JAMA Network
COVID-19 Update December 4, 2021
These articles on COVID-19 were published across the JAMA Network in the last week.
JAMA Network
COVID-19 Update December 4, 2021
These articles on COVID-19 were published across the JAMA Network in the last week.
Journal of Adolescent Health
December 2021 Volume 69 Issue 6 p861-1054
https://www.jahonline.org/current
How Can We Best Use COVID-19 Vaccines in Adolescents? A Perspective From the United States
Donna L. Tyungu, Sean T. O’Leary, Amy B. Middleman
Published online: September 22, 2021
p881-883
Journal of Adolescent Health
December 2021 Volume 69 Issue 6 p861-1054
https://www.jahonline.org/current
COVID-19 Vaccines for Adolescents: Leveraging the ABCs of Communication
Beth L. Hoffman, Todd Wolynn, Jaime E. Sidani
Published online: October 14, 2021
p884-885
Journal of Adolescent Health
December 2021 Volume 69 Issue 6 p861-1054
https://www.jahonline.org/current
Original Articles
Parent and Peer Norms are Unique Correlates of COVID-19 Vaccine Intentions in a Diverse Sample of U.S. Adolescents
Adam A. Rogers, Rachel E. Cook, Julie A. Button
Published online: September 22, 2021
p910-916
Journal of Adolescent Health
December 2021 Volume 69 Issue 6 p861-1054
https://www.jahonline.org/current
Adolescent Health Briefs
COVID-19 Vaccine Sentiments Among African American or Black Adolescents in Rural Alabama
Henna Budhwani, Tiffani Maycock, Wilnadia Murrell, Tina Simpson
Published online: September 24, 2021
Journal of Community Health
Volume 46, issue 6, December 2021
https://link.springer.com/journal/10900/volumes-and-issues/46-6
Original Paper
COVID-19 Vaccination and Intention to Vaccinate Among a Sample of College Students in New Jersey
Authors (first, second and last of 5)
Aleksandar Kecojevic, Corey H. Basch, Nicole K. Davi
Published: 27 April 2021
Pages: 1059 – 1068
Journal of Community Health
Volume 46, issue 6, December 2021
https://link.springer.com/journal/10900/volumes-and-issues/46-6
COVID-19 Vaccine Hesitancy and Its Determinants Among Adults with a History of Tobacco or Marijuana Use
Authors Yong Yang, Aram Dobalian, Kenneth D. Ward
Content type: Original Paper
Published: 06 May 2021
Pages: 1090 – 1098
Journal of Community Health
Volume 46, issue 6, December 2021
https://link.springer.com/journal/10900/volumes-and-issues/46-6
Primary Care Interventions to Address COVID-19 Vaccine Hesitancy Among Israel Defense Forces Soldiers
Authors (first, second and last of 4) Tomer Talmy, Bar Cohen, Yossi Ben Michael
Content type: Original Paper
Published: 14 May 2021
Pages: 1155 – 1160
Journal of Community Health
Volume 46, issue 6, December 2021
https://link.springer.com/journal/10900/volumes-and-issues/46-6
Knowledge and Attitudes Toward Covid-19 and Vaccines Among a New York Haredi-Orthodox Jewish Community
Authors (first, second and last of 5) Ellie R. Carmody, Devon Zander, Arthur L. Caplan
Content type: Original Paper
Published: 17 May 2021
Pages: 1161 – 1169
Journal of Community Health
Volume 46, issue 6, December 2021
https://link.springer.com/journal/10900/volumes-and-issues/46-6
Human Papillomavirus Vaccination and Pap Smear Rates Among Burmese Refugee Girls in a Healthcare System in Omaha, Nebraska
Authors (first, second and last of 4) Dorothy Xuanxian Kenny, Katherine Hsueh, John Joseph Coté
Content type: Original Paper
Published: 21 May 2021
Pages: 1170 – 1176
Journal of Community Health
Volume 46, issue 6, December 2021
https://link.springer.com/journal/10900/volumes-and-issues/46-6
The Nature and Extent of COVID-19 Vaccination Hesitancy in Healthcare Workers
Authors (first, second and last of 4) Nirbachita Biswas, Toheeb Mustapha, James H. Price
Content type: Review
Published: 20 April 2021
Pages: 1244 – 1251
Journal of Health Care for the Poor and Underserved (JHCPU)
Volume 32, Number 4, November 2021
https://muse.jhu.edu/issue/46802
Table of Contents
Commentaries
Cholera: Still a Major Public Health Issue in Sub-Saharan Africa
Merlyn Dorsainvil
pp. 1734-1741
DOI: 10.1353/hpu.2021.0162
Journal of Health Care for the Poor and Underserved (JHCPU)
Volume 32, Number 4, November 2021
https://muse.jhu.edu/issue/46802
Aftermath of COVID-19: Forestalling Irreparable Medical Brain Drain in Sub-Saharan Africa
Justus Uchenna Onu, Sunday O Oriji, Deborah Oyine Aluh, Tonia C Onyeka
pp. 1742-1751
DOI: 10.1353/hpu.2021.0163
The Lancet
Dec 04, 2021 Volume 398 Number 10316 p2051-2124
https://www.thelancet.com/journals/lancet/issue/current
Editorial
Reinstating universal health coverage on the global agenda
The Lancet
The Lancet
Dec 04, 2021 Volume 398 Number 10316 p2051-2124
https://www.thelancet.com/journals/lancet/issue/current
Comment
Cervical cancers avoided by HPV immunisation
Maggie E Cruickshank, Mihaela Grigore
The Lancet
Dec 04, 2021 Volume 398 Number 10316 p2051-2124
https://www.thelancet.com/journals/lancet/issue/current
Articles
The effects of the national HPV vaccination programme in England, UK, on cervical cancer and grade 3 cervical intraepithelial neoplasia incidence: a register-based observational study
Milena Falcaro, et al.
