Neonatal rotavirus vaccine (RV3-BB) immunogenicity and safety in a neonatal and infant administration schedule in Malawi: a randomised, double-blind, four-arm parallel group dose-ranging study

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Lancet Infectious Diseases
May 2022 Volume 22 Number 5 p563-742, e128-e158
https://www.thelancet.com/journals/laninf/issue/current

 

Neonatal rotavirus vaccine (RV3-BB) immunogenicity and safety in a neonatal and infant administration schedule in Malawi: a randomised, double-blind, four-arm parallel group dose-ranging study
Desiree Witte, et al.

Measuring the effects of COVID-19-related disruption on dengue transmission in southeast Asia and Latin America: a statistical modelling study

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Lancet Infectious Diseases
May 2022 Volume 22 Number 5 p563-742, e128-e158
https://www.thelancet.com/journals/laninf/issue/current

 

Measuring the effects of COVID-19-related disruption on dengue transmission in southeast Asia and Latin America: a statistical modelling study
Yuyang Chen, et al. on behalf of the CMMID COVID-19 Working Group
Open Access

Neonatal rotavirus vaccine (RV3-BB) immunogenicity and safety in a neonatal and infant administration schedule in Malawi: a randomised, double-blind, four-arm parallel group dose-ranging study

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Lancet Infectious Diseases
May 2022 Volume 22 Number 5 p563-742, e128-e158
https://www.thelancet.com/journals/laninf/issue/current

 

Neonatal rotavirus vaccine (RV3-BB) immunogenicity and safety in a neonatal and infant administration schedule in Malawi: a randomised, double-blind, four-arm parallel group dose-ranging study
Desiree Witte, et al.

Estimating the effect of vaccination on antimicrobial-resistant typhoid fever in 73 countries supported by Gavi: a mathematical modelling study

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Lancet Infectious Diseases
May 2022 Volume 22 Number 5 p563-742, e128-e158
https://www.thelancet.com/journals/laninf/issue/current

 

Estimating the effect of vaccination on antimicrobial-resistant typhoid fever in 73 countries supported by Gavi: a mathematical modelling study
Ruthie Birger, et al.

Using big data and mobile health to manage diarrhoeal disease in children in low-income and middle-income countries: societal barriers and ethical implications

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Lancet Infectious Diseases
May 2022 Volume 22 Number 5 p563-742, e128-e158
https://www.thelancet.com/journals/laninf/issue/current

 

Series
Combating Childhood Infections in LMICs: Evaluating the Contribution of Big Data
Using big data and mobile health to manage diarrhoeal disease in children in low-income and middle-income countries: societal barriers and ethical implications
Karen H Keddy, et al.

Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial

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Lancet Respiratory Medicine
May 2022 Volume 10 Number 5 p421-524, e44-e50
https://www.thelancet.com/journals/lanres/issue/current

 

Articles
Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial
Stefan Andreas,et al. on behalf of the NTHi-Mcat-002 study group

Drug delivery systems for RNA therapeutics

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Nature Reviews Genetics
Volume 23 Issue 5, May 2022
https://www.nature.com/nrg/volumes/23/issues/5

 

Review Article | 04 January 2022
Drug delivery systems for RNA therapeutics
RNA therapies can be used to manipulate gene expression or produce therapeutic proteins. Here, the authors describe the growing number of RNA therapies and their molecular mechanisms of action. They also discuss the path from preclinical drug delivery research to clinical approval of these drugs.
Kalina Paunovska, David Loughrey, James E. Dahlman

Computational analysis of cancer genome sequencing data

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Nature Reviews Genetics
Volume 23 Issue 5, May 2022
https://www.nature.com/nrg/volumes/23/issues/5

 

Review Article | 08 December 2021
Computational analysis of cancer genome sequencing data
In this Review the authors provide an overview of key algorithmic developments, popular tools and emerging technologies used in the bioinformatic analysis of genomes. They also describe how such analysis can identify point mutations, copy number alterations, structural variations and mutational signatures in cancer genomes.
Isidro Cortés-Ciriano, Doga C. Gulhan, Peter J. Park

Estimating disease severity of Omicron and Delta SARS-CoV-2 infections

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Nature Reviews Immunology
Volume 22 Issue 5, May 2022
https://www.nature.com/nri/volumes/22/issues/5

 

Comment | 12 April 2022
Estimating disease severity of Omicron and Delta SARS-CoV-2 infections
The Omicron variant of SARS-CoV-2 has been reported to cause milder disease in adults but lead to increased hospital admissions in children. How can we compare disease severity in Omicron and Delta infections, and how should differences be interpreted?
Alex Sigal, Ron Milo, Waasila Jassat

SARS-CoV-2 infection and COVID-19 vaccination in pregnancy

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Nature Reviews Immunology
Volume 22 Issue 5, May 2022
https://www.nature.com/nri/volumes/22/issues/5

 

Progress | 18 March 2022
SARS-CoV-2 infection and COVID-19 vaccination in pregnancy
In this Progress article, Male summarizes our current understanding of the risks associated with SARS-CoV-2 infection in pregnancy. Importantly, the article highlights the now substantial body of evidence supporting the safety and efficacy of COVID-19 vaccination in pregnancy.
Victoria Male

Research on rare diseases: ten years of progress and challenges at IRDiRC

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Nature Reviews Drug Discovery
Volume 21 Issue 5, May 2022
https://www.nature.com/nrd/volumes/21/issues/5

 

Comment | 25 January 2022
Research on rare diseases: ten years of progress and challenges at IRDiRC
The International Rare Diseases Research Consortium (IRDiRC) is a global collaborative initiative launched in 2011, aimed at tackling rare diseases through research. Here, we summarize IRDiRC’s vision and goals and highlight achievements and prospects after its first decade.
Lucia Monaco, Galliano Zanello, David A. Pearce

Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

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Nature Reviews Drug Discovery
Volume 21 Issue 5, May 2022
https://www.nature.com/nrd/volumes/21/issues/5

