Monthly Archives: April 2022

Ethical and practical considerations for cell and gene therapy toward an HIV cure: findings from a qualitative in-depth interview study in the United States

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BMC Medical Ethics
http://www.biomedcentral.com/bmcmedethics/content
(Accessed 09 Apr 2022)

 

Ethical and practical considerations for cell and gene therapy toward an HIV cure: findings from a qualitative in-depth interview study in the United States
HIV cure research involving cell and gene therapy has intensified in recent years. There is a growing need to identify ethical standards and safeguards to ensure cell and gene therapy (CGT) HIV cure research r…
Authors: Karine Dubé, John Kanazawa, Hursch Patel, Michael Louella, Laurie Sylla, Jeff Sheehy, Lynda Dee, Jeff Taylor, Jen Adair, Kim Anthony-Gonda, Boro Dropulić, John A. Sauceda, Michael J. Peluso, Steven G. Deeks and Jane Simoni
Citation: BMC Medical Ethics 2022 23:39
Content type: Research Published on: 9 April 2022

CoronaVac vaccine is effective in preventing symptomatic and severe COVID-19 in pregnant women in Brazil: a test-negative case-control study

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BMC Medicine
http://www.biomedcentral.com/bmcmed/content
(Accessed 09 Apr 2022)

 

CoronaVac vaccine is effective in preventing symptomatic and severe COVID-19 in pregnant women in Brazil: a test-negative case-control study
More doses of CoronaVac have been administered worldwide than any other COVID-19 vaccine. However, the effectiveness of COVID-19 inactivated vaccines in pregnant women is still unknown. We estimated the vaccin…
Authors: Enny S. Paixao, Kerry L. M. Wong, Flavia Jôse Oliveira Alves, Vinicius de Araújo Oliveira, Thiago Cerqueira-Silva, Juracy Bertoldo Júnior, Tales Mota Machado, Elzo Pereira Pinto Junior, Viviane S. Boaventura, Gerson O. Penna, Guilherme Loureiro Werneck, Laura C. Rodrigues, Neil Pearce, Mauricio L. Barreto and Manoel Barral-Netto
Citation: BMC Medicine 2022 20:146
Content type: Research article Published on: 5 April 2022

Global diversity of policy, coverage, and demand of COVID-19 vaccines: a descriptive study

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BMC Medicine
http://www.biomedcentral.com/bmcmed/content
(Accessed 09 Apr 2022)

 

Global diversity of policy, coverage, and demand of COVID-19 vaccines: a descriptive study
Hundreds of millions of doses of coronavirus disease 2019 (COVID-19) vaccines have been administered globally, but progress on vaccination varies considerably between countries. We aimed to provide an overall picture of COVID-19 vaccination campaigns, including policy, coverage, and demand of COVID-19 vaccines.
Authors: Zhiyuan Chen, Wen Zheng, Qianhui Wu, Xinghui Chen, Cheng Peng, Yuyang Tian, Ruijia Sun, Jiayi Dong, Minghan Wang, Xiaoyu Zhou, Zeyao Zhao, Guangjie Zhong, Xuemei Yan, Nuolan Liu, Feiran Hao, Sihong Zhao…
Citation: BMC Medicine 2022 20:130
Content type: Research article Published on: 4 April 2022

“Most of the cases are very similar.”: Documenting and corroborating conflict-related sexual violence affecting Rohingya refugees

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BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 09 Apr 2022)

 

“Most of the cases are very similar.”: Documenting and corroborating conflict-related sexual violence affecting Rohingya refugees
In August 2017, a large population of Rohingya from northern Rakhine state in Myanmar fled to Bangladesh due to “clearance operations” by the Myanmar security forces characterized by widespread and systematic …
Authors: Lindsey Green, Thomas McHale, Ranit Mishori, Linda Kaljee and Shahanoor Akter Chowdhury
Citation: BMC Public Health 2022 22:700
Content type: Research Published on: 9 April 2022

Factors associated with COVID-19 vaccine intent among Latino SNAP participants in Southern California

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BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 09 Apr 2022)

 

Factors associated with COVID-19 vaccine intent among Latino SNAP participants in Southern California
COVID-19 is significantly impacting the health and well-being of the country, particularly for ethnic minority populations and low-income groups. Our goal was to determine COVID-19 vaccination intent in a low-…
Authors: Vanessa P. Scott, Sarah Hiller-Venegas, Kate Edra, Joe Prickitt, Yesenia Esquivel, Blanca Melendrez and Kyung E. Rhee
Citation: BMC Public Health 2022 22:653
Content type: Research article Published on: 5 April 2022

