children aged 2–14 years in African countries, and 9% in ‘transitional’ states, have experienced severe physical violence from caregivers.1 There are a host of negative health and social consequences associated with exposure to physical violence in childhood, especially during this early period. These include increased risk of depressive disorders and suicide attempts,2 poor educational attainment3 and increased risk of perpetrating or experiencing intimate partner …

.

Innovative financing for late-stage global health research and development: the Global Health Investment Fund
Joseph Robert Fitchetta,*, Julia Fan Lib and Rifat Atuna
Author Affiliations
aHarvard School of Public Health, Boston, MA, UK
bSeven Bridges Genomics, London, UK
Abstract
Innovative financing strategies for global health are urgently needed to reinvigorate investment and new tools for impact. Bottleneck areas along the research and development (R&D) pipeline require particular attention, such as the transitions from preclinical discovery to clinical study, and product development to implementation and delivery. Successful organizations mobilizing and disbursing resources through innovating financing mechanisms include UNITAID, the Global Fund, and Gavi, the Vaccine Alliance. Although precise numbers are poorly documented, estimated investment in low-income settings falls seriously short of local need. This commentary discusses the newly established Global Health Investment Fund as a case study to support late-stage global health R&D.

Mass immunization with inactivated polio vaccine in conflict zones – Experience from Borno and Yobe States, North-Eastern Nigeria

Journal of Public Health Policy
Volume 37, Issue 1 (February 2016)
http://www.palgrave-journals.com/jphp/journal/v37/n1/index.html

.
Original Article
Mass immunization with inactivated polio vaccine in conflict zones – Experience from Borno and Yobe States, North-Eastern Nigeria
A polio eradication team explains how they planned and accomplished success with a mass immunization campaign despite warlike conditions in the two Nigerian states. This example offers important lessons
Faisal M Shuaibu, Gerida Birukila, Samuel Usman, Ado Mohammed, Michael Galway, Melissa Corkum, Eunice Damisa, Pascal Mkanda, Frank Mahoney, Gatei Wa Nganda, John Vertefeuille, Anna Chavez, Sule Meleh, Richard Banda, Almai Some, Hyelni Mshelia, Al-Umra Umar, Ogu Enemaku, and Andrew Etsano
J Public Health Pol 37: 36-50; advance online publication, November 5, 2015; doi:10.1057/jphp.2015.34
Abstract
The use of Inactivated Polio Vaccine (IPV) in routine immunization to replace Oral Polio Vaccine (OPV) is crucial in eradicating polio. In June 2014, Nigeria launched an IPV campaign in the conflict-affected states of Borno and Yobe, the largest ever implemented in Africa. We present the initiatives and lessons learned. The 8-day event involved two parallel campaigns. OPV target age was 0–59 months, while IPV targeted all children aged 14 weeks to 59 months. The Borno state primary health care agency set up temporary health camps for the exercise and treated minor ailments for all. The target population for the OPV campaign was 685 674 children in Borno and 113 774 in Yobe. The IPV target population for Borno was 608 964 and for Yobe 111 570. OPV coverage was 105.1 per cent for Borno and 103.3 per cent for Yobe. IPV coverage was 102.9 per cent for Borno and 99.1 per cent for Yobe. (Where we describe coverage as greater than 100 per cent, this reflects original underestimates of the target populations.) A successful campaign and IPV immunization is viable in conflict areas.

The Lancet – Jan 23, 2016

The Lancet
Jan 23, 2016 Volume 387 Number 10016 p311-402 e9-e12
http://www.thelancet.com/journals/lancet/issue/current
.

Editorial
Healthy migration needs a long-term plan
The Lancet
Summary
“It occurred to me that no matter where I lived, geography could not save me”, wrote Isabel Wilkerson in The Warmth of Other Suns, recounting stories of black Americans migrating north in the twentieth century. Today, these same words could be used by international migrants who have relocated either by choice or as refugees, many of whom have inadequate access to health care.

.

Comment
The future leadership of WHO
Sally C Davies, Somsak Akksilp, Keizo Takemi, Precious Matsoso, Jarbas Barbosa Da Silva Junior
Summary
In about 3 month’s time, the Director-General of WHO will call for nominations from the Executive Board and Member States for her successor. The selection process will then be launched and a new Director-General elected in 2017.

Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models

The Lancet
Jan 23, 2016 Volume 387 Number 10016 p311-402 e9-e12
http://www.thelancet.com/journals/lancet/issue/current
.

Comment
Implementation of the malaria candidate vaccine RTS,S/AS01
Brian Greenwood, Ogobara K Doumbo
Published Online: 05 November 2015
Summary
As vaccine manufacturers tackle increasingly intractable pathogens, vaccines will be developed that show efficacy, but that are less efficacious than established vaccines. Consequently, regulatory and public health authorities will be faced with difficult decisions about whether such vaccines should be recommended for implementation and, if so, under what circumstances. The RTS,S/AS01 malaria candidate vaccine provides an important example of such a challenge.

.

Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models
Melissa A Penny, Robert Verity, Caitlin A Bever, Christophe Sauboin, Katya Galactionova, Stefan Flasche, Michael T White, Edward A Wenger, Nicolas Van de Velde, Peter Pemberton-Ross, Jamie T Griffin, Thomas A Smith, Philip A Eckhoff, Farzana Muhib, Mark Jit, Azra C Ghani
367
Open Access
Summary
Background
The phase 3 trial of the RTS,S/AS01 malaria vaccine candidate showed modest efficacy of the vaccine against Plasmodium falciparum malaria, but was not powered to assess mortality endpoints. Impact projections and cost-effectiveness estimates for longer timeframes than the trial follow-up and across a range of settings are needed to inform policy recommendations. We aimed to assess the public health impact and cost-effectiveness of routine use of the RTS,S/AS01 vaccine in African settings.
Methods
We compared four malaria transmission models and their predictions to assess vaccine cost-effectiveness and impact. We used trial data for follow-up of 32 months or longer to parameterise vaccine protection in the group aged 5–17 months. Estimates of cases, deaths, and disability-adjusted life-years (DALYs) averted were calculated over a 15 year time horizon for a range of levels of Plasmodium falciparum parasite prevalence in 2–10 year olds (PfPR2–10; range 3–65%). We considered two vaccine schedules: three doses at ages 6, 7·5, and 9 months (three-dose schedule, 90% coverage) and including a fourth dose at age 27 months (four-dose schedule, 72% coverage). We estimated cost-effectiveness in the presence of existing malaria interventions for vaccine prices of US$2–10 per dose.
Findings
In regions with a PfPR2–10 of 10–65%, RTS,S/AS01 is predicted to avert a median of 93 940 (range 20 490–126 540) clinical cases and 394 (127–708) deaths for the three-dose schedule, or 116 480 (31 450–160 410) clinical cases and 484 (189–859) deaths for the four-dose schedule, per 100 000 fully vaccinated children. A positive impact is also predicted at a PfPR2–10 of 5–10%, but there is little impact at a prevalence of lower than 3%. At $5 per dose and a PfPR2–10 of 10–65%, we estimated a median incremental cost-effectiveness ratio compared with current interventions of $30 (range 18–211) per clinical case averted and $80 (44–279) per DALY averted for the three-dose schedule, and of $25 (16–222) and $87 (48–244), respectively, for the four-dose schedule. Higher ICERs were estimated at low PfPR2–10 levels.
Interpretation
We predict a significant public health impact and high cost-effectiveness of the RTS,S/AS01 vaccine across a wide range of settings. Decisions about implementation will need to consider levels of malaria burden, the cost-effectiveness and coverage of other malaria interventions, health priorities, financing, and the capacity of the health system to deliver the vaccine.
Funding
PATH Malaria Vaccine Initiative; Bill & Melinda Gates Foundation; Global Good Fund; Medical Research Council; UK Department for International Development; GAVI, the Vaccine Alliance; WHO.

The Influence of Women’s Empowerment on Child Immunization Coverage in Low, Lower-Middle, and Upper-Middle Income Countries: A Systematic Review of the Literature

Maternal and Child Health Journal
Volume 20, Issue 1, January 2016
http://link.springer.com/journal/10995/20/1/page/1

.
Original Paper
The Influence of Women’s Empowerment on Child Immunization Coverage in Low, Lower-Middle, and Upper-Middle Income Countries: A Systematic Review of the Literature
Sara Thorpe, Kristin VanderEnde, Courtney Peters…
Abstract
Objectives
An estimated 1.5 million children under five die annually from vaccine preventable diseases, and 17% of these deaths can be averted with vaccination. Predictors of immunization coverage, such as maternal schooling, are well documented; yet, preventable under-five mortality persists. To understand these patterns, researchers are exploring the mother–child relationship through an empowerment framework. This systematic review assesses evidence of the relationship between women’s agency as a component of empowerment and vaccine completion among children <5 years in lower-income countries.
Methods
We searched in Socindex, Pubmed, Web of Science and Women’s Studies International for peer-reviewed articles focused on two measures of women’s agency—decision-making and freedom of movement—and child vaccination. Our initial search identified 406 articles and abstracts for screening; 12 studies met the inclusion and exclusion criteria.
Results
A majority (83 %) of studies revealed at least one positive association of measures for women’s agency with immunization coverage. These relationships varied by geographic location, and most studies focused on women’s decision making rather than freedom of movement. No included study came from Latin America or the Middle East.
Conclusions
Overall, women’s agency, typically measured by decision-making, was positively associated with the odds of complete childhood immunizations. Yet, the concept of agency was inconsistently defined and operationalized. Future research should address these inconsistencies and focus on under-represented geographic regions including Latin America and the Middle East.

PLoS Medicine (Accessed 23 January 2016)

PLoS Medicine
http://www.plosmedicine.org/
(Accessed 23 January 2016)

.
Editorial
Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors
Darren B. Taichman, Joyce Backus, Christopher Baethge, Howard Bauchner, Peter W. de Leeuw, Jeffrey M. Drazen, John Fletcher, Frank A. Frizelle, Trish Groves, Abraham Haileamlak, Astrid James, Christine Laine, Larry Peiperl, Anja Pinborg, Peush Sahni, Sinan Wu
| published 20 Jan 2016 | PLOS Medicine
10.1371/journal.pmed.1001950

.

