Mumps: A Pain in the Neck

Journal of the Pediatric Infectious Diseases Society (JPIDS)
Volume 7, Issue 2  June 2018
https://academic.oup.com/jpids/issue

On Vaccination
Mumps: A Pain in the Neck
Stanley A Plotkin
Journal of the Pediatric Infectious Diseases Society, Volume 7, Issue 2, 15 May 2018, Pages 91–92, https://doi.org/10.1093/jpids/piy038
Extract
Of the 3 components of the measles-mumps-rubella (MMR) vaccine, the measles and rubella components are fulfilling their tasks of providing long-lasting immunity; however, the mumps component has not been as successful. Frequent outbreaks of mumps have been occurring in previously vaccinated young adults, particularly when they live in groups such as in universities or military barracks [1–6]. In my opinion, the causes of the problem are clear—poor B-cell memory after vaccination and a change in the genotype of the circulating mumps strains that makes them less affected by antibodies to the vaccine strain. Decreased boosts from exposure to wild-type…