Duke – Launch and Scale Speedometer
The Race for Global COVID-19 Vaccine Equity
A flurry of nearly 200 COVID-19 vaccine candidates are moving forward through the development and clinical trials processes at unprecedented speed; more than ten candidates are already in Phase 3 large-scale trials and several have received emergency or limited authorization. Our team has aggregated and analyzed publicly available data to track the flow of procurement and manufacturing and better understand global equity challenges. We developed a data framework of relevant variables and conducted desk research of publicly available information to identify COVID vaccine candidates and status, deals and ongoing negotiations for procurement and manufacturing, COVID burden by country, and allocation and distribution plans. We have also conducted interviews with public officials in key countries to better understand the context and challenges facing vaccine allocation and distribution
[accessed 24 July 2021]
See our COVID Vaccine Purchases research
See our COVID Vaccine Manufacturing research
See our COVID Vaccine Donations & Exports research

Global Dashboard on COVID-19 Vaccine Equity
The Dashboard is a joint initiative of UNDP, WHO and the University of Oxford with cooperation across the UN system, anchored in the SDG 3 Global Action Plan for Healthy Lives and Well-being for All.

Dashboard on Vaccine Equity [accessed 30 Oct 2021]: https://data.undp.org/vaccine-equity/
See also visualization on Vaccine Access and Vaccine Affordability

COVID Vaccines – OCHA:: HDX

COVID-19 Data Explorer: Global Humanitarian Operations
COVID-19 Vaccine Roll-out
30 Oct 2021 | COVAX (WHO,GAVI,CEPI), UNDESA, Press Reports | DATA
Global COVID-19 Figures: 245M total confirmed cases; 5.0M total confirmed deaths
Global vaccines administered: 6.97B
Number of Countries: 29 [29 week ago]
COVAX Allocations Round 4-6 (Number of Doses): 120M [120M week ago]
COVAX Delivered (Number of Doses): 120M [120M week ago]
Other Delivered (Number of Doses): 210M [200M week ago]
Total Delivered (Number of Doses): 330M [320M week ago]
Total Administered (Number of Doses): 2706M [256M week ago]

Multilateral Leaders Task Force on COVID-19 [IMF, World Bank Group, WHO, WTO]
A joint initiative from the International Monetary Fund, World Bank Group, World Health Organization, and World Trade Organization to accelerate access to COVID-19 vaccines, therapeutics and diagnostics by leveraging multilateral finance and trade solutions, particularly in low- and middle-income countries. Website accessed 30 Oct 2021: https://data.covid19taskforce.com/data The global view below is complemented by country-specific dashboards here.

Our World in Data
Coronavirus (COVID-19) Vaccinations [Accessed 30 Oct 2021]
:: 49.3% of the world population has received at least one dose of a COVID-19 vaccine.
:: 7 billion doses have been administered globally, and 24.08 million are now administered each day.
:: Only 3.5% of people in low-income countries have received at least one dose.

CDC-ACIP
Next ACIP Meetings
:: November 2-3, 2021 – Draft Agenda

White House [U.S.]
Briefing Room – Selected Major COVID Announcements
Fact Sheet: Biden Administration Announces Additional Actions to Increase COVID-⁠19 Screening Testing in Schools and Keep Students Safe
October 29, 2021 • Statements and Releases

Press Briefing by White House COVID-⁠19 Response Team and Public Health Officials
October 27, 2021 • Press Briefings

A Proclamation on Advancing the Safe Resumption of Global Travel During the COVID-⁠19 Pandemic
October 25, 2021 • Presidential Actions

Europe: COVID-19 Vaccines – Announcements/Regulatory Actions/Deployment

European Medicines Agency
News & Press Releases
Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 25-28 October 2021
News 29/10/2021
:: PRAC assessing further data on risk of myocarditis and pericarditis with mRNA vaccines
:: COVID-19 vaccines: PRAC finds insufficient evidence on a possible link with multisystem inflammatory syndrome
:: PRAC starts review of signal of capillary leak syndrome with Spikevax

News: Spikevax: EMA recommendation on booster (new)
CHMP, Last updated: 25/10/2021

::::::

European Centre for Disease Prevention and Control
https://www.ecdc.europa.eu/en
Latest Updates
Publication
Contact tracing in the European Union: public health management of persons, including healthcare workers, who have had contact with COVID-19 cases – fourth update
Technical report – 28 Oct 2021

::::::

Accessed 30 Oct 2021
https://vaccinetracker.ecdc.europa.eu/public/extensions/COVID-19/vaccine-tracker.html#uptake-tab

::::::

European Commission
https://ec.europa.eu/commission/presscorner/home/en

Press release 28 October 2021
Commissioner Lenarčič in Bangladesh: EU provides €12 million for displaced Rohingyas in Bangladesh and Myanmar
Commissioner for Crisis Management Janez Lenarčič is concluding today a three-day visit to Bangladesh to see the situation on the ground in the context of the worsening humanitarian crisis affecting Rohingya people.

News 24 October 2021
Von der Leyen focuses on pandemic preparedness at the World Health Summit
Speaking at the Word Health Summit on 24 October, President of the Commission Ursula von der Leyen said that pandemic preparedness was now at the centre of the EU’s action, and that an unprecedented funding of EUR 50 billion euro over seven years was proposed for a health preparedness mission.

Africa: COVID-19 – Announcements/Regulatory Actions/Deployment

Accesses 30 Oct 2021. Full scale, interactive dashboard available at:
https://africacdc.org/covid-19-vaccination/

Russia: COVID-19 Vaccines – Announcements/Regulatory Actions/Deployment

Russia: Sputnik V – “the first registered COVID-19 vaccine”
https://sputnikvaccine.com/newsroom/pressreleases/
Press Releases
Individuals vaccinated with Sputnik V in Argentina are now eligible to enter EU
Press release, 29.10.2021
Moscow, October 29, 2021 – The Russian Direct Investment Fund (RDIF, Russia’s sovereign wealth fund) announces that European Council has recommended adding Argentina to the list of countries for which travel restrictions, imposed as part of the fight with the pandemic, should be lifted.
…. A number of other countries including Bahrain, Jordan, UAE and Chile (where Sputnik V has also been authorized) are also on the list of countries for which travel restrictions are recommended to be lifted by the European Council.
…The total amount of countries, which allow visitors vaccinated with Sputnik V, has reached 101 in total…

Israel joins 100 other countries in accepting the Sputnik V vaccine
Press release, 28.10.2021

GL Rapha becomes the first international partner of RDIF to obtain Russian GMP Certificate for Sputnik family vaccine production in Korea
Press release, 25.10.2021

India: COVID-19 Vaccines – Announcements/Regulatory Actions/Deployment

Ministry of Health and Family Welfare
https://www.mohfw.gov.in/

Government of India – Press Information Bureau
Latest Press Releases
COVID-19 Vaccination Update – Day 288
India’s cumulative vaccination coverage crosses 106 crore landmark milestone
More than 61 lakh Vaccine doses administered today till 7 pm
Posted On: 30 OCT 2021 8:53PM by PIB Delhi

Indian Council for Medical Research (ICMR)
https://www.icmr.gov.in/media.html
Press Releases
No new digest content identified.

China: COVID-19 Vaccines – Announcements/Regulatory Actions/Deployment

Vaccination of young children begins around country
2021-10-26
Many provinces in China have started vaccinating children aged 3 to 11, as the number of COVID-19 cases has grown due to small recent outbreaks related to tour groups in Gansu province and the Inner Mongolia autonomous region.
Cities including Changde, Hunan province, and Jinhua, Zhejiang province, have also started vaccinating kids in that age group. Places in Fujian and Anhui provinces plan to start vaccination programs for the young.
According to announcements in different places, the whole vaccination process for kids should be supervised and approved by their parents after examination by a doctor.

