American Journal of Tropical Medicine and Hygiene
Volume 106 (2022): Issue 2 (Feb 2022)
https://www.ajtmh.org/view/journals/tpmd/106/2/tpmd.106.issue-2.xml

 

Perspective Pieces
Resilient Clinical Trial Infrastructure in Response to the COVID-19 Pandemic: Lessons Learned from the TOGETHER Randomized Platform Clinical Trial
Jamie I. Forrest, Angeli Rawat, Felipe Duailibe, Christina M. Guo, Sheila Sprague, Paula McKay, Gilmar Reis, and Edward J. Mills
Volume/Issue: Volume 106: Issue 2
Article Category: Perspective
DOI: https://doi.org/10.4269/ajtmh.21-1202

Immunogenicity of Oxford-AstraZeneca COVID-19 Vaccine in Vietnamese Health-Care Workers

American Journal of Tropical Medicine and Hygiene
Volume 106 (2022): Issue 2 (Feb 2022)
https://www.ajtmh.org/view/journals/tpmd/106/2/tpmd.106.issue-2.xml

 

Articles
Immunogenicity of Oxford-AstraZeneca COVID-19 Vaccine in Vietnamese Health-Care Workers
Nguyen Van Vinh Chau, Lam Anh Nguyet, Nguyen Thanh Truong, Le Mau Toan, Nguyen Thanh Dung, Le Manh Hung, Mai Thanh Nhan, Dinh Nguyen Huy Man, Nghiem My Ngoc, Huynh Phuong Thao, Tran Nguyen Hoang Tu, Huynh Kim Mai, Do Thai Hung, Nguyen Thi Han Ny, Le Kim Thanh, Nguyen To Anh, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Lam Minh Yen, Marc Choisy, Tran Tan Thanh, Guy Thwaites, Le Van Tan, and for the Oxford University Clinical Research Unit COVID-19 Research Group
Volume/Issue: Volume 106: Issue 2
Article Category: Research Article
DOI: https://doi.org/10.4269/ajtmh.21-0849

Characteristics and Outcomes of Hospitalized Pregnant Women With Influenza, 2010 to 2019 – A Repeated Cross-Sectional Study

Annals of Internal Medicine
February 2022 Volume 175, Issue 2
http://annals.org/aim/issue

 

Original Research
Characteristics and Outcomes of Hospitalized Pregnant Women With Influenza, 2010 to 2019 – A Repeated Cross-Sectional Study
Rachel Holstein, MPH, Fatimah S. Dawood, MD, Alissa O’Halloran, MSPH, Charisse Cummings, MPH, … et al.

Neutralization of SARS-CoV-2 Variants in Transplant Recipients After Two and Three Doses of mRNA-1273 Vaccine

Annals of Internal Medicine
February 2022 Volume 175, Issue 2
http://annals.org/aim/issue

 

Neutralization of SARS-CoV-2 Variants in Transplant Recipients After Two and Three Doses of mRNA-1273 VaccineSecondary Analysis of a Randomized Trial
FREE

 

Deepali Kumar, MD, Victor H. Ferreira, PhD, Victoria G. Hall, MBBS, Queenie Hu, PhD, … et al.

COVID-19 vaccine hesitancy among different population groups in China: a national multicenter online survey

BMC Infectious Diseases
http://www.biomedcentral.com/bmcinfectdis/content
(Accessed 19 Feb 2022)

 

COVID-19 vaccine hesitancy among different population groups in China: a national multicenter online survey
COVID-19 vaccine has been available in China since the beginning of the 2021, however, certain numbers of people are reluctant for some reasons to vaccinate. The high vaccine coverage is crucial for controllin…
Authors: Yiman Huang, Xiaoyou Su, Weijun Xiao, Hao Wang, Mingyu Si, Wenjun Wang, Xiaofen Gu, Li Ma, Li Li, Shaokai Zhang, Chunxia Yang, Yanqin Yu and Youlin Qiao
Citation: BMC Infectious Diseases 2022 22:153
Content type: Research article
Published on: 14 February 2022