The Lancet
Dec 04, 2021 Volume 398 Number 10316 p2051-2124
https://www.thelancet.com/journals/lancet/issue/current
Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study
Noam Barda, et al.
The Lancet
Dec 04, 2021 Volume 398 Number 10316 p2051-2124
https://www.thelancet.com/journals/lancet/issue/current
Health Policy
How an outbreak became a pandemic: a chronological analysis of crucial junctures and international obligations in the early months of the COVID-19 pandemic
Sudhvir Singh, et al.
Published: November 08, 2021
Summary
Understanding the spread of SARS-CoV-2, how and when evidence emerged, and the timing of local, national, regional, and global responses is essential to establish how an outbreak became a pandemic and to prepare for future health threats. With that aim, the Independent Panel for Pandemic Preparedness and Response has developed a chronology of events, actions, and recommendations, from December, 2019, when the first cases of COVID-19 were identified in China, to the end of March, 2020, by which time the outbreak had spread extensively worldwide and had been characterised as a pandemic. Datapoints are based on two literature reviews, WHO documents and correspondence, submissions to the Panel, and an expert verification process. The retrospective analysis of the chronology shows a dedicated initial response by WHO and some national governments, but also aspects of the response that could have been quicker, including outbreak notifications under the International Health Regulations (IHR), presumption and confirmation of human-to-human transmission of SARS-CoV-2, declaration of a Public Health Emergency of International Concern, and, most importantly, the public health response of many national governments. The chronology also shows that some countries, largely those with previous experience with similar outbreaks, reacted quickly, even ahead of WHO alerts, and were more successful in initially containing the virus. Mapping actions against IHR obligations, the chronology shows where efficiency and accountability could be improved at local, national, and international levels to more quickly alert and contain health threats in the future. In particular, these improvements include necessary reforms to international law and governance for pandemic preparedness and response, including the IHR and a potential framework convention on pandemic preparedness and response.
The Lancet Child & Adolescent Health
Dec 2021 Volume 5 Number 12 p837-904, e44-e46
https://www.thelancet.com/journals/lanchi/issue/current
Comment
Eliminating malaria in southeast Asia requires more attention on adolescent girls
Abena Poku-Awuku, et al.
Lancet Digital Health
Dec 2021 Volume 3 Number 12 e751-e829
https://www.thelancet.com/journals/landig/issue/current
Review
Blockchain applications in health care for COVID-19 and beyond: a systematic review
Wei Yan Ng, et al.
Summary
The COVID-19 pandemic has had a substantial and global impact on health care, and has greatly accelerated the adoption of digital technology. One of these emerging digital technologies, blockchain, has unique characteristics (eg, immutability, decentralisation, and transparency) that can be useful in multiple domains (eg, management of electronic medical records and access rights, and mobile health). We conducted a systematic review of COVID-19-related and non-COVID-19-related applications of blockchain in health care. We identified relevant reports published in MEDLINE, SpringerLink, Institute of Electrical and Electronics Engineers Xplore, ScienceDirect, arXiv, and Google Scholar up to July 29, 2021. Articles that included both clinical and technical designs, with or without prototype development, were included. A total of 85 375 articles were evaluated, with 415 full length reports (37 related to COVID-19 and 378 not related to COVID-19) eventually included in the final analysis. The main COVID-19-related applications reported were pandemic control and surveillance, immunity or vaccine passport monitoring, and contact tracing. The top three non-COVID-19-related applications were management of electronic medical records, internet of things (eg, remote monitoring or mobile health), and supply chain monitoring. Most reports detailed technical performance of the blockchain prototype platforms (277 [66·7%] of 415), whereas nine (2·2%) studies showed real-world clinical application and adoption. The remaining studies (129 [31·1%] of 415) were themselves of a technical design only. The most common platforms used were Ethereum and Hyperledger. Blockchain technology has numerous potential COVID-19-related and non-COVID-19-related applications in health care. However, much of the current research remains at the technical stage, with few providing actual clinical applications, highlighting the need to translate foundational blockchain technology into clinical use.
