Uptake and acceptability of human papillomavirus self-sampling in rural and remote aboriginal communities: evaluation of a nurse-led community engagement model

BMC Health Services Research
http://www.biomedcentral.com/bmchealthservres/content
(Accessed 16 May 2020)

 

Uptake and acceptability of human papillomavirus self-sampling in rural and remote aboriginal communities: evaluation of a nurse-led community engagement model
Aboriginal women experience disproportionately higher rates of cervical cancer mortality yet are less likely to participate in screening for early detection. This study sought to determine whether a community-…
Authors: Tegan Dutton, Jo Marjoram, Shellie Burgess, Laurinne Montgomery, Anne Vail, Nichole Callan, Sunil Jacob, David Hawkes, Marion Saville and Jannine Bailey
Citation: BMC Health Services Research 2020 20:398
Content type: Research article
Published on: 11 May 2020

Prioritising access to pandemic influenza vaccine: a review of the ethics literature

BMC Medical Ethics
http://www.biomedcentral.com/bmcmedethics/content
(Accessed 16 May 2020)

 

Prioritising access to pandemic influenza vaccine: a review of the ethics literature
Authors: Jane H. Williams and Angus Dawson
Citation: BMC Medical Ethics 2020 21:40
Content type: Review
Published on: 14 May 2020
Abstract
Background
The world is threatened by future pandemics. Vaccines can play a key role in preventing harm, but there will inevitably be shortages because there is no possibility of advance stockpiling. We therefore need some method of prioritising access.
Main text
This paper reports a critical interpretative review of the published literature that discusses ethical arguments used to justify how we could prioritise vaccine during an influenza pandemic. We found that the focus of the literature was often on proposing different groups as priorities (e.g. those with pre-existing health conditions, the young, the old, health care workers etc.). Different reasons were often suggested as a means of justifying such priority groupings (e.g. appeal to best overall outcomes, fairness, belonging to a vulnerable or ‘at risk’ group etc.). We suggest that much of the literature, wrongly, assumes that we are able to plan priority groups prior to the time of a particular pandemic and development of a particular vaccine. We also point out the surprising absence of various issues from the literature (e.g. how vaccines fit within overall pandemic planning, a lack of specificity about place, issues of global justice etc.).
Conclusions
The literature proposes a wide range of ways to prioritise vaccines, focusing on different groups and ‘principles’. Any plan to use pandemic vaccine must provide justifications for its prioritisation. The focus of this review was influenza pandemic vaccines, but lessons can be learnt for future allocations of coronavirus vaccine, if one becomes available.

Assessing the epidemiological impact on cervical cancer of switching from 4-valent to 9-valent HPV vaccine within a gender-neutral vaccination programme in Switzerland

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 16 May 2020)

 

Assessing the epidemiological impact on cervical cancer of switching from 4-valent to 9-valent HPV vaccine within a gender-neutral vaccination programme in Switzerland
An infection with high-risk human papillomavirus (HPV) is the obligatory aetiological factor for the development of cervical cancer. In Switzerland, the prevention strategy for cervical cancer is based on prim…
Authors: André B. Kind, Andrew Pavelyev, Smita Kothari, Nadia El Mouaddin, Aurélie Schmidt, Edith Morais, Patrik Guggisberg and Florian Lienert
Citation: BMC Public Health 2020 20:671
Content type: Research article
Published on: 12 May 2020

Interventions to increase uptake of cervical screening in sub-Saharan Africa: a scoping review using the integrated behavioral model

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 16 May 2020)

 

Interventions to increase uptake of cervical screening in sub-Saharan Africa: a scoping review using the integrated behavioral model
Sub-Saharan Africa (SSA) experiences disproportionate burden of cervical cancer incidence and mortality due in part to low uptake of cervical screening, a strategy for prevention and down-staging of cervical c…
Authors: Breanne E. Lott, Mario J. Trejo, Christina Baum, D. Jean McClelland, Prajakta Adsul, Purnima Madhivanan, Scott Carvajal, Kacey Ernst and John Ehiri
Citation: BMC Public Health 2020 20:654
Content type: Research article
Published on: 11 May 2020

 Vaccination card availability and childhood immunization in Senegal

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 16 May 2020)

Vaccination card availability and childhood immunization in Senegal
The World Health Organization recommends recording vaccination status according to maternal recall in countries where administrative reporting systems are insufficiently reliable, as maternal recall in develop…

 

Grounding Value‐Based Drug Pricing in Population Health

Clinical Pharmacology & Therapeutics
Volume 107, Issue 6 Pages: 1263-1457 June 2020
https://ascpt.onlinelibrary.wiley.com/toc/15326535/2020/107/6

 

Perspectives
Grounding Value‐Based Drug Pricing in Population Health
Anna Kaltenboeck, Maura Calsyn, Geert W.J. Frederix, Justin Lowenthal, David Mitchell, Bruce Rector, Ameet Sarpatwari
Pages: 1290-1292
First Published:17 January 2020

Access to innovative medicines by pharma companies: Sustainable initiatives for global health or useful advertisement?

Global Public Health
Volume 15, 2020 Issue 6
http://www.tandfonline.com/toc/rgph20/current

 

Article
Access to innovative medicines by pharma companies: Sustainable initiatives for global health or useful advertisement?
Michele de Medeiros Rocha, Emmanuel Paiva de Andrade, Edna Ribeiro Alves, João Carlos Cândido & Marcello de Miranda Borio
Pages: 777-789
Published online: 18 Feb 2020
ABSTRACT
Research & Development on new medicines plays an important role in life and well-being, making pharmaceutical companies important players in global health. Accessibility and financing new medicines, however, poses challenges for governments and patients around the world. Due to pricing and aggressive patent policy issues, pharma companies started to adopt access to medicines as a strategy to not only improve their public image but also to increase their economic performance. More than a useful institutional advertisement to attract new business, initiatives to improve access to medicines must be socially responsible and sustainable. Using content analysis methodology from CSR reports, the present study evaluated how 44 global companies are positioning themselves regarding access, whether these initiatives are aligned to existing access programmes and whether the actions disclosed on behalf of access are sustainable. We have identified 13 major access to medicines approaches that were classified into intrinsic, potentially sustainable and robust actions. We concluded that companies overvalue the term access to medicine. This can generate initiatives focused on advertisements rather than long-term actions and highlights the need for clear global criteria for companies and programmes that want to effectively publicise access to medicines as a social responsibility strategy.

