Announcements

Announcements

 
Paul G. Allen Frontiers Group    [to 20 Apr 2019]
https://www.alleninstitute.org/news-press/
News
Gene drives get a precision upgrade
April 16, 2019
Method to fine tune DNA could be used to engineer malaria-resistant mosquitoes, reduce
 
 
BMGF – Gates Foundation [to 20 Apr 2019]
http://www.gatesfoundation.org/Media-Center/Press-Releases
No new digest content identified.
 
 
Bill & Melinda Gates Medical Research Institute [to 20 Apr 2019]
https://www.gatesmri.org/
The Bill & Melinda Gates Medical Research Institute is a non-profit biotech organization. Our mission is to develop products to fight malaria, tuberculosis, and diarrheal diseases—three major causes of mortality, poverty, and inequality in developing countries. The world has unprecedented scientific tools at its disposal; now is the time to use them to save the lives of the world’s poorest people
No new digest content identified.
 
 
CARB-X [to 20 Apr 2019]

Home


CARB-X is a non-profit public-private partnership dedicated to accelerating antibacterial research to tackle the global rising threat of drug-resistant bacteria.
No new digest content identified.
 
 
CEPI – Coalition for Epidemic Preparedness Innovations [to 20 Apr 2019]

Home page


No new digest content identified.
 
 
Clinton Health Access Initiative, Inc. (CHAI) [to 20 Apr 2019]

About


No new digest content identified.
EDCTP    [to 20 Apr 2019]
http://www.edctp.org/
The European & Developing Countries Clinical Trials Partnership (EDCTP) aims to accelerate the development of new or improved drugs, vaccines, microbicides and diagnostics against HIV/AIDS, tuberculosis and malaria as well as other poverty-related and neglected infectious diseases in sub-Saharan Africa, with a focus on phase II and III clinical trials
Latest news
15 April 2019
WANECAM consortium kicks off clinical study for next-generation antimalarial drug
The West African Network for Clinical Trials of Antimalarial Drugs (WANECAM), a consortium of ten academic organisations in Africa and Europe, starts off the ‘WANECAM 2’ study in Bamako, Mali with a meeting on 15 April 2019. EDCTP invests EUR 10 million in the project. WANECAM will conduct clinical trials of a novel antimalarial combination comprising KAF156 (ganaplacide) and lumefantrine in a new once-daily formulation. The project is led by Professor Abdoulaye Djimdé of the Université des Sciences, Techniques et Technologies de Bamako…The above message is based on the consortium press release (PDF)…
 
 
Emory Vaccine Center [to 20 Apr 2019]
http://www.vaccines.emory.edu/
No new digest content identified.
 
 
European Medicines Agency [to 20 Apr 2019]
http://www.ema.europa.eu/ema/
News and press releases
No new digest content identified.
 
 
European Vaccine Initiative [to 20 Apr 2019]
http://www.euvaccine.eu/news-events
Latest news
No new digest content identified.
 
 
FDA [to 20 Apr 2019]
https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/default.htm
No new digest content identified.
 
 
Fondation Merieux [to 20 Apr 2019]

Accueil


No new digest content identified.
 
 
Gavi [to 20 Apr 2019]
https://www.gavi.org/
Latest News
Challenging impossible: eight game-changing approaches to vaccination
17 April 2019
Making sure that vaccines reach as many children as possible around the world requires a healthy dose of innovation. For World Immunization Week 2019, we are showcasing a series of innovations – from cutting-edge to low-tech – that further our mission to create equal access to new and underused vaccines for children living in the world’s poorest countries.
 
 
GHIT Fund [to 20 Apr 2019]
https://www.ghitfund.org/newsroom/press
GHIT was set up in 2012 with the aim of developing new tools to tackle infectious diseases that devastate the world’s poorest people. Other funders include six Japanese pharmaceutical
No new digest content identified.

Global Fund [to 20 Apr 2019]
https://www.theglobalfund.org/en/news/
News
No new digest content identified.

Hilleman Laboratories [to 20 Apr 2019]
http://www.hillemanlabs.org/
No new digest content identified.

Human Vaccines Project [to 20 Apr 2019]

Press Releases


No new digest content identified.

