Organization Announcements

::::::

 

Organization Announcements
Editor’s Note:
Careful readers will note that the number and range of organizations now monitored in our Announcements section below has grown as the impacts of the pandemic have spread across global economies, supply chains and programmatic activity of multilateral agencies and INGOs.

Paul G. Allen Frontiers Group [to 16 Oct 2021]
https://alleninstitute.org/what-we-do/frontiers-group/new s-press/
News
No new digest content identified.

BARDA – U.S. Department of HHS [to 16 Oct 2021]
https://www.phe.gov/about/barda/Pages/default.aspx
News
No new digest content identified.

BMGF – Gates Foundation [to 16 Oct 2021]
https://www.gatesfoundation.org/ideas/media-center
Press Releases and Statements
No new digest content identified.

Bill & Melinda Gates Medical Research Institute [to 16 Oct 2021]
https://www.gatesmri.org/
The Bill & Melinda Gates Medical Research Institute is a non-profit biotech organization. Our mission is to develop products to fight malaria, tuberculosis, and diarrheal diseases—three major causes of mortality, poverty, and inequality in developing countries. The world has unprecedented scientific tools at its disposal; now is the time to use them to save the lives of the world’s poorest people
No new digest content identified.

CARB-X [to 16 Oct 2021]
https://carb-x.org/
News
10.12.2021  |
CARB-X 2020-21 Annual Report: CARB-X surpasses all goals in first five years in combatting antibiotic resistant-bacteria
CARB-X closed its fifth fiscal year on July 31, 2021 with US$361 million awarded to 92 projects funding since inception. In its latest fiscal year, CARB-X invested in 25 new projects across all three pillars – preventatives, diagnostics, and therapeutics. This year saw two more successful graduations from the portfolio, four more First-in Human programs launch, and several strategic augmentations of the portfolio including in the areas of: gonorrhea, bacteriophage, vaccines, peptides and polymyxins, and anti-virulence factors.

Center for Vaccine Ethics and Policy – GE2P2 Global Foundation [to 16 Oct 2021]
https://centerforvaccineethicsandpolicy.net/
News/Analysis/Statements
:: Past weekly editions and posting of all segments of Vaccines and Global Health: The Week in Review are available here.
:: [NEW] Informed Consent: A Monthly Review – October 2021 is now posted here

CEPI – Coalition for Epidemic Preparedness Innovations [to 16 Oct 2021]
http://cepi.net/
Latest News
Could chicken eggs help end the COVID-19 pandemic?
CEPI is supporting PATH’s work as part of an international consortium developing a new egg-based vaccine to tackle COVID-19, inspired by influenza vaccines in longtime use.
11 Oct 2021

 

CEPI opens Call to evaluate fractional COVID-19 booster and third shots as part of efforts to stretch global vaccine supply
CEPI will make up to US $25m funding available as part of the Call, with the intention to fund several clinical trials looking at dose-sparing booster shots for different COVID-19 vaccine candidates.
11 Oct 2021

DARPA – Defense Advanced Research Projects Agency [to 16 Oct 2021
https://www.darpa.mil/news
News
No new digest content identified.

Duke Global Health Innovation Center [to 16 Oct 2021]
https://dukeghic.org/
Our Blog
No new digest content identified.

EDCTP [to 16 Oct 2021]
http://www.edctp.org/
The European & Developing Countries Clinical Trials Partnership (EDCTP) aims to accelerate the development of new or improved drugs, vaccines, microbicides and diagnostics against HIV/AIDS, tuberculosis and malaria as well as other poverty-related and neglected infectious diseases in sub-Saharan Africa, with a focus on phase II and III clinical trials
News
12 October 2021
First EDCTP and Africa CDC-supported Epidemiologists and Biostatisticians start their training

Emory Vaccine Center [to 16 Oct 2021]
http://www.vaccines.emory.edu/
Vaccine Center News
No new digest content identified.

European Vaccine Initiative [to 16 Oct 2021]
http://www.euvaccine.eu/
Latest News
No new digest content identified.

Fondation Merieux [to 16 Oct 2021]
http://www.fondation-merieux.org/
News, Events
No new digest content identified.

Gavi [to 16 Oct 2021]
https://www.gavi.org/
News releases
11 October 2021
Vigne des Nations: 2020 vintage awarded to Gavi by Geneva Canton, for its action for global health
… This recognition honours the commitment of this organisation to guaranteeing fair and equitable access to vaccines around the world…

11 October 2021
First Swiss-donated doses ship to Sierra Leone, as part of 4 million dose pledge

GHIT Fund [to 16 Oct 2021]
https://www.ghitfund.org/newsroom/press
GHIT was set up in 212 with the aim of developing new tools to tackle infectious diseases that
No new digest content identified.

Global Fund [to 16 Oct 2021]
https://www.theglobalfund.org/en/news/
News & Stories
News
Drug-resistant TB: Business as usual no longer an option
14 October 2021 by Dr. Mohammed Yassin, Global Fund Senior Tuberculosis Advisor

Global Research Collaboration for Infectious Disease Preparedness [GloPID-R] [to 16 Oct 2021]
https://www.glopid-r.org/news/
News
No new digest content identified.

Hilleman Laboratories [to 16 Oct 2021]
http://www.hillemanlabs.org/
Website reports “under maintenance” at inquiry

Human Vaccines Project [to 16 Oct 2021]
http://www.humanvaccinesproject.org/
News
HVP COVID Report
Oct 15, 2021
Kristen Jill Abboud: Should We Get Back to Worrying About the Flu?

IAVI [to 16 Oct 2021]
https://www.iavi.org/newsroom
Latest News
No new digest content identified.

 

International Coalition of Medicines Regulatory Authorities [ICMRA]
http://www.icmra.info/drupal/en/news
Selected Statements, Press Releases, Research
No new digest content identified.

ICRC [to 16 Oct 2021]
https://www.icrc.org/en/whats-new
Selected News Releases, Statements, Reports
Ahead of COP26, Red Cross Red Crescent Movement’s five asks to world leaders: “It is not too late to act: the survival of humanity depends on the actions we take today”
14/10/2021

 

IFFIm
http://www.iffim.org/
Press Releases/Announcements
No new digest content identified.

