BMC Public Health (Accessed 8 July 2017)

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 8 July 2017)

Research article
Seasonal influenza vaccination coverage and its determinants among nursing homes personnel in western France
Influenza-associated deaths is an important risk for the elderly in nursing homes (NHs) worldwide. Vaccination coverage among residents is high but poorly effective due to immunosenescence. Hence, vaccination …
Christelle Elias, Anna Fournier, Anca Vasiliu, Nicolas Beix, Rémi Demillac, Hélène Tillaut, Yvonnick Guillois, Serge Eyebe, Bastien Mollo and Pascal Crépey
BMC Public Health 2017 17:634
Published on: 7 July 2017

Research article
Will the European Union reach the United Nations Millennium declaration target of a 50% reduction of tuberculosis mortality between 1990 and 2015?
The Millennium Development Goals (MDG) provide targets for 2015. MDG 6 includes a target to reduce the tuberculosis (TB) death rate by 50% compared with 1990. We aimed to assess whether this target was reached…
Marieke J. van der Werf, Sandro Bonfigli and Frantiska Hruba
BMC Public Health 2017 17:629
Published on: 6 July 2017

Research article
Determinants of complete immunization among senegalese children aged 12–23 months: evidence from the demographic and health survey
The expanded Programme on Immunization (EPI) is one of the most cost-effective interventions to reduce childhood mortality and morbidity. However, determinants of childhood immunization have not been well stud…
Mouhamed Abdou Salam Mbengue, Moussa Sarr, Adama Faye, Ousseynou Badiane, Fatou Bintou Niang Camara, Souleymane Mboup and Tandakha Ndiaye Dieye
BMC Public Health 2017 17:630
Published on: 6 July 2017

Research
Using surrogate vaccines to assess feasibility and acceptability of future HIV vaccine trials in men: a randomised trial in inner-city Johannesburg, South Africa
Developing an effective HIV vaccine is the overriding priority for HIV prevention research. Enrolling and maintaining cohorts of men into HIV vaccine efficacy trials is a necessary prerequisite for the develop…
Lucy Chimoyi, Mphatso Kamndaya, Emilie Venables, Nina von Knorring, Jonathan Stadler, Catherine MacPhail, Matthew F. Chersich, Helen Rees and Sinead Delany-Moretlwe
BMC Public Health 2017 17(Suppl 3):4355
Published on: 4 July 2017

Hepatitis B virus vaccination status and associated factors among health care workers in Shashemene Zonal Town, Shashemene, Ethiopia: a cross sectional study

BMC Research Notes
http://www.biomedcentral.com/bmcresnotes/content
(Accessed 8 July 2017)

Research article
Hepatitis B virus vaccination status and associated factors among health care workers in Shashemene Zonal Town, Shashemene, Ethiopia: a cross sectional study
Hepatitis B virus (HBV) remains a major global health problem. More than three-quarters of HBV infection occur in Asia, the Middle East and Africa. Healthcare workers (HCWs) are at risk of acquiring HBV, hepat…
Tsega-Ab Abebaw, Zewdie Aderaw and Bereket Gebremichael
BMC Research Notes 2017 10:260
Published on: 6 July 2017

Bulletin of the World Health Organization Volume 95, Number 7, July 2017, 481-544

Bulletin of the World Health Organization
Volume 95, Number 7, July 2017, 481-544
http://www.who.int/bulletin/volumes/95/7/en/

EDITORIALS
Data sharing statements for clinical trials: a requirement of the International Committee of Medical Journal Editors
Darren B Taichman, Peush Sahni, Anja Pinborg, Larry Peiperl, Christine Laine, Astrid James, Sung-Tae Hong, Abraham Haileamlak, Laragh Gollogly, Fiona Godlee, Frank A Frizelle, Fernando Florenzano, Jeffrey M Drazen, Howard Bauchner, Christopher Baethge & Joyce Backus
http://dx.doi.org/10.2471/BLT.17.196733

Systems science for universal health coverage
Timothy G Evans & Marie Paule Kieny
http://dx.doi.org/10.2471/BLT.17.192542

RESEARCH
Implementation research to improve quality of maternal and newborn health care, Malawi
Stephan Brenner, Danielle Wilhelm, Julia Lohmann, Christabel Kambala, Jobiba Chinkhumba, Adamson S Muula & Manuela De Allegri
http://dx.doi.org/10.2471/BLT.16.178202
We observed 33 health facilities, 23 intervention facilities and 10 control facilities and 401 pregnant women across four districts. The scheme improved the availability of both functional equipment and essential drug stocks in the intervention facilities. We observed positive effects in respect to drug procurement and clinical care activities at non-intervention facilities, likely in response to improved district management performance. Birth assistants’ adherence to clinical protocols improved across all studied facilities as district health managers supervised and coached clinical staff more actively.

PERSPECTIVES
Strengthening health systems for universal health coverage and sustainable development
Marie Paule Kieny, Henk Bekedam, Delanyo Dovlo, James Fitzgerald, Jarno Habicht, Graham Harrison, Hans Kluge, Vivian Lin, Natela Menabde, Zafar Mirza, Sameen Siddiqi & Phyllida Travis
http://dx.doi.org/10.2471/BLT.16.187476

Taking distrust of science seriously to overcome public distrust in science, scientists need to stop pretending that there is a scientific consensus on controversial issues when there is not

EMBO Reports
01 July 2017; volume 18, issue 7
http://embor.embopress.org/content/18/7?current-issue=y

Science & Society
Taking distrust of science seriously to overcome public distrust in science, scientists need to stop pretending that there is a scientific consensus on controversial issues when there is not

Scientific disputes on controversial issues – from endocrine disrupting chemicals to climate change – risk increasing public distrust in science if scientists pretend that there is a consensus when in fact there is not.
Geoffrey C Kabat

Operational Research during the Ebola Emergency PDF Version [PDF – 772 KB – 6 pages]

Emerging Infectious Diseases
Volume 23, Number 7—July 2017
http://wwwnc.cdc.gov/eid/

Perspective
Operational Research during the Ebola Emergency PDF Version [PDF – 772 KB – 6 pages]
Fitzpatrick et al.
Abstract
Operational research aims to identify interventions, strategies, or tools that can enhance the quality, effectiveness, or coverage of programs where the research is taking place. Médecins Sans Frontières admitted ≈5,200 patients with confirmed Ebola virus disease during the Ebola outbreak in West Africa and from the beginning nested operational research within its emergency response. This research covered critical areas, such as understanding how the virus spreads, clinical trials, community perceptions, challenges within Ebola treatment centers, and negative effects on non-Ebola healthcare. Importantly, operational research questions were decided to a large extent by returning volunteers who had first-hand knowledge of the immediate issues facing teams in the field. Such a method is appropriate for an emergency medical organization. Many challenges were also identified while carrying out operational research across 3 different countries, including the basic need for collecting data in standardized format to enable comparison of findings among treatment centers.

International Journal of Community Medicine and Public Health Vol 4, No 7 (2017) July 2017

International Journal of Community Medicine and Public Health
Vol 4, No 7 (2017)  July 2017
http://www.ijcmph.com/index.php/ijcmph/issue/view/26

Review Articles
MERS: an emerging disease of the 21st century
Mohamed Osman Bala, Mohamad Abdel Halim Chehab, Nagah Abdel Aziz Selim
DOI: 10.18203/2394-6040.ijcmph20172806

Original Research Articles
Coverage and compliance of mass drug administration against lymphatic filariasis in Kalaburgi district
Mallikarjun K. Biradar, Sharankumar Holyachi
DOI: 10.18203/2394-6040.ijcmph20172848

Adverse events following immunization with pentavalent vaccine among infants attending the immunization clinic at a tertiary hospital in Eastern India
Shamshad Ahmad, Jayita Pal, Amiya Das, Sonalinandini Samanta

JAMA July 4, 2017, Vol 318, No. 1, Pages 7-102

JAMA
July 4, 2017, Vol 318, No. 1, Pages 7-102
http://jama.jamanetwork.com/issue.aspx

Viewpoint
Financing and Distribution of Pharmaceuticals in the United States
Matan C. Dabora, MD, MBA; Namrata Turaga, MD, MBA; Kevin A. Schulman, MD
free access
JAMA. 2017;318(1):21-22. doi:10.1001/jama.2017.5607
This Viewpoint identifies stakeholders in the financing and distribution of pharmaceuticals in the United States and describes their flow from manufacturers through distributors, managers, and retailers to patients.

No Shortcuts on the Long Road to Evidence-Based Genomic Medicine
Muin J. Khoury, MD, PhD
JAMA. 2017;318(1):27-28. doi:10.1001/jama.2017.6315
This Viewpoint discusses the 2017 National Academies of Sciences, Engineering, and Medicine (NASEM) report on improving the system of evaluation of genetic testing so that implementation of genomic medicine in clinical settings can be evidence-based.
Rapid advances in genomics have led to a new era of precision medicine, resulting in a substantial increase in the number of genetic tests available for research and clinical practice. As of April 27, 2017, the Genetic Testing Registry,1 maintained and updated by the National Institutes of Health, contained information on 49 521 tests conducted at 492 laboratories for 10 733 disease conditions involving 16 223 genes. These tests cover a wide variety of diseases, rare and common, for different types of applications such as diagnosis, treatment, and prevention.

The Influence of Maternally Derived Antibody and Infant Age at Vaccination on Infant Vaccine Responses An Individual Participant Meta-analysis

JAMA Pediatrics
July 2017, Vol 171, No. 7, Pages 611-716
http://archpedi.jamanetwork.com/issue.aspx

Original Investigation
The Influence of Maternally Derived Antibody and Infant Age at Vaccination on Infant Vaccine Responses An Individual Participant Meta-analysis
Merryn Voysey, MSc; Dominic F. Kelly, PhD; Thomas R. Fanshawe, PhD; et al.
JAMA Pediatr. 2017;171(7):637-646. doi:10.1001/jamapediatrics.2017.0638
Key Points
Question  What is the potential for and extent of maternal antibody interference in infant vaccine responses?
Findings  In this individual participant data meta-analysis of the serum of 7630 infants, maternal antibody concentrations and the infant’s age at first vaccination both influenced infant vaccine responses. These effects are seen for almost all antigens contained in global immunization programs, are not removed by more widely spaced schedules, and influence immune response for some vaccines even at the age of 24 months.
Meaning  Prenatal immunization programs containing multicomponent vaccines have the potential to interfere with current immunization programs; however, a delayed start to infant immunization may mitigate these inhibitory effects.
Abstract
Importance  The design of infant immunization schedules requires an understanding of the factors that determine the immune response to each vaccine antigen.
Data Sources  Deidentified individual participant data from GlaxoSmithKline clinical trials were obtained through Clinical Study Data Request. The data were requested on January 2, 2015, and final data were received on April 11, 2016.
Study Selection  Immunogenicity trials of licensed or unlicensed vaccines administered to infants were included if antibody concentrations in infants were measured prior to the first dose of vaccine.
Data Extraction and Synthesis  The database was examined; studies that appeared to have appropriate data were reviewed.
Main Outcomes and Measures  Antigen-specific antibody concentration measured 1 month after priming vaccine doses, before booster vaccination, and 1 month after booster vaccine doses.
Results  A total of 7630 infants from 32 studies in 17 countries were included. Mean (SD) age at baseline was 9.0 (2.3) weeks; 3906 (51.2%) were boys. Preexisting maternal antibody inhibited infant antibody responses to priming doses for 20 of 21 antigens. The largest effects were observed for inactivated polio vaccine, where 2-fold higher maternal antibody concentrations resulted in 20% to 28% lower postvaccination antibody concentration (geometric mean ratios [GMRs], type 1: 0.80; 95% CI, 0.78-0.83; type 2: 0.72; 95% CI, 0.69-0.74; type 3: 0.78; 95% CI, 0.75-0.82). For acellular pertussis antigens, 2-fold higher maternal antibody was associated with 11% lower postvaccination antibody for pertussis toxoid (GMR, 0.89; 95% CI, 0.87-0.90) and filamentous hemagglutinin (GMR, 0.89; 95% CI, 0.88-0.90) and 22% lower pertactin antibody (GMR, 0.78; 95% CI, 0.77-0.80). For tetanus and diphtheria, these estimates were 13% (GMR, 0.87; 95% CI, 0.86-0.88) and 24% (GMR, 0.76; 95% CI, 0.74-0.77), respectively. The influence of maternal antibody was still evident in reduced responses to booster doses of acellular pertussis, inactivated polio, and diphtheria vaccines at 12 to 24 months of age. Children who were older when first immunized had higher antibody responses to priming doses for 18 of 21 antigens, after adjusting for the effect of maternal antibody concentrations. The largest effect was seen for polyribosylribitol phosphate antibody, where responses were 71% higher per month (GMR, 1.71; 95% CI, 1.52-1.92).
Conclusions and Relevance  Maternal antibody concentrations and infant age at first vaccination both influence infant vaccine responses. These effects are seen for almost all vaccines contained in global immunization programs and influence immune response for some vaccines even at the age of 24 months. These data highlight the potential for maternal immunization strategies to influence established infant programs.