Mitigating the SARS-CoV-2 Delta disease burden in Australia by non-pharmaceutical interventions and vaccinating children: a modelling analysis

BMC Medicine
http://www.biomedcentral.com/bmcmed/content
(Accessed 19 Feb 2022)

 

Mitigating the SARS-CoV-2 Delta disease burden in Australia by non-pharmaceutical interventions and vaccinating children: a modelling analysis
In countries with high COVID-19 vaccination rates the SARS-CoV-2 Delta variant resulted in rapidly increasing case numbers. This study evaluated the use of non-pharmaceutical interventions (NPIs) coupled with …
Authors: George J. Milne, Julian Carrivick and David Whyatt
Citation: BMC Medicine 2022 20:80
Content type: Research article
Published on: 18 February 2022

Stakeholders’ hopes and concerns about the COVID-19 vaccines in Southeastern Nigeria: a qualitative study

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 19 Feb 2022)

 

Stakeholders’ hopes and concerns about the COVID-19 vaccines in Southeastern Nigeria: a qualitative study
Equitable access and high uptake of safe and effective vaccines is critical to ending the COVID-19 pandemic. To ensure the success of these vaccines, particularly in many developing and under-developed parts o…
Authors: Uchechukwu Madukaku Chukwuocha, Chiagoziem Ogazirilem Emerole, Greg Ndubeze Iwuoha, Ugonma Winnie Dozie, Princewill Ugochukwu Njoku, Chidinma Onyebuchi Akanazu, Precious Okechukwu Eteike and Charlotte Hemingway
Citation: BMC Public Health 2022 22:330
Content type: Research
Published on: 16 February 2022

The lived experiences of a COVID-19 immunization programme: vaccine hesitancy and vaccine refusal

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 19 Feb 2022)

 

The lived experiences of a COVID-19 immunization programme: vaccine hesitancy and vaccine refusal
The COVID-19 pandemic has resulted in a global health emergency and lock-down measures to curb the uncontrolled transmission chain. Vaccination is an effective measure against COVID-19 infections. In Malaysia …
Authors: Nee Nee Chan, Khang Wei Ong, Ching Sin Siau, Kai Wei Lee, Suat Cheng Peh, Shakila Yacob, Yook Chin Chia, Vei Ken Seow and Pei Boon Ooi
Citation: BMC Public Health 2022 22:296
Content type: Research
Published on: 14 February 2022

SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans

Cell
Feb 17, 2022 Volume 185 Issue 4 p579-746
https://www.cell.com/cell/current

 

Articles
SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans
Philip A. Mudd, et al.
Analysis of draining lymph nodes of individuals vaccinated with BNT162b2 mRNA vaccine against SARS-CoV-2 identifies viral-spike-specific follicular helper CD4+ T cells that persist for months and contribute to long-term immunity.

From research ‘on’ to research ‘with’ children about their family lives: A scoping review of ethical and methodological challenges

Child Care, Health and Development
Volume 48, Issue 2, Pages: 177-357 March 2022
https://onlinelibrary.wiley.com/toc/13652214/current

 

REVIEW ARTICLES
From research ‘on’ to research ‘with’ children about their family lives: A scoping review of ethical and methodological challenges
Anne-Catherine Dubois, Magali Lahaye, Isabelle Aujoulat
Pages: 203-216
First Published: 02 December 2021

Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3)

Clinical Trials

Volume 19 Issue 1, February 2022
https://journals.sagepub.com/toc/ctja/19/1

Design
Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3) Daniel D Murray, Abdel G Babiker, Jason V Baker, Christina E Barkauskas, Samuel M Brown, Christina C Chang, Victoria J Davey, Annetine C Gelijns, Adit A Ginde, Birgit Grund, Elizabeth Higgs, Fleur Hudson, Virginia L Kan, H Clifford Lane, Thomas A Murray, Roger Paredes, Mahesh KB Parmar, Sarah Pett, Andrew N Phillips, Mark N Polizzotto, Cavan Reilly, Uriel Sandkovsky, Shweta Sharma, Marc Teitelbaum, B Taylor Thompson, Barnaby E Young, James D Neaton, Jens D Lundgrenon behalf of the TICO Study Group
First Published October 10, 2021; pp. 52–61