Emergencies

POLIO
Public Health Emergency of International Concern (PHEIC)
https://polioeradication.org/polio-today/polio-now/this-week/

Polio this week as of 26 October 2021
:: On 25 October, the GPEI marked World Polio Day with this year’s theme being “Delivering on a promise”. Several online events were held to mark the day including a discussion on ‘Role of Women in Polio Eradication’ hosted by UNICEF which included a number of speakers. The recording of the event is available here.
:: It has been 30 years since the countries of the Americas defeated polio back in 1991. Read more on what 30 years without the disease means for the Region and the world.
:: While tremendous progress has been made in the fight against polio, wild poliovirus remains endemic to two countries and the threat of cVDPV outbreaks continues to loom. Watch this animation to learn how the GPEI intends to reinvigorate polio prevention and outbreak response with the bold new Strategy for 2022-2026.
Summary of new WPV and cVDPV viruses this week (AFP cases and ES positives):
:: Cameroon: one cVDPV2 case
:: Guinea-Bissau: three cVDPV2 cases
:: Madagascar: one cVDPV1 case and eight positive environmental samples
:: Mauritania: one cVDPV2 positive environmental sample
:: Nigeria: 42 cVDPV2 cases and two positive environmental samples
:: Senegal: one cVDPV2 case and one positive environmental sample

::::::
::::::

WHO/OCHA Emergencies

Health emergencies list – WHO
“The health emergencies list details the disease outbreaks, disasters and humanitarian crises where WHO plays an essential role in supporting countries to respond to and recover from emergencies with public health consequences.”
Afghanistan crisis [Last apparent update: 5 Aug 2021]

Crisis in Northern Ethiopia [Last apparent update: 18 Oct 2021]

Ebola outbreak, Democratic Republic of the Congo, 2021 [Last apparent update: 17 Aug 2021]

Ebola outbreak outbreak, N’Zerekore, Guinea, 2021 [Last apparent update: 17 Aug 2021]

Coronavirus disease (COVID-19) pandemic [See COVID above]

Ebola outbreak, Equateur Province, Democratic Republic of the Congo, 2020
[Last apparent update: 17 Aug 2021]

Ebola outbreak, North Kivu, Ituri, Democratic Republic of the Congo, 2018 – 2020
[Last apparent update: 17 Aug 2021]

Ebola outbreak, Democratic Republic of the Congo, 2018 [Last apparent update: 24 July 2018]

Yemen crisis [Last apparent update: 12 February 2021]

Syria crisis [Last apparent update: 18 June 2021]

Somalia crisis [Last apparent update: 24 March 2018]

Nigeria crisis [Last apparent update: 1 Oct 2021]

Ebola outbreak, Democratic Republic of the Congo, 2017 [Last apparent update: 17 Aug 2021]

Zika virus disease outbreak, 2015-2016 [Last apparent update: 24 Jan 2020]

Ebola outbreak: West Africa, 2014-2016 [Last apparent update: 17 Aug 2021]

Iraq crisis [Last apparent update: 9 Jan 2008]

South Sudan crisis [Last apparent update: 23 Sep 2020]

Avian influenza A (H7N9) virus outbreak [Last apparent update: 13 September 2021]

Middle East respiratory syndrome (MERS-CoV) outbreak [Last apparent update: 8 July 2019]

Influenza A (H1N1) virus, 2009-2010 pandemic [Last apparent update: 10 Aug 2010]

::::::

UN OCHA – Current Emergencies
Current Corporate Emergencies
Afghanistan
Afghanistan: Weekly Humanitarian Update (18 – 24 October 2021)

Northern Ethiopia
[No new reports identified]

::::::
::::::

WHO & Regional Offices [to 30 Oct 2021]
https://www.who.int/
29 October 2021
Statement
An appeal to G20 leaders to make vaccines accessible to people on the move
[See COVID above for detail]

29 October 2021
News release
World Health Organization Secretariat announcement regarding the election of the next WHO Director-General
The appointment of the next Director-General of the World Health Organization will take place at the Seventy-fifth World Health Assembly in May 2022 (WHA75). The Director-General is WHO’s chief technical and administrative officer.
The election process began when Member States, through a circular letter sent by the WHO Secretariat in April 2021, were invited to submit proposals for candidates for the Director-General position. The deadline for submission of proposals was 23 September 2021. The date on which WHO is scheduled to publish information on candidates, including the curricula vitae and other particulars of their qualifications and experience as received from Member States, is to follow the closure of the last WHO Regional Committee meeting of the year.
As today marks the closure of the last Regional Committee meeting, WHO can announce that a single candidate was proposed by Member States by the 23 September 2021 deadline: Dr Tedros Adhanom Ghebreyesus, who is the incumbent Director-General…

28 October 2021
News release
New ACT-Accelerator strategy calls for US$ 23.4 billion international investment to solve inequities in global access to COVID-19 vaccines, tests & treatments
[See COVID above for detail]

27 October 2021
Statement
COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety (GACVS): updated statement regarding myocarditis and pericarditis reported with COVID-19 mRNA vaccines

27 October 2021
Statement
WHO-Unitaid statement on the MPP licensing agreement for molnupiravir
[See COVID above for detail]

27 October 2021
Departmental news
Health – A Political Choice: Solidarity, Science and Solutions

26 October 2021
Departmental news
Journalism in a pandemic: Covering COVID-19 vaccines — What journalists need to know

26 October 2021
Departmental news
Journalism in a pandemic: Covering COVID-19 now and in the future — A self-directed course for journalists

26 October 2021
News release
Top economists call for radical redirection of the economy to put Health for All at the centre in the run-up to G20

26 October 2021
Statement
Statement on the ninth meeting of the International Health Regulations (2005) Emergency Committee regarding the coronavirus disease (COVID-19) pandemic
[See COVID above for detail]

26 October 2021
Departmental news
The use of the WHO costing and budgeting tool for National Action Plans on Antimicrobial Resistance (AMR) in Sierra Leone: lessons learned

26 October 2021
Statement
WHO Statement on Solidarity Trial Vaccines
[See COVID above for detail]

25 October 2021
Departmental news
Adopt One Health, Stop Rabies: India launches new national action plan for dog mediated rabies elimination by 2030

24 October 2021
Departmental news
WHO delivers essential health supplies to Sudan

::::::

Weekly Epidemiological Record, Vol. 96, No. 43, pp. 521–536 29 October 2021
:: Antigenic and genetic characteristics of zoonotic influenza A viruses and development of candidate
vaccine viruses for pandemic preparedness

::::::

WHO Regional Offices
Selected Press Releases, Announcements
WHO African Region AFRO
:: WHO, UNFPA, UNICEF host training on prevention of sexual exploitation and abuse in the Democratic Republic of the Congo 29 October 2021
:: Pursuing the endgame: novel polio vaccine rollout in Africa 26 October 2021
:: Mobile cash in polio response: three things to know 28 October 2021

WHO Region of the Americas PAHO
No new digest content identified

WHO South-East Asia Region SEARO
:: Health Ministers commit to renew, accelerate efforts to end TB in South-East Asia 26 October 2021

WHO European Region EURO
:: WHO/Europe: Keep schools open this winter – but with precautions in place 29-10-2021
:: Improving health in prisons: new WHO Prison Health Framework can improve data quality 28-10-2021
:: WHO/Europe urges countries to collect gender data through their health information systems 28-10-2021
:: “When I got more information, I was sure I needed the vaccine” – immunizing pregnant women against influenza in Kaunas, Lithuania 25-10-2021
:: Q&A on flu in the context of COVID-19 25-10-2021

WHO Eastern Mediterranean Region EMRO
:: ECHO supports the delivery of WHO medical supplies to Kabul 28 October 2021
:: Germany donates 163 000 COVID-19 vaccine doses to Somalia through COVAX Facility
26 October 2021
:: Government of Japan supports Islamic Republic of Iran with US$ 6.3 million grant to strengthen COVID-19 response 26 October 2021
:: Delivering on the promise to protect every Somali child from polio 24 October 2021

WHO Western Pacific Region
:: 29 October 2021 News release Health leaders endorse action plan to end TB in the Region
:: 28 October 2021 News release Regional health leaders agree actions to promote health through schools, harness tradition…
:: 25 October 2021 Regional Director’s opening remarks at the RCM72 virtual press conference

::::::

New WHO Publications [Selected]
https://www.who.int/publications/i
Selected Titles
28 October 2021
Consolidated guidelines on HIV testing services

26 October 2021
Maintaining Essential Health Services during COVID-19

25 October 2021
Interim recommendations for an extended primary series with an additional vaccine dose for COVID-19 vaccination in immunocompromised persons
This interim guidance has been developed on the basis of the advice issued by the Strategic Advisory Group of Experts (SAGE) on Immunization at its meeting on 5 October 2021.

