Volume 10, Issue 1 (March 2018)
Open Access Editorial
Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape—A Summary of This Indispensable Special Issue
by Neal M. Davies and Kishor M. Wasan
Pharmaceutics 2018, 10(1), 13; doi:10.3390/pharmaceutics10010013
Received: 15 January 2018 / Revised: 15 January 2018 / Accepted: 15 January 2018 / Published: 16 January 2018
Canadian Pharmaceutical Scientists have a rich history of groundbreaking research in pharmacokinetics and drug metabolism undertaken primarily throughout its Pharmacy Faculties and within the Pharmaceutical and Biotechnology industry. The principles of drug absorption, distribution, metabolism, and excretion (ADME) is the foundational basis of rationale drug-design, and principled pharmacotherapy. The study of ADME and its descriptive quantitative analysis is the basis of pharmacokinetics. Pharmacokinetics is fundamental in the development of a new chemical entity into a marketable product and is essential in understanding the bioavailability, bioequivalence, and biosimilarities of drugs. Pharmacokinetics and drug metabolism and development studies facilitate an understanding of organ-based functionality. Population pharmacokinetic variability and the modeling of drug concentrations has significant utility in translating individual response in a target patient population underlying advances in precision health.
This special issue serves to highlight and capture the contemporary progress and current landscape of pharmacokinetics and drug metabolism within the prevailing Canadian context and the impact this pharmaceutical sciences research has had on an international scientific community…