Value in Health
June 2019 Volume 22, Issue 6, p619-750
Analytic Considerations in Applying a General Economic Evaluation Reference Case to Gene Therapy
Michael F. Drummond, Peter J. Neumann, Sean D. Sullivan, Frank-Ulrich Fricke, Sean Tunis, Omar Dabbous, Mondher Toumi
Published online: May 16, 2019
:: Gene therapy is a novel approach that uses specific genetic material to treat or prevent disease. It has been argued that these therapies have special characteristics that pose challenges for economic evaluation and may require changes in methods.
:: The article provides a detailed analysis of the special characteristics of gene therapy, discusses what changes in methods may be necessary, and outlines the particular factors to which analysts and decision makers should pay particular attention in the economic evaluation of these therapies.
:: The guidance given should help decision makers undertake a more informed assessment of the costs and benefits of gene therapies.