COVID-19 in Africa: care and protection for frontline healthcare workers

Globalization and Health
http://www.globalizationandhealth.com/
[Accessed 16 May 2020]

 

COVID-19 in Africa: care and protection for frontline healthcare workers
Authors: Matthew F. Chersich, Glenda Gray, Lee Fairlie, Quentin Eichbaum, Susannah Mayhew, Brian Allwood, Rene English, Fiona Scorgie, Stanley Luchters, Greg Simpson, Marjan Mosalman Haghighi, Minh Duc Pham and Helen Rees
Content type: Review
15 May 2020

Impact of international travel dynamics on domestic spread of 2019-nCoV in India: origin-based risk assessment in importation of infected travelers

Globalization and Health
http://www.globalizationandhealth.com/
[Accessed 16 May 2020]

 

Impact of international travel dynamics on domestic spread of 2019-nCoV in India: origin-based risk assessment in importation of infected travelers
Authors: Sachin S. Gunthe and Satya S. Patra
Content type: Commentary
12 May 2020

Exploring why global health needs are unmet by research efforts: the potential influences of geography, industry and publication incentives

Health Research Policy and Systems
http://www.health-policy-systems.com/content
[Accessed 16 May 2020]

 

Exploring why global health needs are unmet by research efforts: the potential influences of geography, industry and publication incentives
Authors: Alfredo Yegros-Yegros, Wouter van de Klippe, Maria Francisca Abad-Garcia and Ismael Rafols
Content type: Research
15 May 2020

Is Africa prepared for tackling the COVID-19 (SARS-CoV-2) epidemic. Lessons from past outbreaks, ongoing pan-African public health efforts, and implications for the future

International Journal of Infectious Diseases
April 2020 Volume 93, p1-388
https://www.ijidonline.com/issue/S1201-9712(20)X0003-8

 

Editorials
Is Africa prepared for tackling the COVID-19 (SARS-CoV-2) epidemic. Lessons from past outbreaks, ongoing pan-African public health efforts, and implications for the future
Nathan Kapata, Chikwe Ihekweazu, Francine Ntoumi, Tajudeen Raji, Pascalina Chanda-Kapata, Peter Mwaba, Victor Mukonka, Matthew Bates, John Tembo, Victor Corman, Sayoki Mfinanga, Danny Asogun, Linzy Elton, Liã Bárbara Arruda, Margaret J. Thomason, Leonard Mboera, Alexei Yavlinsky, Najmul Haider, David Simons, Lara Hollmann, Swaib A. Lule, Francisco Veas, Muzamil Mahdi Abdel Hamid, Osman Dar, Sarah Edwards, Francesco Vairo, Timothy D. McHugh, Christian Drosten, Richard Kock, Giuseppe Ippolito, Alimuddin Zumla
p233–236
Published online: February 28, 2020

Immune response to different types of hepatitis B vaccine booster doses 2–32 years after the primary immunization schedule and its influencing factors

International Journal of Infectious Diseases
April 2020 Volume 93, p1-388
https://www.ijidonline.com/issue/S1201-9712(20)X0003-8

 

Immune response to different types of hepatitis B vaccine booster doses 2–32 years after the primary immunization schedule and its influencing factors
Yu-Liang Zhao, Lu-Lu Pan, Zhi-Yong Hao, Fei Jin, Yan-Hong Zhang, Min-Jie Li, Xin-Jiang Zhang, Bi-Hua Han, Hai-Song Zhou, Tian-Li Ma, Feng Wang, Jing-Chen Ma, Li-Peng Shen, Qi Li
p62–67
Published online: January 28, 2020

Evaluation of the effectiveness of pneumococcal conjugate vaccine for children in Korea with high vaccine coverage using a propensity score matched national population cohort

International Journal of Infectious Diseases
April 2020 Volume 93, p1-388
https://www.ijidonline.com/issue/S1201-9712(20)X0003-8

 

Evaluation of the effectiveness of pneumococcal conjugate vaccine for children in Korea with high vaccine coverage using a propensity score matched national population cohort
Sangho Sohn, Kwan Hong, Byung Chul Chun
p146–150
Published online: January 23, 2020

Ethics Committee Reviews of Applications for Research Studies at 1 Hospital in China During the 2019 Novel Coronavirus Epidemic

JAMA
May 12, 2020, Vol 323, No. 18, Pages 1749-1862
https://jamanetwork.com/journals/jama/currentissue

 

Research Letter
Ethics Committee Reviews of Applications for Research Studies at 1 Hospital in China During the 2019 Novel Coronavirus Epidemic
Hui Zhang, MBBS; Fengmin Shao, MD, PhD; Jianqin Gu, MD, PhD; et al.
free access has active quiz
JAMA. 2020;323(18):1844-1846. doi:10.1001/jama.2020.4362
This study reviews research ethics committee applications for COVID-19–related research at a Chinese hospital in February 2020 to characterize study type, approval rate and review time, reason for revision or denial, and issues with informed consent.
…Results
Ethics review conferences, held once every month in nonepidemic periods, were held 4 times in 35 days. The mean time was 2.13 days from application submissions until an initial review decision was made. For applications that required modifications, the mean time was 1.81 days for the resubmission to be reviewed again.
Forty-one applications were reviewed, including interventional studies (n = 21); diagnostic studies (n = 7); observational studies (n = 10); and other types (n = 3). Six (14.6%) were approved; 4 (9.8%), rejected; and 31 (75.6%), referred for modification.
Of the 4 rejected applications, 2 were denied because 1 involved a new, unapproved interferon-alfa treatment and another involved traditional Chinese medicine with many potential adverse reactions, so the potential risks outweighed benefits. The other 2 studies were denied because the laboratory biosafety level was inadequate, which may have led to virus leakage.
Of the 31 applications that required modifications, the issues with the research proposals and informed consent forms are indicated in Table 1 and Table 2. The most frequent issues with proposals were lack of statistical basis for the sample size calculation and deficiencies in inclusion and exclusion criteria. The most frequent issues with informed consent forms were that patients were not informed of the risks and that compensation was unreasonable.

