Waxing Understanding of Waning Immunity

Journal of Infectious Diseases
Volume 217, Issue 6, 5 March 2018

Waxing Understanding of Waning Immunity
Benjamin A Lopman; Virginia E Pitzer
The Journal of Infectious Diseases, Volume 217, Issue 6, 5 March 2018, Pages 851–853, https://doi.org/10.1093/infdis/jix670
(See the major article by Rogawski et al, on pages 861–8.)
…Of the approximately 150000 deaths due to rotavirus infection that occur globally every year, >90% are among children in settings of low and low/middle incomes [1, 2]. To counter this burden, the World Health Organization recommends that rotavirus vaccination be included in the immunization program of all countries. Despite the clear signs of progress in reducing the rotavirus disease burden globally [3], there are 2 related challenges specific to lower-income settings that hamper rotavirus vaccines from preventing more deaths and severe diarrheal disease [4]. First, rotavirus vaccines are less effective in low-income as compared to high-income…