Essay
Sharing Individual Participant Data (IPD) within the Context of the Trial Reporting System (TRS)
Deborah A. Zarin, Tony Tse
| published 19 Jan 2016 | PLOS Medicine
10.1371/journal.pmed.1001946

Factors Contributing to Maternal and Child Mortality Reductions in 146 Low- and Middle-Income Countries between 1990 and 2010

PLoS One
http://www.plosone.org/
[Accessed 23 January 2016]

.
Research Article
Factors Contributing to Maternal and Child Mortality Reductions in 146 Low- and Middle-Income Countries between 1990 and 2010
David M. Bishai, Robert Cohen, Y. Natalia Alfonso, Taghreed Adam, Shyama Kuruvilla, Julian Schweitzer
| published 19 Jan 2016 | PLOS ONE
Abstract
Introduction
From 1990–2010, worldwide child mortality declined by 43%, and maternal mortality declined by 40%. This paper compares two sources of progress: improvements in societal coverage of health determinants versus improvements in the impact of health determinants as a result of technical change.
Methods
This paper decomposes the progress made by 146 low- and middle-income countries (LMICs) in lowering childhood and maternal mortality into one component due to better health determinants like literacy, income, and health coverage and a second component due to changes in the impact of these health determinants. Health determinants were selected from eight distinct health-impacting sectors. Health determinants were selected from eight distinct health-impacting sectors. Regression models are used to estimate impact size in 1990 and again in 2010. Changes in the levels of health determinants were measured using secondary data.
Findings
The model shows that respectively 100% and 89% of the reductions in maternal and child mortality since 1990 were due to improvements in nationwide coverage of health determinants. The relative share of overall improvement attributable to any single determinant varies by country and by model specification. However, in aggregate, approximately 50% of the mortality reductions were due to improvements in the health sector, and the other 50% of the mortality reductions were due to gains outside the health sector.
Conclusions
Overall, countries improved maternal and child health (MCH) from 1990 to 2010 mainly through improvements in the societal coverage of a broad array of health system, social, economic and environmental determinants of child health. These findings vindicate efforts by the global community to obtain such improvements, and align with the post-2015 development agenda that builds on the lessons from the MDGs and highlights the importance of promoting health and sustainable development in a more integrated manner across sectors.

A systematic review and meta-analysis on the safety of newly adjuvanted vaccines among children

Vaccine
Volume 34, Issue 6, Pages 703-874 (3 February 2016)
http://www.sciencedirect.com/science/journal/0264410X/34/6

.

Review Article
A systematic review and meta-analysis on the safety of newly adjuvanted vaccines among children
Pages 714-722
Jorgen Stassijns, Kaatje Bollaerts, Marc Baay, Thomas Verstraeten
Abstract
Introduction
New adjuvants such as the AS- or the MF59-adjuvants improve vaccine efficacy and facilitate dose-sparing. Their use in influenza and malaria vaccines has resulted in a large body of evidence on their clinical safety in children.
Methods
We carried out a systematic search for safety data from published clinical trials on newly adjuvanted vaccines in children ≤10 years of age. Serious adverse events (SAEs), solicited AEs, unsolicited AEs and AEs of special interest were evaluated for four new adjuvants: the immuno-stimulants containing adjuvant systems AS01 and AS02, and the squalene containing oil-in-water emulsions AS03 and MF59. Relative risks (RR) were calculated, comparing children receiving newly adjuvanted vaccines to children receiving other vaccines with a variety of antigens, both adjuvanted and unadjuvanted.
Results
Twenty-nine trials were included in the meta-analysis, encompassing 25,056 children who received at least one dose of the newly adjuvanted vaccines. SAEs did not occur more frequently in adjuvanted groups (RR 0.85, 95%CI 0.75–0.96). Our meta-analyses showed higher reactogenicity following administration of newly adjuvanted vaccines, however, no consistent pattern of solicited AEs was observed across adjuvant systems. Pain was the most prevalent AE, but often mild and of short duration. No increased risks were found for unsolicited AEs, febrile convulsions, potential immune mediated diseases and new onset of chronic diseases.
Conclusions
Our meta-analysis did not show any safety concerns in clinical trials of the newly adjuvanted vaccines in children ≤10 years of age. An unexplained increase of meningitis in one Phase III AS01-adjuvanted malaria trial and the link between narcolepsy and the AS03-adjuvanted pandemic vaccine illustrate that continued safety monitoring is warranted.

General practitioners’ attitudes and behaviors toward HPV vaccination: A French national survey

Vaccine
Volume 34, Issue 6, Pages 703-874 (3 February 2016)
http://www.sciencedirect.com/science/journal/0264410X/34/6

.

General practitioners’ attitudes and behaviors toward HPV vaccination: A French national survey
Original Research Article
Pages 762-768
Fanny Collange, Lisa Fressard, Céline Pulcini, Rémy Sebbah, Patrick Peretti-Watel, Pierre Verger
Abstract
Objective
General practitioners (GPs) play a crucial role in human papillomavirus (HPV) vaccine acceptance in France. We sought to study: (1) GPs’ perceptions of its risks and efficacy and their recommendation behavior; (2) the relative importance of factors associated with the frequency of their recommendations.
Methods
Cross-sectional observational study in 2014 nested in a national panel of 1712 randomly selected GPs in private practice in France (response rate: 92.4%). We used model averaging to analyze the associations of self-reported frequency of GPs’ HPV vaccine recommendations with their perception of its risk-benefit balance and their opinions about the utility of vaccines in general.
Results
Overall, 72% of participants reported frequently recommending HPV vaccination; 60% considered that not enough is known about its risks. The model averaging showed that the factors most associated with infrequent recommendation of this vaccine by GPs were: unfavorable perceptions of its risk-benefit balance (OR = 0.13; 95%CI = 0.09–0.21; partial R2 = 0.10), a decision not to vaccinate one’s own daughter(s) with this vaccine (OR = 0.13; 95%CI = 0.07–0.24; partial R2 = 0.05), and doubts about vaccine utility in general (OR = 0.78; 95%CI = 0.71–0.86; partial R2 = 0.03).
Conclusion
Although nearly three-quarters of French GPs frequently recommended the HPV vaccine, our findings indicate that a substantial percentage of them are hesitant about it. Doubts about its risks and efficacy strongly influence their recommendation behavior. More research is warranted to help design and evaluate tailored tools and multicomponent intervention strategies to address physician’s hesitancy about this vaccine.