The COVID-19 Pandemic in the USA Clinical Update

JAMA
May 12, 2020, Vol 323, No. 18, Pages 1749-1862
https://jamanetwork.com/journals/jama/currentissue

 

Viewpoint
The COVID-19 Pandemic in the USA Clinical Update
Saad B. Omer, MBBS, PhD; Preeti Malani, MD, MSJ; Carlos del Rio, MD
free access has active quiz has multimedia has audio
JAMA. 2020;323(18):1767-1768. doi:10.1001/jama.2020.5788
This Viewpoint provides a summary update of coronavirus disease 2019 (COVID-19) in the US, discussing case-fatality rates, interpretation of polymerase chain reaction test results, duration of immunity, reinfection, and more.
Audio Interview: Coronavirus (COVID-19) Update: Clinical Review

A Framework for Rationing Ventilators and Critical Care Beds During the COVID-19 Pandemic

JAMA
May 12, 2020, Vol 323, No. 18, Pages 1749-1862
https://jamanetwork.com/journals/jama/currentissue

 

A Framework for Rationing Ventilators and Critical Care Beds During the COVID-19 Pandemic
Douglas B. White, MD, MAS; Bernard Lo, MD
free access has active quiz has multimedia has audio
JAMA. 2020;323(18):1773-1774. doi:10.1001/jama.2020.5046
This Viewpoint describes a framework for rationing ventilators during the COVID-19 pandemic should intensive care units find themselves with more patients than they can care for, using a score-based system that incorporates patients’ likelihood of surviving to hospital discharge and beyond and their role in the public health response to the outbreak.
Audio Interview: Coronavirus (COVID-19) Update: Fairly Rationing ICU Care

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)A Review

JAMA
May 12, 2020, Vol 323, No. 18, Pages 1749-1862
https://jamanetwork.com/journals/jama/currentissue

 

Review
Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)A Review
James M. Sanders, PhD, PharmD; Marguerite L. Monogue, PharmD; Tomasz Z. Jodlowski, PharmD; et al.
free access has active quiz
JAMA. 2020;323(18):1824-1836. doi:10.1001/jama.2020.6019
This narrative review summarizes what is currently known about how SARS-CoV-2 infects cells and causes disease as a basis for considering whether chloroquine, remdisivir and other antivirals, or other existing drugs might be effective treatment for coronavirus disease 2019 (COVID-19).

Current regulatory approaches for accessing potential COVID-19 therapies

Journal of Pharmaceutical Policy and Practice
https://joppp.biomedcentral.com/
[Accessed 16 May 2020]

 

Current regulatory approaches for accessing potential COVID-19 therapies
Authors: Vesa Halimi, Armond Daci, Simona Stojanovska, Irina Panovska-Stavridis, Milena Stevanovic, Venko Filipce and Aleksandra Grozdanova
Content type: Commentary
16 May 2020
Abstract
This commentary aims to elaborate challenges in the regulatory approaches for accessing and investigating COVID-19 potential therapies either with off-label use, compassionate use, emergency use or for clinical trials. Since no therapies have been formally approved and completely effective and safe to date, the best clinical choice is acquired only after consistent and fair communication and collaboration between licensed clinicians, researchers, regulatory authorities, manufacturers and patients.

Reviving the US CDC

The Lancet
May 16, 2020 Volume 395 Number 10236 p1521-1586, e83-e89
https://www.thelancet.com/journals/lancet/issue/current

 

Editorial
Reviving the US CDC
The Lancet
The COVID-19 pandemic continues to worsen in the USA with 1·3 million cases and an estimated death toll of 80 684 as of May 12. States that were initially the hardest hit, such as New York and New Jersey, have decelerated the rate of infections and deaths after the implementation of 2 months of lockdown. However, the emergence of new outbreaks in Minnesota, where the stay-at-home order is set to lift in mid-May, and Iowa, which did not enact any restrictions on movement or commerce, has prompted pointed new questions about the inconsistent and incoherent national response to the COVID-19 crisis.

The US Centers for Disease Control and Prevention (CDC), the flagship agency for the nation’s public health, has seen its role minimised and become an ineffective and nominal adviser in the response to contain the spread of the virus. The strained relationship between the CDC and the federal government was further laid bare when, according to The Washington Post, Deborah Birx, the head of the US COVID-19 Task Force and a former director of the CDC’s Global HIV/AIDS Division, cast doubt on the CDC’s COVID-19 mortality and case data by reportedly saying: “There is nothing from the CDC that I can trust”. This is an unhelpful statement, but also a shocking indictment of an agency that was once regarded as the gold standard for global disease detection and control. How did an agency that was the first point of contact for many national health authorities facing a public health threat become so ill-prepared to protect the public’s health?