Reimagining peer review as an expert elicitation process

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BMC Research Notes
http://www.biomedcentral.com/bmcresnotes/content
(Accessed 09 Apr 2022)

 

Reimagining peer review as an expert elicitation process
Journal peer review regulates the flow of ideas through an academic discipline and thus has the power to shape what a research community knows, actively investigates, and recommends to policymakers and the wid…
Authors: Alexandru Marcoci, Ans Vercammen, Martin Bush, Daniel G. Hamilton, Anca Hanea, Victoria Hemming, Bonnie C. Wintle, Mark Burgman and Fiona Fidler
Citation: BMC Research Notes 2022 15:127
Content type: Commentary Published on: 5 April 2022

Original research: Vaccination coverage among COVID-19 prevention and control management teams at primary healthcare facilities in China and their attitudes towards COVID-19 vaccine: a cross-sectional online survey

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BMJ Open
April 2022 – Volume 12 – 4
https://bmjopen.bmj.com/content/12/4

 

Original research: Vaccination coverage among COVID-19 prevention and control management teams at primary healthcare facilities in China and their attitudes towards COVID-19 vaccine: a cross-sectional online survey (7 April, 2022)
Yun-Yun Yan, Hai-Tang Wang, Teng-Yang Fan, Xian-Jin Sun, Zhao-Hui Du, Xiao-Ming Sun

Original research: Safety and immunogenicity of an inactivated virus particle vaccine for SARS-CoV-2, BIV1-CovIran: findings from double-blind, randomised, placebo-controlled, phase I and II clinical trials among healthy adults

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BMJ Open
April 2022 – Volume 12 – 4
https://bmjopen.bmj.com/content/12/4

 

Original research: Safety and immunogenicity of an inactivated virus particle vaccine for SARS-CoV-2, BIV1-CovIran: findings from double-blind, randomised, placebo-controlled, phase I and II clinical trials among healthy adults (8 April, 2022)
Minoo Mohraz, Mohammadreza Salehi, Payam Tabarsi, Mohsen Abbasi-Kangevari, Seyyed-Hadi Ghamari, Erfan Ghasemi, Maryam Amini Pouya, Negar Rezaei, Naser Ahmadi, Kazem Heidari, Mohammad-Reza Malekpour, Mojtaba Nasiri, Ali Akbar Amirzargar, Sahar Saeedi Moghaddam, Bagher Larijani, Hamed Hosseini

Global genomic surveillance strategy for pathogens with pandemic and epidemic potential 2022–2032

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Bulletin of the World Health Organization
Volume 100(4);  2022 Apr 1
https://www.ncbi.nlm.nih.gov/pmc/issues/404046/

 

Editorials
Global genomic surveillance strategy for pathogens with pandemic and epidemic potential 2022–2032
Lisa L Carter, M Anne Yu, Jilian A Sacks, Céline Barnadas, Dmitriy Pereyaslov, Sébastien Cognat, Sylvie Briand, Michael J Ryan, Gina Samaan
Bull World Health Organ. 2022 Apr 1; 100(4): 239–239A. Published online 2022 Apr 1. doi: 10.2471/BLT.22.288220
PMCID: PMC8958828

WHO recommendations for resilient health systems

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Bulletin of the World Health Organization
Volume 100(4);  2022 Apr 1
https://www.ncbi.nlm.nih.gov/pmc/issues/404046/

 

WHO recommendations for resilient health systems
Tedros Adhanom Ghebreyesus, Zsuzsanna Jakab, Michael J Ryan, Jaouad Mahjour, Suraya Dalil, Stella Chungong, Gerard Schmets, Geraldine Mcdarby, Redda Seifeldin, Sohel Saikat
Bull World Health Organ. 2022 Apr 1; 100(4): 240–240A. Published online 2022 Apr 1. doi: 10.2471/BLT.22.287843
PMCID: PMC8958831

Expansion of the measles and rubella laboratory network, India

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Bulletin of the World Health Organization
Volume 100(4);  2022 Apr 1
https://www.ncbi.nlm.nih.gov/pmc/issues/404046/

 