Future pandemics and vaccination: Public opinion and attitudes across three European countries

Vaccine
Volume 34, Issue 6, Pages 703-874 (3 February 2016)
http://www.sciencedirect.com/science/journal/0264410X/34/6

.

Future pandemics and vaccination: Public opinion and attitudes across three European countries
Original Research Article
Pages 803-808
Domino Determann, Esther W. de Bekker-Grob, Jeff French, Helene A. Voeten, Jan Hendrik Richardus, Enny Das, Ida J. Korfage
Abstract
Background
Understanding public opinion and attitudes regarding vaccination is crucial for successful outbreak management and effective communication at the European level.
Methods
We explored national differences by conducting focus group discussions in The Netherlands, Poland and Sweden. Discussions were structured using concepts from behavioural models.
Results
Thematic analysis revealed that participants would base their vaccination decision on trade-offs between perceived benefits and barriers of the vaccine also taking into account the seriousness of the new outbreak. Except for those having chronic diseases, participants expected a low infection risk, resulting in a low willingness to get vaccinated. Information about the health status of cases was considered important since this might change perceived susceptibility. Participants displayed concerns about vaccine safety due to the limited available time to produce and test vaccines in the acute situation of a new pandemic. Swedish participants mentioned their tendency of doing the right thing and following the rules, as well as to get vaccinated because of solidarity with other citizens and social influences. This appeared much less prominent for the Dutch and Polish participants. However, Swedish participants indicated that their negative experiences during the Influenza A/H1N1 2009 pandemic decreases their acceptance of future vaccinations. Polish participants lacked trust in their national (public) health system and government, and were therefore sceptical about the availability and quality of vaccines in Poland.
Conclusions
Although participants overall expressed similar considerations, important differences between countries stand out, such as previous vaccination experiences, the degree of adherence to social norms, and the degree of trust in health authorities.

Review: Current Advances in Virus-Like Particles as a Vaccination Approach against HIV Infection

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines
(Accessed 23 January 2016)

.
Review: Current Advances in Virus-Like Particles as a Vaccination Approach against HIV Infection
by Chongbo Zhao, Zhujun Ao and Xiaojian Yao
Vaccines 2016, 4(1), 2; doi:10.3390/vaccines4010002 (registering DOI) – published 22 January 2016
Abstract:
HIV-1 virus-like particles (VLPs) are promising vaccine candidates against HIV-1 infection. They are capable of preserving the native conformation of HIV-1 antigens and priming CD4+ and CD8+ T cell responses efficiently via cross presentation by both major histocompatibility complex (MHC) class I and II molecules. Progress has been achieved in the preclinical research of HIV-1 VLPs as prophylactic vaccines that induce broadly neutralizing antibodies and potent T cell responses. Moreover, the progress in HIV-1 dendritic cells (DC)-based immunotherapy provides us with a new vision for HIV-1 vaccine development. In this review, we describe updates from the past 5 years on the development of HIV-1 VLPs as a vaccine candidate and on the combined use of HIV particles with HIV-1 DC-based immunotherapy as efficient prophylactic and therapeutic vaccination strategies.

Assessing Patient-Reported Outcomes in Pediatric Populations With Vaccine-Preventable Infectious Diseases: A Systematic Review of the Literature (the PROCHID Study)

Value in Health
January 2016 Volume 19, Issue 1, p1-122
http://www.valueinhealthjournal.com/current

.
Systematic Reviews
Assessing Patient-Reported Outcomes in Pediatric Populations With Vaccine-Preventable Infectious Diseases: A Systematic Review of the Literature (the PROCHID Study)
Michael Herdman, Christopher K. Hoyle, Victoria Coles, Stuart Carroll, Nancy Devlin
p109–119
Abstract
Objective
To investigate the use of patient-reported outcomes (PROs) in pediatric populations with vaccine-preventable infectious diseases in high-income Western countries.
Methods
Systematic review of PRO use in populations younger than 18 years with any of 17 infectious diseases for which vaccines are available or in development. The search was limited to studies performed in Europe, North America, Australia, and New Zealand and published between January 1, 1990, and July 31, 2013. Searches were conducted in Scopus and PsycINFO, and reference lists were manually searched. Results are reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Results
Of 6410 titles and abstracts and 174 full-text articles reviewed, 17 full-text articles were included for data extraction. The largest number of PRO studies was carried out in patients with anogenital warts and rotavirus gastroenteritis. No PRO studies were identified for nine conditions. A total of 24 PRO measures (12 generic and 12 disease-specific) were used in the studies reviewed. Most of the instruments used were of high quality. Proxy responses were occasionally obtained when self-report would have been feasible. No validated disease-specific instruments for children with any of the conditions studied were found.
Conclusions
The paucity of studies and PRO instruments to assess pediatric health status in vaccine-preventable infectious diseases, and the lack of a standardized approach to measurement, makes it difficult to capture the impact of disease and the benefit of vaccination and could potentially hinder decision making. Guidelines from relevant bodies to steer research in this area would be useful.