In the decades following its founding in 1946, the CDC became a national pillar of public health and globally respected. It trained cadres of applied epidemiologists to be deployed in the USA and abroad. CDC scientists have helped to discover new viruses and develop accurate tests for them. CDC support was instrumental in helping WHO to eradicate smallpox. However, funding to the CDC for a long time has been subject to conservative politics that have increasingly eroded the agency’s ability to mount effective, evidence-based public health responses. In the 1980s, the Reagan administration resisted providing the sufficient budget that the CDC needed to fight the HIV/AIDS crisis. The George W Bush administration put restrictions on global and domestic HIV prevention and reproductive health programming.

The Trump administration further chipped away at the CDC’s capacity to combat infectious diseases. CDC staff in China were cut back with the last remaining CDC officer recalled home from the China CDC in July, 2019, leaving an intelligence vacuum when COVID-19 began to emerge. In a press conference on Feb 25, Nancy Messonnier, director of the CDC’s National Center for Immunization and Respiratory Diseases, warned US citizens to prepare for major disruptions to movement and everyday life. Messonnier subsequently no longer appeared at White House briefings on COVID-19. More recently, the Trump administration has questioned guidelines that the CDC has provided. These actions have undermined the CDC’s leadership and its work during the COVID-19 pandemic.

There is no doubt that the CDC has made mistakes, especially on testing in the early stages of the pandemic. The agency was so convinced that it had contained the virus that it retained control of all diagnostic testing for severe acute respiratory syndrome coronavirus 2, but this was followed by the admission on Feb 12 that the CDC had developed faulty test kits. The USA is still nowhere near able to provide the basic surveillance or laboratory testing infrastructure needed to combat the COVID-19 pandemic.

But punishing the agency by marginalising and hobbling it is not the solution. The Administration is obsessed with magic bullets—vaccines, new medicines, or a hope that the virus will simply disappear. But only a steadfast reliance on basic public health principles, like test, trace, and isolate, will see the emergency brought to an end, and this requires an effective national public health agency. The CDC needs a director who can provide leadership without the threat of being silenced and who has the technical capacity to lead today’s complicated effort.

The Trump administration’s further erosion of the CDC will harm global cooperation in science and public health, as it is trying to do by defunding WHO. A strong CDC is needed to respond to public health threats, both domestic and international, and to help prevent the next inevitable pandemic. Americans must put a president in the White House come January, 2021, who will understand that public health should not be guided by partisan politics.

What policy makers need to know about COVID-19 protective immunity

The Lancet
May 16, 2020 Volume 395 Number 10236 p1521-1586, e83-e89
https://www.thelancet.com/journals/lancet/issue/current

 

Comment
What policy makers need to know about COVID-19 protective immunity
Daniel M Altmann, Daniel C Douek, Rosemary J Boyton
… Most of the available COVID-19 serology data derive from people who have been hospitalised with severe infection.8,18 In this group, around 90% develop IgG antibodies within the first 2 weeks of symptomatic infection and this appearance coincides with disappearance of virus,18 supporting a causal relationship between these events. However, a key question concerns antibodies in non-hospitalised individuals who either have milder disease or no symptoms. Anecdotal results from community samples yield estimates of under 10% of tested “controls” developing specific IgG antibodies. We await larger seroprevalence datasets, but it seems likely that natural exposure during this pandemic might, in the short to medium term, not deliver the required level of herd immunity and there will be a substantial need for mass vaccination programmes…

Artificial intelligence and the future of global health

The Lancet
May 16, 2020 Volume 395 Number 10236 p1521-1586, e83-e89
https://www.thelancet.com/journals/lancet/issue/current

 

Review
Artificial intelligence and the future of global health
Nina Schwalbe, Brian Wahl
Summary
Concurrent advances in information technology infrastructure and mobile computing power in many low and middle-income countries (LMICs) have raised hopes that artificial intelligence (AI) might help to address challenges unique to the field of global health and accelerate achievement of the health-related sustainable development goals. A series of fundamental questions have been raised about AI-driven health interventions, and whether the tools, methods, and protections traditionally used to make ethical and evidence-based decisions about new technologies can be applied to AI. Deployment of AI has already begun for a broad range of health issues common to LMICs, with interventions focused primarily on communicable diseases, including tuberculosis and malaria. Types of AI vary, but most use some form of machine learning or signal processing. Several types of machine learning methods are frequently used together, as is machine learning with other approaches, most often signal processing. AI-driven health interventions fit into four categories relevant to global health researchers: (1) diagnosis, (2) patient morbidity or mortality risk assessment, (3) disease outbreak prediction and surveillance, and (4) health policy and planning. However, much of the AI-driven intervention research in global health does not describe ethical, regulatory, or practical considerations required for widespread use or deployment at scale. Despite the field remaining nascent, AI-driven health interventions could lead to improved health outcomes in LMICs. Although some challenges of developing and deploying these interventions might not be unique to these settings, the global health community will need to work quickly to establish guidelines for development, testing, and use, and develop a user-driven research agenda to facilitate equitable and ethical use.

Adapting the ordre public and morality exclusion of European patent law to accommodate emerging technologies

Nature Biotechnology
Volume 38 Issue 5, May 2020
https://www.nature.com/nbt/volumes/38/issues/5

 

Patents | 11 May 2020
Adapting the ordre public and morality exclusion of European patent law to accommodate emerging technologies
Patent law’s existing public policy exclusion should be reinterpreted and a new method introduced for assessing the moral and public policy implications of commercializing emerging technologies.