Rapid research response to the COVID-19 pandemic: perspectives from a National Institute for Health Biomedical Research Centre

Health Research Policy and Systems
http://www.health-policy-systems.com/content
[Accessed 19 Feb 2022]

 

Rapid research response to the COVID-19 pandemic: perspectives from a National Institute for Health Biomedical Research Centre
With over 5 million COVID-19 deaths at the time of writing, the response of research leaders was and is critical to developing treatments to control the global pandemic. As clinical research leaders urgently r…
Authors: Lorna R. Henderson, Helen McShane and Vasiliki Kiparoglou
Citation: Health Research Policy and Systems 2022 20:24
Content type: Commentary
Published on: 19 February 2022

Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants

JAMA
February 15, 2022, Vol 327, No. 7, Pages 605-693
https://jamanetwork.com/journals/jama/currentissue

 

Original Investigation
Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants
Emma K. Accorsi, PhD; Amadea Britton, MD; Katherine E. Fleming-Dutra, MD; et al.
free access has active quiz
JAMA. 2022;327(7):639-651. doi:10.1001/jama.2022.0470
This case-control study uses data from the Centers for Disease Control and Prevention Increasing Community Access to Testing platform to estimate the association between receipt of 3 doses of Pfizer-BioNTech BNT162b2 or Moderna mRNA-1273 vaccine, compared with 2 doses or unvaccinated, and symptomatic SARS-CoV-2 infection, stratified by Omicron and Delta variant.

Comparison of mRNA-1273 and BNT162b2 Vaccines on Breakthrough SARS-CoV-2 Infections, Hospitalizations, and Death During the Delta-Predominant Period

JAMA
February 15, 2022, Vol 327, No. 7, Pages 605-693
https://jamanetwork.com/journals/jama/currentissue

 

Research Letter
Comparison of mRNA-1273 and BNT162b2 Vaccines on Breakthrough SARS-CoV-2 Infections, Hospitalizations, and Death During the Delta-Predominant Period
Lindsey Wang; Pamela B. Davis, MD, PhD; David C. Kaelber, MD, PhD, MPH; et al.
free access has active quiz
JAMA. 2022;327(7):678-680. doi:10.1001/jama.2022.0210
This study examines breakthrough SARS-CoV-2 infections, hospitalizations, and mortality in March-August 2021, when the Delta variant predominated, among a general US cohort vaccinated with mRNA-1273 or BNT162b2.

COVID-19 Therapeutics for Nonhospitalized Patients

JAMA
February 15, 2022, Vol 327, No. 7, Pages 605-693
https://jamanetwork.com/journals/jama/currentissue

 

Viewpoint
COVID-19 Therapeutics for Nonhospitalized Patients
Rajesh T. Gandhi, MD; Preeti N. Malani, MD, MSJ; Carlos del Rio, MD
JAMA. 2022;327(7):617-618. doi:10.1001/jama.2022.0335
This Viewpoint provides a summary of currently available therapeutics for nonhospitalized patients with COVID-19 in the setting of the Omicron variant including principles for equitable allocation.