 

Review Article | 16 March 2022
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
Natural products derived from bacteria are an important source of potential new drug compounds, such as antibiotics and anticancer agents, but how to efficiently mine this resource remains a challenge. In their Review, Hemmerling and Piel discuss newly developed computational tools and strategies to access biosynthetic novelty in bacterial genomes. They consider the opportunities and challenges associated with different bacterial sources, including cultivated, ecology-based and previously untapped bacterial ‘dark matter’.
Franziska Hemmerling, Jörn Piel

Combining rapid diagnostic tests to estimate primary and post-primary dengue immune status at the point of care

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PLoS Neglected Tropical Diseases
http://www.plosntds.org/
(Accessed 07 May 2022)

 

Combining rapid diagnostic tests to estimate primary and post-primary dengue immune status at the point of care
Joseph R. Biggs, Ava Kristy Sy, James Ashall, Marsha S. Santoso, Oliver J. Brady, Mary Anne Joy Reyes, Mary Ann Quinones, William Jones-Warner, Amadou O. Tandoc, Nemia L. Sucaldito, Huynh Kim Mai, Le Thuy Lien, Hung Do Thai, Hien Anh Thi Nguyen, Dang Duc Anh, Chihiro Iwasaki, Noriko Kitamura, Marnix Van Loock, Guillermo Herrera-Taracena, Joris Menten, Freya Rasschaert, Liesbeth Van Wesenbeeck, Sri Masyeni, Sotianingsih Haryanto, Benediktus Yohan, Eva Cutiongco-de la Paz, Lay-Myint Yoshida, Stephane Hue, Maria Rosario Z. Capeding, Carmencita D. Padilla, R. Tedjo Sasmono, Julius Clemence R. Hafalla, Martin L. Hibberd
Research Article | published 04 May 2022 PLOS Neglected Tropical Diseases
https://doi.org/10.1371/journal.pntd.0010365

Which vaccine attributes foster vaccine uptake? A cross-country conjoint experiment

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PLoS One
http://www.plosone.org/
[Accessed 07 May 2022]

 

Which vaccine attributes foster vaccine uptake? A cross-country conjoint experiment
Sabrina Stöckli, Anna Katharina Spälti, Joseph Phillips, Florian Stoeckel, Matthew Barnfield, Jack Thompson, Benjamin Lyons, Vittorio Mérola, Paula Szewach, Jason Reifler
Research Article | published 04 May 2022 PLOS ONE
https://doi.org/10.1371/journal.pone.0266003

A qualitative study of COVID-19 vaccine intentions and mistrust in Black Americans: Recommendations for vaccine dissemination and uptake

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PLoS One
http://www.plosone.org/
[Accessed 07 May 2022]

 

A qualitative study of COVID-19 vaccine intentions and mistrust in Black Americans: Recommendations for vaccine dissemination and uptake
Lu Dong, Laura M. Bogart, Priya Gandhi, James B. Aboagye, Samantha Ryan, Rosette Serwanga, Bisola O. Ojikutu
Research Article | published 03 May 2022 PLOS ONE
https://doi.org/10.1371/journal.pone.0268020

The perceived effectiveness and hidden inequity of postpandemic fiscal stimuli

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PNAS – Proceedings of the National Academy of Sciences of the United States
May 3, 2022 vol. 119 no. 18
https://www.pnas.org/toc/pnas/119/18

 

Sustainability Science
Research Article April 25, 2022 Dataset Open Access
The perceived effectiveness and hidden inequity of postpandemic fiscal stimuli
The world has committed trillions in fiscal expenditures to reboot the economy in the post–COVID-19 era. However, the effectiveness and the equity impacts of current fiscal stimuli are not fully understood. Using an extended adaptive regional input–output …
Yaxin Zhang, Xinzhu Zheng, […]Can Wang

Factors that differentiate COVID-19 vaccine intentions among Indiana parents: Implications for targeted vaccine promotion

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Preventive Medicine
Volume 158 May 2022
https://www.sciencedirect.com/journal/preventive-medicine/vol/158/suppl/C

 

Research article Full text access
Factors that differentiate COVID-19 vaccine intentions among Indiana parents: Implications for targeted vaccine promotion
Katharine J. Head, Gregory D. Zimet, Constantin T. Yiannoutsos, Ross D. Silverman, … Nir Menachemi
Article 107023

Missed routine pediatric care and vaccinations in US children during the first year of the COVID-19 pandemic

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Preventive Medicine
Volume 158 May 2022
https://www.sciencedirect.com/journal/preventive-medicine/vol/158/suppl/C

 

Research article Full text access
Missed routine pediatric care and vaccinations in US children during the first year of the COVID-19 pandemic
Chloe A. Teasdale, Luisa N. Borrell, Yanhan Shen, Spencer Kimball, … Denis Nash
Article 107025

The Impact of COVID-19 Pandemic Lockdown on Routine Immunization in the Province of Laghman, Afghanistan

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Risk Management and Healthcare Policy
https://www.dovepress.com/risk-management-and-healthcare-policy-archive56
[Accessed 07 May 2022]

 

Original Research
The Impact of COVID-19 Pandemic Lockdown on Routine Immunization in the Province of Laghman, Afghanistan
Abid Z, Castro Delgado R, Cernuda Martinez JA, Arcos González P
Risk Management and Healthcare Policy 2022, 15:901-908
Published Date: 5 May 2022

Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa

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Science
Volume 376| Issue 6593| 6 May 2022
https://www.science.org/toc/science/current

 

Research Articles
Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa
BY Juliet R. C. Pulliam, et al.
06 May 2022
Open Access
Analysis of routine surveillance data from South Africa indicates that the Omicron variant of SARS-CoV-2 evades immunity from prior infection.