IAVI [to 20 Apr 2019]
https://www.iavi.org/newsroom
No new digest content identified.

IFFIm
http://www.iffim.org/library/news/press-releases/
09 April 2019
IFFIm issues sukuk to the Islamic Development Bank
Private transaction raised US$ 50 million for immunisation.
 
 
IFRC   [to 20 Apr 2019]
http://media.ifrc.org/ifrc/news/press-releases/
Selected Press Releases, Announcements
Syria: Heaviest flooding in decade worsens humanitarian crisis in Al Hasakeh region
Damascus/Beirut/Geneva, 17 April 2019 – Heavy rains have caused the worst flooding in a decade across Syria’s Al Hasakeh region, where 118,000 people are facing near complete destruction of their homes and livelihoods. The majority of the affected popu …
17 April 2019
 
 
Iran
Iran floods: Two million people in need of humanitarian aid
Tehran/Geneva, 15 April 2019 – An estimated 2 million people – one in every 40 people in Iran – need humanitarian assistance as a result of the massive floods that have swept across the country. Heavy rains and flash floods have affected more than 2,00 …
15 April 2019
 
 
Mozambique
Mozambique Cyclone: Signs of recovery, but long road still ahead
Beira/Nairobi/Geneva, 14 April 2019 – One month after the worst disaster in Mozambique’s recent history, signs of recovery are beginning to emerge as people return home and as the deadly cholera outbreak appears to be starting to abate. However, hundre …
14 April 2019
 
 
IVAC  [to 20 Apr 2019]
https://www.jhsph.edu/research/centers-and-institutes/ivac/index.html
No new digest content identified.
 
 
IVI   [to 20 Apr 2019]
http://www.ivi.int/
IVI News & Announcements
[Undated]
IVI-led CAPTURA consortium wins Fleming Fund award for work on antimicrobial resistance (AMR) data across Asia
SEOUL, South Korea — An international consortium, led by the International Vaccine Institute (IVI), has received funding from the UK’s Fleming Fund Regional Grants to conduct the Capturing Data on Antimicrobial Resistance (AMR) Patterns and Trends in Use in Regions of Asia (CAPTURA) project. The CAPTURA consortium also includes the Public Health Surveillance Group (PHSG), the Brigham and Women’s Hospital, and the University of Oxford’s Big Data Institute (BDI)…
 
 
JEE Alliance  [to 20 Apr 2019]
https://www.jeealliance.org/
Selected News and Events
Strategic Partnership for International Health Regulations (2005) and Health Security
19.4.2019
The implementation of the International Health Regulations (2005) Monitoring and Evaluation Framework will draw on WHO’s convening role to facilitate strategic cooperation and generate
 
 
MSF/Médecins Sans Frontières  [to 20 Apr 2019]
http://www.msf.org/
Selected News; Project Updates, Reports [as presented on website]
DRC Ebola outbreaks
Crisis update – April 2019
Crisis Update 18 Apr 2019
 
 
Ethiopia
Alarming rates of malnutrition among displaced people in sout…
Press Release 17 Apr 2019
 
 
Libya
Detained refugees trapped, Libyan families flee, as fighting worsens in Tripoli
Project Update 17 Apr 2019
 
 
Cyclone Idai & Southern Africa flooding
MSF emergency response to Cyclone Idai and flooding
Crisis Update 17 Apr 2019
 
 
Colombia
Assisting Venezuelan migrants in Colombia
Project Update 17 Apr 2019
 
 
South Sudan
There’s a lot to be done to address the uncountable health needs
Voices from the Field 16 Apr 2019
 
 
NIH  [to 20 Apr 2019]
http://www.nih.gov/news-events/news-releases
April 18, 2019
NIH funds study in four states to reduce opioid related deaths by 40 percent over three years
— Findings to serve as a blueprint for communities nationwide
 
 
Decline in measles vaccination is causing a preventable global resurgence of the disease
April 18, 2019 — Decline in measles vaccination is causing a preventable global resurgence of the disease
[See Milestones/Perspectives above for details]
 
 
In rare cases, immune system fails despite HIV suppression
April 18, 2019 — NIH scientists identify paradoxical response to HIV medication in five individuals
 
 
Novel antibody may suppress HIV for up to four months
April 17, 2019 — NIH researchers, international collaborators report results of small, open-label study
 
 
Gene therapy restores immunity in infants with rare immunodeficiency disease
April 17, 2019 — NIH scientists and funding contributed to development of experimental treatment
 
 
PATH  [to 20 Apr 2019]
https://www.path.org/media-center/
No new digest content identified.
 