Intellectual property rights trump the right to health: Canada’s Access to Medicines Regime and TRIPs flexibilities in the context of Bolivia’s quest for vaccines

Journal of Global Ethics
Volume 17, Issue 3, 2021
http://www.tandfonline.com/toc/rjge20/current

 

Article
Intellectual property rights trump the right to health: Canada’s Access to Medicines Regime and TRIPs flexibilities in the context of Bolivia’s quest for vaccines
James Crombie
Pages: 353-366
Published online: 16 Dec 2021

Describing the Epidemiology of COVID-19 in Nigeria: An Analysis of the First Year of the Pandemic

Journal of Health Care for the Poor and Underserved (JHCPU)
Volume 33, Number 1, February 2022
https://muse.jhu.edu/issue/47329

 

Table of Contents
Original Papers
Describing the Epidemiology of COVID-19 in Nigeria: An Analysis of the First Year of the Pandemic
Obinna Oleribe, Olatayo Olawepo, Oliver Ezechi, Princess Osita-Oleribe, Michael Fertleman, Simon D. Taylor-Robinson
pp. 33-46
DOI: 10.1353/hpu.2022.0005

Parents’ Behaviors and Experiences Associated with Four Vaccination Behavior Groups for Childhood Vaccine Hesitancy

Maternal and Child Health Journal
Volume 26, issue 2, February 2022
https://link.springer.com/journal/10995/volumes-and-issues/26-2

 

Articles
Parents’ Behaviors and Experiences Associated with Four Vaccination Behavior Groups for Childhood Vaccine Hesitancy
Morgan E. Ellithorpe, Robyn Adams, Fashina Aladé
Content type: OriginalPaper
Published: 07 January 2022
Pages: 280 – 288

Pandemics disable people — the history lesson that policymakers ignore

Nature
Volume 602 Issue 7897, 17 February 2022
https://www.nature.com/nature/volumes/602/issues/7897

 

Comment | 16 February 2022
Pandemics disable people — the history lesson that policymakers ignore
Influenza, polio and more have shown that infections can change lives even decades later. Why the complacency over possible long-term effects of COVID-19?
Laura Spinney

Recent Orange and Purple Book legislation suggests a need to bridge drug and biologic patent regimes

Nature Biotechnology
Volume 40 Issue 2, February 2022
https://www.nature.com/nbt/volumes/40/issues/2

 

Patents | 15 February 2022
Recent Orange and Purple Book legislation suggests a need to bridge drug and biologic patent regimes
Additional changes could make the registries of drug patents published by the FDA, called the Orange and Purple Books, more useful and reduce barriers to effective competition from generic and biosimilar drugs.
Bryan S. Walsh, Jonathan J. Darrow, Aaron S. Kesselheim

Evaluating stability of attenuated Sabin and two novel type 2 oral poliovirus vaccines in children

njp Vaccines
https://www.nature.com/npjvaccines/
[Accessed 19 Feb 2022]

 

7, Article number: 19 (2022]
Open access
Evaluating stability of attenuated Sabin and two novel type 2 oral poliovirus vaccines in children
Rahnuma Wahid. Laina Mercer, John O. Konz
Abstract
Novel oral poliovirus vaccine type 2 (nOPV2) is being developed to reduce the rare occurrence of disease and outbreaks associated with the genetic instability of the Sabin vaccine strains. Children aged 1 to 5 years were enrolled in two related clinical studies to assess safety, immunogenicity, shedding rates and properties of the shed virus following vaccination with nOPV2 (two candidates) versus traditional Sabin OPV type 2 (mOPV2). The anticipated pattern of reversion and increased virulence was observed for shed Sabin-2 virus, as assessed using a mouse model of poliovirus neurovirulence. In contrast, there were significantly reduced odds of mouse paralysis for shed virus for both nOPV2 candidates when compared to shed Sabin-2 virus. Next-generation sequencing of shed viral genomes was consistent with and further supportive of the observed neurovirulence associated with shed Sabin-2 virus, as well as the reduced reversion to virulence of shed candidate viruses. While shed Sabin-2 showed anticipated A481G reversion in the primary attenuation site in domain V in the 5’ untranslated region to be associated with increased mouse paralysis, the stabilized domain V in the candidate viruses did not show polymorphisms consistent with reversion to neurovirulence. The available data from a key target age group for outbreak response confirm the superior genetic and phenotypic stability of shed nOPV2 strains compared to shed Sabin-2 and suggest that nOPV2 should be associated with less paralytic disease and potentially a lower risk of seeding new outbreaks.