Standards of Conducts for Biostatisticians and Stem Cell Researchers: A Call for Self-formulated Aspirational Ethics Over Built-in Prohibitive Ethics

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Science and Engineering Ethics
Volume 28, issue 2, April 2022
https://link.springer.com/journal/11948/volumes-and-issues/28-2

 

Original Research/Scholarship – Open Access
Standards of Conducts for Biostatisticians and Stem Cell Researchers: A Call for Self-formulated Aspirational Ethics Over Built-in Prohibitive Ethics
Keiko Sato & Mika Suzuki
Published: 17 March 2022
Abstract
We proposed the Standards of Conducts to provide a general framework that will serve as the basis for guiding each biostatistician and stem cell researcher to formulate their personal standards, rather than as rules with which they are required to comply. Given the responsibility and characteristics of their work, they are expected to maintain independence and work autonomously as professionals. Each of the Standards of Conducts comprises a preamble, mission and values to uphold, Standards of Conducts (10 items), and background. When one internalizes “self-formulated” standards, to make excuses for oneself would be akin to a self-betrayal; responsible actions can be anticipated. If one begins and continues to consider “who I am and what do I work for,” this will become their inner energy, and a source of motivation and pride to inspire oneself. In addition, this aspirational style might help citizens to recognize the autonomous stance of the professional body and that they share the same values.

SIRVA (Shoulder Injury Related to Vaccine Administration) following mRNA COVID-19 Vaccination: Case discussion and literature review

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Vaccine
Volume 40, Issue 18 Pages 2525-2646 (20 April 2022)
https://www.sciencedirect.com/journal/vaccine/vol/40/issue/18

 

Review article Full text access
SIRVA (Shoulder Injury Related to Vaccine Administration) following mRNA COVID-19 Vaccination: Case discussion and literature review
Wen Loong Paul Yuen, Sir Young James Loh, Dehao Bryan Wang
Pages 2546-2550

Vaccine events raising public concern and associated immunization program policy and practice changes, China, 2005–2021

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Vaccine
Volume 40, Issue 18 Pages 2525-2646 (20 April 2022)
https://www.sciencedirect.com/journal/vaccine/vol/40/issue/18

 

Research article Abstract only
Vaccine events raising public concern and associated immunization program policy and practice changes, China, 2005–2021
Xiaoxue Liu, Wenzhou Yu, Zundong Yin, Lance Rodewald, … Lingsheng Cao
Pages 2561-2567

Healthcare worker perspectives on COVID-19 vaccines: Implications for increasing vaccine acceptance among healthcare workers and patients

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Vaccine
Volume 40, Issue 18 Pages 2525-2646 (20 April 2022)
https://www.sciencedirect.com/journal/vaccine/vol/40/issue/18

 

Research article Full text access
Healthcare worker perspectives on COVID-19 vaccines: Implications for increasing vaccine acceptance among healthcare workers and patients
Christine M. Thomas, Kelly Searle, Alma Galván, Amy K. Liebman, … William M. Stauffer
Pages 2612-2618

Efficacy and safety of a quadrivalent influenza vaccine in children aged 6–35 months: A global, multiseasonal, controlled, randomized Phase III study

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Vaccine
Volume 40, Issue 18 Pages 2525-2646 (20 April 2022)
https://www.sciencedirect.com/journal/vaccine/vol/40/issue/18

 

Research article Open access
Efficacy and safety of a quadrivalent influenza vaccine in children aged 6–35 months: A global, multiseasonal, controlled, randomized Phase III study
Susanna Esposito, Jos Nauta, Giulia Lapini, Emanuele Montomoli, Serge van de Witte
Pages 2626-2634

Pre-Print Servers

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Pre-Print Servers

 

Gates Open Research
https://gatesopenresearch.org/browse/articles

Research Article metrics
Revised
The impact of surveillance and other factors on detection of emergent and circulating vaccine derived polioviruses [version 2; peer review: 2 approved, 1 approved with reservations]
Megan Auzenbergs, Holly Fountain, Grace Macklin, Hil Lyons, Kathleen M O’Reilly
Peer Reviewers Yvonne Maldonado; Walter A. Orenstein; Svea Closser
Funder
Bill and Melinda Gates Foundation
LATEST VERSION PUBLISHED 05 May 2022

Research Article metrics AWAITING PEER REVIEW
Sexual and reproductive health and rights knowledge, perceptions, and experiences of adolescent learners from three South African townships: qualitative findings from the Girls Achieve Power (GAP Year) Trial [version 1; peer review: awaiting peer review]
Melanie Pleaner, Cecilia Milford, Alison Kutywayo, Nicolette Naidoo, Saiqa Mullick
Peer Reviewers Invited
Funder
Bill and Melinda Gates Foundation
PUBLISHED 03 May 2022

 

medRxiv
https://www.medrxiv.org/content/about-medrxiv
medRxiv is a free online archive and distribution server for complete but unpublished manuscripts (preprints) in the medical, clinical, and related health sciences. Preprints are preliminary reports of work that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information. medRxiv is for the distribution of preprints – complete but unpublished manuscripts – that describe human health research conducted, analyzed, and interpreted according to scientific principles…

Estimates of excess mortality for the five Nordic countries during the Covid-19 pandemic 2020-2021
Kasper Planeta Kepp, Jonas Planeta Bjork, Kristoffer T Baek, Tea Lallukka
medRxiv 2022.05.07.22274789; doi: https://doi.org/10.1101/2022.05.07.22274789

Assessing the feasibility of sustaining a ‘Zero-COVID’ policy in China in the era of highly transmissible variants
Yan Wang, Kaiyuan Sun, Zhaomin Feng, Lan Yi, Yanpeng Wu, Hengcong Liu, Quanyi Wang, Marco Ajelli, Cecile Viboud, Hongjie Yu
medRxiv 2022.05.07.22274792; doi: https://doi.org/10.1101/2022.05.07.22274792