Lancet Global Health
Dec 2021 Volume 9 Number 12 e1623-e1769
https://www.thelancet.com/journals/langlo/issue/current
Editorial
A bright future in typhoid vaccines
The Lancet Global Health
Lancet Global Health
Dec 2021 Volume 9 Number 12 e1623-e1769
https://www.thelancet.com/journals/langlo/issue/current
Comment
Reaching zero-dose children in India: progress and challenges ahead
Manoj V Murhekar, Muthusamy, Santhosh Kumar
Lancet Global Health
Dec 2021 Volume 9 Number 12 e1623-e1769
https://www.thelancet.com/journals/langlo/issue/current
Navigating the violent process of decolonisation in global health research: a guideline
Muneera A Rasheed
Lancet Global Health
Dec 2021 Volume 9 Number 12 e1623-e1769
https://www.thelancet.com/journals/langlo/issue/current
Ethical considerations for introducing RTS,S/AS01 in countries with moderate to high Plasmodium falciparum malaria transmission
Jeff D’Souza, David Nderitu
Lancet Global Health
Dec 2021 Volume 9 Number 12 e1623-e1769
https://www.thelancet.com/journals/langlo/issue/current
Articles
Genomic epidemiology and the role of international and regional travel in the SARS-CoV-2 epidemic in Zimbabwe: a retrospective study of routinely collected surveillance data
Tapfumanei Mashe, et al. on behalf of the COVID-19 Genomics UK Consortium, and the SARS-CoV-2 Research Group
Lancet Global Health
Dec 2021 Volume 9 Number 12 e1623-e1769
https://www.thelancet.com/journals/langlo/issue/current
Articles
Progress in reaching unvaccinated (zero-dose) children in India, 1992–2016: a multilevel, geospatial analysis of repeated cross-sectional surveys
Mira Johri, Sunil Rajpal, S V Subramanian
Summary
Background
Reaching zero-dose children (infants who receive no routine vaccinations) is a global strategic priority. We studied zero-dose children in India over 24 years to clarify aggregate trends and the contribution of large-scale social, economic, and geographical inequalities to these.
Methods
We did a multilevel, geospatial analysis of repeated cross-sectional surveys of all four rounds (1992–2016) of India’s National Family Health Survey to study the prevalence, distribution, and drivers of zero-dose (no first dose of diphtheria, tetanus, and pertussis) vaccination status. We included all children born to participating women who were aged 12–23 months at the time of the survey, as this is the standard age at which immunisation data are assessed. Children who died before the survey and those missing data on key outcomes or correlates were excluded. The outcome was child zero-dose vaccination status. We also compared the prevalence of nutritional deficits among zero-dose versus vaccinated children. For the most recent survey, we produced geospatial estimates identifying the prevalence of zero-dose children across states and districts and used these to project head count.
Findings
We examined 393 167 children for eligibility. 72 848 children were included in the final analytic data set. The proportion of zero-dose children in India declined from 33·4% (95% CI 32·5–34·2) in 1992 to 10·1% (9·8–10·4) in 2016. Progress notwithstanding, in 2016, zero-dose children remained concentrated among disadvantaged groups (prevalence in the bottom wealth quintile 15·3%, 95% CI 14·6–16·0; prevalence among mothers with no education 16·8%, 16·1–17·4). Compared with vaccinated children, zero-dose children were more likely to suffer from malnutrition in all survey rounds (prevalence of severe stunting in 1992: zero dose 41·3%, 95% CI 39·2–43·8 vs vaccinated 28·5%, 27·2–29·7; 2016: zero dose 24·9%, 23·6–26·2 vs vaccinated 18·7%, 18·3–19·1). In 2016, there were an estimated 2·88 (95% CI 2·86–2·89) million zero-dose children in India, concentrated in less developed states and districts and several urban areas.
Interpretation
Over a 24-year period in India, child zero-dose status was shaped by large-scale social inequalities and remained a consistent marker of generalised vulnerability. Interventions that address this cycle of intergenerational inequities should be prioritised.