IFRC [to 16 Oct 2021]
http://media.ifrc.org/ifrc/news/press-releases/
Selected Press Releases, Announcements
14/10/2021
Ahead of COP26, Red Cross Red Crescent Movement’s five asks to world leaders: “It is not too late to act: the survival of humanity depends on the actions we take today”

14/10/2021
Palau and Cook Islands lead the world on COVID-19 vaccinations
Kuala Lumpur/Suva, 14 October 2021 – The small Pacific country of Palau has more than 99 per cent of its eligible population fully vaccinated, contesting top spot in the world for COVID-19 vaccination rates, according to government data.
Other Pacific nations have also raced up the global vaccine leader board. The Cook Islands has 96 per cent of the eligible population fully vaccinated while 96 per cent have received their first jab in Fiji, according to Cook Islands and Fiji Government data...

Institut Pasteur [to 16 Oct 2021]
https://www.pasteur.fr/en/press-area
Press Documents
No new digest content identified.

IOM / International Organization for Migration [to 16 Oct 2021]
http://www.iom.int/press-room/press-releases
News – Selected
News 15 Oct 2021
Free Movement of People a Top Priority, Say West African Nations

News 12 Oct 2021
Global Migration Under Spotlight at EU-IOM Strategic Cooperation Meeting

ISC / International Science Council [to 16 Oct 2021]
https://council.science/current/
ISC is a non-governmental organization with a unique global membership that brings together 40 international scientific Unions and Associations and over 140 national and regional scientific organizations including Academies and Research Councils.
News Press
Sir Peter Gluckman, paediatrician, biomedical scientist and science-policy expert becomes President of the International Science Council
14.10.2021

News Press
New Governing Board elected to provide scientific and strategic leadership to the International Science Council
14.10.2021
… “The new Board takes on leadership of the ISC at a critical time and I am honoured and privileged to be given the responsibility of chairing the Board,” said Peter Gluckman, incoming President of the ISC. Membership of the Governing Board reflects the multi-disciplinarity of the Council’s membership base, as well as regional and gender diversity.
The new Governing Board faces the ongoing challenge of ensuring that science has an increasing impact on the multilateral agenda. The natural and social sciences have a critical role to play as the world faces complex challenges from COVID-19 to climate change, and from conflict reduction to inequality, health inequalities, poverty, food, water and energy challenges, and coexistence with rapidly advancing technologies. These issues are compounded by disinformation and the politicisation of knowledge. At the same time, the nature and conduct of science is changing rapidly and the ISC has a critical role to play in working with the scientific community, the policy community and society to ensure better outcomes for people and the planet.
Amongst its duties, the Governing Board provides strategic leadership and develops priority activity and business plans for approval by the General Assembly, as well as monitoring the implementation and performance of such plans. The Board oversees the scientific activities and other operations of the Council and reports to the General Assembly, as well as proposing budgetary outlines and the scale of annual dues to be paid by Members…

News Press
Ten outstanding individual scientists and organizations celebrated in first ever ISC Awards
13.10.2021

IVAC [to 16 Oct 2021]
https://www.jhsph.edu/research/centers-and-institutes/ivac/index.html
Updates; Events
No new digest content identified.

IVI [to 16 Oct 2021]
http://www.ivi.int/
IVI News & Announcements
No new digest content identified.

Johns Hopkins Center for Health Security [to 16 Oct 2021]
https://www.centerforhealthsecurity.org/news/center-news/
Center News
No new digest content identified.

MSF/Médecins Sans Frontières [to 16 Oct 2021]
http://www.msf.org/
Latest [Selected Announcements]
Haiti
Two months after the earthquake, health needs remain high
Project Update 15 Oct 2021

Lebanon
Breaking barriers to mental health care in Lebanon
Project Update 14 Oct 2021

Syria
Worst wave yet of COVID-19 in northern Syria overwhelms health system
Press Release 13 Oct 2021

Mental health
Mental health care needs enormous around the world
Project Update 10 Oct 2021

National Academy of Medicine – USA [to 16 Oct 2021]
https://nam.edu/programs/
Selected News/Programs/Events
Oct 2021
Crossing the Policy and Equity Chasm: Lessons from Compounding Health Crises (NAM Annual Meeting 2021)
Time: 8:00 AM
The National Academy of Medicine will hold its annual meeting on Sunday and Monday, October 17-18, 2021. Due to the ongoing COVID-19 pandemic and in an abundance of caution, the Annual Meeting will be held entirely virtually. In order to help support this event, the symposium will cost $50 to attend live on October 17 and 18.

National Academy of Sciences – USA [to 16 Oct 2021]
http://www.nasonline.org/news-and-multimedia/
News
No new digest content identified.

National Vaccine Program Office – U.S. HHS [to 16 Oct 2021]
https://www.hhs.gov/vaccines/about/index.html
Upcoming Meetings/Latest Updates
No new digest content identified.

NIH [to 16 Oct 2021]
http://www.nih.gov/news-events/news-releases
News Releases
Antibody treatment for MIS-C works by depleting inflammatory immune cells
October 15, 2021 — NIH-funded study explains how intravenous immune globulin helps children with rare COVID condition.

NIH RADx initiative expands COVID-19 testing innovation for additional types of rapid tests
October 14, 2021 — The home and point-of-care testing platforms target the need for high-performance, low-cost home tests and point-of-care tests that can potentially detect multiple respiratory infections.

New, highly innovative NIH research awards to address health disparities and advance health equity
October 13, 2021 — Eleven grants were awarded to support the work of exceptionally creative researchers across the United States through the NIH Common Fund’s Transformative Research to Address Health Disparities and Advance Health Equity initiative.

PATH [to 16 Oct 2021]
https://www.path.org/media-center/
Press Releases
Real-world performance of nOPV2 reinforces strong safety profile
October 11, 2021 by PATH
Experts endorse successful completion of initial use period
The Strategic Advisory Group of Experts on Immunization (SAGE) – an independent group of scientific experts that advises the World Health Organization (WHO) on vaccines and immunization – has endorsed the strong safety performance of nOPV2 use in real-world settings. SAGE reviewed data from the initial use period for nOPV2, which began in November 2020.
Since 2015, PATH has helped advance the development of nOPV2 by serving as the convener of the product development consortium; providing technical input into manufacturing and clinical trials; overseeing the development and execution of novel tests to assess the vaccine’s genetic stability; and facilitating data-sharing among partners.
In November 2020, the vaccine received a recommendation for initial use under WHO’s Emergency Use Listing (EUL) procedure, based on the urgent need to contain outbreaks and on promising clinical data from Phase 1 and Phase 2 nOPV2 trials….
Fact sheet

Sabin Vaccine Institute [to 16 Oct 2021]
http://www.sabin.org/updates/pressreleases
Statements and Press Releases
No new digest content identified.