Media/Policy Watch [to 23 January 2016]

Media/Policy Watch
This section is intended to alert readers to substantive news, analysis and opinion from the general media on vaccines, immunization, global; public health and related themes. Media Watch is not intended to be exhaustive, but indicative of themes and issues CVEP is actively tracking. This section will grow from an initial base of newspapers, magazines and blog sources, and is segregated from Journal Watch above which scans the peer-reviewed journal ecology.

We acknowledge the Western/Northern bias in this initial selection of titles and invite suggestions for expanded coverage. We are conservative in our outlook in adding news sources which largely report on primary content we are already covering above. Many electronic media sources have tiered, fee-based subscription models for access. We will provide full-text where content is published without restriction, but most publications require registration and some subscription level.

.

New York Times
http://www.nytimes.com/
Accessed 23 January 2016
Mosquito-Borne Zika Virus Found in 3 New York State Patients
January 23, 2016 – By RICK ROJAS – State health officials said on Friday that three people in New York State, including one from Queens, tested positive for Zika, a mosquito-borne virus that has prompted concern as it has spread rapidly, mostly in Latin America and the Caribbean.
All three had traveled to places outside the United States where the virus had been spreading. Besides the person from New York City, the patients were from Nassau and Orange Counties. One person has fully recovered, and the two others are recovering without complications, according to a statement the State Health Department issued on Friday…

In Pakistan, a Final Push to Wipe Out Polio
January 21, 2016 – By BINA SHAH –
…One effort to resolve that problem was the introduction in Punjab last year of a smartphone app on which the region’s 3,700 vaccinators could keep track of their work. Now, instead of going household to household, they go to a center where children have been assembled for vaccination. The vaccinators then send the data via phone to a central office. Using this approach, vaccinators’ attendance rates, which at times had been as low as 21 percent, have risen to 95 percent to 100 percent.

Officials also have analyzed satellite images to target population clusters, and have produced a color-coded map showing where vaccinations have and haven’t reached children in need.
By now, the rates of vaccination with the two types of antigens have risen beyond 70 percent, a critical threshold toward the goal of eradication.

Encouraged by those results, the Punjab government and the World Bank plan to invest in 10,000 more vaccinator smartphones, which will also capture a child’s photo and the mother’s cellphone number, enabling automatic reminders to a mother that a child is due for a vaccine scheduled near home.

The Punjab government is eager to share its technological know-how with the rest of the nation. One target area this year is remote Khyber Pakhtunkhwa.
And if Sindh and Baluchistan follow suit, there’s every chance that Pakistan can catch up quickly to the rest of the world. A polio-free Pakistan — and globe — may be coming sooner than you think.

.

Wall Street Journal
http://online.wsj.com/home-page?_wsjregion=na,us&_homepage=/home/us
Accessed 23 January 2016
Gates Foundation Sees Possible End to Polio Soon
By Khadeeja Safdar, Rebecca Blumenstein
Jan. 22, 2016 1:35 pm ET

World
Health Threats Spur Vaccine Hunt
Ebola and Zika virus have catapulted the threat of infectious-disease epidemics to a top spot at Davos
By Betsy McKay
Updated Jan. 21, 2016 3:35 a.m. ET

.

Washington Post
http://www.washingtonpost.com/
Accessed 23 January 2016
As Zika virus spreads, El Salvador asks women not to get pregnant until 2018
Several Latin American countries are urging a pause in having babies.
Joshua Partlow | Foreign | Jan 22, 2016

More pandemics are inevitable, and the U.S. is grossly underprepared
Just as nations invest in military preparedness, a panel says, so should they confront disease.
Editorial Board | Editorial-Opinion | Jan 21, 2016
WHILE IT has not gained much attention in the United States, Brazil has been struck in recent months with an outbreak of Zika virus that has infected hundreds of thousands of people. Most of the time the symptoms are mild and flu-like, but in some cases health officials say the virus has led to birth defects in babies born to women who were infected in pregnancy. The virus is spread by small insects such as mosquitoes or fleas, and there is no known vaccine to prevent infection.

The Zika story might seem easy to dismiss if one is not living in Brazil. Is this just another unpleasant headline about misery far away?

Not quite. In the aftermath of the mishandled and tardy reaction to the Ebola epidemic in West Africa in which more than 11,000 people died, an independent and authoritative commission was set up in the United States to look ahead and draw lessons from this and other recent waves of infectious disease. The 17-member Commission on a Global Health Risk Framework for the Future issued its final report on Jan. 13, and the panel’s conclusions are a wake-up call about the threat of pandemic disease that could originate almost anywhere and spread everywhere. Despite all the advances of science, “the global community has massively underestimated the risks that pandemics present to human life and livelihoods,” the group declared. “There are very few risks facing humankind that threaten loss of life on the scale of pandemics.”

The 1918 influenza pandemic killed anywhere from 50 million to 100 million people; in catastrophic mortality events since 1900, only World War II caused more deaths. Since it first appeared, HIV/AIDS has killed more than 35 million. Although the tolls have been far lower, five outbreaks in the past 15 years have been worrying: severe acute respiratory syndrome, or SARS; two influenza waves, H5N1 and H1N1; Ebola; and Middle East respiratory syndrome, or MERS.

As the world becomes more globalized with the movement of goods and people, as climate change disrupts the environment, and as pathogens move between humans and animals, cocktails of infectious disease will form, spread and sicken. Already a dozen cases of Zika virus have been reported in the United States, so far only among people who had traveled outside the country. “The threat from infectious diseases is growing,” the panel warns, adding that “the conditions for infectious disease emergence and contagion are more dangerous than ever.” Moreover, “further outbreaks of new, dormant, or even well-known diseases are a certainty.”