Comparing human and AI performance in medical machine learning: An open-source Python library for the statistical analysis of reader study data
Scott Mayer McKinney
medRxiv 2022.05.06.22274773; doi: https://doi.org/10.1101/2022.05.06.22274773

Reporting Rates for VAERS Death Reports Following COVID-19 Vaccination, December 14, 2020-November 17, 2021
Brendan Day, David Menschik, Deborah Thompson, Christopher Jankosky, John Su, Pedro Moro, Craig Zinderman, Kerry Welsh, Narayan Nair
medRxiv 2022.05.05.22274695; doi: https://doi.org/10.1101/2022.05.05.22274695

School immunization coverage during the COVID-19 pandemic: A retrospective cohort study
Hannah Sell, Yuba Raj Paudel, Donald Voaklander, Shannon E MacDonald
medRxiv 2022.05.04.22274665; doi: https://doi.org/10.1101/2022.05.04.22274665

Deep learning identified genetic variants associated with COVID-19 related mortality
Zihuan Liu, Wei Dai, Shiying Wang, Yisha Yao, Heping Zhang
medRxiv 2022.05.05.22274731; doi: https://doi.org/10.1101/2022.05.05.22274731

A quasi-experimental cohort study evaluating a conditional economic incentive on first-dose COVID-19 vaccination rates among older adults in South Africa
Candice Maylene Chetty-Makkan, Harsha Thirumurthy, Elizabeth F Bair, Simamkele Bokolo, Candy Day, Korstiaan Wapenaar, Jesse Werner, Lawrence Long, Brendan Maughan-Brown, Sophie J S Pascoe, Jacqui Miot, Alison Buttenheim
medRxiv 2022.05.06.22274712; doi: https://doi.org/10.1101/2022.05.06.22274712

COVID-19 vaccine effectiveness during a prison outbreak when the Omicron was the dominant circulating variant, Zambia, December 2021
John Simwanza, Jonas Z. Hines, Danny Sinyange, Nyambe Sinyange, Chilufya Mulenga, Sarah Hanyinza, Patrick Sakubita, Nelia Langa, Haggai Nowa, Priscilla Gardner, Ngonda Saasa, Gabriel Chipeta, James Simpungwe, Warren Malambo, Busiku Hamainza, Nathan Kapata, Muzala Kapina, Kunda Musonda, Mazyanga Liwewe, Consity Mwale, Sombo Fwoloshi, Lloyd B. Mulenga, Simon Agolory, Victor Mukonka, Roma Chilengi
medRxiv 2022.05.06.22274701; doi: https://doi.org/10.1101/2022.05.06.22274701

Covid-19 vaccine effectiveness against general SARS-CoV-2 infection from the omicron variant: A retrospective cohort study
Lior Rennert, Zichen Ma, Christopher McMahan, Delphine Dean
medRxiv 2022.05.06.22274771; doi: https://doi.org/10.1101/2022.05.06.22274771

Covid-19 vaccine effectiveness against general SARS-CoV-2 infection from the omicron variant: A retrospective cohort study
Lior Rennert, Zichen Ma, Christopher McMahan, Delphine Dean
medRxiv 2022.05.06.22274771; doi: https://doi.org/10.1101/2022.05.06.22274771

Uganda Genome Resource: A rich research database for genomic studies of communicable and non-communicable diseases in Africa
Segun Fatumo, Joseph Mugisha, Opeyemi Soremekun, Allan Kalungi, Richard Mayanja, Christopher Kintu, Ronald Makanga, Ayoub Kakande, Andrew Abaasa, Gershim Asiki, Robert Kalyesubula, Robert Newton, Moffat Nyirenda, Manjinder S Sandhu, Pontiano Kaleebu
medRxiv 2022.05.05.22274740; doi: https://doi.org/10.1101/2022.05.05.22274740

The spread and burden of the COVID-19 pandemic in sub-Saharan Africa: comparison between predictions and actual data and lessons learned
Christophe Dongmo Fokoua-Maxime, Yahia Bellouche, Dillonne Ngonpong Tchigui-Ariolle, Tchana Loic Tchato-Yann, Simeon Pierre Choukem
medRxiv 2022.05.04.22274692; doi: https://doi.org/10.1101/2022.05.04.22274692

Antibody responses to AZD1222 vaccination in West Africa
Adam Abdullahi, David Oladele, Steven A. Kemp, James Ayorinde, Abideen Salako, Fehintola Ige, Douglas Fink, Chika Onwuamah, Qosim Osuolale, Rufai Abubakar, Azuka Okuruawe, Gideon Liboro, Oluwatosin Odubela, Gregory Ohihoin, Oliver Ezechi, Olagoke Usman, Sunfay Mogaji, Adedamola Dada, Soraya Ebrahimi, Lourdes Ceron Gutierrez, Sani H. Aliyu, Rainer Doffinger, Rosemary Audu, Richard Adegbola, Petra Mlcochova, Babatunde Lawal Solako, Ravindra K. Gupta
medRxiv 2022.05.04.22274668; doi: https://doi.org/10.1101/2022.05.04.22274668

The cost and cost-effectiveness of novel tuberculosis vaccines in low- and middle-income countries: a modelling study
Allison Portnoy, Rebecca A. Clark, Matthew Quaife, Chathika K. Weerasuriya, Christinah Mukandavire, Roel Bakker, Arminder K. Deol, Shelly Malhotra, Nebiat Gebreselassie, Matteo Zignol, So Yoon Sim, Raymond C.W. Hutubessy, Inés Garcia Baena, Nobuyuki Nishikiori, Mark Jit, Richard G. White, Nicolas A. Menzies
medRxiv 2022.05.04.22274654; doi: https://doi.org/10.1101/2022.05.04.22274654