UNAIDS [to 16 Oct 2021]
http://www.unaids.org/en
Selected Press Releases/Reports/Statements
13 October 2021
Community mobilization and digital technologies accelerate the response to HIV and COVID-19 in Gabon

12 October 2021
Partnering to strengthen community engagement in the HIV and COVID-19 responses in Namibia

11 October 2021
Helping Haiti build a sustainable HIV response

11 October 2021
People living with HIV at higher risk of COVID-19 illness but have lower access to COVID-19 vaccines

UNHCR Office of the United Nations High Commissioner for Refugees [to 16 Oct 2021]
http://www.unhcr.org/en-us/media-centre.htmlS
Selected News Releases, Announcements
World Food Day: Celebrating efforts to strengthen local food systems for displaced and host communities
13 Oct 2021

UNICEF [to 16 Oct 2021]
https://www.unicef.org/media/press-releases
Press Releases, News Notes, Statements [Selected]
Press release
10/15/2021
UNICEF: 75 years of engagement in and with Europe, but no time to celebrate!
“Bold and effective commitment to children’s rights are important more than ever before in the EU, and with the EU for the world”, says UNICEF’s Deputy Executive Director, Charlotte Petri Gornitza

Press release
10/15/2021
FACT SHEET: On Global Handwashing Day, UNICEF warns that 3 in 10 people do not have basic handwashing facilities at home to fight off infectious diseases

Unitaid [to 16 Oct 2021]
https://unitaid.org/
Featured News
No new digest content identified.

Vaccine Equity Cooperative [nee Initiative] [to 16 Oct 2021]
https://vaccineequitycooperative.org/news/
News
No new digest content identified.

Vaccination Acceptance & Demand Initiative [Sabin) [to 16 Oct 2021]
https://www.vaccineacceptance.org/
Announcements
No new digest content identified.

Vaccine Confidence Project [to 16 Oct 2021]
http://www.vaccineconfidence.org/
News, Research and Reports
Coronavirus global impact
Launched April 2, 2020 and recurring every 3 days, Premise Data is utilizing its global network of Contributors to assess economic, social, and health sentiment surrounding the coronavirus (COVID-19).

Vaccine Education Center – Children’s Hospital of Philadelphia [to 16 Oct 2021]
http://www.chop.edu/centers-programs/vaccine-education-center
News
No new digest content identified.

Wellcome Trust [to 16 Oct 2021]
https://wellcome.ac.uk/news
News and reports
No new digest content identified.

The Wistar Institute [to 16 Oct 2021]
https://www.wistar.org/news/press-releases
Press Releases
Press Release
Oct. 14, 2021
Dr. Anthony Fauci and Philadelphia FIGHT’s Jane Shull Receive Wistar Legacy Award at 25th Anniversary of Jonathan Lax Memorial Lecture
Virtual event celebrates local HIV research and advocacy influencers/communities that paved way for global HIV impact

WFPHA: World Federation of Public Health Associations [to 16 Oct 2021]
https://www.wfpha.org/
Latest News
Reducing Maternal Mortality Ratio in low- and Middle Income Countries
Oct 14, 2021
Reducing Maternal Mortality Ratio in low- and Middle-income CountriesThe World Health Organization (WHO) has long identified maternal mortality as a global priority for improving global health outcomes. Yet, the United Nations Millennium…

Policy Statement on Climate Change
Oct 14, 2021
Policy Statement on Climate ChangeClimate change is a global problem. It is harming human health and wellbeing today, and we have clear evidence that lack of effective response will render the global poor, people living in low lying areas, along…

Polio Eradication: Last Battle?
Oct 12, 2021
Polio Eradication: Last Battle?Poliomyelitis (polio) is a highly infectious viral disease that attacks the nervous system and can cause irreversible paralysis and death. There is no cure for polio, it can only be prevented through immunisation….

World Bank [to 16 Oct 2021]
http://www.worldbank.org/en/news/all
Selected News, Announcements
Accelerating COVID-19 Vaccine Uptake to Boost Malawi’s Economic Recovery
Since the onset of the COVID-19 pandemic, many countries including Malawi have struggled to mitigate its impact amid limited fiscal support and fragile health systems. The pandemic has plunged the continent…
Date: October 13, 2021 Type: Opinion

Improving Maternal and Children Health Care in Times of Cholera
Challenge Ten months after a devastating earthquake hit in 2010, a severe cholera outbreak placed additional pressure on Haiti’s already fragile health system, further compromising the welfare and health…
Date: October 13, 2021 Type: Result Brief

Low-Income Country Debt Rises to Record $860 Billion in 2020
Debt reduction, restructuring, and transparency needed to help low-income countries overcome debt challenges
WASHINGTON, Oct. 11, 2021— Governments around the world responded to the COVID-19 pandemic with massive fiscal, monetary, and financial stimulus packages. While these measures were aimed at addressing the health emergency, cushioning the impact of the pandemic on the poor and vulnerable and putting countries on a path to recovery, the resulting debt burden of the world’s low-income countries rose 12% to a record $860 billion in 2020, according to a new World Bank report.
Even prior to the pandemic, many low- and middle-income countries were in a vulnerable position, with slowing economic growth and public and external debt at elevated levels. External debt stocks of low- and middle-income countries combined rose 5.3% in 2020 to $8.7 trillion. According to the new International Debt Statistics 2022 report, an encompassing approach to managing debt is needed to help low- and middle-income countries assess and curtail risks and achieve sustainable debt levels.
“We need a comprehensive approach to the debt problem, including debt reduction, swifter restructuring and improved transparency,” said World Bank Group President David Malpass. “Sustainable debt levels are vital for economic recovery and poverty reduction.”
The deterioration in debt indicators was widespread and impacted countries in all regions. Across all low- and middle-income countries, the rise in external indebtedness outpaced Gross National Income (GNI) and export growth. Low- and middle-income countries’ external debt-to-GNI ratio (excluding China) rose to 42% in 2020 from 37% in 2019 while their debt-to-export ratio increased to 154% in 2020 from 126% in 2019…

World Customs Organization – WCO [to 16 Oct 2021]
http://www.wcoomd.org/
Latest News – Selected Items
13 October 2021
WCO concludes the cycle of regional consultations on the Strategic Plan with the Asia/Pacific region

World Organisation for Animal Health (OIE) [to 16 Oct 2021]
https://www.oie.int/en/media/news/
Press Releases, Statements
No new digest content identified.