25 October 2021
Guidance on selecting, commissioning and using freeze-preventative vaccine carriers

CDC/ACIP [U.S.] [to 30 Oct 2021]
http://www.cdc.gov/media/index.html
https://www.cdc.gov/vaccines/acip/index.html
Latest News Releases, Announcements [Selected]
New CDC Study: Vaccination Offers Higher Protection than Previous COVID-19 Infection
Friday, October 29, 2021
Today, CDC published new science reinforcing that vaccination is the best protection against COVID-19. In a new MMWR examining more than 7,000 people across 9 states who were hospitalized with COVID-like illness, CDC found that those who were unvaccinated and had a recent infection were 5 times more likely to have COVID-19 than those who were recently fully vaccinated and did not have a prior infection…

CDC To Invest $26 Million in Advanced Outbreak Forecasting and Analytics
Tuesday, October 26, 2021
…The agency will provide $21 million to support research and development of advanced infectious disease models and analytical tools. The awards will support three years of work at five leading academic institutions: University at Albany, State University of New York; Johns Hopkins University; Stanford University; the University of Utah and Harvard T.H. Chan School of Public Health.
The CDC also announced $5 million to support collaborations with the National Science Foundation and the Department of Energy to further advance federal infectious disease modeling capabilities. These funds will support rapid-response research projects and provide access to high performance computing resources…

CDC’s Framework for Conditional Sailing Order Temporarily Extended Through January 15, 2022 Monday, October 25, 2021

CDC Issues Orders Operationalizing the President’s Safer, More Stringent International Travel System Monday, October 25, 2021

Next ACIP Meetings
No registration is required to watch the webcast.
:: November 2-3, 2021 – Draft Agenda

MMWR News Synopsis Friday, October 29, 2021
Selected Content
:: Routine Vaccination Coverage — Worldwide, 2020
:: Severity of Disease Among Adults Hospitalized with Laboratory-Confirmed COVID-19 Before and During the Period of SARS-CoV-2 B.1.617.2 (Delta) Predominance — COVID-NET, 14 States, January–August 2021
:: COVID-19 Vaccination and Non-COVID-19 Mortality Risk — Seven Integrated Health Care Organizations, United States, December 14, 2020–July 31, 2021

Coronavirus Disease 2019 (COVID-19)– CDC
Approximately 25 announcements/reports/data summaries.
10/29/21
New CDC Study: Vaccination Offers Higher Protection than Previous COVID-19 Infection

10/29/21
Overall US COVID-19 Vaccine Distribution and Administration Update as of Fri, 29 Oct 2021 06:00:00 EST

Africa CDC [to 30 Oct 2021]
http://www.africacdc.org/
News
The First International Conference on Public Health in Africa (CPHIA), organized by the Africa Centres for Disease Control and Prevention (Africa CDC)
27 October 2021
The first International Conference on Public Health in Africa (CPHIA) will focus on the deployment of the COVID-19 vaccine, the strengthening of health systems and the lessons learned from the fight against COVID-19…
The virtual CPHIA, which will take place from December 14-16, 2021, will provide a unique platform for African researchers, policy makers and stakeholders from across the globe to share perspectives and research findings in public health.
Registration for the conference is now open at: www.cphia2021.com

China CDC http://www.chinacdc.cn/en/

National Health Commission of the People’s Republic of China [to 30 Oct 2021]
http://en.nhc.gov.cn/
News
Oct 30: Daily briefing on novel coronavirus cases in China
On Oct 29, 31 provincial-level regions and the Xinjiang Production and Construction Corps on the Chinese mainland reported 78 new cases of confirmed infections.

National Medical Products Administration – PRC [to 30 Oct 2021]
http://english.nmpa.gov.cn/news.html
News
HPV shots expected to benefit world
2021-10-29
The World Health Organization’s recent approval of China’s first self-developed vaccine against the human papillomavirus is expected to expand affordable access to the cancer-preventing doses in developing countries, officials and experts have said.

Over 2.254b COVID-19 vaccine doses administered on Chinese mainland
2021-10-29
More than 2.254 billion doses of COVID-19 vaccines had been administered on the Chinese mainland as of Oct 27, data from the National Health Commission showed on Oct 28.

Q&A: COVID-19 vaccine shots for children
2021-10-2

Vaccination of young children begins around country
2021-10-26
Many provinces in China have started vaccinating children aged 3 to 11, as the number of COVID-19 cases has grown due to small recent outbreaks related to tour groups in Gansu province and the Inner Mongolia autonomous region.

CCDC Weekly – Weekly Reports: Current Volume (3)
2021-10-22 / No. 43
View  PDF of this issue
2021-10-29 / No. 44 WORLD FLU DAY ISSUE
:: Editorial: Let’s Get Vaccinated for Both Flu and COVID-19: On the World Flu Day 2021
:: Vital Surveillances: Epidemiological and Virological Surveillance of Seasonal Influenza Viruses — China, 2020–2021
:: Outbreak Reports: Genetic Characterization of Two Human Cases Infected with the Avian Influenza A (H5N6) Viruses — Guangxi Zhuang Autonomous Region, China, 2021
:: Review: Epidemiological and Genetic Characteristics of the H3 Subtype Avian Influenza Viruses in China
:: Review: Leveraging Global Influenza Surveillance and Response System for the COVID-19 Pandemic Response and Beyond

::::::

 
 
Organization Announcements
Editor’s Note:
Careful readers will note that the number and range of organizations now monitored in our Announcements section below has grown as the impacts of the pandemic have spread across global economies, supply chains and programmatic activity of multilateral agencies and INGOs.
 
 
Paul G. Allen Frontiers Group [to 30 Oct 2021]
https://alleninstitute.org/news-press/
News
No new digest content identified.
 
 
BARDA – U.S. Department of HHS [to 30 Oct 2021]
https://www.phe.gov/about/barda/Pages/default.aspx
News
No new digest content identified.
 
 
BMGF – Gates Foundation [to 30 Oct 2021]
https://www.gatesfoundation.org/ideas/media-center
Press Releases and Statements
 
 
Bill & Melinda Gates Medical Research Institute [to 30 Oct 2021]
https://www.gatesmri.org/
The Bill & Melinda Gates Medical Research Institute is a non-profit biotech organization. Our mission is to develop products to fight malaria, tuberculosis, and diarrheal diseases—three major causes of mortality, poverty, and inequality in developing countries. The world has unprecedented scientific tools at its disposal; now is the time to use them to save the lives of the world’s poorest people
No new digest content identified.
 
 
CARB-X [to 30 Oct 2021]
https://carb-x.org/
News
No new digest content identified.
 
 
Center for Vaccine Ethics and Policy – GE2P2 Global Foundation [to 30 Oct 2021]
https://centerforvaccineethicsandpolicy.net/
News/Analysis/Statements
:: Past weekly editions and posting of all segments of Vaccines and Global Health: The Week in Review are available here.
:: [NEW] Informed Consent: A Monthly Review – October 2021 is now posted here
 
 
CEPI – Coalition for Epidemic Preparedness Innovations [to 30 Oct 2021]
http://cepi.net/
Latest News
Statement from Dr Richard Hatchett, CEO of CEPI, following the G20 Health & Finance Ministers meeting
The G20 must redouble their efforts to end the COVID-19 pandemic and commit funding and leadership to prepare the world for future pandemic threats.
End Pandemics
29 Oct 2021

Unleashing the power of science to work for everyone everywhere
With the right investments, leaders of the G20 nations can help CEPI and the world prepare for almost any pathogen – old or new, known or unknown – that we might encounter.
COVID-19
28 Oct 2021

Vaccine production efforts across key regions mapped in first-of-its-kind study to prepare for future pandemics
CEPI’s landscaping exercise revealed vaccine manufacturing capacity needs to be expanded and diversified in Africa, Latin America-Caribbean, the Middle East, as well as further improvements in South East Asia-Western Pacific.
Blog
27 Oct 2021
 
 
DARPA – Defense Advanced Research Projects Agency [to 30 Oct 2021
https://www.darpa.mil/news
News
No new digest content identified.
 
 
Duke Global Health Innovation Center [to 30 Oct 2021]
https://dukeghic.org/
Our Blog
No new digest content identified.
 
 
EDCTP [to 30 Oct 2021]
http://www.edctp.org/
The European & Developing Countries Clinical Trials Partnership (EDCTP) aims to accelerate the development of new or improved drugs, vaccines, microbicides and diagnostics against HIV/AIDS, tuberculosis and malaria as well as other poverty-related and neglected infectious diseases in sub-Saharan Africa, with a focus on phase II and III clinical trials
News
No new digest content identified.
 