Lancet Infectious Diseases
Dec 2021 Volume 21 Number 12 p1613-1758, e363-e406
https://www.thelancet.com/journals/laninf/issue/current
Articles
Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy children and adolescents: a double-blind, randomised, controlled, phase 1/2 clinical trial
Bihua Han, et al.
Lancet Infectious Diseases
Dec 2021 Volume 21 Number 12 p1613-1758, e363-e406
https://www.thelancet.com/journals/laninf/issue/current
Comment
COVID-19 vaccines for children younger than 12 years: are we ready?
Xiaohui Zou, Bin Cao
Lancet Infectious Diseases
Dec 2021 Volume 21 Number 12 p1613-1758, e363-e406
https://www.thelancet.com/journals/laninf/issue/current
Lancet Infectious Diseases
Dec 2021 Volume 21 Number 12 p1613-1758, e363-e406
https://www.thelancet.com/journals/laninf/issue/current
Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial
Paul R Chapman, et al.
Lancet Infectious Diseases
Dec 2021 Volume 21 Number 12 p1613-1758, e363-e406
https://www.thelancet.com/journals/laninf/issue/current
Review
Migration and outbreaks of vaccine-preventable disease in Europe: a systematic review
Anna Deal, et al. in collaboration with the European Society of Clinical Microbiology and Infectious Diseases Study Group for Infections in Travellers and Migrants (ESGITM)
Lancet Infectious Diseases
Dec 2021 Volume 21 Number 12 p1613-1758, e363-e406
https://www.thelancet.com/journals/laninf/issue/current
Grand Round
Complexities in the treatment of coinfection with HIV, hepatitis B, hepatitis C, and tuberculosis
Umang Arora, et al.
Lancet Respiratory Medicine
Dec 2021 Volume 9 Number 12 p1343-1478, e110-e122
https://www.thelancet.com/journals/lanres/issue/current
Articles
Safety and immunogenicity of CpG 1018 and aluminium hydroxide-adjuvanted SARS-CoV-2 S-2P protein vaccine MVC-COV1901: interim results of a large-scale, double-blind, randomised, placebo-controlled phase 2 trial in Taiwan
Szu-Min Hsieh, et al.
Lancet Respiratory Medicine
Dec 2021 Volume 9 Number 12 p1343-1478, e110-e122
https://www.thelancet.com/journals/lanres/issue/current
COVID-19 hospital admissions and deaths after BNT162b2 and ChAdOx1 nCoV-19 vaccinations in 2·57 million people in Scotland (EAVE II): a prospective cohort study
Utkarsh Agrawal, et al.
Lancet Respiratory Medicine
Dec 2021 Volume 9 Number 12 p1343-1478, e110-e122
https://www.thelancet.com/journals/lanres/issue/current
Personal View
Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity?
Gregory Milne, et al.
Nature Reviews Genetics
Volume 22 Issue 12, December 2021
https://www.nature.com/nrg/volumes/22/issues/12
Review Article | 17 September 2021
The biological and clinical significance of emerging SARS-CoV-2 variants
In this Review, the authors describe our latest understanding of the emergence and properties of SARS-CoV-2 genetic variants, particularly those designated as WHO (World Health Organization) ‘variants of concern’. They focus on the consequences of these variants for antibody-mediated virus neutralization, with important implications for reinfection risk and for vaccine effectiveness.
Kaiming Tao, Philip L. Tzou, Robert W. Shafer
Nature Reviews Immunology
Volume 21 Issue 12, December 2021
https://www.nature.com/nri/volumes/21/issues/12
Comment | 18 October 2021
Lessons from vaccine-induced immune thrombotic thrombocytopenia
Here, John Kelton and colleagues provide an overview of vaccine-induced immune thrombotic thrombocytopenia (VITT), a very rare complication that has been observed following vaccination with adenoviral vector-based COVID-19 vaccines.
John Greenhow Kelton, Donald Mitchell Arnold, Ishac Nazy
Nature Reviews Immunology
Volume 21 Issue 12, December 2021
https://www.nature.com/nri/volumes/21/issues/12
Progress | 19 October 2021
The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions?
Individuals with asymptomatic COVID-19 can transmit the virus and may be at risk of long-term disease. In this Progress article, Boyton and Altman present current insights into immune responses in asymptomatic SARS-CoV-2 infection and discuss the relevance of asymptomatic disease for public health strategies.