WTO – World Trade Organisation [to 16 Oct 2021]
http://www.wto.org/english/news_e/news_e.htm
WTO News and Events
Members pursue convergence for an IP COVID-19 response
14 October 2021
At a meeting of the Council for Trade-Related Aspects of Intellectual Property Rights (TRIPS) on 13-14 October 2021, WTO members noted encouraging exchanges at recent small group discussions and bilateral meetings which helped to identify points of convergence on how to provide a common intellectual property (IP) response to COVID-19. The chair of the TRIPS Council, Ambassador Dagfinn Sørli of Norway, announced he would continue to consult with members on how to move towards a consensus before the WTO’s 12th Ministerial Conference (MC12), to be held on 30 November — 3 December
News item
[See COVID above for detail]

WTO briefs members and observers on COVID-19 related initiatives and analysis
12 October 2021
Over 180 representatives from 111 members and observers participated on 12 October in a virtual information session on the WTO Secretariat’s work to support equitable access to COVID-19 vaccines.
Deputy Director-General Anabel González hosted the Virtual Information Session on Access to COVID-19 Vaccines, Collaborative Initiatives and Analysis on Supply Chains and Tariffs. She briefed participants on the Secretariat’s contributions to a range of collaborative initiatives, such as the Multilateral Leaders Task Force on COVID-19, the WHO, WIPO, WTO Trilateral Cooperation in support of capacity building, the COVAX Manufacturing Task Force and the Access to COVID-19 Tools (ACT) Accelerator.
The programme included presentations on the most recent information notes prepared by the WTO Secretariat:
:: update of the Indicative List of Trade-Related Bottlenecks and Trade-Facilitating Measures on Critical Products to Combat COVID-19, a Joint Indicative List of Critical COVID-19 Vaccine Inputs,
:: new report on COVID-19 vaccines production and tariffs on vaccine inputs,
:: comments by the Coalition for Epidemic Preparedness Innovations (CEPI) and the World Health Organization (WHO).
The recording of the session is available here. The programme and background materials are available here. The WTO COVID-19 gateway is available here.
News item

 

::::::

ARM [Alliance for Regenerative Medicine] [to 16 Oct 2021]
https://alliancerm.org/press-releases/
Selected Press Releases
No new digest content identified.

BIO [to 16 Oct 2021]
https://www.bio.org/press-releases
Press Releases, Letters, Testimony, Comments [Selected]
No new digest content identified.

DCVMN – Developing Country Vaccine Manufacturers Network [to 16 Oct 2021]
http://www.dcvmn.org/
News; Upcoming events
No new digest content identified.

ICBA – International Council of Biotechnology Associations [to 16 Oct 2021]
https://internationalbiotech.org/news/
News
No new digest content identified.

IFPMA [to 16 Oct 2021]
http://www.ifpma.org/resources/news-releases/
Selected Press Releases, Statements, Publications
R&D-based pharmaceutical industry’s innovative partnerships to meet urgent global supply needs
05 October 2021

 

International Generic and Biosimilar Medicines Association [IGBA]
https://www.igbamedicines.org/
News
No new digest content identified.

International Alliance of Patients’ Organizations – IAPO [to 16 Oct 2021]
https://www.iapo.org.uk/news/topic/6
Press and media [Selected]
No new digest content identified.

PhRMA [to 16 Oct 2021]
http://www.phrma.org/
Latest News [Selected]
New report shows more than 260 medicines in development to fight neurodegenerative diseases
October 12, 2021
Today, PhRMA released a new report detailing the more than 260 medicines in development for 29 neurodegenerative diseases.
Blog Post

Palliative Surgery

AMA Journal of Ethics
Volume 23, Number 10: E757-831
https://journalofethics.ama-assn.org/issue/palliative-surgery

 

Palliative Surgery
Palliative care is not just for dying patients. In fact, dying patients are living patients, and all patients deserve palliation. Contrary to popular belief among many patients and clinicians, palliative interventions can be invasive and include not only medical, but surgical care. In any case, palliative care should be defined by intention: partnering clinicians, patients, and their loved ones aim neither to cure disease nor to prolong life, but to improve the quality of a patient’s life at any needed time. Quality of life is motivated by goal-elucidating conversation, counseling, and symptom management-directed intervention. This issue investigates surgical palliation specifically, with sharp focus on intention formation and trust preservation.

Intention to COVID-19 vaccination and associated factors among health care workers: A systematic review and meta-analysis of cross-sectional studies

American Journal of Infection Control
October 2021 Volume 49 Issue 10 p1215-1342
http://www.ajicjournal.org/current

 

State of the Science Review
Intention to COVID-19 vaccination and associated factors among health care workers: A systematic review and meta-analysis of cross-sectional studies
Chuxuan Luo, et al.
Published online: July 14, 2021
p1295-1304

Implementation of a COVID-19 Mass Vaccination Clinic to College Students in Montana

American Journal of Public Health
October 2021 111(10)
http://ajph.aphapublications.org/toc/ajph/current

 

NOTES FROM THE FIELD
Implementation of a COVID-19 Mass Vaccination Clinic to College Students in Montana
Immunization/Vaccines, Other Race/Ethnicity, Race/Ethnicity
Sally Moyce, Julie Ruff, Ann Galloway and Sarah Shannon
111(10), pp. 1776–1779

COVID-19 Case Rates After Surveillance and Vaccinations in a Statewide Psychiatric Hospital System

American Journal of Public Health
October 2021 111(10)
http://ajph.aphapublications.org/toc/ajph/current

 

NOTES FROM THE FIELD
COVID-19 Case Rates After Surveillance and Vaccinations in a Statewide Psychiatric Hospital System
Immunization/Vaccines, Surveillance, Mental Health, Statistics/Evaluation/Research, Health Care Facilities/Services
Thomas E. Smith, Ian T. Rodgers, Daniel J. Silverman, Sally R. Dreslin, Mark Olfson, Lisa B. Dixon and Melanie M. Wall
111(10), pp. 1780–1783

Levels of explainable artificial intelligence for human-aligned conversational explanations

Artificial Intelligence – An International Journal
Volume 299 October 2021
https://www.sciencedirect.com/journal/artificial-intelligence/vol/299/suppl/C

 

Research article Abstract only
Levels of explainable artificial intelligence for human-aligned conversational explanations
Richard Dazeley, Peter Vamplew, Cameron Foale, Charlotte Young, … Francisco Cruz
Article 103525
This paper aims to define levels of explanation and describe how they can be integrated to create a human-aligned conversational explanation system.

