Quantifying the Impact of Natural Immunity on Rotavirus Vaccine Efficacy Estimates: A Clinical Trial in Dhaka, Bangladesh (PROVIDE) and a Simulation Study

Journal of Infectious Diseases
Volume 217, Issue 6, 5 March 2018
https://academic.oup.com/jid/issue

MAJOR ARTICLES AND BRIEF REPORTS
VIRUSES
Editor’s Choice
Quantifying the Impact of Natural Immunity on Rotavirus Vaccine Efficacy Estimates: A Clinical Trial in Dhaka, Bangladesh (PROVIDE) and a Simulation Study
Elizabeth T Rogawski; James A Platts-Mills; E Ross Colgate; Rashidul Haque; K Zaman
The Journal of Infectious Diseases, Volume 217, Issue 6, 5 March 2018, Pages 861–868, https://doi.org/10.1093/infdis/jix668
In clinical trials of rotavirus vaccines, high rotavirus incidence leads to predictably lower vaccine efficacy estimates due to the acquisition of natural immunity in unvaccinated children. This phenomenon contributes to the low vaccine efficacy observed in trials in low-resource settings.