CDC/ACIP [to 13 Jul 2019]

CDC/ACIP [to 13 Jul 2019]
Thursday, July 11, 2019
TRANSCRIPT of July 9, 2019, CDC Vital Signs: Nationwide Outbreak of Acute Flaccid Myelitis—United States, 2018

CDC Lab Research Shows Two Treatments Effective Against DRC Ebola Strain
Tuesday, July 9, 2019
[See DRC – Ebola above for detail]

CDC Telebriefing-New Vital Signs Report – CDC reports on largest acute flaccid myelitis (AFM) outbreak: doctors should recognize symptoms early and report all suspected cases
Tuesday, July 9, 2019

CDC Urges Doctors to Rapidly Recognize and Report AFM Cases
Tuesday, July 9, 2019

MMWR News Synopsis for July 12, 2019
Changes in HIV Preexposure Prophylaxis (PrEP) Awareness and Use Among Men Who Have Sex with Men — 20 Urban Areas, 2014 and 2017
Use of a daily pill for HIV prevention – HIV preexposure prophylaxis or PrEP – has increased but remains too low, particularly among gay and bisexual African American and Latino men. More gay and bisexual men at high risk for HIV are using PrEP. CDC analyzed data from more than 7,800 interviews with gay and bisexual men at high risk for HIV in 20 U.S. cities. The analysis found that reported PrEP use increased from 6% to 35% — and that reported awareness of PrEP increased from 60% to 90% — among the survey participants between 2014 and 2019. Despite those increases, PrEP use remains too low. African American and Latino gay and bisexual men reported lower PrEP awareness and use than white gay and bisexual men. To end the HIV epidemic in the United States, healthcare providers should routinely test their patients for HIV, assess HIV-negative patients for indications of HIV risk, and appropriately prescribe PrEP.

Vital Signs: Surveillance for Acute Flaccid Myelitis — United States, 2018

Africa CDC [to 13 Jul 2019]

Africa CDC [to 13 Jul 2019]
AUC and Government of China Sign Exchange of Letters of Agreement for the Construction of Africa CDC Headquarters Building
…The signing of the Exchange of Letters of Agreement is an important step towards actualization of the construction project. It paves the way for the signing of an Agreement on the Economic and Technical Cooperation for the provision of the grant aid for the construction, commencement of the project design, and subsequent laying of the foundation.

China CDC

China CDC
No new digest content identified.


National Health Commission of the People’s Republic of China
All children with leukemia included in national centralized treatment and management system
China’s program of leukemia centralized treatment and management has covered all children in the country, and already benefited 35,000 kids, according to the National Health Commission.

Chinese hospital publishes brain tumor database
China’s leading neurosurgery hospital has published a database of 2,000 gene samples from Chinese patients with glioma, a type of brain tumor.

All poor rural areas to get basic healthcare access
All residents in impoverished rural areas are expected to have access to basic healthcare services provided by certified doctors by the end of the year.



Paul G. Allen Frontiers Group [to 13 Jul 2019]
Press Release
Advancing Leading Edge Cancer Research in a $4.5 Million Collaboration
July 11, 2019
LLS, The Mark Foundation for Cancer Research and The Paul G. Allen Frontiers Group Join Forces to Advance Leading Edge Cancer Research

BMGF – Gates Foundation [to 13 Jul 2019]
No new digest content identified.

Bill & Melinda Gates Medical Research Institute [to 13 Jul 2019]
The Bill & Melinda Gates Medical Research Institute is a non-profit biotech organization. Our mission is to develop products to fight malaria, tuberculosis, and diarrheal diseases—three major causes of mortality, poverty, and inequality in developing countries. The world has unprecedented scientific tools at its disposal; now is the time to use them to save the lives of the world’s poorest people
No new digest content identified.

CARB-X [to 13 Jul 2019]
CARB-X is a non-profit public-private partnership dedicated to accelerating antibacterial research to tackle the global rising threat of drug-resistant bacteria.
No new digest content identified.

CEPI – Coalition for Epidemic Preparedness Innovations [to 13 Jul 2019]
10 July 2019
CEPI awards contract worth up to US$12.5 million to consortium led by Wageningen Bioveterinary Research to develop a human vaccine against Rift Valley fever
With support from the EU’s Horizon 2020 programme, CEPI will provide funding for vaccine manufacturing, preclinical research, and a phase 1 study to assess a single-dose vaccine candidate.