Assessment of the appropriateness of the i-CONSENT guidelines recommendations for improving understanding of the informed consent process in clinical studies

BMC Medical Ethics
http://www.biomedcentral.com/bmcmedethics/content
(Accessed 16 Oct 2021)

 

Assessment of the appropriateness of the i-CONSENT guidelines recommendations for improving understanding of the informed consent process in clinical studies
The H2020 i-CONSENT project has developed a set of guidelines that offer ethical recommendations and practical tools aimed at making the informed consent process in clinical studies more comprehensive, tailored, and inclusive. An analysis of the appropriateness of some of its novel recommendations was carried out by a group of experts representing different stakeholders.
Authors: Jaime Fons-Martinez, Cristina Ferrer-Albero and Javier Diez-Domingo
Content type: Research
13 October 2021

Knowledge, attitudes and perceptions towards COVID-19 vaccinations: a cross-sectional community survey in Bangladesh

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 16 Oct 2021)

 

Knowledge, attitudes and perceptions towards COVID-19 vaccinations: a cross-sectional community survey in Bangladesh
Several vaccines have been approved for use against coronavirus disease (COVID-19) and distributed globally in different regions. However, general community knowledge, attitudes and perceptions towards COVID-1…
Authors: Md. Saiful Islam, Abu Bakkar Siddique, Rejina Akter, Rafia Tasnim, Md. Safaet Hossain Sujan, Paul R. Ward and Md. Tajuddin Sikder
Citation: BMC Public Health 2021 21:1851
Content type: Research
Published on: 13 October 2021

Determinants of HPV-vaccination uptake and subgroups with a lower uptake in the Netherlands

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 16 Oct 2021)

 

Determinants of HPV-vaccination uptake and subgroups with a lower uptake in the Netherlands
In the Netherlands, the HPV-vaccine uptake was 52% during the 2009 catch-up campaign (birth cohorts 1993–1996). This increased to 61% in the regular immunization program (birth cohorts 2000–2001). However for …
Authors: A. C. de Munter, T. M. Schurink-van t Klooster, A. van Lier, R. Akkermans, H. E. de Melker and W. L. M. Ruijs
Citation: BMC Public Health 2021 21:1848
Content type: Research
Published on: 12 October 2021

The knowledge, attitudes and beliefs of midwives on the vaccination coverage rates in Perth’s Aboriginal children

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 16 Oct 2021)

 

The knowledge, attitudes and beliefs of midwives on the vaccination coverage rates in Perth’s Aboriginal children
Midwives are well placed to promote vaccination awareness throughout a women’s pregnancy and strengthen childhood vaccination demand following hospital discharge. In Perth, Western Australia, Aboriginal childr…
Authors: Rebecca Carman, Lesley Andrew and Amanda Devine
Citation: BMC Public Health 2021 21:1845
Content type: Research
Published on: 12 October 2021

Original research: A mixed methods study to develop a tool to assess institutional readiness to conduct knowledge translation activities in low-income and middle-income countries

BMJ Open
October 2021 – Volume 11 – 10
https://bmjopen.bmj.com/content/11/10

 

Articles
Original research: A mixed methods study to develop a tool to assess institutional readiness to conduct knowledge translation activities in low-income and middle-income countries (11 October, 2021)
Anna Kalbarczyk, Aditi Rao, Olakunle Alonge
This study identifies a tool for assessing readiness of LMIC academic institutions to conduct KT and unique opportunities for building capacity. The organisational focus of these factors underscores the need for strategies that address organisational systems and structures in addition to individual skills. Future research will be conducted to understand determinants of these factors and develop a comprehensive set of capacity building strategies responsive to academic institutions in LMICs.

The surprise element: A hallmark of creativity in scientists, artists, and comedians

Cell
Oct 14, 2021 Volume 184 Issue 21 p5261-5496
https://www.cell.com/cell/current

 

Commentary
The surprise element: A hallmark of creativity in scientists, artists, and comedians
Joseph L. Goldstein
Truly creative works of science and art produce unexpected and surprising results—just like the punch line of a good joke that generates an unfamiliar twist on a familiar idea. Surprise stimulates curiosity, which triggers a search to reveal the mystery of things unknown.

Delivering the message: How a novel technology enabled the rapid development of effective vaccines

Cell
Oct 14, 2021 Volume 184 Issue 21 p5261-5496
https://www.cell.com/cell/current

 

Benchmarks
Delivering the message: How a novel technology enabled the rapid development of effective vaccines
Lucy Shapiro, Richard Losick
This year’s Lasker∼Debakey Clinical Research Award honors Katalin Karikó and Drew Weissman for the development of a therapeutic technology based on nucleoside-modification of messenger RNA, enabling the rapid development of the highly effective COVID-19 vaccines.

Malaria PK/PD and the Role Pharmacometrics Can Play in the Global Health Arena: Malaria Treatment Regimens for Vulnerable Populations

Clinical Pharmacology & Therapeutics
Volume 110, Issue 4 Pages: 827-1135 October 2021
https://ascpt.onlinelibrary.wiley.com/toc/15326535/current

 

Review
Open Access
Malaria PK/PD and the Role Pharmacometrics Can Play in the Global Health Arena: Malaria Treatment Regimens for Vulnerable Populations
Emma Hughes, Erika Wallender, Ali Mohamed Ali, Prasanna Jagannathan, Radojka M. Savic
Pages: 926-940
First Published:24 March 2021

Assuring Access to Safe Medicines in Pregnancy and Breastfeeding

Clinical Pharmacology & Therapeutics
Volume 110, Issue 4 Pages: 827-1135 October 2021
https://ascpt.onlinelibrary.wiley.com/toc/15326535/current

 

Mini-Review
Open Access
Assuring Access to Safe Medicines in Pregnancy and Breastfeeding
Janet Nooney, Shannon Thor, Corinne de Vries, John Clements, Leyla Sahin, Wei Hua, Darcie Everett, Cosimo Zaccaria, Robert Ball, Agnes Saint-Raymond, Lynne Yao, June Raine, Sandra Kweder
Pages: 941-945
First Published:21 February 2021
Free Access