Progress in Ebola Virus Vaccine Development

Journal of Infectious Diseases
Volume 215, Issue 12   15 June 2017
https://academic.oup.com/jid/issue

Editor’s Choice
Progress in Ebola Virus Vaccine Development
Matthias J. Schnell
Extract
It has been a long journey of almost 20 years for the vesicular stomatitis virus (VSV)–based vaccine against Ebola virus (EBOV) to finally enter clinical trials for safety and efficacy. In 1996 the first VSV-based vector research was published by Rose’s group at Yale University [1], and by 1998 Feldmann, Klenk and Volchkov had used a VSV-EBOV chimera as a model system for EBOV biology and pathogenicity. These initial studies of pathogenicity were expanded in 2003 in early vaccine development with the VSV deleted of its own glycoprotein (GP) but expressing instead the EBOV GP.

Six-Month Safety Data of Recombinant Vesicular Stomatitis Virus–Zaire Ebola Virus Envelope Glycoprotein Vaccine in a Phase 3 Double-Blind, Placebo-Controlled Randomized Study in Healthy Adults

Journal of Infectious Diseases
Volume 215, Issue 12   15 June 2017
https://academic.oup.com/jid/issue

MAJOR ARTICLES AND BRIEF REPORTS
VIRUSES
Editor’s Choice
Six-Month Safety Data of Recombinant Vesicular Stomatitis Virus–Zaire Ebola Virus Envelope Glycoprotein Vaccine in a Phase 3 Double-Blind, Placebo-Controlled Randomized Study in Healthy Adults
Scott A. Halperin; Jose R. Arribas; Richard Rupp; Charles P. Andrews; Laurence Chu
findings support the use of this vaccine in persons at risk for Ebola virus disease.
Abstract
Background.
This study (NCT02503202) evaluated the safety of recombinant vesicular stomatitis virus–Zaire Ebola virus envelope glycoprotein vaccine (rVSVΔG-ZEBOV-GP).
Methods.
Overall, 1197 subjects were randomized 2:2:2:2:1; 1194 were vaccinated with 1 dose of 1 of 3 lots of rVSVΔG- ZEBOV-GP (2 × 107 plaque-forming units [pfu], n = 797; combined-lots group), a single high-dose lot of rVSVΔG-ZEBOV-GP (1 × 108 pfu, n = 264; high-dose group), or placebo (n = 133). Daily temperatures and adverse events (AEs) were recorded days 1 to 42 postvaccination. Solicited AEs included injection-site AEs from days 1 to 5, and joint pain, joint swelling, vesicular lesions (blisters), and rashes from days 1 to 42. Serious AEs (SAEs) were recorded through 6 months postvaccination.
Results.
Fever (≥38.0°C) was observed in 20.2% of combined lots (3.2% with ≥39.0°C), 32.2% of high-dose (4.3% with ≥39.0°C), and 0.8% of placebo (0.8% with ≥39.0°C). Incidences of AEs of interest (days 1–42) were arthralgia (17.1% combined lots, 20.4% high-dose, 3.0% placebo), arthritis (5.1% combined lots, 4.2% high-dose, 0.0% placebo), and rash (3.8% combined lots, 3.8% high-dose, 1.5% placebo). Twenty-one SAEs and 2 deaths were reported, all assessed by investigators as unrelated to vaccine.
Conclusions.
rVSVΔG-ZEBOV-GP was generally well-tolerated, with increased rates of injection-site and systemic AEs compared to placebo, and no vaccine-related SAEs or deaths. These findings support the use of rVSVΔG-ZEBOV-GP vaccine in persons at risk for Ebola virus disease.
Clinical Trials Registration.
NCT02503202.

Anticipating the emergence of infectious diseases

Journal of the Royal Society – Interface
01 July 2017; volume 14, issue 132
http://rsif.royalsocietypublishing.org/content/current

Life Sciences–Physics interface
Open Access
Research article:
Anticipating the emergence of infectious diseases
Tobias S. Brett, John M. Drake, Pejman Rohani
R. Soc. Interface 2017 14 20170115; DOI: 10.1098/rsif.2017.0115. Published 5 July 2017
Abstract
In spite of medical breakthroughs, the emergence of pathogens continues to pose threats to both human and animal populations. We present candidate approaches for anticipating disease emergence prior to large-scale outbreaks. Through use of ideas from the theories of dynamical systems and stochastic processes we develop approaches which are not specific to a particular disease system or model, but instead have general applicability. The indicators of disease emergence detailed in this paper can be classified into two parallel approaches: a set of early-warning signals based around the theory of critical slowing down and a likelihood-based approach. To test the reliability of these two approaches we contrast theoretical predictions with simulated data. We find good support for our methods across a range of different model structures and parameter values.

Tetanus–diphtheria–pertussis vaccine may suppress the immune response to subsequent immunization with pneumococcal CRM197-conjugate vaccine (coadministered with quadrivalent meningococcal TT-conjugate vaccine): a randomized, controlled trial

Journal of Travel Medicine
Volume 24, Issue 4, July-August 2017
https://academic.oup.com/jtm/issue/24/4

Original Article
Tetanus–diphtheria–pertussis vaccine may suppress the immune response to subsequent immunization with pneumococcal CRM197-conjugate vaccine (coadministered with quadrivalent meningococcal TT-conjugate vaccine): a randomized, controlled trial
Mohamed Tashani; Leon Heron; Melanie Wong; Harunor Rashid; Robert Booy

The Lancet Jul 08, 2017 Volume 390 Number 10090 p95-202 e19-e33

The Lancet
Jul 08, 2017 Volume 390 Number 10090 p95-202  e19-e33
http://www.thelancet.com/journals/lancet/issue/current

Series
Right Care
Evidence for overuse of medical services around the world
Shannon Brownlee, Kalipso Chalkidou, Jenny Doust, Adam G Elshaug, Paul Glasziou, Iona Heath, Somil Nagpal, Vikas Saini, Divya Srivastava, Kelsey Chalmers, Deborah Korenstein

Right Care
Evidence for underuse of effective medical services around the world
Paul Glasziou, Sharon Straus, Shannon Brownlee, Lyndal Trevena, Leonila Dans, Gordon Guyatt, Adam G Elshaug, Robert Janett, Vikas Saini

Right Care
Drivers of poor medical care
Vikas Saini, Sandra Garcia-Armesto, David Klemperer, Valerie Paris, Adam G Elshaug, Shannon Brownlee, John P A Ioannidis, Elliott S Fisher

Right Care
Levers for addressing medical underuse and overuse: achieving high-value health care
Adam G Elshaug, Meredith B Rosenthal, John N Lavis, Shannon Brownlee, Harald Schmidt, Somil Nagpal, Peter Littlejohns, Divya Srivastava, Sean Tunis, Vikas Saini

Sub-Regional Assessment of HPV Vaccination Among Female Adolescents in the Intermountain West and Implications for Intervention Opportunities

Maternal and Child Health Journal
Volume 21, Issue 7, July 2017
https://link.springer.com/journal/10995/21/7/page/1

Original Paper
Sub-Regional Assessment of HPV Vaccination Among Female Adolescents in the Intermountain West and Implications for Intervention Opportunities
Julia Bodson, Qian Ding, Echo L. Warner
Abstract
Objectives
We investigated the similarities and differences in the factors related to human papillomavirus (HPV) vaccination of female adolescents in three sub-regions of the Intermountain West (IW). Methods
We analyzed 2011–2012 National Immunization Survey-Teen data. Respondents (parents) who were living in the IW and who had daughters aged 13–17 years old with provider-verified immunization records were included in our analyses. East, Central, and West sub-regions were defined based on geographic contiguity and similarity in HPV vaccination rates and sociodemographic characteristics. Survey-weighted Chi square tests and multivariable Poisson regressions were performed.
Results
In all three sub-regions, older teen age and receipt of other recommended adolescent vaccinations were significantly associated with HPV vaccination. In the East sub-region, providers’ facility type and source of vaccines were significantly related to HPV vaccination. In the Central sub-region, teens with married parents were significantly less likely to be vaccinated than were those with unmarried parents. In the West sub-region, non-Hispanic teens were significantly less likely to be vaccinated than were Hispanic teens.
Conclusions for Practice
In order to improve HPV vaccine coverage in the IW, region-wide efforts to target younger teens and to promote the HPV vaccine with other recommended adolescent vaccinations should be supplemented with sub-regional attention to the health care system (East sub-region), to married parents (Central sub-region), and to non-Hispanic teens (West sub-region).

Preserving the Fogarty International Center — Benefits for Americans and the World

New England Journal of Medicine
July 6, 2017  Vol. 377 No. 1
http://www.nejm.org/toc/nejm/medical-journal

Perspective
Preserving the Fogarty International Center — Benefits for Americans and the World
P.K. Drain, R. Subbaraman, and D.C. Heimburger
Excerpt
… The FIC has been instrumental in extending the frontiers of health research around the globe and ensuring that advances in science are implemented to reduce the burden of disease, promote health, and extend longevity for all people. By facilitating rare training experiences for U.S. scientists in LMICs, the center has created a cadre of productive researchers with the capacity to find solutions with regard to global diseases such as Zika and Ebola that will continue to threaten human health everywhere. FIC funding of training experiences for LMIC researchers has undergirded the NIH’s capacity to conduct multinational studies, yielding insights that have transformed the care of patients in the United States and many other countries. For these reasons, we believe the U.S. Congress, the President, and the NIH should ensure that the FIC’s funding is sustained. Preservation of the FIC and its globally oriented mission represents a critical investment in the health of the American people as well as the global community.

The Changing Face of Clinical Trials: Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both

New England Journal of Medicine
July 6, 2017  Vol. 377 No. 1
http://www.nejm.org/toc/nejm/medical-journal

Review Article
The Changing Face of Clinical Trials: Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both
Woodcock and L.M. LaVange
Summary
Master protocols come in different sizes and shapes but share many commonalities. All require increased planning efforts and coordination to satisfy the objectives of different stakeholders. Innovative design elements help ensure that maximum information is obtained from the research effort, and the infrastructure required for implementation increases data quality and trial efficiencies, as compared with those in stand-alone trials. If designed correctly, master protocols can last many years, even decades, with innovations from the laboratory translating quickly to clinical evaluation. As the targets for new drugs become more and more precise, there is no alternative but to move forward with these coordinated research efforts.

 

Genomic Characterization Helps Dissecting an Outbreak of Listeriosis in Northern Italy

PLoS Currents: Outbreaks
http://currents.plos.org/outbreaks/
[Accessed 8 July 2017]

Research Article
Genomic Characterization Helps Dissecting an Outbreak of Listeriosis in Northern Italy
July 6, 2017 ·
Introduction
Listeria monocytogenes (Lm) is a bacterium widely distributed in nature and able to contaminate food processing environments, including those of dairy products. Lm is a primary public health issue, due to the very low infectious dose and the ability to produce severe outcomes, in particular in elderly, newborns, pregnant women and immunocompromised patients.
Methods
In the period between April and July 2015, an increased number of cases of listeriosis was observed in the area of Pavia, Northern Italy. An epidemiological investigation identified a cheesemaking small organic farm as the possible origin of the outbreak. In this work we present the results of the retrospective epidemiological study that we performed using molecular biology and genomic epidemiology methods. The strains sampled from patients and those from the target farm’s cheese were analyzed using PFGE and whole genome sequencing (WGS) based methods. The performed WGS based analyses included: a) in-silico MLST typing; b) SNPs calling and genetic distance evaluation; c) determination of the resistance and virulence genes profiles; d) SNPs based phylogenetic reconstruction.
Results
Three of the patient strains and all the cheese strains resulted to belong to the same phylogenetic cluster, in Sequence Type 29. A further accurate SNPs analysis revealed that two of the three patient strains and all the cheese strains were highly similar (0.8 SNPs of average distance) and exhibited a higer distance from the third patient isolate (9.4 SNPs of average distance).
Discussion
Despite the global agreement among the results of the PFGE and WGS epidemiological studies, the latter approach agree with epidemiological data in indicating that one the patient strains could have originated from a different source. This result highlights that WGS methods can allow to better

Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action

PLoS Medicine
http://www.plosmedicine.org/
(Accessed 8 July 2017)

Policy Forum
Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action
Teodora Wi, Monica M. Lahra, Francis Ndowa, Manju Bala, Jo-Anne R. Dillon, Pilar Ramon-Pardo, Sergey R. Eremin, Gail Bolan, Magnus Unemo
| published 07 Jul 2017 PLOS Medicine
https://doi.org/10.1371/journal.pmed.1002344

Mosquitoes on a plane: Disinsection will not stop the spread of vector-borne pathogens, a simulation study

PLoS Neglected Tropical Diseases
http://www.plosntds.org/
(Accessed 8 July 2017)

Research Article
Mosquitoes on a plane: Disinsection will not stop the spread of vector-borne pathogens, a simulation study
Luis Mier-y-Teran-Romero, Andrew J. Tatem, Michael A. Johansson
| published 03 Jul 2017 PLOS Neglected Tropical Diseases
https://doi.org/10.1371/journal.pntd.0005683
Abstract
Mosquito-borne diseases are increasingly being recognized as global threats, with increased air travel accelerating their occurrence in travelers and their spread to new locations. Since the early days of aviation, concern over the possible transportation of infected mosquitoes has led to recommendations to disinsect aircraft. Despite rare reports of mosquitoes, most likely transported on aircraft, infecting people far from endemics areas, it is unclear how important the role of incidentally transported mosquitoes is compared to the role of traveling humans. We used data for Plasmodium falciparum and dengue viruses to estimate the probability of introduction of these pathogens by mosquitoes and by humans via aircraft under ideal conditions. The probability of introduction of either pathogen by mosquitoes is low due to few mosquitoes being found on aircraft, low infection prevalence among mosquitoes, and high mortality. Even without disinsection, introduction via infected human travelers was far more likely than introduction by infected mosquitoes; more than 1000 times more likely for P. falciparum and more than 200 times more likely for dengue viruses. Even in the absence of disinsection and under the most favorable conditions, introduction of mosquito-borne pathogens via air travel is far more likely to occur as a result of an infected human travelling rather than the incidental transportation of infected mosquitoes. Thus, while disinsection may serve a role in preventing the spread of vector species and other invasive insects, it is unlikely to impact the spread of mosquito-borne pathogens.