Media attention and Vaccine Hesitancy: Examining the mediating effects of Fear of COVID-19 and the moderating role of Trust in leadership

PLoS One
http://www.plosone.org/
[Accessed 19 Feb 2022]

 

Research Article
Media attention and Vaccine Hesitancy: Examining the mediating effects of Fear of COVID-19 and the moderating role of Trust in leadership
Lulin Zhou, Sabina Ampon-Wireko, Xinglong Xu, Prince Edwudzie Quansah, Ebenezer Larnyo
Research Article | published 18 Feb 2022 PLOS ONE
https://doi.org/10.1371/journal.pone.0263610

Infection and vaccination status of COVID-19 among healthcare professionals in academic platform: Prevision vs. reality of Bangladesh context

PLoS One
http://www.plosone.org/
[Accessed 19 Feb 2022]

 

Infection and vaccination status of COVID-19 among healthcare professionals in academic platform: Prevision vs. reality of Bangladesh context
Bilkis Banu, Nasrin Akter, Sujana Haque Chowdhury, Kazi Rakibul Islam, Md. Tanzeerul Islam, Sarder Mahmud Hossain
Research Article | published 18 Feb 2022 PLOS ONE
https://doi.org/10.1371/journal.pone.0263078

Hepatitis vaccination adherence and completion rates and factors associated with low compliance: A claims-based analysis of U.S. adults

PLoS One
http://www.plosone.org/
[Accessed 19 Feb 2022]

 

Hepatitis vaccination adherence and completion rates and factors associated with low compliance: A claims-based analysis of U.S. adults
Joyce LaMori, Xue Feng, Christopher D. Pericone, Marco Mesa-Frias, Obiageli Sogbetun, Andrzej Kulczycki
Research Article | published 17 Feb 2022 PLOS ONE
https://doi.org/10.1371/journal.pone.0264062

Determinants of vaccine coverage and timeliness in a northern Pakistani village

PLoS One
http://www.plosone.org/
[Accessed 19 Feb 2022]

 

Determinants of vaccine coverage and timeliness in a northern Pakistani village
Alexandra F. Jamison, Benjamin J. J. McCormick, Ejaz Hussain, Elizabeth D. Thomas, Syed Iqbal Azam, Chelsea L. Hansen, Zeba A. Rasmussen
Research Article | published 17 Feb 2022 PLOS ONE
https://doi.org/10.1371/journal.pone.0263712

To vax or not to vax: Predictors of anti-vax attitudes and COVID-19 vaccine hesitancy prior to widespread vaccine availability

PLoS One
http://www.plosone.org/
[Accessed 19 Feb 2022]

 

To vax or not to vax: Predictors of anti-vax attitudes and COVID-19 vaccine hesitancy prior to widespread vaccine availability
Hannah A. Roberts, D. Angus Clark, Claire Kalina, Carter Sherman, Sarah Brislin, Mary M. Heitzeg, Brian M. Hicks
Research Article | published 15 Feb 2022 PLOS ONE
https://doi.org/10.1371/journal.pone.0264019

Global systemic risk and resilience for novel coronavirus in postpandemic era

Risk Analysis
Volume 42, Issue 1 January 2022
https://onlinelibrary.wiley.com/toc/15396924/current

 

Special Issue: Global Systemic Risk and Resilience for Novel Coronavirus in Post‐Pandemic Era
EDITORIAL
Free Access
Global systemic risk and resilience for novel coronavirus in postpandemic era
Desheng Dash Wu, Jade Mitchell, James H. Lambert
Pages: 1-4
First Published: 12 February 2022

Empower with evidence

Science
Volume 375| Issue 6582| 18 Feb 2022
https://www.science.org/toc/science/current

 