Benefit-Risk Assessment of Off-Label Drug Use in Children: The Bravo Framework

Clinical Pharmacology Worldwide: A Global Health Perspective
Larissa Wenning, Goonaseelan (Colin) Pillai, Todd C. Knepper, Katarina Ilic, Ali Mohamed Ali, Jennifer E. Hibma

 

Tutorial
Open Access
Benefit-Risk Assessment of Off-Label Drug Use in Children: The Bravo Framework
Tjitske M. van der Zanden, Miriam G. Mooij, Nienke J. Vet, Antje Neubert, Wolfgang Rascher, Florian B. Lagler, Christoph Male, Helene Grytli, Thomas Halvorsen, Matthijs de Hoog, Saskia N. de Wildt
Pages: 952-965
First Published:18 June 2021

Policy and planning for large epidemics and pandemics – challenges and lessons learned from COVID-19

Current Opinion in Infectious Diseases
October 2021 – Volume 34 – Issue 5
https://journals.lww.com/co-infectiousdiseases/pages/currenttoc.aspx

 

Policy and planning for large epidemics and pandemics – challenges and lessons learned from COVID-19
Sharp, Ashley; Jain, Vageesh; Alimi, Yewande; More
Current Opinion in Infectious Diseases. 34(5):393-400, October 2021.

COVID-19 transmission and the safety of air travel during the pandemic: a scoping review

Current Opinion in Infectious Diseases
October 2021 – Volume 34 – Issue 5
https://journals.lww.com/co-infectiousdiseases/pages/currenttoc.aspx

 

COVID-19 transmission and the safety of air travel during the pandemic: a scoping review
Khatib, Aisha N.; McGuinness, Sarah; Wilder-Smith, Annelies
Current Opinion in Infectious Diseases. 34(5):415-422, October 2021.

Supplement: E-Mental-Health: Exploring the Evidence Base and Stakeholders’ Perspectives on Internet-Based Interventions for the Prevention of Mental Health Conditions

The European Journal of Public Health
SUPPLEMENT – Volume 31, Issue Supplement_1, July 2021
https://academic.oup.com/eurpub/issue/31/Supplement_1

 

Supplement: E-Mental-Health: Exploring the Evidence Base and Stakeholders’ Perspectives on Internet-Based Interventions for the Prevention of Mental Health Conditions
Mental illness represents an enormous personal, social and societal burden for European citizens1 calling for the need to expand existing models of mental healthcare delivery. In Europe, the Internet is a key source of health information,2 and technology-enhanced (psychological) interventions such as Internet- and mobile-delivered applications (‘eHealth’3 and ‘m-Health’4) have become increasingly popular and studied. There is already strong evidence of the efficacy of online interventions for the prevention and treatment of several psychological disorders5,6 and meta-analyses show effect sizes similar to face-to-face interventions.7

Artificial intelligence enables comprehensive genome interpretation and nomination of candidate diagnoses for rare genetic diseases

Genome Medicine
https://genomemedicine.biomedcentral.com/articles
[Accessed 16 Oct 2021]

 

Research
Artificial intelligence enables comprehensive genome interpretation and nomination of candidate diagnoses for rare genetic diseases
Clinical interpretation of genetic variants in the context of the patient’s phenotype is becoming the largest component of cost and time expenditure for genome-based diagnosis of rare genetic diseases. Artific…
Authors: Francisco M. De La Vega, Shimul Chowdhury, Barry Moore, Erwin Frise, Jeanette McCarthy, Edgar Javier Hernandez, Terence Wong, Kiely James, Lucia Guidugli, Pankaj B. Agrawal, Casie A. Genette, Catherine A. Brownstein, Alan H. Beggs, Britt-Sabina Löscher, Andre Franke, Braden Boone…
Citation: Genome Medicine 2021 13:153
Published on: 14 October 2021

Governance of health research in four eastern and southern African countries

Health Research Policy and Systems
http://www.health-policy-systems.com/content
[Accessed 16 Oct 2021]

 

Governance of health research in four eastern and southern African countries
Health research governance is an essential function of national health research systems. Yet many African countries have not developed strong health research governance structures and processes. This paper pre…
Authors: Pamela A. Juma, Catherine M. Jones, Rhona Mijumbi-Deve, Clare Wenham, Tiny Masupe, Joelle Sobngwi-Tambekou, Godfrey Biemba, Namuunda Mtombo and Justin Parkhurst
Citation: Health Research Policy and Systems 2021 19:132
Content type: Research
Published on: 13 October 2021

Localisation and local humanitarian action

Humanitarian Exchange Magazine
Number 79, May 2021
https://odihpn.org/magazine/localisation-and-local-humanitarian-action/

 

Localisation and local humanitarian action
by HPN October 2020
The theme of this edition of Humanitarian Exchange is localisation+ and local humanitarian action. Five years ago this week, donors, United Nations (UN) agencies,  non-governmental organisations (NGOs), the International Committee of the Red Cross (ICRC) and International Federation of Red Cross and Red Crescent Societies (IFRC) committed within the Grand Bargain to increase multi-year investments in the institutional capacities of local and national responders, and to provide at least 25% of humanitarian funding to them as directly as possible. Since then, there is increasing consensus at policy and normative level, underscored by the Covid-19 pandemic, that local leadership should be supported.  Localisation has gone from a fringe conversation among policy-makers and aid agencies in 2016 to a formal priority under the Grand Bargain. Wider global movements on anti-racism and decolonisation have also brought new momentum to critical reflections on where power, knowledge and capacity reside in the humanitarian system. Yet progress has been slow and major gaps remain between the rhetoric around humanitarian partnerships, funding and coordination and practices on the ground.

Transition to endemicity: Understanding COVID-19

Immunity [NEW JOURNAL ADDED]
Oct 12, 2021 Volume 54 Issue 10 p2169-2436
https://www.cell.com/immunity/current

 

Primer
Transition to endemicity: Understanding COVID-19
Rustom Antia, M. Elizabeth Halloran
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease, coronavirus disease 2019 (COVID-19), has caused a devastating pandemic worldwide. Here, we explain basic concepts underlying the transition from an epidemic to an endemic state, where a pathogen is stably maintained in a population. We discuss how the number of infections and the severity of disease change in the transition from the epidemic to the endemic phase and consider the implications of this transition in the context of COVID-19.