 
Emory Vaccine Center [to 30 Oct 2021]
http://www.vaccines.emory.edu/
Vaccine Center News
No new digest content identified.
 
 
European Vaccine Initiative [to 30 Oct 2021]
http://www.euvaccine.eu/
Latest News
No new digest content identified.
 
 
Fondation Merieux [to 30 Oct 2021]
http://www.fondation-merieux.org/
News, Events
No new digest content identified.
 
 
Gavi [to 30 Oct 2021]
https://www.gavi.org/
News releases
28 October 2021
Combining vaccines with nutrition: a game-changer against COVID-19 and future pandemics say Gavi and SUN
Malnutrition and infectious diseases together cause millions of preventable child deaths every year and contribute to a vicious cycle of poor health, stunted growth, poverty and exclusion
Rolling out immunisation and nutrition programmes together significantly increases the number of people reached and reduces delivery costs
Gavi, the Vaccine Alliance, and the Scaling Up Nutrition (SUN) Movement have now partnered to launch this innovative two-pronged healthcare approach
This approach is a game-changer in supporting communities to be resilient to future pandemics, especially for vulnerable people including women and children
 
 
GHIT Fund [to 30 Oct 2021]
https://www.ghitfund.org/newsroom/press
GHIT was set up in 2012 with the aim of developing new tools to tackle infectious diseases that
No new digest content identified.
 
 
Global Fund [to 30 Oct 2021]
https://www.theglobalfund.org/en/news/
News & Stories
No new digest content identified.
 
 
Global Research Collaboration for Infectious Disease Preparedness [GloPID-R] [to 30 Oct 2021]
https://www.glopid-r.org/news/
News
No new digest content identified.
 
 
Hilleman Laboratories [to 30 Oct 2021]
http://www.hillemanlabs.org/
Website reports “under maintenance” at inquiry
 
 
Human Vaccines Project [to 30 Oct 2021]
http://www.humanvaccinesproject.org/
News
HVP COVID Report
Oct 28, 2021
Allison Greaney: Vaccines Are Holding up Against Delta, but What Will Come Next?
 
 
IAVI [to 30 Oct 2021]
https://www.iavi.org/newsroom
Latest News
PRESS RELEASES
IAVI and the Biomedical Advanced Research and Development Authority partner to advance filovirus vaccine candidates
NEW YORK – OCTOBER 27, 2021 – IAVI announced today the award of up to US$126 million from the Biomedical Advanced Research and Development Authority (BARDA) at the U.S. Department of Health and Human Services to develop two recombinant vesicular stomatitis virus (rVSV)-vectored filovirus vaccine candidates. This award supports preclinical activities and includes options for clinical development up to and inclusive of a Phase II clinical trial of IAVI’s rVSV Sudan ebolavirus vaccine candidate (rVSVΔG-SUDV-GP). Optional work that would continue the development of IAVI’s Marburg virus vaccine candidate (rVSVΔG-MARV-GP) that is currently supported by the Defense Threat Reduction Agency of the U.S. Department of Defense could be funded at a later date.
No licensed vaccines against Sudan ebolavirus (SUDV) or Marburg virus (MARV) are currently available…

International Coalition of Medicines Regulatory Authorities [ICMRA]
http://www.icmra.info/drupal/en/news
Selected Statements, Press Releases, Research
No new digest content identified.
 
 
ICRC [to 30 Oct 2021]
https://www.icrc.org/en/whats-new
Selected News Releases, Statements, Reports
Actions must speak louder than words: 5 asks to achieve equity in vaccine delivery
A people’s vaccine should protect the affluent and the poor, the elderly as well as the young, forcibly displaced persons, migrants regardless of their immigration status, and other often neglected populations, both in urban areas and in rural commun
28-10-2021 | Statement
[See COVID above for detail]

When conflict and climate change collide – ICRC warning ahead of COP26
Bamako/Geneva (ICRC) – Climate change is everywhere, but in Mali, a country battered by nearly a decade of conflict, it is pushing families to the brink.Hawa Dicko told me in a dusty, sprawling displacement camp how she lost her home twice – first be
28-10-2021 | News release

ICRC President Peter Maurer: Education for front-line communities must be a priority
On the occasion of the 4th International Conference on the Safe Schools Declaration, which took place from 25 to 27 October 2021 in Abuja, Nigeria, ICRC President Peter Maurer delivered the following pre-recorded message in the closing segment.
27-10-2021 | Statement

IFFIm
http://www.iffim.org/
Press Releases/Announcements
No new digest content identified.
 
 
IFRC [to 30 Oct 2021]
http://media.ifrc.org/ifrc/news/press-releases/
Selected Press Releases, Announcements
28/10/2021
Red Cross Red Crescent report reveals extent of the impact on people forced to flee their homes by floods, fires and drought around the world

25/10/2021
Urgent action needed as COVID-19 overwhelms PNG h\health system
 
 
Institut Pasteur [to 30 Oct 2021]
https://www.pasteur.fr/en/press-area
Press Documents
No new digest content identified.
 
 
IOM / International Organization for Migration [to 30 Oct 2021]
http://www.iom.int/press-room/press-releases
News – Selected
News 29 Oct 2021
Niger’s Leadership on Migration Acknowledged During High-Level IOM Visit

News 29 Oct 2021
IOM Launches Institutional Strategy on Migration, Environment and Climate Change for Next Decade

News 29 Oct 2021
Open Letter to G20 Heads of State and Government – An Appeal to Make Vaccines Accessible to People on the Move
[See COVID above for detail]

News 29 Oct 2021
IOM Marks 60 Years of International Migration Journal
 
 
ISC / International Science Council [to 30 Oct 2021]
https://council.science/current/
ISC is a non-governmental organization with a unique global membership that brings together 40 international scientific Unions and Associations and over 140 national and regional scientific organizations including Academies and Research Councils.
Blog
International scientific advisors call for science and innovation to be at the centre of action on climate change
29.10.2021
In a statement released by the UK Government Office for Science, senior scientific advisors from around the world, including members of the ISC’s Governing Board, and network of affliated bodies and committees, as well as representatives of the ISC Membership, call for ambitious, science-based strategies to ‘keep the 1.5°C temperature goal alive’.

News
Members of International Science Council commit to work for change in scientific publishing, and endorse eight principles for reform
25.10.2021
As the 2021 Open Access week begins, the scientific community as represented by the International Science Council’s members has approved a resolution committing to work to reform scholarly publishing, and to endorse eight fundamental principles for scientific publishing that contributes to the advancement of science as a global public good.
 
 
IVAC [to 30 Oct 2021]
https://www.jhsph.edu/research/centers-and-institutes/ivac/index.html
Updates; Events
No new digest content identified.
 
 
IVI [to 30 Oct 2021]
http://www.ivi.int/
IVI News & Announcements
IVI and JEDI partner for innovations in health and science
October 25, 2021 – SEOUL, Republic of Korea, PARIS, France, BRUSSELS, Belgium, BERLIN, Germany – The International Vaccine Institute (IVI) and the Joint European Disruptive Initiative (JEDI) signed a Memorandum of Understanding to establish a collaborative relationship. Both organizations are dedicated to advancing innovations in health and science. IVI and JEDI will explore many cooperation routes, in particular around innovative approaches to zoonoses, infectious diseases and in addressing the global threat of antimicrobial resistance (AMR)…
 
 
Johns Hopkins Center for Health Security [to 30 Oct 2021]
https://www.centerforhealthsecurity.org/news/center-news/
Center News
New Report: Navigating the World that COVID-19 Made: A Strategy for Revamping the Pandemic Research and Development Preparedness and Response Ecosystem
October 29, 2021
[See COVID above for detail]
 
 
MSF/Médecins Sans Frontières [to 30 Oct 2021]
http://www.msf.org/
Latest [Selected Announcements]
Haiti
Haiti fuel crisis severely limits access to vital medical care
Press Release 27 Oct 2021

Mediterranean migration
Nearly 400 people rescued from the Mediterranean need a place of safety
Project Update 26 Oct 2021
 
 
National Academy of Medicine – USA [to 30 Oct 2021]
https://nam.edu/programs/
Selected News/Programs/Events
No new digest content identified.
 
 
National Academy of Sciences – USA [to 30 Oct 2021]
http://www.nasonline.org/news-and-multimedia/
News
No new digest content identified.
 