Research
Expansion of the measles and rubella laboratory network, India
Deepa Sharma, Lucky Sangal, Neetu Vijay, Uma Nalavade, Kaveri Krishnasamy, Shailesh Pawar, Harmanmeet Kaur, Jitendra Narayan, Sneha Rane, Manish Narkar, Ramesh Arumugam, Dhanagaran D, AP Sugunan, Anukumar Balakrishnan, Bestin Joseph, Jyotirmayee Turuk, Jyotsnamayee Sabat, Prakash Sahoo, Pradip Barde, Lalit Sahare, Mahendra Ukey, Manoj Kumar, Nikesh Sinha, Zulfiquar Ali Bhuttoo, Paluru Vijayachari, Punnam Chander, Shivangi Sharma, Venkatesha D, Gayathree L, Chethan Sharma, Pankaj Bhatnagar, Kristin VanderEnde, Nirmal Kaundal, Ratnesh Murugan, Pradeep Haldar, Deepak Gadkari, Neeraj Aggarwal, Nivedita Gupta
Bull World Health Organ. 2022 Apr 1; 100(4): 247–255. Published online 2022 Feb 3. doi: 10.2471/BLT.21.286999
PMCID: PMC8958835

Screening for Hepatitis B in partners and children of women positive for surface antigen, Burkina Faso

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Bulletin of the World Health Organization
Volume 100(4);  2022 Apr 1
https://www.ncbi.nlm.nih.gov/pmc/issues/404046/

 

Screening for Hepatitis B in partners and children of women positive for surface antigen, Burkina Faso
Alice Nanelin Guingané, Rémi Kaboré, Yusuke Shimakawa, Eric Nagaonlé Somé, Dramane Kania, Amandine Pisoni, Nicolas Nagot, Rachel King, Roger Sombié, Nicolas Meda, Philippe Van de Perre, Edouard Tuaillon
Bull World Health Organ. 2022 Apr 1; 100(4): 256–267. Published online 2022 Feb 22. doi: 10.2471/BLT.21.287015
PMCID: PMC8958837

Protecting noncommunicable disease prevention policy in trade and investment agreements

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Bulletin of the World Health Organization
Volume 100(4);  2022 Apr 1
https://www.ncbi.nlm.nih.gov/pmc/issues/404046/

 

Policy & Practice
Protecting noncommunicable disease prevention policy in trade and investment agreements
Anne Marie Thow, Amandine Garde, L Alan Winters, Ellen Johnson, Andi Mabhala, Paul Kingston, Pepita Barlow
Bull World Health Organ. 2022 Apr 1; 100(4): 268–275. Published online 2022 Feb 28. doi: 10.2471/BLT.21.287395
PMCID: PMC8958824

Therapeutic Innovations in Neuroscience

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Clinical Pharmacology & Therapeutics
Volume 111, Issue 4 Pages: 705-971 April 2022
https://ascpt.onlinelibrary.wiley.com/toc/15326535/current

 

Therapeutic Innovations in Neuroscience
The theme of this issue of Clinical Pharmacology & Therapeutics (CPT) encompasses neuroscience in the broad sense to include neurology and psychiatry, nonclinical and clinical aspects, novel clinical trial methodologies, and modeling and simulation approaches applicable to central nervous system (CNS) drug development and therapy. While naturally the last two years have been dominated by coronavirus disease 2019 (COVID-19), it is important not to forget that drug development for other indications has not been stopped, albeit many trials were affected in terms of delays in recruitment and collection of clinical data.

Gender-based violence experiences among Palestinian women during the COVID-19 pandemic: mental health professionals’ perceptions and concerns

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Conflict and Health
http://www.conflictandhealth.com/
[Accessed 09 Apr 2022]

 

Gender-based violence experiences among Palestinian women during the COVID-19 pandemic: mental health professionals’ perceptions and concerns
Authors: Fayez Mahamid, Guido Veronese and Dana Bdier
Content type: Research 4 April 2022

Science in times of war: oppose Russian aggression but support Russian scientists

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EMBO Reports
Volume 23 Issue 4 5 April 2022
https://www.embopress.org/toc/14693178/current

 

Opinion 15 March 2022 Free Access
Science in times of war: oppose Russian aggression but support Russian scientists
Eugene V Koonin
In the face of Russia’s invasion of the Ukraine, the global scientific community must continue to support their Russian colleagues without endorsing their government.
Science & Society23 February 2022 Open Access

Science in times of war: oppose Russian aggression but support Russian scientists

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EMBO Reports
Volume 23 Issue 4 5 April 2022
https://www.embopress.org/toc/14693178/current

 

Opinion 15 March 2022 Free Access
Science in times of war: oppose Russian aggression but support Russian scientists
Eugene V Koonin
In the face of Russia’s invasion of the Ukraine, the global scientific community must continue to support their Russian colleagues without endorsing their government.
Science & Society23 February 2022 Open Access

Lamarck redux and other false arguments against SARS-CoV-2 vaccination: Pseudoscientific arguments against vaccination do not stand up to scrutiny

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EMBO Reports
Volume 23 Issue 4 5 April 2022
https://www.embopress.org/toc/14693178/current

Lamarck redux and other false arguments against SARS-CoV-2 vaccination: Pseudoscientific arguments against vaccination do not stand up to scrutiny
Emanuel Goldman

 

The COVID-19 pandemic has triggered a new bout of anti-vaccination propaganda. These are often grounded in pseudoscience and misinterpretation of evolutionary biology.