COVID-19 vaccination program in the mainland of China: a subnational descriptive analysis on target population size and current progress

Infectious Diseases of Poverty
http://www.idpjournal.com/content
[Accessed 16 Oct 2021]

 

COVID-19 vaccination program in the mainland of China: a subnational descriptive analysis on target population size and current progress
Authors: Wen Zheng, Xuemei Yan, Zeyao Zhao, Juan Yang and Hongjie Yu
Content type: Research Article
15 October 2021

Demographic and KAP determinants of COVID-19 vaccine hesitancy and vaccine refusal: a cross-sectional study in Indian population

International Journal of Community Medicine and Public Health
Vol 8, No 10 (2021) October 2021
https://www.ijcmph.com/index.php/ijcmph/issue/view/81

 

Original Research Articles
Demographic and KAP determinants of COVID-19 vaccine hesitancy and vaccine refusal: a cross-sectional study in Indian population
Meghna Gupta, Rohit Goyal, Shruti Aggarwal, Mansunderbir Singh, Vitull K. Gupta, Nikita Garg
DOI: 10.18203/2394-6040.ijcmph20213664

Public knowledge, attitude, practice towards acceptance of COVID-19 Vaccine: a prospective cross-sectional study in Bangalore

International Journal of Community Medicine and Public Health
Vol 8, No 10 (2021) October 2021
https://www.ijcmph.com/index.php/ijcmph/issue/view/81

 

Public knowledge, attitude, practice towards acceptance of COVID-19 Vaccine: a prospective cross-sectional study in Bangalore
Nishchitha S., Sunil Kumar D., Chandan N., Arun Gopi, Narayan Murthy M. R., Anil S. Bilimale
DOI: 10.18203/2394-6040.ijcmph20213792

Surveillance for Adverse Events After COVID-19 mRNA Vaccination

JAMA
October 12, 2021, Vol 326, No. 14, Pages 1353-1452
https://jamanetwork.com/journals/jama/currentissue

 

Original Investigation
Surveillance for Adverse Events After COVID-19 mRNA Vaccination
Nicola P. Klein, MD, PhD; Ned Lewis, MPH; Kristin Goddard, MPH; et al.
free access has active quiz
JAMA. 2021;326(14):1390-1399. doi:10.1001/jama.2021.15072
This study reports an interim analysis of safety surveillance data of 23 serious outcomes following vaccination with 1 of the mRNA COVID-19 vaccines based on comprehensive health records from a large US population.

Estimated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Based on Blood Donations, July 2020-May 2021

JAMA
October 12, 2021, Vol 326, No. 14, Pages 1353-1452
https://jamanetwork.com/journals/jama/currentissue

 

Estimated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Based on Blood Donations, July 2020-May 2021
Jefferson M. Jones, MD, MPH; Mars Stone, PhD; Hasan Sulaeman, MS; et al.
free access has active quiz
JAMA. 2021;326(14):1400-1409. doi:10.1001/jama.2021.15161
This study estimates trends in SARS-CoV-2 seroprevalence related to infection and vaccination in the US population.

COVID-19 Vaccination of Minors Without Parental ConsentRespecting Emerging Autonomy and Advancing Public Health

JAMA Pediatrics
October 2021, Vol 175, No. 10, Pages 990-1088
https://jamanetwork.com/journals/jamapediatrics/currentissue

 

Viewpoint
COVID-19 Vaccination of Minors Without Parental ConsentRespecting Emerging Autonomy and Advancing Public Health
Larissa Morgan, JD, MBE; Jason L. Schwartz, PhD; Dominic A. Sisti, PhD
free access
JAMA Pediatr. 2021;175(10):995-996. doi:10.1001/jamapediatrics.2021.1855
This Viewpoint discusses allowing minors to consent and receive the COVID-19 vaccine without parental authorization.

Summary of Literature on Pediatric Real-world Evidence and Effectiveness

JAMA Pediatrics
October 2021, Vol 175, No. 10, Pages 990-1088
https://jamanetwork.com/journals/jamapediatrics/currentissue

 

Research Letter
Summary of Literature on Pediatric Real-world Evidence and Effectiveness
Ann W. McMahon, MD, MS; Kenneth Quinto, MD, MPH; Amy Abernethy, MD, PhD; et al.
JAMA Pediatr. 2021;175(10):1077-1079. doi:10.1001/jamapediatrics.2021.2149
This cross-sectional study investigates the use of real-world data and real-world evidence in informing medicine efficacy in pediatric literature.

Striving for evidence-based health care with eHealth and technology in a time of half-truths and disinformation

JBI Evidence Synthesis
October 2021 – Volume 19 – Issue 10
https://journals.lww.com/jbisrir/Pages/currenttoc.aspx

 

EDITORIALS
Striving for evidence-based health care with eHealth and technology in a time of half-truths and disinformation
Dol, Justine; Dennis, Cindy-Lee
JBI Evidence Synthesis. 19(10):2474-2475, October 2021.

India’s role in COVID-19 vaccine diplomacy

Journal of Travel Medicine
Volume 28, Issue 7, October 2021
https://academic.oup.com/jtm/issue

 

Perspectives
India’s role in COVID-19 vaccine diplomacy
Khan Sharun, MVSc, Kuldeep Dhama, PhD
Journal of Travel Medicine, Volume 28, Issue 7, October 2021, taab064, https://doi.org/10.1093/jtm/taab064
Indian vaccine manufacturers such as Serum Institute of India, Bharat Biotech, Dr Reddy’s Laboratories, Biological E Limited, Aurobindo Pharma and Indian Immunologicals have already secured the license to manufacture major vaccine candidates. The ability of the country to manufacture cost-effective COVID-19 vaccines will help to meet the global vaccine requirements.

Unintended health and societal consequences of international travel measures during the COVID-19 pandemic: a scoping review

Journal of Travel Medicine
Volume 28, Issue 7, October 2021
https://academic.oup.com/jtm/issue

 

Review
Unintended health and societal consequences of international travel measures during the COVID-19 pandemic: a scoping review
Carmen Klinger, MSc, Jacob Burns, MSc, Ani Movsisyan, PhD, Renke Biallas, MSc, Susan L Norris, MD …
Journal of Travel Medicine, Volume 28, Issue 7, October 2021, taab123, https://doi.org/10.1093/jtm/taab123

COVID-19 in fully vaccinated Everest trekkers in Nepal

Journal of Travel Medicine
Volume 28, Issue 7, October 2021
https://academic.oup.com/jtm/issue

 

Rapid Communications
COVID-19 in fully vaccinated Everest trekkers in Nepal
Bhawana Amatya, MD, Prativa Pandey, MD, Suvash Dawadi, MD, Shanta Manandhar, MD
Journal of Travel Medicine, Volume 28, Issue 7, October 2021, taab098, https://doi.org/10.1093/jtm/taab098
COVID-19 in a fully mRNA-1273 vaccinated aspiring Everest summiteer and an Everest trekker who had two doses of ChAdOx1nCoV-19 is presented. Delta B.1.617.2 variant was sequenced in one of the cases. Travellers should be wary of starting up travel to under-vaccinated regions, particularly if they are at high risk for severe disease.