Clinton Health Access Initiative, Inc. (CHAI) [to 13 Jul 2019]
No new digest content identified.

EDCTP [to 13 Jul 2019]
The European & Developing Countries Clinical Trials Partnership (EDCTP) aims to accelerate the development of new or improved drugs, vaccines, microbicides and diagnostics against HIV/AIDS, tuberculosis and malaria as well as other poverty-related and neglected infectious diseases in sub-Saharan Africa, with a focus on phase II and III clinical trials
Latest news
12 July 2019
Director General Jean-Eric Paquet visits EDCTP-funded CHAPS adolescent study in Cape Town
On 8 July 2019, the European Commission Director-General for Research and Innovation, Jean-Eric Paquet, visited the Emavulandleni Research Centre in Cape Town, South Africa, together with colleagues from the European Commission, the Department of Science and Technology of South Africa, the South African Medical Research Council and EDCTP. This research centre is one of the sites for the EDCTP-funded ‘Combined HIV Adolescent Prevention Study’ (CHAPS), led by Professor Linda Gail-Bekker and conducted South Africa, Uganda and Zimbabwe.

Emory Vaccine Center [to 13 Jul 2019]
No new digest content identified.

European Medicines Agency [to 13 Jul 2019]
News and press releases
Press release: EU and US reach a milestone in mutual recognition of inspections of medicines manufacturers
Last updated: 12/07/2019

Press release: Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 8-11 July 2019
PRAC, Last updated: 11/07/2019

News: Guido Rasi elected chair of International Coalition of Medicines Regulatory Authorities (ICMRA)
Last updated: 08/07/2019

European Vaccine Initiative [to 13 Jul 2019]
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FDA [to 13 Jul 2019]
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Fondation Merieux [to 13 Jul 2019]
No new digest content identified.

Gavi [to 13 Jul 2019]
No new digest content identified.

GHIT Fund [to 13 Jul 2019]
GHIT was set up in 2012 with the aim of developing new tools to tackle infectious diseases that devastate the world’s poorest people. Other funders include six Japanese pharmaceutical
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Global Fund [to 13 Jul 2019]
No new digest content identified.

Hilleman Laboratories [to 13 Jul 2019]
No new digest content identified.

Human Vaccines Project [to 13 Jul 2019]
No new digest content identified.

IAVI [to 13 Jul 2019]
No new digest content identified.

International Coalition of Medicines Regulatory Authorities (ICMRA)
Monday 8 July 2019
Election of New Chair and Vice Chairs of ICMRA (July 2019)
…ICMRA brings together the leaders of regulatory authorities around the world to provide
strategic direction for enhanced cooperation on common scientific, regulatory or safety
challenges, improved communication and information sharing and effective global crisis
response mechanisms…

No new digest content identified.

IFRC [to 13 Jul 2019]
Selected Press Releases, Announcements
Asia Pacific, Bangladesh
Cox’s Bazar: Heavy rains trigger landslides in camps, Red Crescent response efforts underway
Cox’s Bazar/Kuala Lumpur/Geneva, 11 July 2019 – Heavy rains triggered landslides in camps in Cox’s Bazar housing more than 900,000 people from Rakhine state, Myanmar. Bangladesh Red Crescent Society response operations are underway in seven camps where …
11 July 2019

IVAC [to 13 Jul 2019]
No new digest content identified.

IVI [to 13 Jul 2019]
IVI News & Announcements
IVI exchanged a memorandum of understanding with the Armed Forces Medical Research Institute (AFMRI)
July 12, 2019 – SEOUL, South Korea. Today IVI exchanged a memorandum of understanding with the Armed Forces Medical Research Institute (AFMRI), the Korean military’s only institution dedicated to medical research and development, prevention of diseases, and promotion of health of military personnel.
Through this partnership, IVI and AFMRI will seek the exchange of research resources and close cooperation for the development of a vaccine against human adenovirus type 55, which is reported to cause outbreaks of acute respiratory diseases among military trainees and in school populations around the world. Both parties will also aim to facilitate discussions to explore and conduct joint research projects, and to support the vaccination of the Armed Forces…

JEE Alliance [to 13 Jul 2019]
Selected News and Events
No new digest content identified.

