May 15, 2018, Vol 319, No. 19, Pages 1953-2054
In the Era of Precision Medicine and Big Data, Who Is Normal?
Arjun K. Manrai, PhD; Chirag J. Patel, PhD; John P. A. Ioannidis, MD, DSc
JAMA. 2018;319(19):1981-1982. doi:10.1001/jama.2018.2009
In this Viewpoint, John Ioannidis and colleagues discuss the challenges and potential benefits of defining what is “healthy” in an era of precision medicine, when defining normal will require that each person be assigned to an increasingly narrow and granular reference population.