 
National Vaccine Program Office – U.S. HHS [to 30 Oct 2021]
https://www.hhs.gov/vaccines/about/index.html
Upcoming Meetings/Latest Updates
No new digest content identified.
 
 
NIH [to 30 Oct 2021]
http://www.nih.gov/news-events/news-releases
News Releases
NIH researchers identify how two people controlled HIV after stopping treatment
October 29, 2021 — Different mechanisms suppressed the virus in each person.

NIH, FDA and 15 private organizations join forces to increase effective gene therapies for rare diseases
October 27, 2021 — While there are approximately 7,000 rare diseases, only two heritable diseases currently have FDA-approved gene therapies.
The National Institutes of Health, U.S. Food and Drug Administration, 10 pharmaceutical companies and five non-profit organizations have partnered to accelerate development of gene therapies for the 30 million Americans who suffer from a rare disease. While there are approximately 7,000 rare diseases, only two heritable diseases currently have FDA-approved gene therapies. The newly launched Bespoke Gene Therapy Consortium (BGTC), part of the NIH Accelerating Medicines Partnership (AMP) program and project-managed by the Foundation for the National Institutes of Health (FNIH), aims to optimize and streamline the gene therapy development process to help fill the unmet medical needs of people with rare diseases.
“Most rare diseases are caused by a defect in a single gene that could potentially be targeted with a customized or ‘bespoke’ therapy that corrects or replaces the defective gene,” said NIH Director Francis S. Collins, M.D., Ph.D. “There are now significant opportunities to improve the complex development process for gene therapies that would accelerate scientific progress and, most importantly, provide benefit to patients by increasing the number of effective gene therapies.”…

NIH awards nearly $75M to catalyze data science research in Africa
October 26, 2021 — New program will establish data science research and training network across the continent.
The National Institutes of Health is investing about $74.5 million over five years to advance data science, catalyze innovation and spur health discoveries across Africa. Under its new Harnessing Data Science for Health Discovery and Innovation in Africa (DS-I Africa) program, the NIH is issuing 19 awards to support research and training activities. DS-I Africa is an NIH Common Fund program that is supported by the Office of the Director and 11 NIH Institutes, Centers and Offices.
Awards will establish a consortium consisting of a data science platform and coordinating center, seven research hubs, seven data science research training programs and four projects focused on studying the ethical, legal and social implications of data science research. Awardees have a robust network of partnerships across the African continent and in the United States, including numerous national health ministries, nongovernmental organizations, corporations, and other academic institutions…
 
 
PATH [to 30 Oct 2021]
https://www.path.org/media-center/
Press Releases
No new digest content identified.
 
 
Sabin Vaccine Institute [to 30 Oct 2021]
http://www.sabin.org/updates/pressreleases
Statements and Press Releases
No new digest content identified.
 
 
UNAIDS [to 30 Oct 2021]
http://www.unaids.org/en
Selected Press Releases/Reports/Statements
31 October 2021
Western and central Africa HIV summit

29 October 2021
Brandy Rodriguez leaves legacy of courageous advocacy and community support

29 October 2021
Zero Discrimination Platform relaunched in Central African Republic

29 October 2021
Getting unconditional cash to marginalized households during COVID-19

28 October 2021
Bangkok Metropolitan Administration receives award for innovations on PrEP and key population-led services

26 October 2021
ASEAN cities protecting the gains of the HIV response during the COVID-19 pandemic

25 October 2021
Financial shortfalls hold back the HIV response in western and central Africa

UNHCR Office of the United Nations High Commissioner for Refugees [to 30 Oct 2021]
http://www.unhcr.org/en-us/media-centre.htmlS
Selected News Releases, Announcements
Open letter to G20 Heads of State and Government – UNHCR, IOM & WHO
An appeal to G20 leaders to make vaccines accessible to people on the move
29 Oct 2021
[See COVID above for detail]

Actions must speak louder than words: five asks to achieve equity in vaccine delivery
Joint UN/ Red Cross/Red Crescent Statement
28 Oct 2021
[See COVID above for detail]

New data visualization on COVID-19 eviction and homelessness risks for Venezuelan refugees and migrants
25 Oct 2021
 
 
UNICEF [to 30 Oct 2021]
https://www.unicef.org/media/press-releases
Press Releases, News Notes, Statements [Selected]
Press release
10/28/2021
New ACT-Accelerator strategy calls for US$ 23.4 billion international investment to solve inequities in global access to COVID-19 vaccines, tests & treatments
Joint statement from the ACT-Accelerator partners
[See COVID above for detail]

Statement
10/27/2021
Urgent action needed now to ensure sufficient COVID vaccine syringe supply to meet 2022 vaccination targets 
Increased demand, supply chain disruptions, and ‘syringe nationalism’ could lead to significant challenges in 2022 without immediate action
[See COVID above for detail]

Press release
10/27/2021
G20 members have received 15 times more COVID-19 vaccine doses per capita than sub-Saharan African countries
Ahead of the G20 Leaders’ Summit this weekend, 48 UNICEF Africa ambassadors and supporters unite, calling on countries to deliver doses by December.
[See COVID above for detail]

Remarks
10/25/2021
Opening remarks for UNICEF virtual event on the ‘Role of Women in Polio Eradication’ – 25 Oct 2021
UNICEF Executive Director Henrietta Fore

Remarks
10/25/2021
Keynote Speech to the World Health Summit 2021 – 24 October 2021
UNICEF Executive Director Henrietta Fore
 
 
Unitaid [to 30 Oct 2021]
https://unitaid.org/
Featured News
29 October 2021
Unitaid statement at the G20 Joint Finance and Health Ministers’ Meeting

27 October 2021
WHO-Unitaid statement on the MPP licensing agreement for molnupiravir
[See COVID above for detail]
 
 
Vaccine Equity Cooperative [nee Initiative] [to 30 Oct 2021]
https://vaccineequitycooperative.org/news/
News
No new digest content identified.
 
 
Vaccination Acceptance & Demand Initiative [Sabin) [to 30 Oct 2021]
https://www.vaccineacceptance.org/
Announcements
No new digest content identified.
 
 
Vaccine Confidence Project [to 30 Oct 2021]
http://www.vaccineconfidence.org/
News, Research and Reports
Coronavirus global impact
Launched April 2, 2020 and recurring every 3 days, Premise Data is utilizing its global network of Contributors to assess economic, social, and health sentiment surrounding the coronavirus (COVID-19).
 
 
Vaccine Education Center – Children’s Hospital of Philadelphia [to 30 Oct 2021]
http://www.chop.edu/centers-programs/vaccine-education-center
News
Vaccine Update Newsletter – October 2021
Vaccine Update is our monthly email newsletter that will keep you up to date on current vaccine-related issues.
 
 
Wellcome Trust [to 30 Oct 2021]
https://wellcome.ac.uk/news
News and reports
Explainer
What treatments are working for Covid-19?
28 October 2021
From existing antivirals to new antibody therapies – researchers are working tirelessly to find the best drugs to treat Covid-19.

Explainer
Four reasons why health must be at the heart of climate action
25 October 2021
Climate change is one of the most urgent health challenges of our time. Ahead of COP26, we outline some of the damaging effects of climate change on health, and why climate action cannot ignore the evidence.
 
 
The Wistar Institute [to 30 Oct 2021]
https://www.wistar.org/news/press-releases
Press Releases
No new digest content identified.
 
 
WFPHA: World Federation of Public Health Associations [to 30 Oct 2021]
https://www.wfpha.org/
Latest News
No new digest content identified.
 