Estimated severe pneumococcal disease cases and deaths before and after pneumococcal conjugate vaccine introduction in children younger than 5 years of age in South Africa

PLoS One
http://www.plosone.org/
[Accessed 8 July 2017]

Research Article
Estimated severe pneumococcal disease cases and deaths before and after pneumococcal conjugate vaccine introduction in children younger than 5 years of age in South Africa
Claire von Mollendorf, Stefano Tempia, Anne von Gottberg, Susan Meiring, Vanessa Quan, Charles Feldman, Jeane Cloete, Shabir A. Madhi, Katherine L. O’Brien, Keith P. Klugman, Cynthia G. Whitney, Cheryl Cohen
| published 03 Jul 2017 PLOS ONE
https://doi.org/10.1371/journal.pone.0179905

A Multiple Streams analysis of the decisions to fund gender-neutral HPV vaccination in Canada

Preventive Medicine
Volume 100, Pages 1-298 (July 2017)
http://www.sciencedirect.com/science/journal/00917435/100?sdc=1

Review Articles
A Multiple Streams analysis of the decisions to fund gender-neutral HPV vaccination in Canada
Review Article
Pages 123-131
Gilla K. Shapiro, Juliet Guichon, Gillian Prue, Samara Perez, Zeev Rosberger
Abstract
In Canada, the human papillomavirus (HPV) vaccine is licensed and recommended for females and males. Although all Canadian jurisdictions fund school-based HPV vaccine programs for girls, only six jurisdictions fund school-based HPV vaccination for boys. The research aimed to analyze the factors that underpin government decisions to fund HPV vaccine for boys using a theoretical policy model, Kingdon’s Multiple Streams framework. This approach assesses policy development by examining three concurrent, but independent, streams that guide analysis: Problem Stream, Policy Stream, and Politics Stream. Analysis from the Problem Stream highlights that males are affected by HPV-related diseases and are involved in transmitting HPV infection to their sexual partners. Policy Stream analysis makes clear that while the inclusion of males in HPV vaccine programs is suitable, equitable, and acceptable; there is debate regarding cost-effectiveness. Politics Stream analysis identifies the perspectives of six different stakeholder groups and highlights the contribution of government officials at the provincial and territorial level. Kingdon’s Multiple Streams framework helps clarify the opportunities and barriers for HPV vaccine policy change. This analysis identified that the interpretation of cost-effectiveness models and advocacy of stakeholders such as citizen-advocates and HPV-affected politicians have been particularly important in galvanizing policy change.

Motivational and contextual determinants of HPV-vaccination uptake: A longitudinal study among mothers of girls invited for the HPV-vaccination

Preventive Medicine
Volume 100, Pages 1-298 (July 2017)
http://www.sciencedirect.com/science/journal/00917435/100?sdc=1

Original Research Article
Motivational and contextual determinants of HPV-vaccination uptake: A longitudinal study among mothers of girls invited for the HPV-vaccination
Pages 41-49
Mirjam Pot, Hilde M. van Keulen, Robert A.C. Ruiter, Iris Eekhout, Liesbeth Mollema, Theo W.G.M. Paulussen
Abstract
Background
In the Netherlands, HPV-vaccination uptake among 12-year-old girls remains to be lower (61% in 2016) than expected. The present study is about 1) replicating the extent to which social-psychological determinants found in earlier cross-sectional studies explain HPV-vaccination intention, and 2) testing whether HPV-vaccination intention, as well as other social-psychological determinants, are good predictors of future HPV-vaccination uptake in a longitudinal design.
Methods
A random sample of mothers of girls invited for the vaccination in 2015 was drawn from the Dutch vaccination register (Praeventis) (N = 36,000) and from three online panels (N = 2483). Two months prior to the vaccination of girls, their mothers were requested to complete a web-based questionnaire by letter (Praeventis sample) or by e-mail (panel samples). HPV-vaccination uptake was derived from Praeventis. Backward linear and logistic regression analyses were conducted to examine most dominant predictors of HPV-vaccination intention and uptake, respectively. The total sample used for data analyses consisted of 8062 mothers. Response rates were 18% for the Praeventis sample and 47% for the panel samples.
Results
HPV-vaccination intention was best explained by attitude, beliefs, subjective norms, habit, and perceived relative effectiveness of the vaccination; they explained 83% of the variance in HPV-vaccination intention. Intention appeared to be the only stable predictor of HPV-vaccination uptake and explained 43% of the variance in HPV-vaccination uptake.
Conclusions
These results confirm what was found by earlier cross-sectional studies, and provide strong leads for selecting relevant targets in the planning of future communication strategies aiming to improve HPV-vaccination uptake.

Public Health Reports Volume 132, Issue 4, July/August 2017

Public Health Reports
Volume 132, Issue 4, July/August 2017
http://phr.sagepub.com/content/current

Executive Perspective
Advances in Public Health Surveillance and Information Dissemination at the Centers for Disease Control and Prevention
First Published June 13, 2017; pp. 403–410
Chesley L. Richards, Michael F. Iademarco, Delton Atkinson, Robert W. Pinner, Paula Yoon, William R. Mac Kenzie, Brian Lee, Judith R. Qualters, Thomas R. Frieden

Reports and Recommendations
Evaluation of the 2010 National Vaccine Plan Mid-course Review: Recommendations From the National Vaccine Advisory Committee
Approved by the National Vaccine Advisory Committee on February 7, 2017
First Published June 23, 2017; pp. 411–430

Commentary
An Antipoverty Agenda for Public Health: Background and Recommendations
First Published May 24, 2017; pp. 431–435
Jeff Levin

Engaging Community and Faith-Based Organizations in the Zika Response, United States, 2016
First Published June 6, 2017; pp. 436–442
Scott Santibañez, Jonathan Lynch, Y. Peter Paye, Haley McCalla, Joanna Gaines, Kimberly Konkel, Luis J. Ocasio Torres, Wayne A. North, Anna Likos, Katherine Lyon Daniel

Longitudinal Trends in Vaccine Hesitancy in a Cohort of Mothers Surveyed in Washington State, 2013-2015
First Published June 6, 2017; pp. 451–454
Nora B. Henrikson, Melissa L. Anderson, Douglas J. Opel, John Dunn, Edgar K. Marcuse, David C. Grossman
Abstract
Parents who refuse or delay vaccines because of vaccine hesitancy place children at increased risk for vaccine-preventable disease. How parental vaccine hesitancy changes as their children age is not known. In 2015, we conducted a follow-up survey of 237 mothers enrolled in a 2-arm clinic-level cluster randomized trial (n = 488) in Washington State that was completed in 2013. We surveyed mothers at their baby’s birth, age 6 months, and age 24 months using a validated measure of vaccine hesitancy. Both mean hesitancy scores (mean 4.1-point reduction; 95% CI, 2.5-5.6; P = .01) and the proportion of mothers who were vaccine hesitant (9.7% at baseline vs 5.9% at 24 months; P = .01) decreased significantly from child’s birth to age 24 months. Changes from baseline were similar for first-time mothers and experienced mothers. Individual item analysis suggested that the decrease may have been driven by increases in maternal confidence about the safety and efficacy of vaccines. Our results suggest that hesitancy is a dynamic measure that may peak around childbirth and may remit as experience with vaccines accumulates.

The scientists’ apprentice

Science         
07 July 2017  Vol 357, Issue 6346
http://www.sciencemag.org/current.dtl
Special Issue – The cyberscientist
Introduction to special issue

The scientists’ apprentice
Tim Appenzeller
Summary
Big data has met its match. In field after field, the ability to collect data has exploded, overwhelming human insight and analysis. But the computing advances that helped deliver the data have also conjured powerful new tools for making sense of it all. In a revolution that extends across much of science, researchers are unleashing artificial intelligence (AI), often in the form of artificial neural networks, on these mountains of data. Unlike earlier attempts at AI, such “deep learning” systems don’t need to be programmed with a human expert’s knowledge. Instead, they learn on their own, often from large training data sets, until they can see patterns and spot anomalies in data sets far larger and messier than human beings can cope with.

Marketing of unproven stem cell–based interventions: A call to action

Science Translational Medicine
05 July 2017  Vol 9, Issue 397
http://stm.sciencemag.org/

Perspective
Marketing of unproven stem cell–based interventions: A call to action
By Douglas Sipp, Timothy Caulfield, Jane Kaye, Jan Barfoot, Clare Blackburn, Sarah Chan, Michele De Luca, Alastair Kent, Christopher McCabe, Megan Munsie, Margaret Sleeboom-Faulkner, Jeremy Sugarman, Esther van Zimmeren, Amy Zarzeczny, John E. J. Rasko
Science Translational Medicine05 Jul 2017 Restricted Access
Commercial promotion of unsupported therapeutic uses of stem cells is a global problem that should be addressed by coordinated approaches at the national and international levels.

From Google Scholar & other sources: Selected Journal Articles, Newsletters, Dissertations, Theses, Commentary

From Google Scholar & other sources: Selected Journal Articles, Newsletters, Dissertations, Theses, Commentary

The Journal of Infection in Developing Countries
Vol 11 No 06: June 2017
Immune response to hepatitis B vaccine among north Iranian healthcare workers and its related factors
F Joukar, F Mansour-Ghanaei, MR Naghipour…
Abstract
Introduction: Hepatitis B virus (HBV) is an important occupational risk among healthcare workers (HCWs). Vaccination is the most cost-effective method of preventing and controlling HBV infection. Several factors have been suggested to effect response to the vaccine. The present study aimed to evaluate vaccine response among north Iranian HCWs and to determine the factors influencing vaccine response.
Methodology: Response to the standard three-dose vaccination regimen was evaluated in term of anti-hepatitis B surface antigen level among 1,010 HCWs using an enzyme-linked immunosorbent assay (ELISA) method. Logistic regression was applied to predict antibody response, with related factors including sex, age, years of working experience, marital status, history of transfusion, smoking, history of needle stick injury, rheumatic disease, steroid use, and elapsed time from vaccination measurement.
Results: Of the 1,010 HCWs, 898 (88.9%) acquired protective levels of antibody (> 10 IU/mL). Compared with those < 30 years of age, HCWs older than 50 years and between 40 and 50 years of age were more likely to have non-protective anti-HBs levels (odds ratio=4.48; p=0.001 and odds ratio=1.85; p=0.03, respectively).
Conclusions: HBV vaccine efficacy and immune response were satisfactory among north Iranian HCWs. Since it is predicted that anti-HBs levels decrease with aging, testing for anti-HBs titer is desirable for HCWs older than 50 years of age.

Media/Policy Watch

Media/Policy Watch
This watch section is intended to alert readers to substantive news, analysis and opinion from the general media and selected think tanks and similar organizations on vaccines, immunization, global public health and related themes. Media Watch is not intended to be exhaustive, but indicative of themes and issues CVEP is actively tracking. This section will grow from an initial base of newspapers, magazines and blog sources, and is segregated from Journal Watch above which scans the peer-reviewed journal ecology.