Analysis of immunization time, amplitude, and adverse events of seven different vaccines against SARS-CoV-2 across four different countries
Maria Elena Romero-Ibarguengoitia, Arnulfo González-Cantú, Chiara Pozzi, Riccardo Levi, Maximiliano Mollura, Riccardo Sarti, Miguel Angel Sanz-Sánchez, Diego Rivera-Salinas, Yodira Guadalupe Hernández-Ruíz, Ana Gabriela Armendariz-Vázquez, Gerardo Francisco Del Rio-Parra, Irene Antonieta Barco-Flores, Rosalinda González-Facio, Elena Azzolini, Riccardo Barbieri, Alessandro Rodrigo de Azevedo Dias, Milton Henriques-Guimaraes Júnior, Alessandra Bastos-Borges, Cecilia Acciardi, Graciela Paez-Bo, Mauro Martins Teixeira, Maria Rescigno
medRxiv 2022.03.11.22272153; doi: https://doi.org/10.1101/2022.03.11.22272153 Revision

Mondo: Unifying diseases for the world, by the world
Nicole A Vasilevsky, Nicolas A Matentzoglu, Sabrina Toro, Joseph E Flack IV, Harshad Hegde, Deepak R Unni, Gioconda F Alyea, Joanna S Amberger, Larry Babb, James P Balhoff, Taylor I Bingaman, Gully A Burns, Orion J Buske, Tiffany J Callahan, Leigh C Carmody, Paula Carrio Cordo, Lauren E Chan, George S Chang, Sean L Christiaens, Louise C Daugherty, Michel Dumontier, Laura E Failla, May J Flowers, H. Alpha Garrett Jr., Jennifer L Goldstein, Dylan Gration, Tudor Groza, Marc Hanauer, Nomi L Harris, Jason A Hilton, Daniel S Himmelstein, Charles Tapley Hoyt, Megan S Kane, Sebastian Köhler, David Lagorce, Abbe Lai, Martin Larralde, Antonia Lock, Irene López Santiago, Donna R Maglott, Adriana J Malheiro, Birgit H M Meldal, Monica C Munoz-Torres, Tristan H Nelson, Frank W Nicholas, David Ochoa, Daniel P Olson, Tudor I Oprea, David Osumi-Sutherland, Helen Parkinson, Zoë May Pendlington, Ana Rath, Heidi L Rehm, Lyubov Remennik, Erin R Riggs, Paola Roncaglia, Justyne E Ross, Marion F Shadbolt, Kent A Shefchek, Morgan N Similuk, Nicholas Sioutos, Damian Smedley, Rachel Sparks, Ray Stefancsik, Ralf Stephan, Andrea L Storm, Doron Stupp, Gregory S Stupp, Jagadish Chandrabose Sundaramurthi, Imke Tammen, Darin Tay, Courtney L Thaxton, Eloise Valasek, Jordi Valls-Margarit, Alex H Wagner, Danielle Welter, Patricia L Whetzel, Lori L Whiteman, Valerie Wood, Colleen H Xu, Andreas Zankl, Xingmin Aaron Zhang, Christopher G Chute, Peter N Robinson, Christopher J Mungall, Ada Hamosh, Melissa A Haendel
medRxiv 2022.04.13.22273750; doi: https://doi.org/10.1101/2022.04.13.22273750 Revision

Continued Emergence and Evolution of Omicron in South Africa: New BA.4 and BA.5 lineages
Houriiyah Tegally, Monika Moir, Josie Everatt, Marta Giovanetti, Cathrine Scheepers, Eduan Wilkinson, Kathleen Subramoney, Sikhulile Moyo, Daniel G. Amoako, Cheryl Baxter, Christian L. Althaus, Ugochukwu J. Anyaneji, Dikeledi Kekana, Raquel Viana, Jennifer Giandhari, Richard J. Lessells, Tongai Maponga, Dorcas Maruapula, Wonderful Choga, Mogomotsi Matshaba, Simnikiwe Mayaphi, Nokuzola Mbhele, Mpaphi B. Mbulawa, Nokukhanya Msomi, NGS-SA consortium, Yeshnee Naidoo, Sureshnee Pillay, Tomasz Janusz Sanko, James E. San, Lesley Scott, Lavanya Singh, Nonkululeko A. Magini, Pamela Smith-Lawrence, Wendy Stevens, Graeme Dor, Derek Tshiabuila, Nicole Wolter, Wolfgang Preiser, Florette K. Treurnicht, Marietjie Venter, Michaela Davids, Georginah Chiloane, Adriano Mendes, Caitlyn McIntyre, Aine O’Toole, Christopher Ruis, Thomas P. Peacock, Cornelius Roemer, Carolyn Williamson, Oliver G. Pybus, Jinal Bhiman, Allison Glass, Darren P. Martin, Andrew Rambaut, Simani Gaseitsiwe, Anne von Gottberg, Tulio de Oliveira
medRxiv 2022.05.01.22274406; doi: https://doi.org/10.1101/2022.05.01.22274406

Vaccine Stockpile Sharing For Selfish Objectives
Shashwat Shivam, Joshua S. Weitz, Yorai Wardi
medRxiv 2022.04.28.22274446; doi: https://doi.org/10.1101/2022.04.28.22274446

Wellcome Open Research [to 07 May 2022]
https://wellcomeopenresearch.org/browse/articles
[Accessed 07 May 2022]

Wellcome Open Research provides all Wellcome researchers with a place to rapidly publish any results they think are worth sharing. All articles benefit from rapid publication, transparent peer review and editorial guidance on making all source data openly available.