 
World Bank [to 30 Oct 2021]
http://www.worldbank.org/en/news/all
Selected News, Announcements
Joint Statement of the Multilateral Leaders Taskforce on the Strategies to Accelerate the Supply and Deployment of COVID-19 Vaccines Following its Fifth Meeting
ROME, October 30, 2021 — The heads of the International Monetary Fund, World Bank Group, World Health Organization and World Trade Organization met to discuss strategies to accelerate the…
Date: October 30, 2021 Type: Statement
[See COVID above for detail]

Remarks by World Bank Group President David Malpass to the G20 Leaders’ Summit – Session I: Global Economy and Health
Thank you, Prime Minister Draghi. The developing world faces multiple severe problems. The pandemic and the scarcity of COVID-19 vaccines are the most immediate. In addition, the recovery is being undercut…
Date: October 30, 2021 Type: Speeches and Transcripts
[See COVID above for detail]

Working towards Universal Health Coverage in East Asia and the Pacific
Highlights – Countries in East Asia and the Pacific have committed to providing universal health coverage for their populations – so they can access quality health care when they need it without falling into…
Date: October 29, 2021 Type: Brief

World Bank: Pandemic Threatens to Drive Unprecedented Number of Children into Learning Poverty
WASHINGTON D.C., October 29, 2021— The COVID-19 pandemic could drive up learning poverty, the share of 10-year-olds who cannot read a basic text, to around 70 percent in low- and middle-income countries…
Date: October 29, 2021 Type: Press Release

Remarks by World Bank Group President David Malpass at the G20 Joint Finance and Health Ministerial
Rome – October 29, 2021 Thank you, Ministers Franco and Speranza. I welcome the Italian G20 presidency’s efforts to improve coordination on pandemic preparedness and response. As we enter the third year…
Date: October 29, 2021 Type: Speeches and Transcripts

World Customs Organization – WCO [to 30 Oct 2021]
http://www.wcoomd.org/
Latest News – Selected Items
29 October 2021
Release of the Harmonized System Committee’s working documents on WCO public database

29 October 2021
The annual International Customs Forum was held in Moscow

28 October 2021
Latest edition of WCO News now available
 
 
World Organisation for Animal Health (OIE) [to 30 Oct 2021]
https://www.oie.int/en/media/news/
Press Releases, Statements
Supporting investment decisions for animal health
28 October 2021
Given that we live in a world of interconnectedness, the importance of data and improving datasets is paramount to achieving evidence-based policy-making at international and national levels. The Global Burden of Animal Diseases (GBADs) programme  will act as an essential piece of a bigger digital transformation at the World Organisation for Animal Health (OIE) and it will act in complementarity with other OIE datasets and workstreams such as the Training Platform  , Observatory   and PVS Pathway.
 
 
WTO – World Trade Organisation [to 30 Oct 2021]
http://www.wto.org/english/news_e/news_e.htm
WTO News and Events
New WTO report on G20 shows restraint in new pandemic-related trade restrictions
28 October 2021
G20 economies have continued to roll back COVID-19-related trade-restrictive measures and demonstrated restraint in the imposition of new ones, but the value of trade covered by pandemic-related restrictions still in place now exceeds that of trade-facilitating measures, according to the latest WTO Trade Monitoring Report on G20 trade measures released today (28 October). Ahead of a G20 leaders’ summit in Rome this weekend, Director-General Ngozi Okonjo-Iweala called on G20 economies to continue to unwind pandemic-related trade restrictions and to push for a strong WTO response to the pandemic at the 12th Ministerial Conference.

::::::

ARM [Alliance for Regenerative Medicine] [to 30 Oct 2021]
https://alliancerm.org/press-releases/
Selected Press Releases
The Alliance for Regenerative Medicine Announces Election of 2022 Officers, Executive Committee, and Board of Directors
Washington, DC – October 21, 2021
 
 
BIO [to 30 Oct 2021]
https://www.bio.org/press-releases
Press Releases, Letters, Testimony, Comments [Selected]
No new digest content identified.
 
 
DCVMN – Developing Country Vaccine Manufacturers Network [to 30 Oct 2021]
http://www.dcvmn.org/
News; Upcoming events
No new digest content identified.
 
 
ICBA – International Council of Biotechnology Associations [to 30 Oct 2021]
https://internationalbiotech.org/news/
News
No new digest content identified.
 
 
IFPMA [to 30 Oct 2021]
http://www.ifpma.org/resources/news-releases/
Selected Press Releases, Statements, Publications
Bolstering action against future pandemics: pharma policy perspectives on delivering medical countermeasures
25 October 2021
:: Future pandemic preparedness discussions cannot and must not overshadow the need for urgent joint action to redistribute COVID-19 vaccines through COVAX and donations.
:: Planning for better pandemic preparedness requires measures to develop effective and safe pandemic products even faster to save lives and livelihoods, which requires first pathogen sharing, second, strong incentive frameworks and third, a sustainable innovation ecosystem.
:: To ensure equitable access to those products for people worldwide requires more effective collaboration with governments, multilateral organizations, regulators, and other companies and sectors.
[See Milestones/Perspective above for detail]

 
 
 
International Generic and Biosimilar Medicines Association [IGBA]
https://www.igbamedicines.org/
News
No new digest content identified.
 
 
International Alliance of Patients’ Organizations – IAPO [to 30 Oct 2021]
https://www.iapo.org.uk/news/topic/6
Press and media [Selected]
No new digest content identified.
 
 
PhRMA [to 30 Oct 2021]
http://www.phrma.org/
Latest News [Selected]
No new digest content identified.

Journal Watch
Vaccines and Global Health: The Week in Review continues its weekly scanning of key peer-reviewed journals to identify and cite articles, commentary and editorials, books reviews and other content supporting our focu-s on vaccine ethics and policy. Journal Watch is not intended to be exhaustive, but indicative of themes and issues the Center is actively tracking. We selectively provide full text of some editorial and comment articles that are specifically relevant to our work. Successful access to some of the links provided may require subscription or other access arrangement unique to the publisher.
If you would like to suggest other journal titles to include in this service, please contact David Curry at: david.r.curry@centerforvaccineethicsandpolicy.org

AMA Journal of Ethics
Volume 23, Number 10: E757-831
https://journalofethics.ama-assn.org/issue/palliative-surgery

Palliative Surgery
Palliative care is not just for dying patients. In fact, dying patients are living patients, and all patients deserve palliation. Contrary to popular belief among many patients and clinicians, palliative interventions can be invasive and include not only medical, but surgical care. In any case, palliative care should be defined by intention: partnering clinicians, patients, and their loved ones aim neither to cure disease nor to prolong life, but to improve the quality of a patient’s life at any needed time. Quality of life is motivated by goal-elucidating conversation, counseling, and symptom management-directed intervention. This issue investigates surgical palliation specifically, with sharp focus on intention formation and trust preservation.

American Journal of Preventive Medicine
November 2021 Volume 61 Issue 5 p619-770
https://www.ajpmonline.org/current

Research Articles
Hepatitis B Vaccination Among Adults With Diabetes Mellitus, U.S., 2018
Peng-jun Lu, Mei-Chuan Hung, Anup Srivastav, Walter W. Williams, Aaron M. Harris
Published online: July 19, 2021
p652-664

American Journal of Preventive Medicine
November 2021 Volume 61 Issue 5 p619-770
https://www.ajpmonline.org/current

Factors Associated With Human Papillomavirus Vaccine Series Completion Among Adolescents
Lisa N. Mansfield, Susan G. Silva, Elizabeth I. Merwin, Richard J. Chung, Rosa M. Gonzalez-Guarda
Published online: July 10, 2021
p701-708

BMC Infectious Diseases
http://www.biomedcentral.com/bmcinfectdis/content
(Accessed 30 Oct 2021)

COVID-19 underreporting and its impact on vaccination strategies
Underreporting cases of infectious diseases poses a major challenge in the analysis of their epidemiological characteristics and dynamical aspects. Without accurate numerical estimates it is difficult to preci…
Authors: Vinicius Albani, Jennifer Loria, Eduardo Massad and Jorge Zubelli
Citation: BMC Infectious Diseases 2021 21:1111
Content type: Research
Published on: 28 October 2021

BMC Medicine
http://www.biomedcentral.com/bmcmed/content
(Accessed 30 Oct 2021)

Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project
Adaptive designs offer great promise in improving the efficiency and patient-benefit of clinical trials. An important barrier to further increased use is a lack of understanding about which additional resource…
Authors: Nina Wilson, Katie Biggs, Sarah Bowden, Julia Brown, Munyaradzi Dimairo, Laura Flight, Jamie Hall, Anna Hockaday, Thomas Jaki, Rachel Lowe, Caroline Murphy, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar…
Citation: BMC Medicine 2021 19:251
Content type: Research article
Published on: 26 October 2021

Cell
Oct 28, 2021 Volume 184 Issue 22 p5497-5690
https://www.cell.com/cell/current

Commentary
Emergency drug use in a pandemic: Harsh lessons from COVID-19
Gail Cross, Jessica S.Y. Ho, William Zacharias, Anand D. Jeyasekharan, Ivan Marazzi
The scientific and clinical communities have both experienced several harsh lessons on clinical care management and drug development during the COVID-19 pandemic. Here, we discuss several key lessons learned and describe a framework within which our two communities can work together and invest in to improve future pandemic responses.