The commission insists that pandemic risks must be treated not as distant, unavoidable possibilities but as real national security threats. Just as nations invest in military preparedness, the panel says, so should they confront disease. In fact, this has been long neglected in many places. The panel calls for measures to bolster public health systems in individual countries; creating a rapid-response capability; strengthening the World Health Organization; and funding research and development of new therapies, all for about $4.5 billion a year. That’s the equivalent of three Powerball drawings like the one on the day of the panel’s report.

Vaccines and Global Health: The Week in Review 16 January 2016

Vaccines and Global Health: The Week in Review is a weekly digest  summarizing news, events, announcements, peer-reviewed articles and research in the global vaccine ethics and policy space. Content is aggregated from key governmental, NGO, international organization and industry sources, key peer-reviewed journals, and other media channels. This summary proceeds from the broad base of themes and issues monitored by the Center for Vaccine Ethics & Policy in its work: it is not intended to be exhaustive in its coverage. You are viewing the blog version of our weekly digest, typically comprised of between 30 and 40 posts below all dated with the current issue date

.Request an Email Summary: Vaccines and Global Health : The Week in Review is published as a single email summary, scheduled for release each Saturday evening before midnight (EDT in the U.S.). If you would like to receive the email version, please send your request to david.r.curry@centerforvaccineethicsandpolicy.org.

pdf version A pdf of the current issue is available here:  Vaccines and Global Health_The Week in Review_16 January 2016

blog edition: comprised of the approx. 35+ entries posted below on 17 January 2016.

Twitter:  Readers can also follow developments on twitter: @vaxethicspolicy.
.
Links:  We endeavor to test each link as we incorporate it into any post, but recognize that some links may become “stale” as publications and websites reorganize content over time. We apologize in advance for any links that may not be operative. We believe the contextual information in a given post should allow retrieval, but please contact us as above for assistance if necessary.

.
David R. Curry, MS
Executive Director
Center for Vaccine Ethics and Policy
a program of the
– Division of Medical Ethics, NYU Medical School
– Children’s Hospital of Philadelphia Vaccine Education Center
Associate Faculty, Division of Medical Ethics, NYU Medical School

EBOLA/EVD [to 16 January 2016]

EBOLA/EVD [to 16 January 2016]
Public Health Emergency of International Concern (PHEIC); “Threat to international peace and security” (UN Security Council)

WHO
Editor’s Note:
The regular, weekly Ebola Situation Report was not posted on the WHO website.

.
Latest Ebola outbreak over in Liberia; West Africa is at zero, but new flare-ups are likely to occur
WHO News release
14 January 2016 | Liberia – Today, WHO declares the end of the most recent outbreak of Ebola virus disease in Liberia and says all known chains of transmission have been stopped in West Africa. But the Organization says the job is not over, more flare-ups are expected and that strong surveillance and response systems will be critical in the months to come….

.
New Ebola case in Sierra Leone. WHO continues to stress risk of more flare-ups
WHO statement
15 January 2016
A new case of Ebola has been confirmed in Sierra Leone, reflecting the ongoing risk of new flare-ups of the virus in the Ebola-affected countries.

The Sierra Leone government acted rapidly to respond to this new case. Through the country’s new emergency operations centre, a joint team of local authorities, WHO and partners are investigating the origin of the case, identifying contacts and initiating control measures to prevent further transmission.
WHO stressed in a statement yesterday (14 January), that Guinea, Liberia and Sierra Leone remain at high risk of additional small outbreaks of Ebola in the coming months due to the virus persisting in survivors after recovery.

“We are now at a critical period in the Ebola epidemic as we move from managing cases and patients to managing the residual risk of new infections,” said Dr Bruce Aylward, WHO’s Special Representative for the Ebola Response, yesterday. “We still anticipate more flare-ups and must be prepared for them.”
Sierra Leone is still in a 90-day period of enhanced surveillance following the declaration on 7 November 2015 of the end of Ebola transmission in the country. This period is designed to ensure no hidden chains of transmission have been missed and to detect any new flare-ups of the disease.

.
WHO – Press Conference: Update on Ebola situation (Geneva, 14 January 2016)
14 Jan 2016 [Video: 40:45]
– Subject: Liberia 42-day announcement – Update on Ebola situation in West Africa
Speaker: Dr Rick Brennan, Director, Emergency Risk Management and Humanitarian Response, WHO
[Q&A on ebola vaccines and status begins at about 00:24]

.
United Nations
Briefing on progress of the Ebola outbreak response and recovery efforts and to discuss priorities going forward – General Assembly
13 Jan 2016 [Video: 1:58]

.
WHO Director-General briefs UN General Assembly on Ebola
Dr Margaret Chan
Director-General of the World Health Organization
Briefing to the United Nations General Assembly, New York, United States of America
13 January 2016
[Excerpt, closing comments]
…Since March of last year, WHO has documented ten flare-ups of infection that were not part of the original outbreak. These very small incidents followed the reintroduction of virus persisting in survivors.

The good news is that countries immediately and rapidly stopped each of these flares. Equally reassuring, research shows that casual contact with survivors poses no risk to their families.
Vigilance and response capacity must be maintained throughout 2016. By the end of this year, we expect that all survivors will have cleared the virus.