MSF/Médecins Sans Frontières [to 13 Jul 2019]
Selected News; Project Updates, Reports
The constant cycle of displacement
Project Update 12 Jul 2019

Supporting people in Qayyarah
Project Update 12 Jul 2019

Democratic Republic of Congo
Six years on, still no news of our colleagues held hostage by armed group…
Statement 11 Jul 2019

Annual Report
International Activity Report 2018
10 Jul 2019

The only option for cutaneous leishmaniasis treatment in Khyber Pa…
Project Update 9 Jul 2019

Clinic closure marks milestone for HIV treatment in Myanmar
Project Update 8 Jul 2019

NIH [to 13 Jul 2019]
Friday, July 5, 2019
Novel Method Identifies Patients at Risk for HIV Who May Benefit From Prevention Strategies
NIH-funded studies demonstrate the value of automated prediction algorithms that could be used to prevent new HIV infections

PATH [to 13 Jul 2019]
July 9, 2019 by PATH
PATH applauds recognition for frontline treatment of childhood diarrheal disease by the World Health Organization
New listing for co-packaged ORS-zinc in the WHO essential medicines list could improve access and save lives
Seattle, Washington, USA, July 9, 2019 – PATH applauds a landmark decision this week by the World Health Organization (WHO) to include a new listing for co-packaged oral rehydration salts (ORS) and zinc sulfate in its Model List of Essential Medicines (EML) and Model List of Essential Medicines for Children (EMLc), reinforcing the lifesaving benefits of using ORS and zinc together for pediatric diarrhea management, and achieving alignment with the long-standing recommendation for the use of both therapies as frontline practice. It is estimated that more than 60 percent of childhood diarrheal deaths could be prevented with full coverage of ORS and zinc alongside other community interventions…

Sabin Vaccine Institute [to 13 Jul 2019]
No new digest content identified.

UNAIDS [to 13 Jul 2019]
Selected Press Releases/Reports/Statements
12 July 2019
Charting progress against discrimination
Laws discriminate in many ways, but the criminalization of people is one of the most devastating forms of discrimination. Despite calls for reform and the commitments under the 2030 Agenda for Sustainable Development to remove discriminatory laws and reduce inequalities:

:: Sixty-nine countries still criminalize same-sex sexual relationships.
:: More than 100 countries criminalize drug use or the personal possession of drugs and 98 countries criminalize some form of sex work.
:: One in five people in prison are there because of drug-related crimes and 80% of those are there for personal possession or use.
:: Nineteen countries deport non-nationals on the grounds of their HIV status.

A high-level political forum is meeting in New York, United States of America, from 9 to 18 July to review the progress made against the commitments of Member States towards achieving the Sustainable Development Goals, including those on inequality and on peace, justice and strong institutions…

10 July 2019
Youth networks are saving lives
A study undertaken by Watipa and commissioned by UNAIDS and the PACT as part of its #uproot agenda found that young people play an essential role in demand creation, linkages to care and uptake of services for HIV and sexual and reproductive health and rights.
The report showcasing the results, titled Young people’s participation in community-based responses to HIV: from passive beneficiaries to active agents of change, showed that young people, particularly role models and leaders who are living with HIV, play a critical part in enabling access to HIV treatment and retention in care. The results showed that the support provided by young people to their peers has a positive effect on antiretroviral therapy adherence, navigating disclosure and living positively with HIV. Details of the types of support show that young people are actively involved in peer psychosocial support, peer-to-peer consultations, policy engagement processes, peer mobilization around specific campaigns and projects, and peer-supported hospital and care access…

UNICEF [to 13 Jul 2019]
Selected Statements, Press Releases, Reports
Attack in Afrin, Syria, kills three children and causes significant damage to school
Statement from Geert Cappelaere, UNICEF Regional Director for the Middle East and North Africa

Press release
Vaccination to contain severe measles outbreak underway in the Democratic Republic of the Congo amidst Ebola and mass displacement
Campaign led by the Ministry of Health with support from UNICEF and MSF
[See Milestones above for detail]

Press release
Rohingya refugee children in Cox’s Bazar at risk from flooding and landslides as monsoon rains continue
Education for over 60,000 children in camps and host community is disrupted because of damage to learning centres

At least seven children killed in yet another attack on civilians in northwest Syria
Statement by UNICEF Executive Director Henrietta Fore

Vaccine Confidence Project [to 13 Jul 2019]
No new digest content identified.