The CRISPR Journal
Volume 4, Issue 5 / October 2021
https://www.liebertpub.com/toc/crispr/4/5

Review Article Free
CRISPR-Cas Gene Perturbation and Editing in Human Induced Pluripotent Stem Cells
Max van Essen, Joey Riepsaame, and John Jacob
Pages:634–655
Published Online:28 September 2021
https://doi.org/10.1089/crispr.2021.0063

The CRISPR Journal
Volume 4, Issue 5 / October 2021
https://www.liebertpub.com/toc/crispr/4/5

Free
Determination of Factors Driving the Genome Editing Field in the CRISPR Era Using Bibliometrics
Ying Huang, Yi Zhang, Mengjia Wu, Alan Porter, and Rodolphe Barrangou
Pages:728–738
Published Online:15 October 2021
https://doi.org/10.1089/crispr.2021.0001

Disaster Medicine and Public Health Preparedness
Volume 15 – Issue 4 – August 2021
https://www.cambridge.org/core/journals/disaster-medicine-and-public-health-preparedness/latest-issue

Concepts in Disaster Medicine
Ethical Decision-Making in Humanitarian Medicine: How Best to Prepare?
Kadri Simm
Published online by Cambridge University Press: 13 April 2020, pp. 499-503
Abstract
Ethical decision-making during humanitarian medical response is a topic of great moral as well as practical importance. The context of humanitarian disasters, often characterized by acute time-pressure, lack of resources, the unfamiliarity of circumstances, is stressful for medical professionals. The overall aim of this article is pragmatic, to introduce briefly the importance and context for preparing medical disaster response personnel for ethical decision-making and then to provide a discussion case and explain the particular value-reflection methodology. The focus of methodology is on providing space for the emotional and stressful aspects of ethics training for disasters.

EMBO Reports
Volume 22 Issue 10 5 October 2021
https://www.embopress.org/toc/14693178/current

Science & Society 3 September 2021 Open Access
COVID-19 and the gain of function debates: Improving biosafety measures requires a more precise definition of which experiments would raise safety concerns
Kelsey Lane Warmbrod, Michael G Montague, Gigi Kwik Gronvall
The COVID-19 pandemic has rekindled debates about gain-of-function experiments. This is an opportunity to clearly define safety risks and appropriate countermeasures.

EMBO Reports
Volume 22 Issue 10 5 October 2021
https://www.embopress.org/toc/14693178/current

Science & Society 17 September 2021 Free Access
Lessons from COVID-19: The ongoing pandemic has inspired and advanced research and development across a wide range of fields
Philip Hunter
From immunology to manufacturing to social science: COVID-19 has been a boon for research and development in many research areas.

The European Journal of Public Health
SUPPLEMENT – Volume 31, Issue Supplement_1, July 2021
https://academic.oup.com/eurpub/issue/31/Supplement_1

Supplement: E-Mental-Health: Exploring the Evidence Base and Stakeholders’ Perspectives on Internet-Based Interventions for the Prevention of Mental Health Conditions
Mental illness represents an enormous personal, social and societal burden for European citizens1 calling for the need to expand existing models of mental healthcare delivery. In Europe, the Internet is a key source of health information,2 and technology-enhanced (psychological) interventions such as Internet- and mobile-delivered applications (‘eHealth’3 and ‘m-Health’4) have become increasingly popular and studied. There is already strong evidence of the efficacy of online interventions for the prevention and treatment of several psychological disorders5,6 and meta-analyses show effect sizes similar to face-to-face interventions.7

Humanitarian Exchange Magazine
Number 79, May 2021
https://odihpn.org/magazine/localisation-and-local-humanitarian-action/

Localisation and local humanitarian action
by HPN October 2020
The theme of this edition of Humanitarian Exchange is localisation+ and local humanitarian action. Five years ago this week, donors, United Nations (UN) agencies,  non-governmental organisations (NGOs), the International Committee of the Red Cross (ICRC) and International Federation of Red Cross and Red Crescent Societies (IFRC) committed within the Grand Bargain to increase multi-year investments in the institutional capacities of local and national responders, and to provide at least 25% of humanitarian funding to them as directly as possible. Since then, there is increasing consensus at policy and normative level, underscored by the Covid-19 pandemic, that local leadership should be supported.  Localisation has gone from a fringe conversation among policy-makers and aid agencies in 2016 to a formal priority under the Grand Bargain. Wider global movements on anti-racism and decolonisation have also brought new momentum to critical reflections on where power, knowledge and capacity reside in the humanitarian system. Yet progress has been slow and major gaps remain between the rhetoric around humanitarian partnerships, funding and coordination and practices on the ground.

JAMA
October 26, 2021, Vol 326, No. 16, Pages 1565-1642
https://jamanetwork.com/journals/jama/currentissue

Original Investigation
Association of Receipt of the Ad26.COV2.S COVID-19 Vaccine With Presumptive Guillain-Barré Syndrome, February-July 2021
Emily Jane Woo, MD, MPH; Adamma Mba-Jonas, MD, MPH; Rositsa B. Dimova, PhD; et al.
free access
JAMA. 2021;326(16):1606-1613. doi:10.1001/jama.2021.16496
Based on the Vaccine Adverse Event Reporting System, this article reports on the prevalence of presumptive Guillain-Barré syndrome among recipients of the Ad26.COV2.S (Janssen/Johnson & Johnson) COVID-19 vaccine.

JAMA
October 26, 2021, Vol 326, No. 16, Pages 1565-1642
https://jamanetwork.com/journals/jama/currentissue

Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy
Elyse O. Kharbanda, MD, MPH; Jacob Haapala, MPH; Malini DeSilva, MD, MPH; et al.
free access has active quiz
JAMA. 2021;326(16):1629-1631. doi:10.1001/jama.2021.15494
This study presents findings from case-control surveillance of COVID-19 vaccination during pregnancy and spontaneous abortion.

JAMA Network
COVID-19 Update October 30, 2021

These articles on COVID-19 were published across the JAMA Network in the last week.

Journal of Patient-Centered Research and Reviews
Volume 8, Issue 4 (2021)
https://digitalrepository.aurorahealthcare.org/jpcrr/

Cancer Screening

The Lancet
Oct 30, 2021 Volume 398 Number 10311 p1541-1662, e16
https://www.thelancet.com/journals/lancet/issue/current

Editorial
The climate emergency: a last chance to act?
The Lancet

The Lancet
Oct 30, 2021 Volume 398 Number 10311 p1541-1662, e16
https://www.thelancet.com/journals/lancet/issue/current

Review
The 2021 report of the Lancet Countdown on health and climate change: code red for a healthy future
Marina Romanello, et a;
Executive summary
The Lancet Countdown is an international collaboration that independently monitors the health consequences of a changing climate. Publishing updated, new, and improved indicators each year, the Lancet Countdown represents the consensus of leading researchers from 43 academic institutions and UN agencies. The 44 indicators of this report expose an unabated rise in the health impacts of climate change and the current health consequences of the delayed and inconsistent response of countries around the globe—providing a clear imperative for accelerated action that puts the health of people and planet above all else.
The 2021 report coincides with the UN Framework Convention on Climate Change 26th Conference of the Parties (COP26), at which countries are facing pressure to realise the ambition of the Paris Agreement to keep the global average temperature rise to 1·5°C and to mobilise the financial resources required for all countries to have an effective climate response. These negotiations unfold in the context of the COVID-19 pandemic—a global health crisis that has claimed millions of lives, affected livelihoods and communities around the globe, and exposed deep fissures and inequities in the world’s capacity to cope with, and respond to, health emergencies. Yet, in its response to both crises, the world is faced with an unprecedented opportunity to ensure a healthy future for all.

Nature
Volume 598 Issue 7882, 28 October 2021
https://www.nature.com/nature/volumes/598/issues/7882

Editorial | 27 October 2021
The COVID pandemic must lead to tuberculosis vaccines
The coronavirus crisis has halted decades of progress on TB. But the speed of COVID vaccines shows there can still be hope for advances against neglected diseases.

Researchers and clinicians are upset and frustrated that decades of work in diagnosing, treating and researching tuberculosis (TB)have massively stalled. The slowdown means the world is losing ground against a disease that kills 1.5 million people every year.

