Nature Reviews Genetics
Volume 22 Issue 5, May 2021
Review Article | 06 January 2021
The influence of evolutionary history on human health and disease
Our evolutionary history has resulted in highly complex and sophisticated human physiology. Yet evolutionary footprints have also left us prone to diseases. In this Review, the authors discuss how events from the earliest history of life on Earth through to modern human evolution influence many disease traits and outcomes. They describe how an understanding and application of evolutionary frameworks can inform precision medicine initiatives.
Mary Lauren Benton, Abin Abraham, John A. Capra