We acknowledge the Western/Northern bias in this initial selection of titles and invite suggestions for expanded coverage. We are conservative in our outlook in adding news sources which largely report on primary content we are already covering above. Many electronic media sources have tiered, fee-based subscription models for access. We will provide full-text where content is published without restriction, but most publications require registration and some subscription level.

 

Forbes
http://www.forbes.com/
Accessed 8 July 2017
Vaccine Liability And Causation: Has Europe Gone Overboard?
Jul 6, 2017
Michael I. Krauss, Contributor
A very recent decision by the European Court of Justice gives pause to all who believe that causation must be proven in order to recover in tort. I here discuss the decision and its implications.

New York Times
http://www.nytimes.com/
Accessed 8 July 2017
UN Health Agency’s New Chief Says He Will Check Travel Costs
The new head of the World Health Organization said he is reviewing the agency’s travel expenses, after an Associated Press story revealed the U.N. agency spends more on travel than on fighting AIDS, malaria and tuberculosis combined.
July 07, 2017 – By THE ASSOCIATED PRESS

Cholera Spreads as War and Poverty Batter Yemen
By SHUAIB ALMOSAWA and NOUR YOUSSEF
JULY 7, 2017
Since a severe outbreak began in late April, according to Unicef, cholera has spread to 21 of the country’s 22 provinces, infecting at least 269,608 people and killing at least 1,614. That is more than the total number of cholera deaths reported to the World Health Organization worldwide in 2015.

Washington Post
http://www.washingtonpost.com/
Sudanese doctors urge measures against cholera outbreak
Sudan’s affected areas and helping the government vaccinate against cholera, says the response to cholera
Brian Rohan | AP · Foreign · Jul 2, 2017

Think Tanks et al

Think Tanks et al

Center for Global Development  
http://www.cgdev.org/page/press-center
Accessed 8 July 2017
Publications
What’s In, What’s Out: Designing Benefits for Universal Health Coverage
7/3/17
What’s In, What’s Out: Designing Benefits for Universal Health Coverage argues that the creation of an explicit health benefits plan—a defined list of services that are and are not available—is an essential element in creating a sustainable system of universal health coverage. With contributions from leading health economists and policy experts, the book considers the many dimensions of governance, institutions, methods, political economy, and ethics that are needed to decide what’s in and what’s out in a way that is fair, evidence-based, and sustainable over time.

Vaccines and Global Health: The Week in Review 1 July 2017

Vaccines and Global Health: The Week in Review is a weekly digest  summarizing news, events, announcements, peer-reviewed articles and research in the global vaccine ethics and policy space. Content is aggregated from key governmental, NGO, international organization and industry sources, key peer-reviewed journals, and other media channels. This summary proceeds from the broad base of themes and issues monitored by the Center for Vaccine Ethics & Policy in its work: it is not intended to be exhaustive in its coverage. You are viewing the blog version of our weekly digest, typically comprised of between 30 and 40 posts below all dated with the current issue date

.– Request an Email Summary: Vaccines and Global Health : The Week in Review is published as a single email summary, scheduled for release each Saturday evening before midnight (EDT in the U.S.). If you would like to receive the email version, please send your request to david.r.curry@centerforvaccineethicsandpolicy.org.

 pdf version A pdf of the current issue is available here: Vaccines and Global Health_The Week in Review_1 July 2017

– blog edition: comprised of the approx. 35+ entries posted below.

– Twitter:  Readers can also follow developments on twitter: @vaxethicspolicy.
.
– Links:  We endeavor to test each link as we incorporate it into any post, but recognize that some links may become “stale” as publications and websites reorganize content over time. We apologize in advance for any links that may not be operative. We believe the contextual information in a given post should allow retrieval, but please contact us as above for assistance if necessary.

Support this knowledge-sharing service: Your financial support helps us cover our costs and to address a current shortfall in our annual operating budget. Click here to donate and thank you in advance for your contribution.

.
David R. Curry, MS
Executive Director
Center for Vaccine Ethics and Policy

Milestones :: Perspectives

Milestones :: Perspectives

Editor’s Note:
Dr Tedros Adhanom Ghebreyesus assumes the Director General role today [1 July 2017]. WHO posted the vision statement below:

Vision statement by WHO Director-General
I envision a world in which everyone can live healthy, productive lives, regardless of who they are or where they live.

A world in which everyone can live healthy, productive lives
I envision a world in which everyone can live healthy, productive lives, regardless of who they are or where they live. I believe the global commitment to sustainable development – enshrined in the Sustainable Development Goals – offers a unique opportunity to address the social, economic and political determinants of health and improve the health and well-being of people everywhere.
Achieving this vision will require a strong, effective WHO that is able to meet emerging challenges and achieve the health objectives of the Sustainable Development Goals. We need a WHO – fit for the 21st century – that belongs to all, equally. We need a WHO that is efficiently managed, adequately resourced and results driven, with a strong focus on transparency, accountability and value for money.

Putting people first
The right of every individual to basic health services will be my top priority. I will champion mechanisms to meaningfully listen to, learn from and engage people and communities – including migrant, displaced and disabled individuals; people living in rural, urban slum and low-income areas; and other vulnerable populations.
This engagement – and what we learn from it – will be at the centre of our efforts to mobilize resources and hold authorities accountable for the health of all, regardless of age, gender, income, sexual orientation or religion.

Placing health at the centre of the global agenda
When people are healthy, entire communities and nations thrive – indeed, the whole world benefits. I will engage with Heads of State, Ministers across a wide range of portfolios, multilateral institutions, the UN system, civil society and the private sector to make access to health care and protection from infectious disease outbreaks a central component of the world’s security, economic and development agendas.
This will include implementing the International Health Regulations and addressing emerging threats, such as antimicrobial resistance, climate and environmental change and non-communicable diseases. Such engagement will enable WHO and national health authorities to effectively perform their core functions, reaffirm WHO’s leadership in securing a healthier and safer world, and ultimately drive progress towards the Sustainable Development Goals.

Engaging countries and strengthening partnerships
Improving global health requires effective engagement with all Member States and across multiple sectors. Under my leadership an enhanced and independent WHO will take a science-led and innovation-based approach that is results-oriented and responsive, maximises inclusive partnerships, and ensures collective priority setting with all stakeholders. In particular, I will champion country ownership, so that countries are at the table, as full and equal partners, to guide and make the decisions that will affect the health of their populations.
WHO’s work touches hundreds of millions of lives around the world. Every programme, every initiative, every allocation of funding is so much more than a statistic or line in a budget. It is a life protected. It is a child who gets to see adulthood. It is a parent who watches their child survive and thrive. It is a community living disease free or an entire country or region that is better prepared for emergencies or disasters. This is the difference WHO can make, working hand-in-hand with Member States and global partners.
 
WHO Priorities
WHO posted brief overviews describing these priorities, each led by a quotation from Dr. Tedros as below.
:: Health for all
   The right of every individual to basic health services will be my top priority – Dr Tedros
:: Health emergencies
   I will engage with diverse stakeholders to make health care and protection from infectious
   disease outbreaks a central component of the world’s security, economic and social
   development agendas. – Dr Tedros
:: Women, children and adolescents
   I believe healthy, empowered girls and women have the potential to build stronger
   communities, and nations and ultimately transform entire societies – Dr Tedros
:: The health impacts of climate and environmental change
   Developing and nurturing resilient and effective community based structures and multi-
   sectoral approaches is critical to prevent, mitigate and respond to the health impacts of
   environmental risk factors and climate change. – Dr Tedros
:: A transformed WHO
  Thanks to the actions of WHO, more people are living longer, healthier lives than ever before.
   However, we live in a changing world, and WHO must be able to change with it. – Dr Tedros

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World Bank Launches First-Ever Pandemic Bonds to Support $500 Million Pandemic Emergency Financing Facility
[Editor’s text bolding]
Washington, DC, June 28, 2017 – The World Bank (International Bank for Reconstruction and Development) today launched specialized bonds aimed at providing financial support to the Pandemic Emergency Financing Facility (PEF), a facility created by the World Bank to channel surge funding to developing countries facing the risk of a pandemic.

This marks the first time that World Bank bonds are being used to finance efforts against infectious diseases, and the first time that pandemic risk in low-income countries is being transferred to the financial markets.

The PEF will provide more than $500 million to cover developing countries against the risk of pandemic outbreaks over the next five years, through a combination of bonds and derivatives priced today, a cash window, and future commitments from donor countries for additional coverage.

The transaction, that enables PEF to potentially save millions of lives, was oversubscribed by 200% reflecting an overwhelmingly positive reception from investors and a high level of confidence in the new World Bank sponsored instrument. With such strong demand, the World Bank was able to price the transaction well below the original guidance from the market. The total amount of risk transferred to the market through the bonds and derivatives is $425 million.

“With this new facility, we have taken a momentous step that has the potential to save millions of lives and entire economies from one of the greatest systemic threats we face,” World Bank Group President Jim Yong Kim said. “We are moving away from the cycle of panic and neglect that has characterized so much of our approach to pandemics. We are leveraging our capital market expertise, our deep understanding of the health sector, our experience overcoming development challenges, and our strong relationships with donors and the insurance industry to serve the world’s poorest people. This creates an entirely new market for pandemic risk insurance. Drawing on lessons from the Ebola Outbreak in West Africa, the Facility will help improve health security for everyone. I especially want to thank the World Health Organization and the governments of Japan and Germany for their support in launching this new mechanism.”

The World Bank announced the creation of the PEF in May 2016 at the G7 Finance Ministers and Central Governors meeting in Sendai, Japan. The PEF will quickly channel funding to countries facing a major disease outbreak with pandemic potential. Its unique financing structure combines funding from the bonds issued today with over-the-counter derivatives that transfer pandemic outbreak risk to derivative counterparties. The structure was designed to attract a wider, more diverse set of investors.

The PEF has two windows. The first is an ‘insurance’ window with premiums funded by Japan and Germany, consisting of bonds and swaps including those executed today. The second is a ‘cash’ window, for which Germany provided initial funding of Euro 50 million. The cash window will be available from 2018 for the containment of diseases that may not be eligible for funding under the insurance window…

The bonds will be issued under IBRD’s “capital at risk” program because investors bear the risk of losing part or all of their investment in the bond if an epidemic event triggers pay-outs to eligible countries covered under the PEF.

The PEF covers six viruses that are most likely to cause a pandemic. These include new Orthomyxoviruses (new influenza pandemic virus A), Coronaviridae (SARS, MERS), Filoviridae (Ebola, Marburg) and other zoonotic diseases (Crimean Congo, Rift Valley, Lassa fever).
 
PEF financing to eligible countries will be triggered when an outbreak reaches predetermined levels of contagion, including number of deaths; the speed of the spread of the disease; and whether the disease crosses international borders. The determinations for the trigger are made based on publicly available data as reported by the World Health Organization (WHO).
Countries eligible for financing under the PEF’s insurance window are members of the International Development Association (IDA), the institution of the World Bank Group that provides concessional finance for the world’s poorest countries. The PEF will be governed by a Steering Body, whose voting members include Japan and Germany. WHO and the World Bank serve as non-voting members…

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Featured Journal Content
 
Pediatrics
July 2017, VOLUME 140 / ISSUE 1
http://pediatrics.aappublications.org/content/139/6?current-issue=y
Articles
Childhood Illness and the Gender Gap in Adolescent Education in Low- and Middle-Income Countries
Marcella Alsan, Anlu Xing, Paul Wise, Gary L. Darmstadt, Eran Bendavid
Pediatrics Jul 2017, 140 (1) e20163175; DOI: 10.1542/peds.2016-3175
Abstract
BACKGROUND: Achieving gender equality in education is an important development goal. We tested the hypothesis that the gender gap in adolescent education is accentuated by illnesses among young children in the household.
METHODS: Using Demographic and Health Surveys on 41,821 households in 38 low- and middle-income countries, we used linear regression to estimate the difference in the probability adolescent girls and boys were in school, and how this gap responded to illness episodes among children <5 years old. To test the hypothesis that investments in child health are related to the gender gap in education, we assessed the relationship between the gender gap and national immunization coverage.
RESULTS: In our sample of 120,708 adolescent boys and girls residing in 38 countries, girls were 5.08% less likely to attend school than boys in the absence of a recent illness among young children within the same household (95% confidence interval [CI], 5.50%–4.65%). This gap increased to 7.77% (95% CI, 8.24%–7.30%) and 8.53% (95% CI, 9.32%–7.74%) if the household reported 1 and 2 or more illness episodes, respectively. The gender gap in schooling in response to illness was larger in households with a working mother. Increases in child vaccination rates were associated with a closing of the gender gap in schooling (correlation coefficient=0.34, P=.02).
CONCLUSIONS: Illnesses among children strongly predict a widening of the gender gap in education. Investments in early childhood health may have important effects on schooling attainment for adolescent girls.