Rosemary J. Boyton, Daniel M. Altmann
Nature Reviews Immunology
Volume 21 Issue 12, December 2021
https://www.nature.com/nri/volumes/21/issues/12
Perspective | 17 June 2021
Using cross-species vaccination approaches to counter emerging infectious diseases
Emerging diseases that affect humans often arise due to the crossover of infectious agents from animal reservoirs. In this Perspective, George Warimwe and colleagues discuss the concept of ‘One Health vaccinology’, an approach that aims to use key lessons from human and veterinary immunology to develop more effective vaccination strategies for emerging infectious diseases.
George M. Warimwe, Michael J. Francis, Bryan Charleston
Nature Reviews Immunology
Volume 21 Issue 12, December 2021
https://www.nature.com/nri/volumes/21/issues/12
Perspective | 25 October 2021
Lessons from the elimination of poliomyelitis in Africa
This Perspective chronicles the journey to the elimination of transmission of wild poliovirus in Africa, with a critical discussion of the global, continental, national and community actions that were required and the lessons learnt along the way.
Abdulaziz Mohammed, Oyewale Tomori, John N. Nkengasong
Nature Reviews Drug Discovery
Volume 20 Issue 12, December 2021
https://www.nature.com/nrd/volumes/20/issues/12
Review Article | 06 October 2021
Engineering living therapeutics with synthetic biology
The design of cell-based therapeutics with synthetic biology is a rapidly growing strategy in medicine for the development of effective treatments for a variety of diseases. This article discusses advances in synthetic biology approaches to programme living cells with therapeutic functions as well as challenges for their development.
Andres Cubillos-Ruiz, Tingxi Guo, Jose M. Lora
New England Journal of Medicine
December 2, 2021 Vol. 385 No. 23
http://www.nejm.org/toc/nejm/medical-journal
Original Articles
Myocarditis after Covid-19 Vaccination in a Large Health Care Organization G. Witberg and Others
New England Journal of Medicine
December 2, 2021 Vol. 385 No. 23
http://www.nejm.org/toc/nejm/medical-journal
Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel D. Mevorach and Others
New England Journal of Medicine
December 2, 2021 Vol. 385 No. 23
http://www.nejm.org/toc/nejm/medical-journal
Editorials
Receipt of mRNA Vaccine against Covid-19 and Myocarditis A.L.P. Caforio
New England Journal of Medicine
December 2, 2021 Vol. 385 No. 23
http://www.nejm.org/toc/nejm/medical-journal
Pediatrics
Volume 148, Issue 6 December 2021
https://pediatrics.aappublications.org/
Articles
Mumps in Vaccinated Children and Adolescents: 2007–2019
Leah Shepersky, MPH; Mona Marin, MD; John Zhang, PhD; Huong Pham, MPH; Mariel A. Marlow, PhD, MPH
Pediatrics
Volume 148, Issue 6 December 2021
https://pediatrics.aappublications.org/
The Childhood Vaccination Schedule and the Lack of Association With Type 1 Diabetes
Jason M. Glanz, PhD; Christina L. Clarke, MS; Matthew F. Daley, MD; Jo Ann Shoup, PhD; Simon J. Hambidge, MD, PhD …
PLoS One
http://www.plosone.org/
[Accessed 4 Dec 2021]
Research Article
Will Africans take COVID-19 vaccination?
AbdulAzeez A. Anjorin, Ismail A. Odetokun, Ajibola I. Abioye, Hager Elnadi, Mfon Valencia Umoren, Bamu F. Damaris, Joseph Eyedo, Haruna I. Umar, Jean B. Nyandwi, Mena M. Abdalla, Sodiq O. Tijani, Kwame S. Awiagah, Gbolahan A. Idowu, Sifeuh N. Achille Fabrice, Aala M. O. Maisara, Youssef Razouqi, Zuhal E. Mhgoob, Salim Parker, Osaretin E. Asowata, Ismail O. Adesanya, Maureen A. Obara, Shameem Jaumdally, Gatera F. Kitema, Taofik A. Okuneye, Kennedy M. Mbanzulu, Hajj Daitoni, Ezekiel F. Hallie, Rasha Mosbah, Folorunso O. Fasina
Research Article | published 01 Dec 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0260575
PLoS One
http://www.plosone.org/
[Accessed 4 Dec 2021]
Peer- and community-led responses to HIV: A scoping review
George Ayala, Laurel Sprague, L. Leigh-Ann van der Merwe, Ruth Morgan Thomas, Judy Chang, Sonya Arreola, Sara L. M. Davis, Aditia Taslim, Keith Mienies, Alessandra Nilo, Lillian Mworeko, Felicita Hikuam, Carlos Garcia de Leon Moreno, José Antonio Izazola-Licea
Research Article | published 01 Dec 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0260555