Vaccine Education Center – Children’s Hospital of Philadelphia [to 13 Jul 2019]
No new digest content identified.

Wellcome Trust [to 13 Jul 2019]
Opinion | 11 July 2019
Public health funding: a new approach to address conditions like obesity and cancer
by Sophie Hawkesworth, Portfolio Manager Population Health, Wellcome

The Wistar Institute [to 13 Jul 2019]
Press Release
Jul. 9, 2019
Consortium of HIV Researchers Puts Philadelphia at Global Center of Research Advances Toward a Cure for HIV/AIDS
Wistar and partners unveil educational videos focused on taking part in a cure-directed clinical trial.

World Organisation for Animal Health (OIE) [to 13 Jul 2019]
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BIO [to 13 Jul 2019]
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DCVMN – Developing Country Vaccine Manufacturers Network [to 13 Jul 2019]
No new digest content ide

IFPMA [to 13 Jul 2019]
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PhRMA [to 13 Jul 2019]
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Journal Watch

Journal Watch
Vaccines and Global Health: The Week in Review continues its weekly scanning of key peer-reviewed journals to identify and cite articles, commentary and editorials, books reviews and other content supporting our focu-s on vaccine ethics and policy. Journal Watch is not intended to be exhaustive, but indicative of themes and issues the Center is actively tracking. We selectively provide full text of some editorial and comment articles that are specifically relevant to our work. Successful access to some of the links provided may require subscription or other access arrangement unique to the publisher.
If you would like to suggest other journal titles to include in this service, please contact David Curry at:

Emerging Trends in Clinical Tropical Medicine Research

American Journal of Tropical Medicine and Hygiene
Volume 101, Issue 1, 2019


Perspective Piece
Emerging Trends in Clinical Tropical Medicine Research
Mark K. Huntington, Joe P. Bryan, Troy D. Moon, Pascal J. Imperato, Susan L. F. McLellan, Walter R. Taylor and John S. Schieffelin
The American Society for Tropical Medicine and Hygiene recently inaugurated an award for the best clinical research article published in the society’s journal in the previous year. This article summarizes both the process of selecting the winner and several themes that stood out in those articles which rose to the top for consideration. Themes of note included the importance of doing clinical research outside of referral centers, the complexity that must be considered when implementing interventions, incorporation of both ends of the age spectrum into studies, and considering cost-effectiveness and opportunity cost of interventions.

High Rates of Exposures to Waterborne Pathogens in Indigenous Communities in the Amazon Region of Ecuador

American Journal of Tropical Medicine and Hygiene
Volume 101, Issue 1, 2019


High Rates of Exposures to Waterborne Pathogens in Indigenous Communities in the Amazon Region of Ecuador
Natalia Romero-Sandoval, Lizeth Cifuentes, Gabriela León, Paola Lecaro, Claudia Ortiz-Rico, Philip Cooper and Miguel Martín
Waterborne pathogens, associated with poverty and poor sanitary conditions, are a major cause of morbidity and mortality worldwide. There are limited data on the epidemiology of waterborne pathogens in indigenous populations living in the Amazon region. We did a cross-sectional survey in two indigenous Shuar communities in the Amazon region of Ecuador in which we documented the presence of pathogens representing different sources of environmental contamination of water. We detected protozoa and soil-transmitted helminths by microscopy of fecal samples and the presence of IgG antibodies to hepatitis A and Leptospira spp. in blood samples from individuals older than 2 years and collected data by questionnaire on sociodemographic factors and knowledge of infectious diseases. Seroprevalence for hepatitis A and Leptospira spp. were 98.1% (95% CI: 97.0–99.8) and 50.0% (95% CI: 43.3–56.6), respectively, whereas 62.6% (95% CI: 55.8–69.4) had enteric parasites in stool samples. In participants older than 6 years, eight of 10 had evidence of infection with or exposure to at least one of the pathogens studied. Although prevalence of pathogens varied by age, it did not vary significantly by gender, temporal migration, illiteracy, perceived morbidity, receipt of conditional cash transfers, water boiling practices, poor housing conditions, and anthropometric status. These findings indicate a high level of contamination of drinking water by human pathogens in these indigenous communities and the need for interventions to improve access to and use of clean drinking water in these marginalized communities.