Excerpt
…In our analysis of vaccination rates relative to the education gap, we found a statistically significant and strong negative correlation between the vaccination rates of children <5 years old and the gender gap in education (eg, the higher the vaccination rate, the smaller the gender gap in education; correlation coefficient=0.34, P=.02; Fig 4). The adolescent gender gap in education approaches zero with coverage rates exceeding ∼70% for all 8 vaccines. We performed several specification checks to ensure that our results are robust. These include varying the age of the included older children, using alternative educational outcomes, and splitting the sample by rural and urban location. We describe these supplementary changes in detail. In Supplemental Fig 5, we varied the age thresholds for older children in the following different ways: 10 to 16, 10 to 17, 10 to 18, 11 to 16, 12 to 16, 12 to 17, and 12 to 18. Our results are not sensitive to varying the thresholds….
 
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Emergencies

Emergencies
 
POLIO
Public Health Emergency of International Concern (PHEIC)

Polio this week as of 29 June 2017 [GPEI]
:: In Syria, 15 new cases of circulating vaccine-derived poliovirus type 2 (cVDPV2) were reported in the past week, bringing the total number of cVDPV2 cases in the country to 17.  Sixteen of the 17 cases are from Mayadeen district, Deir-Al-Zour governorate, and one case is from Raqua district, Raqua governorate.  All cases had onset of paralysis between 3 March and 23 May.

:: The 14th report of the Independent Monitoring Board (IMB) has been published, following the group’s meeting in May.[see below]

:: Summary of newly-reported viruses this week:  Syria – 15 new circulating vaccine-derived poliovirus type 2 (cVDPV2) were isolated from acute flaccid paralysis (AFP) cases, and four new cVDPV2 isolated from healthy community contacts.  Pakistan – one new wild poliovirus type 1 (WPV1) isolated from an environmental sample

Weekly country updates as of 21 June 2017
:: Syrian Arab Republic
In Syria, 15 new cases of circulating vaccine-derived poliovirus type 2 (cVDPV2) were reported in the past week, bringing the total number of cVDPV2 cases to 17.  Sixteen of the 17 cases are from Mayadeen district, Deir-Al-Zour governorate, and one case is from Raqua district, Raqua governorate.  All cases had onset of paralysis between 3 March and 23 May.  Additionally, four cVDPV2s were also isolated from healthy community contacts, all from Mayadeen (collected in April and May).
Of a total of 65 acute flaccid paralysis (AFP) cases detected in Deir-Al-Zour since the start of 2017, 16 have now tested positive for cVDPV2 (with the 17th case from Raqua), 22 have tested negative, 5 are pending for final laboratory results and 22 specimens are en route to a laboratory for processing.
Confirmation of these latest cases is not unexpected at this time and does not change the operational situation, as outbreak response plans are being finalized, in line with internationally-agreed outbreak response protocols.  Although access to Deir-Al-Zour is compromised due to insecurity, the Governorate has been partially reached by several vaccination campaigns against polio and other vaccine-preventable diseases since the beginning of 2016. Most recently, two campaigns have been conducted in March and April 2017 using the bivalent oral polio vaccine (OPV). However, only limited coverage was possible through these campaigns.
 
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WHO Grade 3 Emergencies  [to 1 July 2017]
The Syrian Arab Republic 
:: Making the golden hours count: WHO trains Syrian health staff to treat chemical exposure and severe trauma  24 June 2017

Yemen
:: Yemen: cholera outbreak suspected cases exceeds 200 000
NEW YORK/GENEVA, 24 June 2017 – Joint news release UNICEF/WHO: The rapidly spreading cholera outbreak in Yemen has exceeded 200 000 suspected cases, increasing at an average of 5000 a day. We are now facing the worst cholera outbreak in the world.

Iraq  – No new announcements identified.
NigeriaNo new announcements identified.
South SudanNo new announcements identified.
 
 
WHO Grade 2 Emergencies  [to 1 July 2017]
Cameroon  No new announcements identified
Central African Republic  – No new announcements identified. 
Democratic Republic of the Congo  – No new announcements identified. 
EthiopiaNo new announcements identified.
LibyaNo new announcements identified.
MyanmarNo new announcements identified.
Niger  – No new announcements identified.
Ukraine  – No new announcements identified
 
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UN OCHA – L3 Emergencies
The UN and its humanitarian partners are currently responding to three ‘L3’ emergencies. This is the global humanitarian system’s classification for the response to the most severe, large-scale humanitarian crises. 
Iraq
:: Iraq: Mosul Humanitarian Response Situation Report No. 38 (12 to 28 June 2017)

Syrian Arab Republic
:: Syria Crisis: Ar-Raqqa Situation Report No. 10 (19-26 June 2017)

YemenNo new announcements identified

UN OCHA – Corporate Emergencies
When the USG/ERC declares a Corporate Emergency Response, all OCHA offices, branches and sections provide their full support to response activities both at HQ and in the field.
Ethiopia
:: Ethiopia Weekly Humanitarian Bulletin, 27 June 2017

DRC (Kasai crisis)No new announcements identified.
NigeriaNo new announcements identified.
SomaliaNo new announcements identified.

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UNICEF  [to 1 July 2017]
https://www.unicef.org/media/media_94367.html
29 June 2017
UNICEF calls for the protection of children trapped in west Mosul’s violence
BAGHDAD, 29 June 2017 – “Thousands of children continue to be trapped in relentless violence in West Mosul’s Old City neighborhoods as the fighting heavily intensified over the past hours.

Children continue to bear the brunt of multiple emergencies in Sudan
KHARTOUM, Sudan, 28 June 2017 – Over the last few months, Sudan has faced multiple emergencies with the rapid spread of suspected cases of acute watery diarrhea across 12 of its 18 states, a significant influx of South Sudanese refugees, and high rates of malnutrition, especially in the Jebel Marra Area of Central Darfur.
 
UNICEF airlifts lifesaving supplies to Yemen to combat cholera as cases surpass 200,000
SANA’A, 28 June 2017 –Three UNICEF charter planes have delivered 36 tons of lifesaving medical and water purification supplies to Yemen to scale up efforts to combat the world’s worst cholera outbreak.
The supplies included, 750,000 sachets of Oral Rehydration Salt (ORS) enough to treat 10,000 people, 10.5 million water purification tablets and other sanitation items.
“We are in a race against time. Our teams are working with partners not only to provide treatment to the sick and raise awareness among communities, but also to rapidly replenish and distribute supplies and medicines ”, said Dr Sherin Varkey, UNICEF Deputy Representative in Yemen. “More airlifts of critical supplies will continue in the coming days”.
In just two months, cholera has spread to almost every governorate of Yemen. Already more than 1,300 people have died – one quarter of them children. Civil servants, including doctors, nurses, water engineers and rubbish collectors have not been paid for nearly 10 months.
Since the outbreak was reported on 27 April, UNICEF has distributed over 600,000 ORS sachets and 20,000 Intravenous (IV) fluids to oral rehydration points and at homes. With partners, UNICEF has supported the establishment of 488 oral rehydration therapy points and more than 20 Diarrhoea Treatment Centres across the country.

Statement from UNICEF Executive Director Anthony Lake and WHO Director-General Margaret Chan on the cholera outbreak in Yemen as suspected cases exceed 200,000
NEW YORK/GENEVA, 24 June 2017 – “The rapidly spreading cholera outbreak in Yemen has exceeded 200,000 suspected cases, increasing at an average of 5,000 a day. We are now facing the worst cholera outbreak in the world.
“In just two months, cholera has spread to almost every governorate of this war-torn country.  Already more than 1,300 people have died – one quarter of them children – and the death toll is expected to rise.
“UNICEF, WHO and our partners are racing to stop the acceleration of this deadly outbreak. We are working around the clock to detect and track the spread of disease and to reach people with clean water, adequate sanitation and medical treatment. Rapid response teams are going house-to-house to reach families with information about how to protect themselves by cleaning and storing drinking water.
“UNICEF and WHO are taking all measures to scale up prevention and treatment interventions.  We call on authorities in Yemen to strengthen their internal efforts to stop the outbreak from spreading further.
“This deadly cholera outbreak is the direct consequence of two years of heavy conflict. Collapsing health, water and sanitation systems have cut off 14.5 million people from regular access to clean water and sanitation, increasing the ability of the disease to spread.  Rising rates of malnutrition have weakened children’s health and made them more vulnerable to disease. An estimated 30,000 dedicated local health workers who play the largest role in ending this outbreak have not been paid their salaries for nearly 10 months.
“We urge all authorities inside the country to pay these salaries and, above all, we call on all parties to end this devastating conflict.”

::::::

Editor’s Note:
We repeat here the Associated Press report from last week on OCV for Yemen. We have not identified any formal announcement of this action on the WHO website or otherwise about this important intervention.
War-Torn Yemen to Get Cholera Vaccines as Death Toll Mounts
New York Times/ASSOCIATED PRESS
JUNE 21, 2017
GENEVA — The U.N. health agency and some major partners have agreed to send 1 million doses of cholera vaccine to Yemen to help stanch a spiraling and increasingly deadly caseload in the impoverished country, which is already facing war and the risk of famine.
A spokesman for the World Health Organization said Wednesday that it didn’t initially want to publicize last week’s decision because questions remain about when and how the doses could reach the neediest people in a country sliced up along front lines and grappling with a nearly-collapsed health system.
WHO said the 1 million doses for Yemen were approved on June 15 by the International Coordinating Group…

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Editor’s Note:
We will cluster these recent emergencies as below and continue to monitor the WHO webpages for updates and key developments.
EBOLA/EVD  [to 1 July 2017]
http://www.who.int/ebola/en/
WHO AFRO – External Situation Report 28: 30 June 2017
…Since our last update on 27 June, no new confirmed, probable or suspected cases have been reported. Two alerts were reported between 27 June and 28 June. One alert was from Mobenge and the other, a community death in Tobongisa, was considered a suspected case. All the alerts and the suspected cases were subsequently discarded following further investigation…

MERS-CoV [to 1 July 2017]
http://www.who.int/emergencies/mers-cov/en/
DONs- Disease Outbreak News
:: Middle East respiratory syndrome coronavirus (MERS-CoV) – Saudi Arabia   28 June 2017
 
Zika virus  [to 1 July 2017]
http://www.who.int/emergencies/zika-virus/en/
[No new digest content identified]

Yellow Fever  [to 1 July 2017]
http://www.who.int/emergencies/yellow-fever/en/
23 June 2017
WHO issues updated positon paper on yellow fever vaccine
In a revised yellow fever (YF) vaccine position paper published in today’s edition of the Weekly Epidemiological Record, WHO provided updated guidance on the use of fractional dose YF vaccination in the context of YF vaccine supply shortages.
Weekly Epidemiological Record, 23 June 2017, vol. 92, 25 (pp. 345–356)
Yellow fever vaccine: WHO position on the use of fractional doses – June 2017
Global polio eradication: progress towards containment of poliovirus type 2, worldwide 2017
 
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WHO & Regional Offices [to 1 July 2017]

WHO & Regional Offices [to 1 July 2017]

Ending discrimination in health care settings
27 June 2017 – Discrimination in health care is widespread across the world and takes many forms. It violates the most fundamental human rights and affects both users of health care services and health care workers. The new joint United Nations statement on ending discrimination in health care settings calls for health workers to fulfil their responsibilities, but also to have their rights protected. Many health workers, especially women, are themselves vulnerable and victims of discrimination, abuse, and violence.
Read the joint UN statement

Public health surveillance ethics
26 June 2017 — Public health officials regularly collect and analyse data to map disease, spot patterns, identify causes and respond to outbreaks. But surveillance can lead to harm if people’s privacy is violated, or they are stigmatized on the basis of the information they provide about themselves. WHO’s new Guidelines on ethical issues in public health surveillance offer 17 guidelines that can assist everyone involved in surveillance to make the right decisions.

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Disease outbreak news
:: Middle East respiratory syndrome coronavirus (MERS-CoV) – Saudi Arabia   28 June 2017
:: Human infection with avian influenza A(H7N9) virus – China   28 June 2017
:: Lassa Fever – Nigeria   28 June 2017

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Weekly Epidemiological Record, 30 June 2017, vol. 92, 26 (pp. 357–368)
Index of countries/areas; Index, Volume 92, 2017, Nos. 1–26
:: WHO Alliance for the Global Elimination of Trachoma by 2020: progress report on elimination of trachoma, 2014–2016

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WHO Regional Offices
Selected Press Releases, Announcements
WHO African Region AFRO
:: “Call-to-Action” – Putting People First: The Road to Universal Health Coverage in Africa – 28 June 2017
Brazzaville, 28 June 2017 – The World Health Organization’s inaugural Africa Health Forum ‘has concluded with a resounding call to action that all stakeholders in Africa must work together to achieve Universal Health Coverage (UHC), a key aim of the Sustainable Development Goals (SDGs).  Experts from a wide range of backgrounds including academics, ministers of health, intergovernmental agencies, academics, civil society, philanthropic foundations, private sector, and youth organisations attended the two-day landmark event organized by WHO under the theme: ‘Putting people first: The Road to Universal Health Coverage in Africa.’
:: Africa needs to act now to safeguard the health of its youth – 27 June 2017

WHO Region of the Americas PAHO
No new digest content identified.