The next three months are the most critical, as national emergency response mechanisms and partners scale down or close their operations. Responsibility for managing survivor care, surveillance, and the response to further possible flares will shift back to ministries of health.

While the risk of new flares is rapidly declining, these countries continue to need international solidarity to ensure a safe transition and sufficient national response capacity. National leadership is outstanding.

The period of intense vigilance will continue as recovery proceeds. Strong recovery plans, developed by each of the three governments, will make their health systems more resilient, leaving them better prepared to prevent, detect, and respond to future outbreaks.

We are grateful to participants at last July’s International Recovery Conference in New York for their generous support. Ebola delivered an extremely severe and shattering blow to societies and economies.
Recovery will take some time. While the job is by no means finished, no one anticipates that the situation will return to what we were seeing 15 months ago.

The determination is fierce. The many steps taken at national and international levels have had a decisive impact. No one will let this virus take off and run away again…

.

Welcoming End of Ebola Flare-Up in Liberia, Secretary-General Calls upon Global Community to Continue Supporting Affected Countries
14 January 2016
SG/SM/17456-AFR/3302

.
World Bank [to 16 January 2016]
http://www.worldbank.org/en/news/all
January 14, 2016
Statement by World Bank Group President on the Declaration of the End of Latest Ebola Outbreak in Liberia
West Africa Now Has No Known Ebola Cases
WASHINGTON,—World Bank Group President Jim Yong Kim issued the following statement on today’s announcement declaring the end of Ebola transmission…
Date: January 14, 2016 Type: Press Release

.
MSF/Médecins Sans Frontières [to 16 January 2016]
http://www.doctorswithoutborders.org/news-stories/press/press-releases
Press release
End of Ebola Outbreak in West Africa: World Must Learn Lesson for Future Outbreaks, Says MSF
January 14, 2016
BRUSSELS/NEW YORK—As Liberia today celebrates 42 days without any new Ebola infections—effectively marking the end of the Ebola outbreak in West Africa—the international medical humanitarian organization Doctors Without Borders/Médecins Sans Frontières (MSF) calls on the global health community to draw on lessons learned during the epidemic to be better prepared for future similar outbreaks.

“Today is a day of celebration and relief that this outbreak is finally over,” said Joanne Liu, MSF’s international president. “We must all learn from this experience to improve how we respond to future epidemics and to neglected diseases. This Ebola response was not limited by lack of international means but by a lack of political will to rapidly deploy assistance to help communities. The needs of patients and affected communities must remain at the heart of any response and outweigh political interests.”

From the very beginning of the epidemic, MSF responded in the worst affected countries—Guinea, Liberia, and Sierra Leone—by setting up Ebola treatment centers and providing psychological support and conducting health promotion activities, surveillance, and contact tracing. At its peak, MSF employed nearly 4,000 national staff and over 325 international staff to combat the epidemic across the three countries. MSF admitted a total of 10,376 patients to its Ebola treatment centers, of which 5,226 turned out to be confirmed Ebola cases. MSF continues to run support clinics for Ebola survivors in Liberia, Sierra Leone, and Guinea.

“We should congratulate all the people who tirelessly contributed to putting an end to this devastating and unprecedented epidemic, while we should also remember the many health professionals who tragically lost their lives on the Ebola frontline,” said Brice de le Vingne, MSF’s director of operations. “This devastating epidemic hit nearly 40 years after the first discovery of Ebola in 1976, yet the lack of research and development on Ebola meant that even today after the medical trials and at the end of the epidemic, there is no effective treatment. There is also a need to obtain licensure for a new vaccine that has been developed.”
With such an unpredictable disease, it is crucial that vigilance and the capacity to respond to new cases be maintained in the region as well as a well-functioning surveillance and rapid response system.

Ebola survivors are particularly vulnerable, and they face continuing health challenges such as joint pain, chronic fatigue, and hearing and vision problems. They also suffer from stigma in their communities and need specific and tailored care. MSF has invested in setting up Ebola survivor clinics in Liberia, Sierra Leone, and Guinea, providing a comprehensive care package, including medical and psychosocial care and protection against stigma.

“Throughout the epidemic, I witnessed how communities were ripped apart,” said Hilde de Clerck, an MSF epidemiologist who worked in Liberia, Guinea, and Sierra Leone. “Initially, the response from the global health community was really paralyzed by fear. It was a horrible experience being left on our own and constantly running behind the wave of the epidemic. But it was very empowering to see how extremely dedicated all the national staff were, and fortunately other international actors eventually got involved. For the next epidemic, the world should stand ready to intervene much faster and more efficiently.”

MSF responded to the Ebola epidemic in the three worst affected countries—Guinea, Sierra Leone and Liberia—and also responded to cases in Nigeria, Senegal, and Mali, as well as a separate epidemic in Democratic Republic of Congo in 2014. In total, the organization has spent over 96 million euros on tackling the epidemic.

Already-weak public health systems have been seriously damaged by the epidemic, so MSF has also decided to invest efforts in their recovery. New projects on maternal and child health should open soon in different towns of Sierra Leone (Kabala, Magburaka, Kenema), and a new pediatric hospital has already opened in Monrovia (Liberia). MSF continues to run an HIV project in Conakry, Guinea, in collaboration with health authorities.

