El Niño and the shifting geography of cholera in Africa

Biological Sciences – Ecology – Physical Sciences – Statistics:
El Niño and the shifting geography of cholera in Africa
Sean M. Moore, Andrew S. Azman, Benjamin F. Zaitchik, Eric D. Mintz, Joan Brunkard, Dominique Legros, Alexandra Hill, Heather McKay, Francisco J. Luquero, David Olson, and Justin Lessler
PNAS 2017 ; published ahead of print April 10, 2017, doi:10.1073/pnas.1617218114
Significance
In the wake of the 2015–2016 El Niño, multiple cholera epidemics occurred in East Africa, including the largest outbreak since the 1997–1998 El Niño in Tanzania, suggesting a link between El Niño and cholera in Africa. However, little evidence exists for this link. Using high-resolution mapping techniques, we found the cholera burden shifts to East Africa during and following El Niño events. Throughout Africa, cholera incidence increased three-fold in El Niño-sensitive regions, and 177 million people experienced an increase in cholera incidence. Without treatment, the case fatality rate can reach 50%, but accessible, appropriate care nearly eliminates mortality. Climatic forecasts predicting El Niño events 6–12 mo in advance could trigger public health preparations and save lives.
Abstract
The El Niño Southern Oscillation (ENSO) and other climate patterns can have profound impacts on the occurrence of infectious diseases ranging from dengue to cholera. In Africa, El Niño conditions are associated with increased rainfall in East Africa and decreased rainfall in southern Africa, West Africa, and parts of the Sahel. Because of the key role of water supplies in cholera transmission, a relationship between El Niño events and cholera incidence is highly plausible, and previous research has shown a link between ENSO patterns and cholera in Bangladesh. However, there is little systematic evidence for this link in Africa. Using high-resolution mapping techniques, we find that the annual geographic distribution of cholera in Africa from 2000 to 2014 changes dramatically, with the burden shifting to continental East Africa—and away from Madagascar and portions of southern, Central, and West Africa—where almost 50,000 additional cases occur during El Niño years. Cholera incidence during El Niño years was higher in regions of East Africa with increased rainfall, but incidence was also higher in some areas with decreased rainfall, suggesting a complex relationship between rainfall and cholera incidence. Here, we show clear evidence for a shift in the distribution of cholera incidence throughout Africa in El Niño years, likely mediated by El Niño’s impact on local climatic factors. Knowledge of this relationship between cholera and climate patterns coupled with ENSO forecasting could be used to notify countries in Africa when they are likely to see a major shift in their cholera risk.