WHO South-East Asia Region SEARO
No new digest content identified.
 
WHO European Region EURO
:: Countries mark World No Tobacco Day with outreach to all levels of society and across sectors 30-06-2017
:: Exploring synergies between health, climate change mitigation and nature conservation 28-06-2017
:: Europe’s small countries commit to ending childhood obesity 27-06-2017
:: New WHO report provides blueprint for delivering people-centred care for tuberculosis 26-06-2017

WHO Eastern Mediterranean Region EMRO
:: Partnerships, empowerment and action: a multisectoral response to end gender-based violence against women and girls in Asia and the Pacific  28 June 2017
:: Joint United Nations statement on ending discrimination in health care settings 27 June 2017
:: Statement from UNICEF Executive Director Anthony Lake and WHO Director-General Margaret Chan on the cholera outbreak in Yemen as suspected cases exceed 200,000 24 June 2017

WHO Western Pacific Region
:: Let’s talk about it: improving immunization coverage in Solomon Islands
29 June 2017 – Baby Joy looks around the room with bright, curious eyes, closely watching the nurse as she pulls on her white latex gloves. Joy is 17 weeks old, and that means she is overdue to receive four different vaccinations, as per Solomon Islands’ routine immunization schedule. Unfortunately, many children are like Joy: they receive their vaccinations late. In fact, over 25% do not receive the full schedule at all.
 
 
 

CDC/ACIP [to 1 July 2017]

CDC/ACIP [to 1 July 2017]
http://www.cdc.gov/media/index.html
Press Release
Wednesday, June 28, 2017
40th Annual Report on the Health of the Nation Features Long-Term Trends in Health and Health Care Delivery in the United States
CDC today released Health, United States, 2016,…

Press Release
Monday, June 26, 2017
Life at Ground Zero: The Story of the West African Ebola Outbreak
What was it like at ground zero of the worst outbreak of Ebola in history? This month, CDC’s David J. Sencer…

MMWR – June 29, 2017
:: Influenza Update
The 2016-17 flu season was relatively long and moderate in severity. Flu vaccination can vary in how well it works, but remains the best way to prevent influenza illness and associated complications. However, treatment with influenza antiviral medications close to the onset of illness is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for influenza complications. Although summer influenza activity in the United States typically is low, influenza cases and outbreaks do happen in summer months and clinicians should be vigilant in considering influenza when patients have summer respiratory illnesses. Influenza activity in the United States during 2016-17 was low through November, increased during December and peaked in February although there were regional differences in timing. Influenza A(H3N2) viruses were most common through mid-March and were predominate for the season overall, but influenza B viruses were most common from late March through May. Severity indicators (hospitalization and mortality rates) were within the range of what has been observed during previous seasons when influenza A(H3N2) viruses predominated. Final vaccine effectiveness estimates against flu-related outpatient medical visits was 42 percent (95% CI 35%–48%).

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Announcements

Announcements
 
Wellcome Trust  [to 1 July 2017]
https://wellcome.ac.uk/news
News / Published: 29 June 2017
Zika vaccine research: guidance for including pregnant women
New guidance for including pregnant woman and their babies in Zika vaccine research has been published today. It has been issued by a group of international experts in vaccinology, maternal and child health, public health and ethics.
Zika infection in pregnancy can have devastating effects on normal fetal development. But pregnant women are often automatically excluded from vaccine trials over safety concerns.
The guidelines argue that those most at risk from the virus – pregnant women and their babies – should be at the centre of Zika vaccine development.
What the guidance recommends
The guidance, developed with Wellcome funding, sets out how the research community can ensure that any vaccines developed are made available to those most at risk.
It puts forward three principles, each with recommendations directed at policymakers, funders, researchers, oversight bodies, regulatory authorities and the global public health community.
[1] To pursue and prioritise development of  Zika vaccines that can be used by pregnant women.
[2] To ensure data is collected in time to inform judgments about safety and efficacy of vaccine administration in pregnancy.
[3] To ensure pregnant women have fair access to participate in research studies…
 
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FDA [to 1 July 2017]
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/default.htm
June 29, 2017 –
FDA unveils plan to eliminate orphan designation backlog
Today, the U.S. Food and Drug Administration unveiled a strategic plan to eliminate the agency’s existing orphan designation request backlog and ensure continued timely response to all new requests for designation with firm deadlines. The agency’s Orphan Drug Modernization Plan comes a week after FDA Commissioner Scott Gottlieb committed to eliminating the backlog within 90 days and responding to all new requests for designation within 90 days of receipt during his testimony before a Senate subcommittee.
As authorized under the Orphan Drug Act, the Orphan Drug Designation Program provides orphan status to drugs and biologics that are defined as those intended for the safe and effective treatment, diagnosis or prevention of rare diseases, which are generally defined as diseases that affect fewer than 200,000 people in the United States. Orphan designation qualifies the sponsor of the drug for various development incentives, including tax credits for clinical trial costs, relief from prescription drug user fee if the indication is for a rare disease or condition, and eligibility for seven years of marketing exclusivity upon approval. A request for orphan designation is one step that can be taken in the drug development process and is different than the filing of a marketing application with the FDA.
Currently, the FDA has about 200 orphan drug designation requests that are pending review. The number of orphan drug designation requests has steadily increased over the past five years…
 
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IVI   [to 1 July 2017]
http://www.ivi.int/
June 30, 2017, Seoul, Korea
Changes in IVI’s Board of Trustees
The International Vaccine Institute (IVI) today announced several changes in its Board of Trustees (BOT). Three new members will join the Board: Mr. Malcolm Sweeney, Dr. Chris Varma, and Dr. Ros-Mari Bålöw. Each will serve a three-year term, which will take effect on November 16, 2017.
“The new Board members bring diversity and a wealth of experience in areas ranging from global finance to entrepreneurship to international development and cooperation research,” said Dr. Jerome Kim, IVI Director General. “They bring leadership experience from their respective fields, and I am pleased they are joining our board.”
   … Dr. Viveka Persso, who is from the Swedish National Agency for Higher Education was the Swedish representative on the Board since 2012 and also served as Vice Chair of the Board. George Bickerstaff was appointed as Board Vice Chair effectively immediately following Dr. Persson’s departure….
 
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Gavi [to 1 July 2017]
http://www.gavi.org/library/news/press-releases/
29 June 2017
Gavi welcomes US$ 1.5 million contribution from China Merchants Group
The pledge will support Gavi’s mission to immunise 300 million of the world’s poorest children by 2020.
Beijing, 29 June 2017 – China Merchants Charitable Foundation (CMCF), a charity affiliation of China Merchants Group (CMG) will contribute US$ 1.5 million to Gavi, the Vaccine Alliance, to support childhood immunisation in developing countries in 2017-2019. This multi-year pledge from CMG is the first agreement of its kind signed between Gavi and a private sector company in the Asia Pacific region.
“China Merchants Group has a deserved reputation as a global leader in logistics, supply chain and financial services, and this multi-year pledge underlines the company’s unwavering commitment to making a real difference to the lives of children in developing countries,” said Dr Seth Berkley, CEO of Gavi…
 
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GHIT Fund   [to 1 July 2017]
https://www.ghitfund.org/
GHIT was set up in 2012 with the aim of developing new tools to tackle infectious diseases that devastate the world’s poorest people. Other funders include six Japanese pharmaceutical ·
2017.06.28      
Event Report: GHIT Fund Replenishment Press Conference

The GHIT Fund held a press conference at the Kioi conference center in Tokyo on June 1, 2017, announcing its replenishment with a USD 200 million commitment for the next five years (FY2018-FY2022) from its funding partners. The following GHIT Council members participated: Government of Japan (Ministry of Foreign Affairs and Ministry of Health, Labour, and Welfare), Japanese pharmaceutical companies (Astellas Pharma Inc., Chugai Pharmaceutical Co., Ltd., Daiichi Sankyo Company, Ltd., Eisai Co., Ltd., Shionogi & Co., Ltd., and Takeda Pharmaceutical Company, Ltd.), and Foundations (Bill & Melinda Gates Foundation and Welcome Trust)….
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NIH  [to 1 July 2017]
http://www.nih.gov/news-events/news-releases
June 28, 2017
NIH study sheds light on immune responses driving obesity-induced liver disease
Findings in mouse models reveal inflammatory factors that promote liver scarring.
June 27, 2017
Researchers develop microneedle patch for flu vaccination
The patch could be an alternative to needle-and-syringe immunization.
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UNAIDS  [to 1 July 2017]
http://www.unaids.org/
Selected Press Releases & Updates
Press Release
UNAIDS Board seizes opportunities of change to deliver results
Board members unanimously approve US$ 484 million budget for 2018–2019.
GENEVA, 30 June 2017—UNAIDS’ 40th Programme Coordinating Board meeting has concluded in Geneva, Switzerland. Important decisions were taken on redefining the ways in which the Joint Programme works to deliver results efficiently and effectively and continues to advance global efforts to end the AIDS epidemic as part of the Sustainable Development Goals.
The Board affirmed the UNAIDS Joint Programme Action Plan as a way to progressively move towards a refined operating model. The Action Plan strengthens the coherence and effectiveness of UNAIDS’ support to countries and presents clear results and deliverables on joint working, financing, accountability and governance. The Board members also welcomed the final report of the Global Review Panel on the Future of the UNAIDS Joint Programme Model…
Press Release
Germany to double contributions to UNAIDS
The Government of Germany has announced that it will double its funding to UNAIDS in 2017-2018, to €5 million per year. Germany made the announcement at PCB-40.
 
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PhRMA    [to 1 July 2017]
http://www.phrma.org/press-room
June 27, 2017
More Than 50 Medicines and Vaccines in Development for HIV Infection, Treatment and Prevention
America’s biopharmaceutical companies are continuing the fight to conquer the human immunodeficiency virus (HIV), which can develop into acquired immune deficiency syndrome (AIDS), with 52 medicines and vaccines currently in development to help treat and prevent the infection, according to a report released today by PhRMA in partnership with The AIDS Institute.
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Sabin Vaccine Institute  [to 1 July 2017]
http://www.sabin.org/updates/pressreleases
Thursday, June 29, 2017
Thank You for Supporting END7! Changes are coming…

It’s been five years since the Sabin Vaccine Institute launched the END7 campaign to end neglected tropical diseases (NTDs). With your support, we mobilized funding to support programs that treated more than 50 million people, helped increase US and UK funding for NTDs and spread awareness of the global NTD burden.

As of June 1, 2017 we are no longer accepting donations for NTD treatment programs but we are working to ensure END7 advocacy efforts continue uninterrupted. We have concluded END7 fundraising activities and are working with a partner organization to continue advocacy for NTD treatment. END7 student advocacy efforts will continue this fall under the direction of another NTD organization, we will share more details about this exciting transition soon.

The Sabin Vaccine Institute, home of the END7 campaign, is dedicated to making vaccines more accessible, enabling innovation and expanding immunization across the globe. We intend to focus our energy going forward on expanding immunization…
 
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MSF/Médecins Sans Frontières  [to 1 July 2017]
http://www.doctorswithoutborders.org/news-stories/press/press-releases
Press release
Proposed Executive Order Puts Pharma Interests Over People’s Lives
June 27, 2017
A leaked draft of President Trump’s executive order on drug pricing reveals that the White House will perpetuate policies that have led to a broken biomedical research and development (R&D) system and raise drug prices around the world, said the international medical humanitarian organization Doctors Without Borders/Médecins Sans Frontières (MSF).
Press release
Doctors Without Borders Urges India’s Modi to Remain Committed to Affordable Medicines During White House Meeting
June 26, 2017
As U.S. President Donald Trump and Indian Prime Minister Narendra Modi meet at the White House today, Doctors Without Borders/Médecins Sans Frontières (MSF) warned that U.S. pressure on India to change its drug regulatory and patent system could result in millions of people in the U.S. and around the world losing their lifeline of affordable medicines. As an international medical humanitarian organization that relies on affordable generic medicines produced in India to run its medical programs in more than 60 countries, MSF urged Modi to stand strong and protect India’s role as the “pharmacy of the developing world.”
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DCVMN – Developing Country Vaccine Manufacturers Network  [to 1 July 2017]
http://www.dcvmn.org/
[undated]
DCVMN Annual General Meeting
25 September 2017 to 28 September 2017
Seoul / Korea
 
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European Vaccine Initiative  [to 1 July 2017]
http://www.euvaccine.eu/news-events
27 June 2017
EDUFLUVAC workshop
“Four years of European research on the development of universal influenza vaccines: what have we learnt, and how can we move forward?”