POLIO [to 16 January 2016]

POLIO [to 16 January 2016]
Public Health Emergency of International Concern (PHEIC)

Polio this week as of 13 January 2016
:: This week India marks five years without reporting a single case of wild polio, a remarkable achievement. Today, lessons learned in India and Nigeria are being used to drive progress in the last two polio-endemic countries: Pakistan and Afghanistan. Read more here.
:: There are three months to go until the globally synchronized switch from the trivalent to bivalent oral polio vaccine. This will be an important milestone in achieving a polio-free world. Read more here.

Selected content from country-level reports
Afghanistan
:: Subnational Immunization Days (SNIDs) were carried out in the south on 10 to 12 January using bOPV. Further SNIDs are planned from 14 to 16 February, also using bOPV and National Immunization Days (NIDs) are planned from 13 to 15 March using tOPV, prior to the switch. Read more about the switch here.
Pakistan
:: One new wild poliovirus type 1 (WPV1) case was reported in the past week, with onset of paralysis on 2 December 2015 in Punjab province. The total number of WPV1 cases for 2015 is now 52, compared to 296 reported for 2014 by this time last year. A total of 306 cases occurred in Pakistan in 2014.
:: One new WPV1 environmental positive was detected in Peshawar district in Khyber Pakhtunkhwa. The sample was collected on 11 December 2015.
Lao People’s Democratic Republic
:: One new case of circulating vaccine-derived poliovirus type 1 (cVDPV1) was reported in the past week, in Longxan district of Xaysomboune province with onset of paralysis on 18 December 2015. The total number of cVDPV1 cases in 2015 is now six.
:: An emergency outbreak response is continuing in the country, with particular focus on three high-risk provinces.
Myanmar
:: Significant immunization gaps remain in Myanmar, with an estimated 24% of children un- or under-immunized. Vaccination coverage remains particularly low among special at-risk populations. AFP surveillance quality indicators are acceptable at the national level, but subnational gaps persist.
:: While WHO assesses the risk of international spread from Myanmar to be low, surveillance and immunization activities are being strengthened in neighbouring countries.

.
New York Times
http://www.nytimes.com/
Accessed 16 January 2016
Suicide Bomb Near Polio Center in Pakistan Kills at Least 16
By IHSANULLAH TIPU MEHSUDJAN. 13, 2016
ISLAMABAD, Pakistan — At least 16 people were killed on Wednesday in a suicide bombing outside a polio vaccination center in the southwestern Pakistani city of Quetta, officials and witnesses said.

Thirteen of the victims were police officers, said Syed Imtiaz Shah, a senior official with the Quetta police. He said the officers were there to guard polio workers, who are often targeted by Islamist militants in Pakistan.

The attack came on the third day of a vaccination campaign in the province of Baluchistan, of which Quetta is the capital. The bomber, who was also killed, walked up to police officers and detonated what Mr. Shah said amounted to more than 20 pounds of explosives.

A spokesman for the Pakistani Taliban, Muhammad Khurrasani, claimed responsibility for the attack on the militants’ behalf. Two civilians and a paramilitary police officer were also killed, and 10 police officers and nine civilians were wounded…

WHO & Regionals [to 16 January 2016]

WHO & Regionals [to 16 January 2016]

Syrian Arab Republic: Crossing borders with life-saving support
12 January 2016 — Almost 6.5 million Syrians remain displaced within the country and more than 4 million are living in Egypt, Iraq, Jordan, Lebanon and Turkey. WHO’s Emergency Support Team, based in Amman, coordinates the distribution of medical supplies and equipment to Syrian Arab Republic and neighbouring countries dealing with the crisis…

.Appeal for communities under siege in Syria
January 2016 — WHO and UNICEF delivered urgently-needed humanitarian supplies to the besieged communities of Madaya, Foua’a and Kafraya in Syria. Much of the community in Madaya is severely malnourished with only 2 doctors for a town of 40,000.

Zika virus infection: Frequently asked questions
January 2016 — Zika fever is a mosquito-borne viral disease caused by Zika virus, consisting of mild fever, rash, headaches, arthralgia, myalgia, asthenia, and non-purulent conjunctivitis, occurring about 3 to 12 days after the mosquito bite.

Weekly Epidemiological Record (WER) 15 January 2016, vol. 91, 2 (pp. 1¬¬3–20)
Contents:
13 Human rabies transmitted by dogs: current status of global data, 2015

.

:: WHO Regional Offices
WHO African Region AFRO
:: New Ebola Case in Sierra Leone; WHO continues to stress risk of more flare-ups
WHO statement – 15 January 2016

WHO Region of the Americas PAHO
:: PAHO helps countries in the Americas prepare for spread of Zika (01/16/2016)

WHO South-East Asia Region SEARO
:: Five polio-free years; efforts must continue
By Dr Poonam Khetrapal Singh, WHO Regional Director for South-East Asia
On 13 January, WHO South-East Asia Region completes five years without any case of wild poliovirus. This is a remarkable achievement in view of the continued threat of poliovirus importation from the remaining polio-endemic countries.
Countries in the Region have been making commendable efforts, stepping up vigilance against polio and continuing to protect children against the crippling virus. WHO South-East Asia Region reported its last case of wild poliovirus in West Bengal, India, in 2011, which facilitated polio-free certification of the Region on 27 March 2014…

WHO European Region EURO
:: What can countries expect during this year’s influenza season? 13-01-2016

WHO Eastern Mediterranean Region EMRO
:: WHO Regional Director’s statement on urgent and immediate access into Taiz City for delivery of health supplies
14 January 2016
:: WHO’s Regional Director and Minister of Health of Yemen discuss Yemen’s critical health needs
13 January 2016

WHO Western Pacific Region
No new digest content identified.