New England Journal of Medicine
July 12, 2018 Vol. 379 No. 2
Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination
Nemes and Others
Recent Mycobacterium tuberculosis infection confers a predisposition to the development of tuberculosis disease, the leading killer among global infectious diseases. H4:IC31, a candidate subunit vaccine, has shown protection against tuberculosis disease in preclinical models, and observational studies have indicated that primary bacille Calmette–Guérin (BCG) vaccination may offer partial protection against infection.