Research Note metrics AWAITING PEER REVIEW
A longitudinal analysis comparing the proportion of children with excess weight before and during the COVID-19 pandemic [version 1; peer review: awaiting peer review]
Gillian Santorelli, John Wright, Duncan Cooper, Laura Lennon, Sarah Muckle, Jane West
Peer Reviewers Invited
Funders
Economic and Social Research Council
British Heart Foundation
Wellcome
National Institute for Health Research
Medical Research Council
Prevention Research Partnership
NIHR Clinical Research Network
PUBLISHED 06 May 2022

Think Tanks

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Think Tanks
 
 
Brookings [to 07 May 2022]
http://www.brookings.edu/
Accessed 07 May 2022
Latest Research
Coronavirus (COVID-19)
Dismantling the ivory tower’s knowledge boundaries
Jacqueline N. Lane and Hila Lifshitz-Assaf
Tuesday, May 3, 2022
A call for open access as the new normal in the social sciences post-COVID

In response to the COVID-19 crisis, governments, policymakers, foundations, publishers, and researchers poured significant resources into scientific knowledge production on COVID-19 and its impacts while also expanding access to such research. The emphasis on the “open access” publishing model—a set of principles and practices through which research outputs are distributed online, free of cost and access barriers—was a boon to researchers studying the crisis and society in general, dismantling disciplinary and socio-economic boundaries within academia as well as boundaries between academia and the general public. By embracing the open access publishing model outside times of crisis, we could dismantle those boundaries permanently, leading to immeasurable benefits for society…
 
 
Center for Global Development [to 07 May 2022]
https://www.cgdev.org/
Research [Selected]
[No new digest content identified]
 
 
Chatham House [to 07 May 2022]
https://www.chathamhouse.org/
Accessed 07 May 2022
[No new digest content identified]
 
 
CSIS [to 07 May 2022]
https://www.csis.org/
Accessed 07 May 2022
Upcoming Event
An Exit Interview with Henrietta Fore, former Executive Director of UNICEF
May 10, 2022

 
 
Kaiser Family Foundation
https://www.kff.org/search/?post_type=press-release
Accessed 07 May 2022
May 4, 2022 News Release
1 in 5 Parents of Children Under 5 Intend to Get Them a COVID-19 Vaccine Right Away Once Eligible; Most Say Approval Delays Have Not Shaken Their Confidence in Vaccine’s Safety and Effectiveness
About a Third of the Public Thinks the Nation is Facing a New COVID-19 Wave as Cases Rise About a fifth (18%) of parents with children under age 5 say they intend to get their child vaccinated “right away” once federal regulators authorize its use for their child’s age group,…
 
 
ODI [Overseas Development Institute] [to 07 May 2022]
https://odi.org/en/publications/
Publications
Accessed 07 May 2022
[No new digest content identified]
 
 
Rand [to 07 May 2022]
https://www.rand.org/pubs.html
Reports, Selected Journal Articles
[No new digest content identified]
 
 
Urban Institute [to 07 May 2022]
https://www.urban.org/publications
Research Publications
Brief
The Pandemic’s Effects on Early Educators’ Employment and Well-Being
May 5, 2022

Vaccines and Global Health: The Week in Review :: 07 May 2022

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Vaccines and Global Health: The Week in Review is a weekly digest  summarizing news, events, announcements, peer-reviewed articles and research in the global vaccine ethics and policy space. Content is aggregated from key governmental, NGO, international organization and industry sources, key peer-reviewed journals, and other media channels. This summary proceeds from the broad base of themes and issues monitored by the Center for Vaccine Ethics & Policy in its work: it is not intended to be exhaustive in its coverage. You are viewing the blog version of our weekly digest, typically comprised of between 30 and 40 posts below all dated with the current issue date

.– Request an Email Summary: Vaccines and Global Health : The Week in Review is published as a single email summary, scheduled for release each Saturday evening before midnight (EDT in the U.S.). If you would like to receive the email version, please send your request to david.r.curry@centerforvaccineethicsandpolicy.org.

– pdf version:  A pdf of the current issue is available here:

vaccines-and-global-health_the-week-in-review_07-mayl-2022Download

– blog edition: comprised of the approx. 35+ entries posted below.

– Twitter:  Readers can also follow developments on twitter: @vaxethicspolicy.
.
– Links:  We endeavor to test each link as we incorporate it into any post, but recognize that some links may become “stale” as publications and websites reorganize content over time. We apologize in advance for any links that may not be operative. We believe the contextual information in a given post should allow retrieval, but please contact us as above for assistance if necessary.

Support this knowledge-sharing service: Your financial support helps us cover our costs and to address a current shortfall in our annual operating budget. Click here to donate and thank you in advance for your contribution.

.
David R. Curry, MS
Executive Director
Center for Vaccine Ethics and Policy

Vaccines and Global Health: The Week in Review :: 23 April 2022

Vaccines and Global Health: The Week in Review is a weekly digest  summarizing news, events, announcements, peer-reviewed articles and research in the global vaccine ethics and policy space. Content is aggregated from key governmental, NGO, international organization and industry sources, key peer-reviewed journals, and other media channels. This summary proceeds from the broad base of themes and issues monitored by the Center for Vaccine Ethics & Policy in its work: it is not intended to be exhaustive in its coverage. You are viewing the blog version of our weekly digest, typically comprised of between 30 and 40 posts below all dated with the current issue date

.– Request an Email Summary: Vaccines and Global Health : The Week in Review is published as a single email summary, scheduled for release each Saturday evening before midnight (EDT in the U.S.). If you would like to receive the email version, please send your request to david.r.curry@centerforvaccineethicsandpolicy.org.

– pdf version:  A pdf of the current issue is available here:

vaccines-and-global-health_the-week-in-review_23-april-2022_final-1Download

– blog edition: comprised of the approx. 35+ entries posted below.

– Twitter:  Readers can also follow developments on twitter: @vaxethicspolicy.
.
– Links:  We endeavor to test each link as we incorporate it into any post, but recognize that some links may become “stale” as publications and websites reorganize content over time. We apologize in advance for any links that may not be operative. We believe the contextual information in a given post should allow retrieval, but please contact us as above for assistance if necessary.

Support this knowledge-sharing service: Your financial support helps us cover our costs and to address a current shortfall in our annual operating budget. Click here to donate and thank you in advance for your contribution.