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EDCTP    [to 1 July 2017]
http://www.edctp.org/
The European & Developing Countries Clinical Trials Partnership (EDCTP) aims to accelerate the development of new or improved drugs, vaccines, microbicides and diagnostics against HIV/AIDS, tuberculosis and malaria as well as other poverty-related and neglected infectious diseases in sub-Saharan Africa, with a focus on phase II and III clinical trials
28 June 2017
Botswana launch of AMBITION-cm project on HIV-associated cryptococcal meningitis
Almost twenty per cent of HIV-related deaths are directly attributable to cryptococcal meningitis (CM). The AMBITION-cm project was developed to
 
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Industry Watch
:: Takeda and Biological E. Limited Announce Partnership to Develop Low-Cost Combination Vaccines for Low- and Middle-Income Countries around the Globe
Two recently-signed agreements will transfer Takeda’s measles and acellular pertussis vaccine technologies to India-based multi-national company Biological E. Limited (“BE”) to develop low-cost combination vaccines including diphtheria, tetanus and acellular pertussis (DTaP) and measles-rubella (MR) vaccines
OSAKA, Japan & HYDERABAD, India–(BUSINESS WIRE)–Takeda Pharmaceutical Company Limited [TSE: 4502], (“Takeda”) and Biological E. Limited (“BE”) today announced that they have entered into a collaboration whereby two licensing agreements to expedite the development and delivery of affordable combination vaccines have been executed. BE will commercialize the vaccine in India, China and low- and middle-income countries where large, unmet public health needs exist.
Takeda has sold both the measles and pertussis vaccines in the Japanese market for more than 20 years. In heavily populated countries like India, where 25.7 million births occurred in 2015, substantial opportunities remain to deliver critical vaccines to those who need them. In the absence of access to vaccines in many parts of the world, this partnership illustrates Takeda’s desire to forge the kind of collaborations needed to overcome this public health challenge in low- and middle-income countries.
“Access to medicines is one of Takeda’s core values, and these agreements align with Takeda’s strategic goals to make high-impact contributions to global public health, either alone or through partners,” said Rahul Singhvi, Chief Operating Officer, Takeda Vaccine Business Unit. “These two agreements along with our current vaccine pipeline underscore our global commitment to address important infectious diseases across the globe.”

Under these agreements, Takeda will conduct a transfer from Japan to BE its existing measles and acellular pertussis vaccine bulk production technology, including the provision of technical services such as support in infrastructure review, training for production and quality control, technical assistance in process development, preclinical study design and production of clinical batch and the first commercial batches…
 
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Journal Watch

Journal Watch

   Vaccines and Global Health: The Week in Review continues its weekly scanning of key peer-reviewed journals to identify and cite articles, commentary and editorials, books reviews and other content supporting our focus on vaccine ethics and policy. Journal Watch is not intended to be exhaustive, but indicative of themes and issues the Center is actively tracking. We selectively provide full text of some editorial and comment articles that are specifically relevant to our work. Successful access to some of the links provided may require subscription or other access arrangement unique to the publisher.

If you would like to suggest other journal titles to include in this service, please contact David Curry at: david.r.curry@centerforvaccineethicsandpolicy.org

Cost-effectiveness analysis of malaria interventions using disability adjusted life years: a systematic review

BMC Cost Effectiveness and Resource Allocation
http://resource-allocation.biomedcentral.com/
(Accessed 1 July 2017)

Review
Cost-effectiveness analysis of malaria interventions using disability adjusted life years: a systematic review
Malaria continues to be a public health problem despite past and on-going control efforts. For sustenance of control efforts to achieve the malaria elimination goal, it is important that the most cost-effectiv…
Resign Gunda and Moses John Chimbari
Cost Effectiveness and Resource Allocation 2017 15:10
Published on: 1 July 2017

Ethics review of studies during public health emergencies – the experience of the WHO ethics review committee during the Ebola virus disease epidemic

BMC Medical Ethics
http://www.biomedcentral.com/bmcmedethics/content
(Accessed 1 July 2017)

Debate
Ethics review of studies during public health emergencies – the experience of the WHO ethics review committee during the Ebola virus disease epidemic
Emilie Alirol, Annette C. Kuesel, Maria Magdalena Guraiib, Vânia dela Fuente-Núñez, Abha Saxena and Melba F. Gomes
Published on: 26 June 2017
Abstract
Background
Between 2013 and 2016, West Africa experienced the largest ever outbreak of Ebola Virus Disease. In the absence of registered treatments or vaccines to control this lethal disease, the World Health Organization coordinated and supported research to expedite identification of interventions that could control the outbreak and improve future control efforts. Consequently, the World Health Organization Research Ethics Review Committee (WHO-ERC) was heavily involved in reviews and ethics discussions. It reviewed 24 new and 22 amended protocols for research studies including interventional (drug, vaccine) and observational studies.
WHO-ERC reviews
WHO-ERC provided the reviews within on average 6 working days. The WHO-ERC often could not provide immediate approval of protocols for reasons which were not Ebola Virus Disease specific but related to protocol inconsistencies, missing information and complex informed consents. WHO-ERC considerations on Ebola Virus Disease specific issues (benefit-risk assessment, study design, exclusion of pregnant women and children from interventional studies, data and sample sharing, collaborative partnerships including international and local researchers and communities, community engagement and participant information) are presented.
Conclusions
To accelerate study approval in future public health emergencies, we recommend: (1) internally consistent and complete submissions with information documents in language participants are likely to understand, (2) close collaboration between local and international researchers from research inception, (3) generation of template agreements for data and sample sharing and use during the ongoing global consultations on bio-banks, (4) formation of Joint Scientific Advisory and Data Safety Review Committees for all studies linked to a particular intervention or group of interventions, (5) formation of a Joint Ethics Review Committee with representatives of the Ethics Committees of all institutions and countries involved to strengthen reviews through the different perspectives provided without the ‘opportunity costs’ for time to final approval of multiple, independent reviews, (6) direct information exchange between the chairs of advisory, safety review and ethics committees, (7) more Ethics Committee support for investigators than is standard and (8) a global consultation on criteria for inclusion of pregnant women and children in interventional studies for conditions which put them at particularly high risk of mortality or other irreversible adverse outcomes under standard-of-care.

BMC Public Health (Accessed 1 July 2017)

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 1 July 2017)

Research article
Prevalence of high, medium and low-risk medical conditions for pneumococcal vaccination in Catalonian middle-aged and older adults: a population-based study
Updated population-based data on the frequency and distribution of risk factors for pneumococcal disease is scarce. This study investigated the prevalence of distinct comorbidities and underlying risk conditio…
Ochoa-Gondar, I. Hospital, A. Vila-Corcoles, M. Aragon, M. Jariod, C. de Diego and E. Satue

BMC Public Health 2017 17:610
Published on: 29 June 2017

Research article
Implementation of a human papillomavirus vaccination demonstration project in Malawi: successes and challenges
Cervical cancer is a major public health problem in Malawi. The age-standardized incidence and mortality rates are estimated to be 75.9 and 49.8 per 100,000 population, respectively. The availability of the hu…
Kelias Phiri Msyamboza, Beatrice Matanje Mwagomba, Moussa Valle, Hastings Chiumia and Twambilire Phiri
BMC Public Health 2017 17:599
Published on: 26 June 2017

Example-based illustrations of design, conduct, analysis and result interpretation of multi-regional clinical trials

Contemporary Clinical Trials
Volume 58, Pages 1-94 (July 2017)
http://www.sciencedirect.com/science/journal/15517144/58

Study Design, Statistical Design, Study Protocols
Example-based illustrations of design, conduct, analysis and result interpretation of multi-regional clinical trials
Original Research Article
Pages 13-22
Hui Quan, Xuezhou Mao, Yoko Tanaka, Bruce Binkowitz, Gang Li, Josh Chen, Ji Zhang, Peng-Liang Zhao, Soo Peter Ouyang, Mark Chang
Abstract
Extensive research has been conducted in the Multi-Regional Clinical Trial (MRCT) area. To effectively apply an appropriate approach to a MRCT, we need to synthesize and understand the features of different approaches. In this paper, examples are used to illustrate considerations regarding design, conduct, analysis and interpretation of result of MRCTs. We start with a brief discussion of region definitions and the scenarios where different regions have differing requirements for a MRCT. We then compare different designs and models as well as the corresponding interpretation of the results. We highlight the importance of paying special attention to trial monitoring and conduct to prevent potential issues associated with the final trial results. Besides evaluating the overall treatment effect for the entire MRCT, we also consider other key analyses including quantification of regional treatment effects within a MRCT, and assessment of consistency of these regional treatment effects.

Global Health: Science and Practice (GHSP) June 27, 2017, 5 (2)

Global Health: Science and Practice (GHSP)
June 27, 2017, 5 (2)
http://www.ghspjournal.org/content/current

EDITORIALS
Long-Acting HIV Treatment and Prevention: Closer to the Threshold
Substantial progress has been made toward viable, practical long-acting approaches to deliver HIV treatment and prevention through: (1) continued improvements in long-acting antiretrovirals (ARVs); (2) better innovative delivery systems; and (3) collaboration of willing partners to advance new ARVs. More progress on those 3 fronts is still needed to arrive at the goal of optimized HIV treatment and prevention for all who would benefit—and of finally controlling the HIV epidemic.
Matthew Barnhart
Glob Health Sci Pract 2017;5(2):182-187. http://dx.doi.org/10.9745/GHSP-D-17-00206

REVIEWS
Inequitable Access to Health Care by the Poor in Community-Based Health Insurance Programs: A Review of Studies From Low- and Middle-Income Countries
The poor lack equitable access to health care in community-based health insurance schemes. Flexible installment payment plans, subsidized premiums, and elimination of co-pays can increase enrollment and use of health services by the poor.
Chukwuemeka A Umeh, Frank G Feeley
Glob Health Sci Pract 2017;5(2):299-314.

In which developing countries are patents on essential medicines being filed?

Globalization and Health
http://www.globalizationandhealth.com/
[Accessed 1 July 2017]

Research
In which developing countries are patents on essential medicines being filed?
This article is based upon data gathered during a study conducted in partnership with the World Intellectual Property Organization on the patent status of products appearing on the World Health Organization’s …
Reed F Beall, Rosanne Blanchet and Amir Attaran
Globalization and Health 2017 13:38
Published on: 26 June 2017

Data Sharing Statements for Clinical Trials A Requirement of the International Committee of Medical Journal Editors

JAMA
June 27, 2017, Vol 317, No. 24, Pages 2463-2560
http://jama.jamanetwork.com/issue.aspx

Editorial
Data Sharing Statements for Clinical Trials A Requirement of the International Committee of Medical Journal Editors
Darren B. Taichman, MD, PhD; Peush Sahni, MB, BS, MS, PhD; Anja Pinborg, MD; et al.
The International Committee of Medical Journal Editors (ICMJE) believes there is an ethical obligation to responsibly share data generated by interventional clinical trials because trial participants have put themselves at risk. In January 2016 we published a proposal aimed at helping to create an environment in which the sharing of deidentified individual participant data becomes the norm. In response to our request for feedback we received many comments from individuals and groups.1 Some applauded the proposal while others expressed disappointment it did not more quickly create a commitment to data sharing. Many raised valid concerns regarding the feasibility of the proposed requirements, the necessary resources, the real or perceived risks to trial participants, and the need to protect the interests of patients and researchers…

Gravitating towards universal health coverage in the new WHO era

Lancet Global Health
Jul 2017 Volume 5 Number 7 e633-e726
http://www.thelancet.com/journals/langlo/issue/current

Editorial
Gravitating towards universal health coverage in the new WHO era
The Lancet Global Health
Open Access
DOI: http://dx.doi.org/10.1016/S2214-109X(17)30224-3

After a year of intense campaigning not devoid of controversies, WHO has a new leader. The election of Tedros Adhanom Ghebreyesus is the culmination of a series of firsts: he is the first Director-General elected via a more inclusive and transparent election process, the first African to be elected head of the agency, and the first non-physician to take the helm of the world’s foremost health institution. The excitement around this level of novelty is palpable: as Africa rejoices and congratulations converge from all sides of the global health political and technical communities, the overall sentiment wants to be one of hope—hope for the future of the embattled organisation at the hands of an experienced and successful technocrat and diplomat, and hope for renewed impetus to address the most pressing issues threatening the health of populations around the world.

The new WHO DG has laid out his priorities and first on the list is a familiar challenge: advancing universal health coverage (UHC). He has made clear that UHC is to be the “centre of gravity” of WHO’s work under his leadership. As such, he is picking up a process that—as laid out in Margaret Chan’s final report as WHO DG—started with the 1978 Health for All declaration of Alma-Ata and the push for primary health care, and through the ups and downs of an initially misunderstood and several times renewed concept, found a most vibrant expression in the 2010 “World Health Report on Health systems financing: the path to universal coverage”, which concentrated on demonstrating the financial feasibility of UHC. The concept crystallised as a development issue with the 2012 UN General Assembly resolution on UHC, and finally the inclusion of UHC in the 2030 Agenda for Sustainable Development, in SDG3, target 8. A place has been carved for UHC on the global agenda, and Tedros has committed to making it happen. We look forward to seeing how he will tackle this challenge.

