Improving pragmatic clinical trial design using real-world data

Clinical Trials
Volume 16 Issue 3, June 2019
https://journals.sagepub.com/toc/ctja/16/2

 

Design
Improving pragmatic clinical trial design using real-world data
Pragmatic clinical trials often use automated data sources such as electronic health records, claims, or registries to identify eligible individuals and collect outcome information. A specific advantage that this automated data collection often yields is having data on potential participants when design decisions are being made. We outline how this data can be used to inform trial design.
Susan M Shortreed, Carolyn M Rutter, Andrea J Cook, Gregory E Simon
First Published March 13, 2019; pp. 273–282