.
David R. Curry, MS
Executive Director
Center for Vaccine Ethics and Policy

Vaccines and Global Health: The Week in Review :: 30 April 2022

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Vaccines and Global Health: The Week in Review is a weekly digest  summarizing news, events, announcements, peer-reviewed articles and research in the global vaccine ethics and policy space. Content is aggregated from key governmental, NGO, international organization and industry sources, key peer-reviewed journals, and other media channels. This summary proceeds from the broad base of themes and issues monitored by the Center for Vaccine Ethics & Policy in its work: it is not intended to be exhaustive in its coverage. You are viewing the blog version of our weekly digest, typically comprised of between 30 and 40 posts below all dated with the current issue date

.– Request an Email Summary: Vaccines and Global Health : The Week in Review is published as a single email summary, scheduled for release each Saturday evening before midnight (EDT in the U.S.). If you would like to receive the email version, please send your request to david.r.curry@centerforvaccineethicsandpolicy.org.

– pdf version:  A pdf of the current issue is available here:

vaccines-and-global-health_the-week-in-review_30-april-2022-1Download

– blog edition: comprised of the approx. 35+ entries posted below.

– Twitter:  Readers can also follow developments on twitter: @vaxethicspolicy.
.
– Links:  We endeavor to test each link as we incorporate it into any post, but recognize that some links may become “stale” as publications and websites reorganize content over time. We apologize in advance for any links that may not be operative. We believe the contextual information in a given post should allow retrieval, but please contact us as above for assistance if necessary.

Support this knowledge-sharing service: Your financial support helps us cover our costs and to address a current shortfall in our annual operating budget. Click here to donate and thank you in advance for your contribution.

.
David R. Curry, MS
Executive Director
Center for Vaccine Ethics and Policy

Vaccines and Global Health: The Week in Review :: 23 April 2022

Vaccines and Global Health: The Week in Review is a weekly digest  summarizing news, events, announcements, peer-reviewed articles and research in the global vaccine ethics and policy space. Content is aggregated from key governmental, NGO, international organization and industry sources, key peer-reviewed journals, and other media channels. This summary proceeds from the broad base of themes and issues monitored by the Center for Vaccine Ethics & Policy in its work: it is not intended to be exhaustive in its coverage. You are viewing the blog version of our weekly digest, typically comprised of between 30 and 40 posts below all dated with the current issue date

.– Request an Email Summary: Vaccines and Global Health : The Week in Review is published as a single email summary, scheduled for release each Saturday evening before midnight (EDT in the U.S.). If you would like to receive the email version, please send your request to david.r.curry@centerforvaccineethicsandpolicy.org.

– pdf version:  A pdf of the current issue is available here:

vaccines-and-global-health_the-week-in-review_23-april-2022_final-1Download

– blog edition: comprised of the approx. 35+ entries posted below.

– Twitter:  Readers can also follow developments on twitter: @vaxethicspolicy.
.
– Links:  We endeavor to test each link as we incorporate it into any post, but recognize that some links may become “stale” as publications and websites reorganize content over time. We apologize in advance for any links that may not be operative. We believe the contextual information in a given post should allow retrieval, but please contact us as above for assistance if necessary.

Support this knowledge-sharing service: Your financial support helps us cover our costs and to address a current shortfall in our annual operating budget. Click here to donate and thank you in advance for your contribution.

.
David R. Curry, MS
Executive Director
Center for Vaccine Ethics and Policy

UNICEF and WHO warn of ‘perfect storm’ of conditions for measles outbreaks, affecting children

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Measles

UNICEF and WHO warn of ‘perfect storm’ of conditions for measles outbreaks, affecting children
Reported worldwide measles cases increased by 79 per cent in the first two months of 2022, compared to the same period in 2021, as WHO and UNICEF warn conditions ripe for serious outbreaks of vaccine-preventable illnesses

NEW YORK/ GENEVA, 27 April 2022 – An increase in measles cases in January and February 2022 is a worrying sign of a heightened risk for the spread of vaccine-preventable diseases and could trigger larger outbreaks, particularly of measles affecting millions of children in 2022, warn WHO and UNICEF.

 

Pandemic-related disruptions, increasing inequalities in access to vaccines, and the diversion of resources from routine immunization are leaving too many children without protection against measles and other vaccine-preventable diseases.

The risk for large outbreaks has increased as communities relax social distancing practices and other preventive measures for COVID-19 implemented during the height of the pandemic. In addition, with millions of people being displaced due to conflicts and crises including in Ukraine, Ethiopia, Somalia and Afghanistan, disruptions in routine immunization and COVID-19 vaccination services, lack of clean water and sanitation, and overcrowding increase the risk of vaccine-preventable disease outbreaks.

Almost 17,338 measles cases were reported worldwide in January and February 2022, compared to 9,665 during the first two months of 2021. As measles is very contagious, cases tend to show up quickly when vaccination levels decline. The agencies are concerned that outbreaks of measles could also forewarn outbreaks of other diseases that do not spread as rapidly…

 

In 2020, 23 million children missed out on basic childhood vaccines through routine health services, the highest number since 2009 and 3.7 million more than in 2019…

…As countries work to respond to outbreaks of measles and other vaccine-preventable diseases, and recover lost ground, UNICEF and WHO, along with partners such as Gavi, the Vaccine Alliance, the partners of the Measles & Rubella Initiative (M&RI), Bill & Melinda Gates Foundation, and others are supporting efforts to strengthen immunization systems by:
Restoring services and vaccination campaigns so countries can safely deliver routine immunization programmes to fill the gaps left by the backsliding;
Helping health workers and community leaders communicate actively with caregivers to explain the importance of vaccinations;
Rectifying gaps in immunization coverage, including identifying communities and people who have been missed during the pandemic;
Ensuring that COVID-19 vaccine delivery is independently financed and well-integrated into overall planning for immunization services so that it is not carried out at the cost of childhood and other vaccination services;
Implementing country plans to prevent and respond to outbreaks of vaccine-preventable diseases and strengthening immunization systems as part of COVID-19 recovery efforts.

