Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa

New England Journal of Medicine
March 15, 2018   Vol. 378 No. 11
http://www.nejm.org/toc/nejm/medical-journal

Original Article
Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa
Cryptococcal meningitis accounts for more than 100,000 human immunodeficiency virus (HIV)–related deaths per year. We tested two treatment strategies that could be more sustainable in Africa than the standard of 2 weeks of amphotericin B plus flucytosine and more effective than the widely used fluconazole monotherapy.
Síle F. Molloy, Ph.D., Cecilia Kanyama, M.D., Robert S. Heyderman, Ph.D., Angela Loyse, M.D.(Res.), Charles Kouanfack, Ph.D., Duncan Chanda, M.B., Ch.B., Sayoki Mfinanga, M.D., Elvis Temfack, M.D., Shabir Lakhi, M.D., Sokoine Lesikari, M.D., Adrienne K. Chan, M.D., Neil Stone, M.B., B.S., Newton Kalata, M.D., Natasha Karunaharan, M.B., B.S., Kate Gaskell, M.B., Ch.B., Mary Peirse, M.B., Ch.B., Jayne Ellis, M.B., B.S., Chimwemwe Chawinga, B.A., Sandrine Lontsi, M.D., Jean-Gilbert Ndong, M.D., Philip Bright, F.R.C.Path., Duncan Lupiya, C.O., Tao Chen, Ph.D., John Bradley, Ph.D., Jack Adams, B.Sc., Charles van der Horst, M.D., Joep J. van Oosterhout, Ph.D., Victor Sini, M.D., Yacouba N. Mapoure, M.D., Peter Mwaba, Ph.D., Tihana Bicanic, M.D.(Res.), David G. Lalloo, M.D., Duolao Wang, Ph.D., Mina C. Hosseinipour, M.D., Olivier Lortholary, M.D., Shabbar Jaffar, Ph.D., and Thomas S. Harrison, M.D. for the ACTA Trial Study Team