Nature Reviews Genetics
Volume 22 Issue 5, May 2021
Review Article | 11 January 2021
African genetic diversity and adaptation inform a precision medicine agenda
Africa is a continent with deep evolutionary history, which has implications for the genetic underpinnings of disease. In this Review, the authors discuss how genetic features of African populations provide both challenges and opportunities for understanding disease genetics in Africa. They describe how this genetic knowledge — combined with initiatives including capacity-building, data sharing and increased representation of African genomes in genetic variation databases — can be leveraged towards achieving precision medicine approaches in African healthcare.
Luisa Pereira, Leon Mutesa, Michèle Ramsay