 
Sabin Vaccine Institute  [to 20 Apr 2019]
http://www.sabin.org/updates/pressreleases
No new digest content identified.
 
 
UNAIDS [to 20 Apr 2019]
http://www.unaids.org/en
Selected Press Releases/Reports/Statements
18 April 2019
Cyclone Idai flood survivors ‘just want to go home’
 
 
16 April 2019
Côte d’Ivoire signals renewed will to tackle issue of user fees for HIV services
 
 
15 April 2019
Urgent action needed to address HIV in Haut Mbomou, Central African Republic
 
 
15 April 2019
Parental consent is required in the majority of countries worldwide
 
 
UNICEF  [to 20 Apr 2019]
https://www.unicef.org/media/press-releases
Selected Statements, Press Releases, Reports
Statement
Children’s lives and well-being in danger as fighting intensifies in Tripoli, Libya
Joint statement by Henrietta Fore, UNICEF Executive Director, and Virginia Gamba, Special Representative of the Secretary-General for Children and Armed Conflict
18/04/2019
 
 
Press release
Cyclone Idai: Education at risk for more than 305,000 children in Mozambique – UNICEF
More than 3,400 classrooms damaged or destroyed in storm
18/04/2019
 
 
Press release
UNICEF launches #VaccinesWork campaign to inspire support for vaccines
Amid growing outbreaks of vaccine-preventable diseases, UNICEF’s campaign will use social media to show that most parents trust vaccines to protect their children
17/04/2019
[See Milestones/Perspectives above for details]
 
 
Press release
6,000 children reunited with families after years of separation in South Sudan
17/04/2019
 
 
Vaccine Confidence Project  [to 20 Apr 2019]
http://www.vaccineconfidence.org/
No new digest content identified.
 
 
Vaccine Education Center – Children’s Hospital of Philadelphia  [to 20 Apr 2019]
http://www.chop.edu/centers-programs/vaccine-education-center
No new digest content identified.
 
 
Wellcome Trust  [to 20 Apr 2019]
https://wellcome.ac.uk/news
News | 17 April 2019
Four ways we’re working with DFID to thwart epidemics
To prevent future epidemics and improve the response to ones that are already happening, there needs to be evidence, knowledge and the right tools. To help provide these, Wellcome is working with the UK Department for International Development (DFID) in a five-year initiative.
 
 
The Wistar Institute   [to 20 Apr 2019]
https://www.wistar.org/news/press-releases
 
 
Press Release
Apr. 17, 2019
Identification of a Critical Regulator of Immune Suppressive Cells Reveals a Novel Target for Cancer Immunotherapy
Pharmacological block of the FATP2 protein selectively inhibits myeloid-derived suppressor cells and shows antitumor effects in preclinical models.
 
 
Press Release
Apr. 18, 2019
Innovative Synthetic DNA-based Cancer Immunotherapy Approach Shows Tumor-clearing Ability in Preclinical Models
PHILADELPHIA — (April 18, 2019) — Wistar scientists have developed a novel synthetic DNA approach for patient-specific production of cancer-targeting molecules called bispecific T cell engagers. DNA-encoded bispecific T cell engagers (dBiTEs) designed against the HER2 protein were tested in preclinical models of ovarian cancer and induced tumor regression, demonstrating the potential of this novel approach for immunotherapy. Study results were published online in JCI Insights.
 
 
World Organisation for Animal Health (OIE)   [to 20 Apr 2019]
http://www.oie.int/en/for-the-media/press-releases/2019/
No new digest content identified.