And a challenge it will be. The economic case for UHC has been well discussed, the notions of equity and rights seem acquired, and studies are providing increased granularity to the monitoring of the health benefits of UHC. A recent article in The Lancet on an index of health care quality and access based on amenable mortality shows, among other things, how countries such as Tedros’ own Ethiopia, while still not performing well on this index, have been able to go beyond expectations between 1990 and 2015 in terms of access and quality. But clearly progress has been variable and there are gaps in coverage across and within countries. The new DG himself has acknowledged that while UHC has been the focus of the global health community for some time, progress has been slow. He has done so indirectly in our pages during his campaign, in his careful response to an open letter to the DG candidates on a patient-centred R&D agreement, where he recognised that one aspect of UHC—the delivery of quality health products for diseases affecting the most vulnerable population—remains poorly addressed, evoking market failures and lack of political will. Indeed, he has qualified the lack of political commitment, rather than lack of resources, as the biggest constraint for progress in UHC.

Obviously countries moving towards UHC face a number of choices, from policy negotiations and decisions to financing and implementation, that are inherently political. Conflicting priorities between ministries of finance and ministries of health can, and often do, clash. Ideological struggles and political interests also slow down or hamper progress. A case and point is that of the USA, where Barack Obama’s UHC-friendly Affordable Care Act is being hammered down by Donald Trump’s policy proposals.

Venturing into politically-charged terrain is tricky for WHO. The level of comfort is high on technical issues like financing and governance, but work on the political determinants and the political economy of UHC, while key for successful reforms, is not as conspicuous. Yet advocating for the outcome rather than the means to get to UHC, as Tedros has said should be WHO’s strategy, requires it. As Ethiopia’s former Minister of Foreign Affairs, he has undoubtedly gained key experience in high-level political engagement. Those sharp political skills will be invaluable in forging the new road ahead.

Innovative financing instruments for global health 2002–15: a systematic analysis

Lancet Global Health
Jul 2017 Volume 5 Number 7 e633-e726
http://www.thelancet.com/journals/langlo/issue/current

Health Policy
Innovative financing instruments for global health 2002–15: a systematic analysis
Prof Rifat Atun, FRCP, Sachin Silva, MSc, Prof Felicia M Knaul, PhD
Open Access
DOI: http://dx.doi.org/10.1016/S2214-109X(17)30198-5
Summary
Development assistance for health (DAH), the value of which peaked in 2013 and fell in 2015, is unlikely to rise substantially in the near future, increasing reliance on domestic and innovative financing sources to sustain health programmes in low-income and middle-income countries. We examined innovative financing instruments (IFIs)—financing schemes that generate and mobilise funds—to estimate the quantum of financing mobilised from 2002 to 2015. We identified ten IFIs, which mobilised US$8·9 billion (2·3% of overall DAH) in 2002–15. The funds generated by IFIs were channelled mostly through GAVI and the Global Fund, and used for programmes for new and underused vaccines, HIV/AIDS, malaria, tuberculosis, and maternal and child health. Vaccination programmes received the largest amount of funding ($2·6 billion), followed by HIV/AIDS ($1080·7 million) and malaria ($1028·9 million), with no discernible funding targeted to non-communicable diseases.

Lancet Infectious Diseases Jul 2017 Volume 17 Number 7 p673-780 e197-e234

Lancet Infectious Diseases
Jul 2017 Volume 17 Number 7 p673-780   e197-e234
http://www.thelancet.com/journals/laninf/issue/current

Editorial
Between the devil and the deep blue sea
The Lancet Infectious Diseases
Published: July 2017
DOI: http://dx.doi.org/10.1016/S1473-3099(17)30355-9

An unprecedented number of people escaping conflict and poverty have migrated from Asia and Africa towards Europe in recent years. A report from the UN High Commissioner for Refugees estimated that in 2016 alone around 362 376 people crossed the Mediterranean Sea, risking their lives to reach Europe. These new arrivals were in addition to more than 1 million refugees and migrants who had crossed the Mediterranean Sea on makeshift boats in 2015. Because of their geographical location, Greece and Italy have been the countries facing a continuous influx of migrants, mainly people aiming to move to northern European nations. However, with the closure of the borders to migrants in several countries along the Balkan route, including the Greece–Macedonia border, Greece has become the place where migrants are stranded in refugees camps.

At the end of 2016, the population residing in the 51 existing hosting facilities in Greece was estimated to be around 62 700 people. Most refugees reaching Greece have come from Syria, Afghanistan, and Iraq. The situation in the refugee camps varies but overcrowding and poor hygienic conditions prevail, creating a favourable milieu for the spread of infectious diseases. Thus, it is not surprising that, as described in a Newsdesk report in this issue, a high number of cases of hepatitis A were reported in Greek hosting facilities for refugees in 2016. In total, 177 laboratory-confirmed symptomatic cases were reported; of these, 149 (84%) occurred in hosting camps, mostly among Syrian children younger than 15 years. All cases reported symptom onset after their entry into the country. As a consequence, 599 vaccinations (of 309 contacts aged 1–14 years and 290 contacts aged 15 or older) were done during ring vaccination of the 177 reported cases.

Hepatitis A is primarily transmitted through the faecal-oral route, either by person-to-person contact or by consumption of contaminated food or water. Although the disease is mainly asymptomatic in children, its severity increases with age with some adults experiencing acute liver failure, especially in the presence of underlying conditions. A Review in this journal describes the epidemiology of hepatitis A virus infection across Europe during the past 40 years, which shows that susceptibility to the disease in adults is increasing in large parts of Europe because of low endemicity. The emergence of hepatitis A in refugee camps in Greece shows that it is likely that migrants have similar susceptibility to the indigenous population for hepatitis A and that the conditions in which they are detained are extremely poor. Although the outbreak of hepatitis A was contained with interventions that included improving hygienic conditions and ring vaccination of contacts, the effort was complicated by some of the common challenges when dealing with migrants’ health such as tracking population mobility, identification of contacts, and lack of information on vaccination history.

The difficulty of collecting information on the health status of migrants results in a lack of consensus on the best approach for screening and vaccination in this vulnerable population. Although migrants are eligible for universal care in both Greece and Italy, the reality is that access to the local health services remains difficult in these populations, so data on their main health issues are limited. A recent study of migrants in Italy reported that health problems in this population vary depending on the phase of their journey. At arrival in the host country the main issues reported by migrants are physical and psychological traumas, unwanted pregnancies, and scabies. Yet, once migrants settle in a camp, tuberculosis, vaccine preventable diseases such as hepatitis A, and sexually-transmitted infections become the major problem.

Currently, a series of projects supported by the European Union’s Health Programme are aiming at developing a shared system for collection and transmission of health data that should reduce the risk of overtreatment and repetition of diagnostic tests. Better information would also facilitate the implementation of vaccination campaigns to close the gaps caused by migration, which in turn would reduce the chances that outbreaks such as the one described for hepatitis A could occur again.

Efforts to improve screening of the health needs of migrants should reflect a more inclusive attitude of the European Union towards migrants in the future. Migrants have not escaped from tragedy in their countries to meet disease and neglect in refugees camps. They deserve better.

Articles
Estimating the future burden of multidrug-resistant and extensively drug-resistant tuberculosis in India, the Philippines, Russia, and South Africa: a mathematical modelling study
Aditya Sharma, Andrew Hill, Ekaterina Kurbatova, Martie van der Walt, Charlotte Kvasnovsky, Thelma E Tupasi, Janice C Caoili, Maria Tarcela Gler, Grigory V Volchenkov, Boris Y Kazennyy, Olga V Demikhova, Jaime Bayona, Carmen Contreras, Martin Yagui, Vaira Leimane, Sang Nae Cho, Hee Jin Kim, Kai Kliiman, Somsak Akksilp, Ruwen Jou, Julia Ershova, Tracy Dalton, Peter Cegielski for the Global Preserving Effective TB Treatment Study Investigators

Immunogenicity and safety of three aluminium hydroxide adjuvanted vaccines with reduced doses of inactivated polio vaccine (IPV-Al) compared with standard IPV in young infants in the Dominican Republic: a phase 2, non-inferiority, observer-blinded, randomised, and controlled dose investigation trial
Luis Rivera, Rasmus S Pedersen, Lourdes Peña, Klaus J Olsen, Lars V Andreasen, Ingrid Kromann, Pernille I Nielsen, Charlotte Sørensen, Jes Dietrich, Ananda S Bandyopadhyay, Birgit Thierry-Carstensen

Meningococcal serogroup B strain coverage of the multicomponent 4CMenB vaccine with corresponding regional distribution and clinical characteristics in England, Wales, and Northern Ireland, 2007–08 and 2014–15: a qualitative and quantitative assessment
Sydel R Parikh, Lynne Newbold, Stephanie Slater, Maria Stella, Monica Moschioni, Jay Lucidarme, Rosita De Paola, Maria Giuliani, Laura Serino, Stephen J Gray, Stephen A Clark, Jamie Findlow, Mariagrazia Pizza, Mary E Ramsay, Shamez N Ladhani, Ray Borrow

Childhood Illness and the Gender Gap in Adolescent Education in Low- and Middle-Income Countries

Pediatrics
July 2017, VOLUME 140 / ISSUE 1
http://pediatrics.aappublications.org/content/139/6?current-issue=y

Articles
Childhood Illness and the Gender Gap in Adolescent Education in Low- and Middle-Income Countries
Marcella Alsan, Anlu Xing, Paul Wise, Gary L. Darmstadt, Eran Bendavid
Pediatrics Jul 2017, 140 (1) e20163175; DOI: 10.1542/peds.2016-3175
Abstract
BACKGROUND: Achieving gender equality in education is an important development goal. We tested the hypothesis that the gender gap in adolescent education is accentuated by illnesses among young children in the household.
METHODS: Using Demographic and Health Surveys on 41,821 households in 38 low- and middle-income countries, we used linear regression to estimate the difference in the probability adolescent girls and boys were in school, and how this gap responded to illness episodes among children <5 years old. To test the hypothesis that investments in child health are related to the gender gap in education, we assessed the relationship between the gender gap and national immunization coverage.
RESULTS: In our sample of 120,708 adolescent boys and girls residing in 38 countries, girls were 5.08% less likely to attend school than boys in the absence of a recent illness among young children within the same household (95% confidence interval [CI], 5.50%–4.65%). This gap increased to 7.77% (95% CI, 8.24%–7.30%) and 8.53% (95% CI, 9.32%–7.74%) if the household reported 1 and 2 or more illness episodes, respectively. The gender gap in schooling in response to illness was larger in households with a working mother. Increases in child vaccination rates were associated with a closing of the gender gap in schooling (correlation coefficient=0.34, P=.02).
CONCLUSIONS: Illnesses among children strongly predict a widening of the gender gap in education. Investments in early childhood health may have important effects on schooling attainment for adolescent girls.

Excerpt
…In our analysis of vaccination rates relative to the education gap, we found a statistically significant and strong negative correlation between the vaccination rates of children <5 years old and the gender gap in education (eg, the higher the vaccination rate, the smaller the gender gap in education; correlation coefficient=0.34, P=.02; Fig 4). The adolescent gender gap in education approaches zero with coverage rates exceeding ∼70% for all 8 vaccines. We performed several specification checks to ensure that our results are robust. These include varying the age of the included older children, using alternative educational outcomes, and splitting the sample by rural and urban location. We describe these supplementary changes in detail. In Supplemental Fig 5, we varied the age thresholds for older children in the following different ways: 10 to 16, 10 to 17, 10 to 18, 11 to 16, 12 to 16, 12 to 17, and 12 to 18. Our results are not sensitive to varying the thresholds….

 

Vaccination to prevent human papillomavirus infections: From promise to practice

PLoS Medicine
http://www.plosmedicine.org/
(Accessed 1 July 2017)
Essay

Vaccination to prevent human papillomavirus infections: From promise to practice
Paul Bloem, Ikechukwu Ogbuanu
| published 27 Jun 2017 PLOS Medicine
https://doi.org/10.1371/journal.pmed.1002325
Summary points
:: A large proportion of the disease burden related to infection with human papillomavirus (HPV), the most common sexually transmitted infection, can be prevented through vaccination.
:: There is inequity in access to HPV vaccines, and populations with the largest burden of HPV-related diseases have the least access to the vaccines.
:: Affordability and sustainable financing of HPV vaccination are barriers to introduction in low- and middle-income countries because of the relatively high cost of the vaccine and its delivery to a nontraditional target population.