January 28, 2020, Vol 323, No. 4, Pages 295-386
Strategic Need for Large Prospective Studies in Different Populations
Zhengming Chen, DPhil; Jonathan Emberson, MD; Rory Collins, MBBS
JAMA. 2020;323(4):309-310. doi:10.1001/jama.2019.19736
This Viewpoint emphasizes the ability of prospective vs retrospective cohort and case-control studies to reliably identify disease risk factors in populations and discusses the need to collect detailed information about lifestyle and other exposures from large numbers of individuals in various settings with different risk factor levels and disease incidence rates to provide more widely generalizable evidence about the relevance of human exposures to different health conditions.