Nature Reviews Drug Discovery
Volume 21 Issue 4, April 2022
Review Article | 01 February 2022
Identification of neoantigens for individualized therapeutic cancer vaccines
Mutations in cancer cells can generate tumour-specific neoepitopes, which are attractive targets for anticancer vaccines. This Review discusses the mechanisms of neoantigen T cell recognition and computational approaches to predict which neoantigens might confer proficient antitumour immunity in a given clinical context.
Franziska Lang, Barbara Schrörs, Ugur Sahin