If the world fails to protect the economy, COVID-19 will damage health not just now but also in the future

Nature Medicine
Volume 26 Issue 5, May 2020
https://www.nature.com/nm/volumes/26/issues/5

 

Comment | 09 April 2020
If the world fails to protect the economy, COVID-19 will damage health not just now but also in the future
Previous crises have shown how an economic crash has dire consequences for public health. But in the COVID-19 pandemic, the world is entering uncharted territory. The world’s leaders must prepare to preserve health.
Martin McKee & David Stuckler

Policy opportunities to enhance sharing for pandemic research

Science
15 May 2020 Vol 368, Issue 6492
http://www.sciencemag.org/current.dtl

 

Policy Forum
Policy opportunities to enhance sharing for pandemic research
By Michelle Rourke, Mark Eccleston-Turner, Alexandra Phelan, Lawrence Gostin
Science15 May 2020 : 716-718 Full Access
COVID-19 reveals gaps in international law that can inhibit timely sharing of information, samples, and sequences

Effective containment explains subexponential growth in recent confirmed COVID-19 cases in China

Science
15 May 2020 Vol 368, Issue 6492
http://www.sciencemag.org/current.dtl

 

Research Articles
Effective containment explains subexponential growth in recent confirmed COVID-19 cases in China
By Benjamin F. Maier, Dirk Brockmann
Science15 May 2020 : 742-746 Open Access CCBY
Feedback between the epidemic process, the behavioral response to it, and nationwide containment policies can restrain COVID-19.

Childhood vaccinations and adult schooling attainment: Long-term evidence from India’s Universal Immunization Programme

Social Science & Medicine
Volume 250 April 2020
https://www.sciencedirect.com/journal/social-science-and-medicine/vol/250/suppl/C

 

Research article Open access
Childhood vaccinations and adult schooling attainment: Long-term evidence from India’s Universal Immunization Programme
Arindam Nandi, Santosh Kumar, Anita Shet, David E. Bloom, Ramanan Laxminarayan
Article 112885
Highlights
:: Vaccines could provide a broad range of health and non-health benefits.
:: We examined the link between childhood vaccination and adult schooling in India.
:: India’s UIP was associated with 0.2–0.3 additional schooling grades.

Ebola vaccine? Family first! Evidence from using a brief measure on Ebola vaccine demand in a national household survey during the outbreak in Sierra Leone

Vaccine
Volume 38, Issue 22 Pages 3811-3918 (8 May 2020)
https://www.sciencedirect.com/journal/vaccine/vol/38/issue/22

 

Selected Content
Research article Abstract only
Ebola vaccine? Family first! Evidence from using a brief measure on Ebola vaccine demand in a national household survey during the outbreak in Sierra Leone
Mohamed F. Jalloh, Aaron S. Wallace, Rebecca E. Bunnell, Rosalind J. Carter, … Helena Nordenstedt
Pages 3854-3861

Confidence in the National Immunization Program among parents in Sweden 2016 – A cross-sectional survey

Vaccine
Volume 38, Issue 22 Pages 3811-3918 (8 May 2020)
https://www.sciencedirect.com/journal/vaccine/vol/38/issue/22

 

Research article Open access
Confidence in the National Immunization Program among parents in Sweden 2016 – A cross-sectional survey
Emma Byström, Ann Lindstrand, Jakob Bergström, Kristian Riesbeck, Adam Roth
Pages 3909-3917

Are the Objectives Proposed by the WHO for Routine Measles Vaccination Coverage and Population Measles Immunity Sufficient to Achieve Measles Elimination from Europe?

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines
(Accessed 16 May 2020)

 

Open Access Article
Are the Objectives Proposed by the WHO for Routine Measles Vaccination Coverage and Population Measles Immunity Sufficient to Achieve Measles Elimination from Europe?
by Pedro Plans-Rubió
Vaccines 2020, 8(2), 218; https://doi.org/10.3390/vaccines8020218 – 13 May 2020
Viewed by 139
Abstract
Background: The World Health Organization (WHO) proposed two-dose measles vaccination coverage of at least 95% of the population and percentages of measles immunity in the population of 85%−95% in order to achieve measles elimination in Europe. The objectives of this study were: (1) [

From Google Scholar & other sources: Selected Journal Articles, Newsletters, Dissertations, Theses, Commentary

From Google Scholar & other sources: Selected Journal Articles, Newsletters, Dissertations, Theses, Commentary

Dentistry Journal
Published: 9 May 2020
Open Access Article
Human Papillomavirus (HPV) Vaccine Knowledge, Awareness and Acceptance among Dental Students and Post-Graduate Dental Residents
SK Mann, K Kingsley –
Introduction: The recent development of a vaccine that is highly effective against the human papillomavirus (HPV) has been met with widespread clinical and public health professional acceptance. However, social and societal barriers to vaccination may hamper public health efforts to prevent HPV-mediated diseases. Although a few studies have evaluated knowledge or awareness of HPV vaccination among dentists or dental educators, few studies have evaluated the acceptance, knowledge and awareness of HPV vaccination among dental students and post-graduate dental residents. The primary goal of this study is to evaluate survey responses regarding acceptance, knowledge and awareness of HPV vaccination among dental students and post-graduate dental residents.

Media/Policy Watch

Media/Policy Watch
This watch section is intended to alert readers to substantive news, analysis and opinion from the general media and selected think tanks and similar organizations on vaccines, immunization, global public health and related themes. Media Watch is not intended to be exhaustive, but indicative of themes and issues CVEP is actively tracking. This section will grow from an initial base of newspapers, magazines and blog sources, and is segregated from Journal Watch above which scans the peer-reviewed journal ecology.
We acknowledge the Western/Northern bias in this initial selection of titles and invite suggestions for expanded coverage. We are conservative in our outlook in adding news sources which largely report on primary content we are already covering above. Many electronic media sources have tiered, fee-based subscription models for access. We will provide full-text where content is published without restriction, but most publications require registration and some subscription level.

