Human Gene Therapy
Volume 32, Issue 1-2 / January 2021
Bringing Gene Therapies for HIV Disease to Resource-Limited Parts of the World
Joseph M. McCune, Emily H. Turner, Adam Jiang, and Brian P. Doehle
Published Online:30 October 2020
Initiated by the Bill & Melinda Gates Foundation in 2019, the HIV Frontiers Program aims to move work on HIV cure toward interventions that will ultimately be available to all, most especially those in resource-limited parts of the world where the prevalence of disease is high (Fig. 1). It starts with the premise that the journey will be long (15–25 years) and that it will ultimately yield a “single-shot cure,” that is, a product that is delivered percutaneously (in vivo) in a single encounter, safely, and effectively modifying selected cells in the body so that viral replication and spread are suppressed and reinfection blocked.