As the International Union Against Tuberculosis and Lung Disease held its annual conference online last week, Guy Marks, the union’s president, spoke for many when, comparing efforts against COVID-19, he said: “Many of us who work in the [TB] field feel robbed that equivalent efforts to develop a TB vaccine have never been as well committed or funded.”

Marks added: “The failure to deliver COVID-19 vaccines to low- and middle-income countries and end tuberculosis are two sides of the same coin — a devaluation of human life in poor countries.” He has a point. But it doesn’t need to be this way.

Researchers are again urging decision-makers to revive diagnosis, treatment and research programmes for TB and other infectious diseases, such as malaria. And they are saying that much can be learnt from how the creation of COVID-19 vaccines was fast-tracked.

Researchers have been warning that even more people will die from TB and other infectious diseases, such as malaria and HIV, if health systems continue to neglect these infections because of the continuing focus on coronavirus (see Nature 597, 314; 2021). And they are pleading with funders and governments not to drop the ball on TB work.

But their warnings are not being heeded. Not only are more people dying of the disease, but a target to reduce deaths by 90% from 2015 levels by 2030 — part of the United Nations Sustainable Development Goals — is now in peril. According to research published this month, this failure will also lead to profound economic and health losses in the trillions of dollars — with the greatest impact in sub-Saharan Africa (S. Silva et al. Lancet Glob. Health 9, E1372–E1379; 2021).

A crucial problem is that fewer medical professionals have been available to diagnose and treat TB. As a result, the number of people diagnosed with the disease fell from 7.1 million in 2019 to 5.8 million in 2020. India, Indonesia and the Philippines are the most affected countries, according to the World Health Organization’s (WHO’s) latest TB report, published this month (see go.nature.com/3re4n6j).

At the same time, funding has also shrunk. Global spending on TB diagnostic, treatment and prevention services dropped from US$5.8 billion to $5.3 billion in 2020. Moreover, this overall spending is less than half of the WHO’s global target of $13 billion annually by 2022. TB research funding is also half of what it needs to be. The WHO set a separate target for this of $2 billion annually for 2018–22.
In 2019, funding for TB research totalled only $901 million. By contrast, the US National Institutes of Health alone has set aside $4.9 billion for research on COVID-19. Published research in TB seems to be holding up for now, according to an analysis published this week in Nature Index (see Nature 598, S10–S13; 2021).

Some conference delegates spoke of lowering the targets for diagnosing and treating TB (and for other infectious diseases) to account for these and other ground realities. But that would be inadvisable. Although the COVID-19 pandemic is the highest priority for political leaders, wealthier nations and philanthropic donors, the pandemic has also shown how it is possible to boost both research into an infectious disease and treatment — and to do so at speed, which has led to COVID-19 vaccines in record time.

Lessons from COVID-19 must be applied to the fight against TB and other infectious diseases — from extraordinary resource mobilization to the use of emerging technologies, such as messenger RNA and other platforms to create vaccines. Advances in rapid and reliable diagnostics, advanced computation, sequencing and clinical-trial capacity for new vaccines and treatments can all be harnessed for TB and other infectious diseases.

The TB vaccine in use today is essentially the same as the Bacillus Calmette–Guérin (BCG) vaccine introduced in July 1921. The COVID-19 pandemic has shown that it’s possible to produce new vaccines in one year, not 100 — provided that there is funding and political will.

New England Journal of Medicine
October 28, 2021 Vol. 385 No. 18
http://www.nejm.org/toc/nejm/medical-journal

Perspective
Uncomfortable Truths — What Covid-19 Has Revealed about Chronic-Disease Care in America M.H. Chin

New England Journal of Medicine
October 28, 2021 Vol. 385 No. 18
http://www.nejm.org/toc/nejm/medical-journal

Original Articles
Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis S. Pavord and Others

New England Journal of Medicine
October 28, 2021 Vol. 385 No. 18
http://www.nejm.org/toc/nejm/medical-journal

Editorials
Audio Interview: A New Monoclonal Antibody for Covid-19 and Potential Vaccination for Children E.J. Rubin, L.R. Baden, and S. Morrissey

PLoS Medicine
http://www.plosmedicine.org/
(Accessed 30 Oct 2021)

Safety and immunogenicity of 2-dose heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola vaccination in healthy and HIV-infected adults: A randomised, placebo-controlled Phase II clinical trial in Africa
Houreratou Barry, Gaudensia Mutua, Hannah Kibuuka, Zacchaeus Anywaine, Sodiomon B. Sirima, Nicolas Meda, Omu Anzala, Serge Eholie, Christine Bétard, Laura Richert, Christine Lacabaratz, M. Juliana McElrath, Stephen De Rosa, Kristen W. Cohen, Georgi Shukarev, Cynthia Robinson, Auguste Gaddah, Dirk Heerwegh, Viki Bockstal, Kerstin Luhn, Maarten Leyssen, Macaya Douoguih, Rodolphe Thiébaut, the EBL2002 Study group
Research Article | published 29 Oct 2021 PLOS Medicine
https://doi.org/10.1371/journal.pmed.1003813

PLoS Medicine
http://www.plosmedicine.org/
(Accessed 30 Oct 2021)

Medical journal requirements for clinical trial data sharing: Ripe for improvement
Florian Naudet, Maximilian Siebert, Claude Pellen, Jeanne Gaba, Cathrine Axfors, Ioana Cristea, Valentin Danchev, Ulrich Mansmann, Christian Ohmann, Joshua D. Wallach, David Moher, John P. A. Ioannidis
Policy Forum | published 25 Oct 2021 PLOS Medicine
https://doi.org/10.1371/journal.pmed.1003844

PLoS One
http://www.plosone.org/
[Accessed 30 Oct 2021]

Research Article
Misinformation, perceptions towards COVID-19 and willingness to be vaccinated: A population-based survey in Yemen
Ahmad Naoras Bitar, Mohammed Zawiah, Fahmi Y. Al-Ashwal, Mohammed Kubas, Ramzi Mukred Saeed, Rami Abduljabbar, Ammar Ali Saleh Jaber, Syed Azhar Syed Sulaiman, Amer Hayat Khan
Research Article | published 29 Oct 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0248325

PLoS One
http://www.plosone.org/
[Accessed 30 Oct 2021]

Messages that increase COVID-19 vaccine acceptance: Evidence from online experiments in six Latin American countries
Pablo Argote Tironi, Elena Barham, Sarah Zuckerman Daly, Julian E. Gerez, John Marshall, Oscar Pocasangre
Research Article | published 28 Oct 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0259059

PLoS One
http://www.plosone.org/
[Accessed 30 Oct 2021]

Analysis of COVID-19 vaccine non-intent by essential vs non-essential worker, demographic, and socioeconomic status among 101,048 US adults
Tania Elliott, Baligh R. Yehia, Angela L. Winegar, Jyothi Karthik Raja, Ashlin Jones, Erin Shockley, Joseph Cacchione
Research Article | published 28 Oct 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0258540

PLoS One
http://www.plosone.org/
[Accessed 30 Oct 2021]

Invincibility threatens vaccination intentions during a pandemic
James M. Leonhardt, Garret Ridinger, Yu Rong, Amir Talaei-Khoe
Research Article | published 27 Oct 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0258432

PLoS Pathogens
http://journals.plos.org/plospathogens/
[Accessed 30 Oct 2021]

Induction of trained immunity by influenza vaccination – impact on COVID-19
Priya A. Debisarun, Katharina L. Gössling, Ozlem Bulut, Gizem Kilic, Martijn Zoodsma, Zhaoli Liu, Marina Oldenburg, Nadine Rüchel, Bowen Zhang, Cheng-Jian Xu, Patrick Struycken, Valerie A. C. M. Koeken, Jorge Domínguez-Andrés, Simone J. C. F. M. Moorlag, Esther Taks, Philipp N. Ostermann, Lisa Müller, Heiner Schaal, Ortwin Adams, Arndt Borkhardt, Jaap ten Oever, Reinout van Crevel, Yang Li, Mihai G. Netea
Research Article | published 25 Oct 2021 PLOS Pathogens
https://doi.org/10.1371/journal.ppat.1009928

Revista Panamericana de Salud Pública/Pan American Journal of Public Health (RPSP/PAJPH)
https://www.paho.org/journal/en

Selected Articles
25 Oct 2021
SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil
Brief communication | English |