 

The Atlantic
http://www.theatlantic.com/magazine/
Accessed 16 May 2020
Politics
The Most Remarkable Part of Rick Bright’s Testimony
The whistleblower’s claims about the government’s lack of COVID-19 preparedness went largely uncontested, even by the president’s allies.
Russell Berman May 14, 2020

 

BBC
http://www.bbc.co.uk/
Accessed 16 May 2020
Coronavirus Sanofi: French drug giant rows back after vaccine storm
14 May 202
The French pharmaceutical giant Sanofi has rowed back on an apparent promise to prioritise the US market with any potential Covid-19 vaccine.
Sanofi CEO Paul Hudson sparked a row by saying the US government had “the right to the largest pre-order because it’s invested in taking the risk”.
French Prime Minister Edouard Philippe responded by saying access for all was “non-negotiable”.
Sanofi’s chairman has now vowed equal access for everyone…

 

The Economist
http://www.economist.com/
Accessed 16 May 2020
[No new, unique, relevant content]

 

Financial Times
http://www.ft.com/home/uk
Accessed 16 May 2020
Coronavirus: free to read
Why vaccine ‘nationalism’ could slow coronavirus fight |
Health experts fear US-China tensions could hamper global co-operation and limit poorer nations’ access to a treatment
May 14, 2020

Any Covid-19 vaccine must be treated as a global public good
David Pilling
[No new, unique, relevant content]Top of Form
Bottom of Form

 

Forbes
http://www.forbes.com/
Accessed 16 May 2020
May 15, 2020
Unveiling Effort To Speed COVID-19 Vaccine, Trump Says, ‘Vaccine Or No Vaccine, We’re Back’
Dr. Moncef Slaoui will co-lead the effort with Army General Gustave Perna.
By Matt Perez Forbes Staff

 

Foreign Affairs
http://www.foreignaffairs.com/
Accessed 16 May 2020
[No new, unique, relevant content]

 

Foreign Policy
http://foreignpolicy.com/
Accessed 16 May 2020 |
How the Coronavirus Pandemic Will Permanently Expand Government Powers
For Part 4 in our series on the world after the pandemic, we asked 10 leading global thinkers for their predictions.
Analysis |
James Crabtree, Robert D. Kaplan, Robert Muggah, Kumi Naidoo, Shannon O\’Neil, Adam Posen, Kenneth Roth, Bruce Schneier, Stephen M. Walt, Alexandra Wrage

 

If There’s a Vaccine, Who Gets It First?
As researchers around the world race to develop a coronavirus vaccine, questions remain over equitable distribution.
Morning Brief | Audrey Wilson

 

The Guardian
http://www.guardiannews.com/
Accessed 16 May 2020
[No new, unique, relevant content]

 

New Yorker
http://www.newyorker.com/
Accessed 16 May 2020
Daily Comment
Rick Bright and the Pandemic Path Not Taken
The course of the pandemic in this country could have been different; the United States failed, and it didn’t have to.
By Amy Davidson Sorkin
May 15, 2020

Q. & A.
The Danger of Rushing Through Clinical Trials During the Coronavirus Pandemic
An epidemiologist and expert on clinical trials discusses what makes a good trial, why a pandemic is not the time to speed up the drug-approval process, and the most important fixes for our health-care system.
By Isaac Chotiner
May 14, 2020

 

New York Times
http://www.nytimes.com/
Accessed 16 May 2020
Europe
UK to Invest Up to 93 Million Pounds in New Coronavirus Vaccine Centre
The British government will invest up to 93 million pounds ($112 million) to accelerate construction of a new vaccines centre, the Department for Business, Energy and Industrial Strategy said on Saturday.
By Reuters

U.S.
Trump Says Considering Making Vaccine Available Free of Charge
U.S. President Donald Trump said on Friday he was looking at possibly making a coronavirus vaccine available free of charge.
By Reuters

Europe
Costa Rica Seeks Unity for COVID Fight as WHO Assembly Looms
Costa Rica’s president said Friday that COVID-19 can only be defeated if countries shun nationalism and aren’t “selfish,” urging access to diagnostics and treatment tools for everyone as a major meeting of the World Health Organization’s membership looms next week.
By The Associated Press

Health
US Begins ‘Warp Speed’ Vaccine Push as Studies Ramp Up
President Donald Trump vowed to use “every plane, truck and soldier” to distribute COVID-19 vaccines he hopes will be ready by year’s end — even as the country’s top scientists gear up for a master experiment to rapidly tell if any really work.
By The Associated Press

 

Washington Post
https://www.washingtonpost.com/
Accessed 16 May 2020
[No new, unique, relevant content]

Think Tanks et al

Think Tanks et al

Brookings
http://www.brookings.edu/
Accessed 16 May 2020
[No new relevant content]

Center for Global Development [to 16 May 2020]
http://www.cgdev.org/page/press-center
Accessed 16 May 2020
May 15, 2020
More Harm Than Good? The Net Impact of COVID-19 Policies Is What Matters for Health
This is the first in a series of blogs in which we’ll focus on non-COVID-19 excess deaths caused by the response to COVID-19, part of a larger project at CGD to help policymakers minimize the indirect health impacts of the pandemic.
Damian Walker et al.

May 12, 2020
The Indirect Health Effects of COVID-19: Disrupted and Suspended Health Services
The full impacts of COVID-19 and the restrictions adopted to mitigate the pandemic are yet to be fully revealed. We do not know the number of deaths indirectly related to the novel coronavirus around the world, and how these may differ from country to country. We are launching an inventory to track the evolving situation.
Lydia Regan and Y-Ling Chi

May 11, 2020
How to Make Sure the Market Delivers a COVID-19 Vaccine
Every country faces the same fundamental challenge in the face of the COVID-19 pandemic. Their economies and societies cannot fully return to “normal” until we have a safe and effective vaccine. And achieving that goal quickly is not easy. We see four big problems.
Amanda Glassman and Rachel Silverman

 

CSIS
https://www.csis.org/
Accessed 16 May 2020
[No new relevant content]

 

Council on Foreign Relations
http://www.cfr.org/
Accessed 16 May 2020
[No new relevant content]

 

Kaiser Family Foundation
https://www.kff.org/search/?post_type=press-release
Accessed 16 May 2020
[No new relevant content]

Vaccines and Global Health: The Week in Review :: 09 May 2020

.– Request an Email Summary: Vaccines and Global Health : The Week in Review is published as a single email summary, scheduled for release each Saturday evening before midnight (EDT in the U.S.). If you would like to receive the email version, please send your request to david.r.curry@centerforvaccineethicsandpolicy.org.

 pdf version A pdf of the current issue is available here: Vaccines and Global Health_The Week in Review_9 May 2020

– blog edition: comprised of the approx. 35+ entries posted below.