1 in 4 children in Latin America and the Caribbean are exposed to diseases that can be prevented with vaccines

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PAHO

1 in 4 children in Latin America and the Caribbean are exposed to diseases that can be prevented with vaccines
PANAMÁ CITY, 25 April 2022 – In five years, the complete vaccination schedule for diphtheria, tetanus and pertussis (DTP3) in Latin America and the Caribbean has dropped from 90 percent in 2015 to 76 percent in 2020, according to data from the Pan American Health Organization (PAHO) and UNICEF. This means that one in four children in the region has not received the full routine vaccination schedule that would protect them from multiple diseases.

The decrease in vaccination coverage precedes the pandemic; but the cessation or irregular programming of many primary health care services during the pandemic and people’s fear of catching COVID19 during visits to health centers is leaving many children without vaccines.

“The decline in vaccination rates in the region is alarming and puts millions of children and adolescents at risk of dangerous diseases that could be prevented,” said Jean Gough, UNICEF Regional Director for Latin America and Caribbean. “The solution, and it has been proven to be effective: stronger vaccination programmes.”

 

The 14 percentage point drop in vaccine coverage leaves nearly 2.5 million children without the complete DTP vaccination schedule and they are at risk of dangerous preventable diseases. Of them, 1.5 million are “zero doses”: they have not even received the first dose of that vaccine.

Dangerous setback
The decrease in coverage exposes more children to the resurgence of preventable diseases and epidemiological outbreaks have already occurred. In example, while in 2013 only 5 people in the region got diphtheria, in 2018 almost 900 cases were registered, according to PAHO data. Measles sets higher alarms because it is caused by a highly contagious virus: in 2013 there were almost 500 cases; but in 2019, more than 23,000 people got the disease.

“As countries recover from the pandemic, immediate actions are needed to prevent coverage rates from further dropping, because the re-emergence of disease outbreaks poses a serious risk to all of society,” Gough said. “This is an opportunity to restructure primary health care and reinforce the comprehensive and community approach that bring vaccines to the most vulnerable populations. We cannot lose the efforts of past decades and let dangerous diseases threaten the lives of children.”

UNICEF calls on the governments of Latin America and the Caribbean to urgently re-establish and strengthen routine immunization programs, develop campaigns to increase vaccine confidence and implement plans to reach all children and adolescents and their families; especially to the most vulnerable who do not have access to health services, due to their geographic location, migratory status or ethnic identity.

Keynote Address: Breaking the Cycle of Neglect and Panic

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Keynote Address: Breaking the Cycle of Neglect and Panic
Date: April 27, 2022 Type: Speeches and Transcripts

We are meeting to discuss the issues of preparedness and response after more than two years of a global Pandemic. Although the situation has improved, we still need to be cautious given the case numbers in some countries and the low level of vaccination in some parts of the World.

The past two years have brought a lot of hardship: in terms lives lost, impacts on livelihoods and economic opportunities, and the impact on Human Capital through school closures and basic health services. This has further raised concerns about the state of preparedness of the world, and our collective ability to break the cycle of Panic and Neglect.

This is more urgent given what we know about the state of the world. In 2021, the Global Health Security Index showed the extent of the challenge with 70% of countries showed insufficient capacity to respond to health emergencies and deliver essential health services in clinics, hospitals, and community health centers. The pandemic revealed stark disparities in the capacity of countries to prevent and respond to COVID-19 bringing into sharp focus significant under-investments in pandemic preparedness which has amplified inequalities at all levels and highlighted the urgent need for collective action.

 

A recent Bank paper shows that most low- and middle-income countries are already facing tremendous fiscal pressures from the ongoing pandemic and will not be able to mobilize the huge sums necessary for investing in preparedness nor for strengthening their health systems.

To respond to these challenges the global community has shown a strong willingness to lean forward.

Indeed, the IDA20 replenishment, which was hosted by Japan, has culminated in a package which includes ambitious commitments to support countries to strengthen pandemic preparedness and response. The preparedness agenda is front and center of this IDA round.

The G20 and G7 have recently endorsed a new Financial Intermediary Fund (FIF) to strengthen preparedness and response. The FIF is meant to complement the current offerings and close remaining gaps in support of countries around the world.

Furthermore, there is broader and growing awareness of the One Health approach, which offers a framework to think about prevention and preparedness at country level. For instance, this is something that we are reflecting more and more in our World Bank portfolio through entry-points in the agriculture and environment sectors.

All of these efforts have to build on what we know works, and complement it in order to provide needed resources to countries who will have to address many gaps with limited fiscal space and competing needs. This requires collaboration and strong partnerships amongst all of us. No single actor or plan can do it alone.

This is where the Health Emergency Preparedness and Response Program is comes with its mission to catalyze, complement and connect. It has a critical role to play in the network of services and support we are building for our clients. I want here to thank Japan, Australia and Germany for their financing for and partnership in the HEPR program…

…Today’s session provides a valuable forum to delve deeper into the progress made through the HEPR Program funded efforts since the it was approved 18 months ago and the work ahead. It also affords an important opportunity to hear from leaders on the frontlines in countries and communities – essential voices from whom we must all learn as we chart the way forward.

Before I hand over to the team, I would like to leave with two thoughts:
:: First, we need to make strong analytical work at country and global levels a priority. Indeed, key indicators and analysis, as well as in depth work to understand country context will be important to guide policy and investments, but also raise the awareness on what is needed.
:: Second, although there is a momentum now around the agenda of preparedness, this can be sidelined very quickly by other emerging priorities. I count on all partners here to help make sure we maintain the push, and that we all advocate for preparedness to be streamlined throughout all aspects of the recovery.

I look forward to listening to our many partners and friends gathered here today for this event, from the Ministers of Health of Eswatini, Guyana, Togo, and partners from Japan, Australia, WHO and the Africa Center of Excellence for Genomics of Infectious Diseases.