 
BIO    [to 20 Apr 2019]
https://www.bio.org/insights/press-release
Apr 16 2019
Biotechnology Industry Takes Action To Diversify Leadership
The Biotechnology Innovation Organization (BIO) announced today the “Right Mix Matters” campaign to increase diversity and inclusion in the biotech industry. Following on its previously announced goals to increase gender, racial, ethnic and LGBTQ representation on biotech company boards, in C-suites and in functional leadership positions, BIO is providing specific tools to accelerate diversity and thereby advance an even more globally competitive industry.

DCVMN – Developing Country Vaccine Manufacturers Network [to 20 Apr 2019]
http://www.dcvmn.org/
No new digest content identified.

IFPMA [to 20 Apr 2019]

News Releases


No new digest content identified.

PhRMA [to 20 Apr 2019]
http://www.phrma.org/press-room
No new digest content identified.

Journal Watch

Journal Watch

   Vaccines and Global Health: The Week in Review continues its weekly scanning of key peer-reviewed journals to identify and cite articles, commentary and editorials, books reviews and other content supporting our focus on vaccine ethics and policy. Journal Watch is not intended to be exhaustive, but indicative of themes and issues the Center is actively tracking. We selectively provide full text of some editorial and comment articles that are specifically relevant to our work. Successful access to some of the links provided may require subscription or other access arrangement unique to the publisher.

If you would like to suggest other journal titles to include in this service, please contact David Curry at: david.r.curry@centerforvaccineethicsandpolicy.org

Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study

Annals of Internal Medicine
16 April 2019 Vol: 170, Issue 8
http://annals.org/aim/issue

Original Research |16 April 2019
Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study Free
Anders Hviid, DrMedSci; Jørgen Vinsløv Hansen, PhD; Morten Frisch, DrMedSci; Mads Melbye, DrMedSci
Abstract
Background:
The hypothesized link between the measles, mumps, rubella (MMR) vaccine and autism continues to cause concern and challenge vaccine uptake.
Objective:
To evaluate whether the MMR vaccine increases the risk for autism in children, subgroups of children, or time periods after vaccination.
Design:
Nationwide cohort study.
Setting:
Denmark.
Participants:
657 461 children born in Denmark from 1999 through 31 December 2010, with follow-up from 1 year of age and through 31 August 2013.
Measurements:
Danish population registries were used to link information on MMR vaccination, autism diagnoses, other childhood vaccines, sibling history of autism, and autism risk factors to children in the cohort. Survival analysis of the time to autism diagnosis with Cox proportional hazards regression was used to estimate hazard ratios of autism according to MMR vaccination status, with adjustment for age, birth year, sex, other childhood vaccines, sibling history of autism, and autism risk factors (based on a disease risk score).
Results:
During 5 025 754 person-years of follow-up, 6517 children were diagnosed with autism (incidence rate, 129.7 per 100 000 person-years). Comparing MMR-vaccinated with MMR-unvaccinated children yielded a fully adjusted autism hazard ratio of 0.93 (95% CI, 0.85 to 1.02). Similarly, no increased risk for autism after MMR vaccination was consistently observed in subgroups of children defined according to sibling history of autism, autism risk factors (based on a disease risk score) or other childhood vaccinations, or during specified time periods after vaccination.
Limitation:
No individual medical charts were reviewed.
Conclusion:
The study strongly supports that MMR vaccination does not increase the risk for autism, does not trigger autism in susceptible children, and is not associated with clustering of autism cases after vaccination. It adds to previous studies through significant additional statistical power and by addressing hypotheses of susceptible subgroups and clustering of cases.
Primary Funding Source:
Novo Nordisk Foundation and Danish Ministry of Health.
 

 

Development and Performance of a Checklist for Initial Triage After an Anthrax Mass Exposure Event

Annals of Internal Medicine
16 April 2019 Vol: 170, Issue 8
http://annals.org/aim/issue

Original Research |16 April 2019
Development and Performance of a Checklist for Initial Triage After an Anthrax Mass Exposure Event
Nathaniel Hupert, MD, MPH; Marissa Person, MSPH; Dan Hanfling, MD; Rita M. Traxler, MHS; William A. Bower, MD; Katherine Hendricks, MD, MPH&TM
Background:
Population exposure to Bacillus anthracis spores could cause mass casualties requiring complex medical care. Rapid identification of patients needing anthrax-specific therapies will improve patient outcomes and resource use.