– Twitter:  Readers can also follow developments on twitter: @vaxethicspolicy.
.
– Links:  We endeavor to test each link as we incorporate it into any post, but recognize that some links may become “stale” as publications and websites reorganize content over time. We apologize in advance for any links that may not be operative. We believe the contextual information in a given post should allow retrieval, but please contact us as above for assistance if necessary.

Support this knowledge-sharing service: Your financial support helps us cover our costs and to address a current shortfall in our annual operating budget. Click here to donate and thank you in advance for your contribution.

.
David R. Curry, MS
Executive Director
Center for Vaccine Ethics and Policy

Commemorating Smallpox Eradication – a legacy of hope, for COVID-19 and other diseases

Milestones :: Perspectives :: Research

Commemorating Smallpox Eradication – a legacy of hope, for COVID-19 and other diseases
8 May 2020 News release
On 8 May 1980, the 33rd World Health Assembly officially declared: ‘The world and all its peoples have won freedom from smallpox.’

The declaration marked the end of a disease that had plagued humanity for at least 3 000 years, killing 300 million people in the 20th century alone.

It was ended, thanks to a 10-year global effort, spearheaded by the World Health Organization, that involved thousands of health workers around the world to administer half a billion vaccinations to stamp out smallpox.

The US$ 300m price-tag to eradicate smallpox saves the world well over US$ 1 billion every year since 1980.

Speaking at a virtual event hosted at WHO-HQ, involving key players in the eradication effort, WHO Director-General, Dr Tedros Adhanom Ghebreyesus said, “As the world confronts the COVID-19 pandemic, humanity’s victory over smallpox is a reminder of what is possible when nations come together to fight a common health threat.”

…At the event, Dr Tedros unveiled a commemorative postal stamp to recognize the global solidarity that drove the initiative and honour the efforts of health workers who ensured its success.

The stamp, developed by the United Nations Postal Administration (UNPA), in collaboration with WHO, signifies what national unity and global solidary can achieve. Numerous countries, such as Guinea, India, Nigeria, Philippines, Togo and others issued smallpox stamps to show support for, and raise awareness about WHO’s Intensified Smallpox Eradication Programme launched in 1967.

…Following smallpox eradication, WHO and UNICEF launched the Expanded Programme on Immunization, under which 85% of the world’s children are vaccinated and protected from debilitating diseases.

With the potential of a COVID-19 vaccine ahead, ensuring sufficient supplies and reaching people in hard to reach places is a high priority. Addressing vaccine hesitancy poses a significant challenge to stop the virus. Access to accurate public health information and education is critical to ensure that the public has the facts to keep themselves and others safe.

To permanently commemorate the eradication of smallpox and the lessons learned on a global scale, rather than every 10-years, WHO is calling museums, exhibition companies, designers, curators and associations to develop an immersive, interactive and educational exhibition on smallpox and its relevance for COVID-19 and global health security.  The exhibition, which will be unveiled later this year, will promote a better understanding of public health and empower people to keep informed and safe during a pandemic.

COVID-19 – Vaccines Access Funding

Milestones :: Perspectives :: Research

 

COVID-19 – Vaccines Access Funding

Coronavirus Global Response: €7.4 billion raised for universal access to vaccines
Press release 4 May 2020 Brussels
Today, the Commission registered €7.4 billion, equivalent to $8 billion, in pledges from donors worldwide during the Coronavirus Global Response pledging event. This includes a pledge of €1.4 billion by the Commission. This almost reaches the initial target of €7.5 billion and is a solid starting point for the worldwide pledging marathon, which begins today. The aim is to gather significant funding to ensure the collaborative development and universal deployment of diagnostics, treatments and vaccines against coronavirus.

President of the European Commission, Ursula von der Leyen, said: “Today the world showed extraordinary unity for the common good. Governments and global health organisations joined forces against coronavirus. With such commitment, we are on track for developing, producing and deploying a vaccine for all. However, this is only the beginning. We need to sustain the effort and to stand ready to contribute more. The pledging marathon will continue. After governments, civil society and people worldwide need to join in, in a global mobilisation of hope and resolve.”

The pledging event was co-convened by the European Union, Canada, France, Germany, Italy (also incoming G20 presidency), Japan, the Kingdom of Saudi Arabia (also holding the G20 presidency), Norway, Spain and the United Kingdom. The initiative is a response to the call from the World Health Organization (WHO) and a group of health actors for a global collaboration for the accelerated development, production and equitable global access to new coronavirus essential health technologies. The Coronavirus Global Response Initiative is comprised of three partnerships for testing, treating and preventing underpinned by health systems strengthening.

An ongoing pledging marathon
Today is an extraordinary achievement but also the start of a process to mobilise more resources. The initial target of €7.5 billion will not be enough to ensure the distribution of coronavirus health technologies worldwide, as this involves significant costs in terms of production, procurement and distribution.

To help reach the objectives of the Coronavirus Global Response, the European Commission is committing €1 billion in grants and €400 million in guarantees on loans through reprioritisation of Horizon 2020 (€1 billion), RescEU (€80 million), the Emergency Support Instrument (€150 million) and external instruments (€170 million).

€100 million will be donated to CEPI and €158 million to the World Health Organization. EU-funded calls for proposals and subsequent projects under Horizon 2020 will be aligned with the objectives of the three partnerships and subject to open access to data. Funding under RescEU will go towards the procurement, stockpiling and distribution of vaccines, therapeutics and diagnostics.