Articles of Significant Interest in This Issue

Journal of Virology
Volume 95 • Number 21 • October 2021
http://jvi.asm.org/content/current

 

Spotlight 13 October 2021
Articles of Significant Interest in This Issue
https://doi.org/10.1128/JVI.01507-21
Natural isolates and recombinant SARS-CoV-2 viruses rapidly adapt to heparin binding in cultured cells. Shiliaev et al. (e01357-21) report that within a few passages, the viral spike protein acquires mutations in the N-terminal domain and in P1′ position of the furin cleavage site. These mutations are closely located on the protein surface, increasing positive charge in the region and the affinity of the virus to heparan sulfate. These mutations make SARS-CoV-2 mutants dramatically more infectious for the cultured cells and dominant in viral pools. Such viral mutants efficiently use glycosaminoglycans for primary attachment before the high-affinity interaction with the ACE2 receptor.

Malaria vaccine approval: a step change for global health

The Lancet
Oct 16, 2021 Volume 398 Number 10309 p1381-1460
https://www.thelancet.com/journals/lancet/issue/current

 

Editorial
Malaria vaccine approval: a step change for global health
The Lancet
On Oct 6, WHO announced that it will be recommending widespread use of the RTS,S/AS01 (RTS,S) malaria vaccine for children in sub-Saharan Africa and in other regions with moderate-to-high Plasmodium falciparum transmission. Malaria has ravaged people’s lives for centuries; today the burden falls disproportionately on children in tropical regions. 229 million cases were recorded in 2019, and 409 000 people lost their lives, two-thirds of whom were younger than 5 years and living in sub-Saharan Africa. Broad roll-out across the region is now eminently achievable. Challenges remain, but this scientific triumph could be one of the most monumental opportunities in child health for a generation.

RTS,S is the first parasite vaccine to have obtained regulatory approval. Designed to target the sporozoite phase of the lifecycle, it blocks infection of the liver, where the parasite would otherwise mature, multiply, re-enter the bloodstream, and infect erythrocytes. The first attempts at creating a malaria vaccine began in the 1960s, and the road to victory has been difficult. Most trials ended in disappointment and many observers doubted whether a malaria vaccine would ever become a reality. The success of RTS,S is the culmination of generations of scientific ingenuity, three decades of profitless research and development by GSK, the foresight of generous funders, and close collaboration within African communities.

Pivotal phase 3 trials in 2009–14 took place in Burkina Faso, Gabon, Ghana, Kenya, Malawi, Mozambique, and Tanzania. The final results, published in The Lancet in 2015, showed that children in these regions receiving three doses of RTS,S plus a booster dose, between 5 and 17 months of age, would have a 29% reduced risk of severe malaria. Crucial implementation programmes in Kenya, Ghana, Malawi, Burkina Faso, and Mali, which will continue until 2023, have confirmed that, when combined with seasonal malaria chemoprevention, RTS,S can reduce death from malaria by over 70%. Compliance and acceptance are high, despite the complexity of the vaccination schedule, and implementation appears realistic, even in countries with under-resourced health-care infrastructure.

WHO’s endorsement of RTS,S comes at a crucial time in malaria control. Between 2000 and 2015, widespread deployment of simple but innovative control measures turned the tide against malaria. Insecticide-treated mosquito nets, indoor spraying of homes, rapid diagnostic tests, and new treatments and prophylactics are estimated to have averted 7·6 million deaths since 2000. But progress has stagnated over the past 6 years, especially in high-burden countries. Evolving mosquito and parasite populations are escaping detection by diagnostic tests and developing resistance to insecticides and antimalarials. Only last year, WHO warned that global targets of reducing malaria case incidence and mortality rates by at least 90% by 2030 would be missed. There is hope that the vaccine can turbocharge malaria control.

How the vaccine will fit into wider programmes of malaria control remains unclear. Understandably, there are questions over who will pay to make the vaccine available to all who need it, many of whom live in countries with fragile health systems. After a period of stalled development funding for malaria control, there is optimism that international donors will fund vaccination, as noted in a World Report. A reliance on international donors need not be the only option, however. The 2019 Lancet malaria eradication Commission noted that in addition to innovative technology, such as vaccines, domestic funding for malaria control would accelerate progress. Domestic spending on health is woefully low in the sub-Saharan region, and projections suggest that this is unlikely to improve over the next 30 years. But if countries could fund health system strengthening and overcome the barriers to ensure equitable access, they might avoid pitfalls that can come from narrow, vertical approaches to global health issues, which have a history of skewing incentives and neglecting the wider needs of population health.

A strong case for investment in health to reduce child and maternal mortality was made by the Lancet Commission on Investing in Health. For a disease that kills a child every 2 minutes, a vaccine with even a modest 30% efficacy could have a considerable effect on improving child survival. Wide availability of a malaria vaccine will mean that the prospect of ending preventable child mortality within a generation is now a step closer.

Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study

The Lancet
Oct 16, 2021 Volume 398 Number 10309 p1381-1460
https://www.thelancet.com/journals/lancet/issue/current

 

Articles
Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study
Sara Y Tartof, et al.
Background
Vaccine effectiveness studies have not differentiated the effect of the delta (B.1.617.2) variant and potential waning immunity in observed reductions in effectiveness against SARS-CoV-2 infections. We aimed to evaluate overall and variant-specific effectiveness of BNT162b2 (tozinameran, Pfizer–BioNTech) against SARS-CoV-2 infections and COVID-19-related hospital admissions by time since vaccination among members of a large US health-care system.
…Interpretation
Our results provide support for high effectiveness of BNT162b2 against hospital admissions up until around 6 months after being fully vaccinated, even in the face of widespread dissemination of the delta variant. Reduction in vaccine effectiveness against SARS-CoV-2 infections over time is probably primarily due to waning immunity with time rather than the delta variant escaping vaccine protection.