Editorial
Empower with evidence
Susan G. Amara
[Excerpt]
This week (17 to 20 February), the virtual annual meeting of the American Association for the Advancement of Science (AAAS, the publisher of Science) will address the challenges of building the public’s trust and understanding of science by illuminating both great science and innovative initiatives in advocacy, education, and policy. The theme, “Empower with Evidence,” speaks to the critical importance of decision-making, policy-making, and interventions that are grounded in knowledge and facts, not opinions—or worse, misinformation.
The ability of science to transform the world is increasingly threatened by misinformation that is jeopardizing trust in science. As highlighted in Science last week, the world’s information ecosystem is rapidly changing, and online environments have become a powerful open marketplace of facts, ideas, and opinions—where the meaningfulness of science is easily drowned out by the noise.
Solutions to this dilemma include training students and professional scientists to more effectively translate their work to the public, harnessing insights from the behavioral and social sciences to better engage with the public, and working with social media platforms to improve information delivery to a broader audience. These are important efforts, but do they get to the root of the problem?…

Sovereignty, sanctions, and data sharing under international law

Science
Volume 375| Issue 6582| 18 Feb 2022
https://www.science.org/toc/science/current

 

Policy Forum
Sovereignty, sanctions, and data sharing under international law
BY Michelle Rourke, Mark Eccleston-Turner, Stephanie Switzer
17 Feb 2022: 724-726
Pathogen samples and scientific data are bargaining chips in a global argument about who gets what in a pandemic
Abstract
In September 2021, after inaugurating the Berlin-based World Health Organization (WHO) Hub for Pandemic and Epidemic Intelligence, German Health Minister Jens Spahn indicated that sanctions might be an appropriate tool to deal with WHO member states that do not cooperate on data sharing during disease outbreaks. Tedros Adhanom Ghebreyesus, director general of the WHO, affirmed this, stating that “exploring the [idea of ] sanctions may be important” in cases where collaboration fails (1). Such comments indicate that the WHO Hub has been designed without much consideration of data sovereignty and “access and benefit sharing” (ABS) debates occurring across multiple United Nations (UN) bodies, including the WHO. Threats of sanctions do little to promote the ideals of equity and solidarity often touted as foundational to global health governance. They entrench the idea that pathogen samples and associated data are “bargaining chips” rather than vital inputs to public health research and pandemic response.

Impact of the COVID-19 pandemic on pediatric and adolescent vaccinations and well child visits in the United States: A database analysis

Vaccine
Volume 40, Issue 5 Pages 691-832 (31 January 2022)
https://www.sciencedirect.com/journal/vaccine/vol/40/issue/5

 

Research article Open access
Impact of the COVID-19 pandemic on pediatric and adolescent vaccinations and well child visits in the United States: A database analysis
Stephanie A. Kujawski, Lixia Yao, H. Echo Wang, Cristina Carias, Ya-Ting Chen
Pages 706-713

Optimizing vaccine distribution via mobile clinics: a case study on COVID-19 vaccine distribution to long-term care facilities

Vaccine
Volume 40, Issue 5 Pages 691-832 (31 January 2022)
https://www.sciencedirect.com/journal/vaccine/vol/40/issue/5

 

Research article Open access
Optimizing vaccine distribution via mobile clinics: a case study on COVID-19 vaccine distribution to long-term care facilities
Samta Shukla, Francois Fressin, Michelle Un, Henriette Coetzer, Sreekanth K. Chaguturu
Pages 734-741

Vaccine timeliness and prevalence of undervaccination patterns in children ages 0–19 months, U.S., National Immunization Survey-Child 2017

Vaccine
Volume 40, Issue 5 Pages 691-832 (31 January 2022)
https://www.sciencedirect.com/journal/vaccine/vol/40/issue/5

 

Research article Abstract only
Vaccine timeliness and prevalence of undervaccination patterns in children ages 0–19 months, U.S., National Immunization Survey-Child 2017
Rain E. Freeman, Juthika Thaker, Matthew F. Daley, Jason M. Glanz, Sophia R. Newcomer
Pages 765-773