Donors are invited to continue pledging to the Coronavirus Global Response. They can choose which priority to donate to – Test, Treat or Prevent. They can also donate to the horizontal work stream of the Coronavirus Global Response, aiming to help health systems in the world cope with the pandemic.

The Commission will soon announce the breakdown of the amount raised today and how much will go to vaccines, therapeutics, diagnostics and health systems strengthening related to COVID-19.

A cooperation framework to align global efforts
A universal and affordable Access to COVID-19 Tools (ACT-Accelerator) was the main objective of the 24 April call to action from global health partners. For this, significant funding is needed, as well as a solid collaborative structure, with a clarity of purpose to ensure that the donated money is put to good use and to avoid fragmentation of efforts.

Based on discussions with public and private sector partners as well as non-profit organisations, the European Commission proposes a collaborative framework for the ACT-accelerator global response. This framework is designed as a coordination structure to steer and oversee progress made globally in accelerating work on developing vaccines, therapeutics and diagnostics with universal access as well as strengthening health systems as required for meeting these three priorities.

This collaboration framework is intended to be time-bound (2 years, renewable) and build on existing organisations without creating any new structures. In the European Commission’s view, it would bring together partners like the WHO, the Bill and Melinda Gates Foundation, the Wellcome Trust and some of the initial convenor countries  as well as many recognised global health actors such as CEPI, Gavi, the Vaccine Alliance, the Global Fund or UNITAID.

The core of the framework would be three partnerships based on the three priorities of the Coronavirus Global Response. They gather industry, research, foundations, regulators and international organisations, with a “whole-value-chain” approach: from research to manufacturing and deployment. The three partnerships would work as autonomously as possible, with a transversal work stream on enhancing the capacity of health systems and knowledge and data sharing.

The Commission registers and keeps track of pledges up until end of May but will not receive any payments into its accounts. Funds go directly to the recipients. Recipients will, however, not decide alone on the use of the donation, but deploy it in concertation with the partnership.The commitment is for all new vaccines, diagnostics and treatments against coronavirus to be made available globally for an affordable price, regardless of where they were developed.

Next steps
The global response must also include civil society, and the global community of citizens. For that reason, the European Commission is joining forces with NGOs such as Global Citizen and other partners.

The Global Vaccines Summit that Gavi, the Vaccine Alliance, will organise on 4 June will mobilise additional funding to protect the next generation with vaccines. As the world relies on Gavi’s work for making vaccination available everywhere, the success of Gavi’s replenishment will be crucial to the success of the Coronavirus Global Response…

COVID-19 – Africa

Milestones :: Perspectives :: Research

COVID-19 – Africa

New WHO estimates: Up to 190 000 people could die of COVID-19 in Africa if not controlled
07 May 2020
Brazzaville – Eighty-three thousand to 190 000 people in Africa could die of COVID-19 and 29 million to 44 million could get infected in the first year of the pandemic if containment measures fail, a new study by the World Health Organization (WHO) Regional Office for Africa finds. The research, which is based on prediction modelling, looks at 47 countries in the WHO African Region with a total population of one billion.

The new estimates are based on modifying the risk of transmission and disease severity by variables specific to each country in order to adjust for the unique nature of the region. The model predicts the observed slower rate of transmission, lower age of people with severe disease and lower mortality rates compared to what is seen in the most affected countries in the rest of the world. This is largely driven by social and environmental factors slowing the transmission, and a younger population that has benefitted from the control of communicable diseases such as HIV and tuberculosis to reduce possible vulnerabilities.

The lower rate of transmission, however, suggests a more prolonged outbreak over a few years, according to the study which also revealed that smaller African countries alongside Algeria, South Africa and Cameroon were at a high risk if containment measures are not prioritized.

Containment measures, which include contact tracing, isolation, improved personal hygiene practices and physical distancing aim to slow down the transmission of the virus so its effects happen at a rate manageable by the health system. Physical distancing is not about the confinement of people but rather avoiding unnecessary contacts as people live, work and socialize as a means to interrupt transmission.

“While COVID-19 likely won’t spread as exponentially in Africa as it has elsewhere in the world, it likely will smoulder in transmission hotspots,” said Dr Matshidiso Moeti, the WHO Regional Director for Africa. “COVID-19 could become a fixture in our lives for the next several years unless a proactive approach is taken by many governments in the region. We need to test, trace, isolate and treat.”

The predicted number of cases that would require hospitalization would overwhelm the available medical capacity in much of Africa. There would be an estimated 3.6 million–5.5 million COVID-19 hospitalizations, of which 82 000–167 000 would be severe cases requiring oxygen, and 52 000–107 000 would be critical cases requiring breathing support. Such a huge number of patients in hospitals would severely strain the health capacities of countries…

COVID-19 R&D – Vaccine Manufacturing/Scaling

Milestones :: Perspectives :: Research

 

COVID-19 R&D – Vaccine Manufacturing/Scaling

Pfizer and BioNTech Dose First Participants in the U.S. as Part of Global COVID-19 mRNA Vaccine Development Program
:: First participants dosed at NYU Grossman School of Medicine and University of Maryland School of Medicine
:: Pfizer and BioNTech ramping up manufacturing capabilities to further increase production capacity in 2020/2021
May 05, 2020

Milken Institute COVID-19 Tracker Update Identifies More Than 100 Vaccines and Nearly 200 Treatments in Development
Nine vaccines and more than 50 treatment candidates reach clinical trials.
May 04, 2020
The Milken Institute COVID-19 Treatment and Vaccine Tracker has identified more than 111 vaccines and 197 treatments in the pipeline to treat and prevent COVID-19. This is an increase from the 55 treatments and 38 vaccine candidates identified when the Institute first started tracking treatments and vaccines in early March…