Effect of Sotrovimab on Hospitalization or Death Among High-risk Patients With Mild to Moderate COVID-19A Randomized Clinical Trial

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JAMA
April 5, 2022, Vol 327, No. 13, Pages 1209-1300
https://jamanetwork.com/journals/jama/currentissue

 

Original Investigation
Effect of Sotrovimab on Hospitalization or Death Among High-risk Patients With Mild to Moderate COVID-19A Randomized Clinical Trial
Anil Gupta, MD; Yaneicy Gonzalez-Rojas, MD; Erick Juarez, MD; et al.
free access has active quiz
JAMA. 2022;327(13):1236-1246. doi:10.1001/jama.2022.2832
This randomized clinical trial compares the efficacy and adverse events of sotrovimab vs placebo in preventing progression of mild to moderate COVID-19 to severe disease.

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19A Randomized Clinical Trial

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JAMA
April 5, 2022, Vol 327, No. 13, Pages 1209-1300
https://jamanetwork.com/journals/jama/currentissue

 

Caring for the Critically Ill Patient
Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19A Randomized Clinical Trial
REMAP-CAP Writing Committee for the REMAP-CAP Investigators
free access has active quiz
JAMA. 2022;327(13):1247-1259. doi:10.1001/jama.2022.2910
This randomized clinical trial assesses the effect of treatment with an antiplatelet agent vs no antiplatelet therapy on days alive and free of intensive care unit respiratory or cardiovascular organ support within 21 days among patients critically ill with COVID-19.

Association Between 2-Dose vs 3-Dose Hepatitis B Vaccine and Acute Myocardial Infarction

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JAMA
April 5, 2022, Vol 327, No. 13, Pages 1209-1300
https://jamanetwork.com/journals/jama/currentissue

 

Association Between 2-Dose vs 3-Dose Hepatitis B Vaccine and Acute Myocardial Infarction
Katia Bruxvoort, PhD; Jeff Slezak, MS; Lei Qian, PhD; et al.
free access
JAMA. 2022;327(13):1260-1268. doi:10.1001/jama.2022.2540
This large prospective cohort study compares the rates of acute myocardial infarction between recipients of a 2-dose hepatitis B vaccine and recipients of a 3-dose hepatitis B vaccine.

Estimates of SARS-CoV-2 Omicron Variant Severity in Ontario, Canada

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JAMA
April 5, 2022, Vol 327, No. 13, Pages 1209-1300
https://jamanetwork.com/journals/jama/currentissue

 

Research Letter
Estimates of SARS-CoV-2 Omicron Variant Severity in Ontario, Canada
Ana Cecilia Ulloa, MPH; Sarah A. Buchan, PhD; Nick Daneman, MD, MSc; et al.
free access has active quiz has audio
JAMA. 2022;327(13):1286-1288. doi:10.1001/jama.2022.2274
This study examines hospitalizations and deaths associated with the SARS-CoV-2 Omicron variant compared with matched patients infected with the Delta variant.

Expanding Efforts and Support to Respond to the HIV and COVID-19 Intersecting Pandemics

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JAMA
April 5, 2022, Vol 327, No. 13, Pages 1209-1300
https://jamanetwork.com/journals/jama/currentissue

 

Viewpoint
Expanding Efforts and Support to Respond to the HIV and COVID-19 Intersecting Pandemics
Lawrence Corey, MD; Russell Corbett-Detig, PhD; Chris Beyrer, MD, MPH
free access
JAMA. 2022;327(13):1227-1228. doi:10.1001/jama.2022.3517
This Viewpoint discusses the generation of SARS-CoV-2 variants of concern globally and the need for increased access to COVID-19 vaccination in Africa, particularly for people living with HIV and for households and people living in densely populated communities.

The potential of mitochondrial genome engineering

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Nature Reviews Genetics
Volume 23 Issue 4, April 2022
https://www.nature.com/nrg/volumes/23/issues/4

 

Review Article | 02 December 2021
The potential of mitochondrial genome engineering
The authors review the field of mammalian mitochondrial genome engineering, culminating in the recent development of mitochondrially targeted programmable nucleases and base editors. They describe research that led to the development of animal models of mitochondrial disease, as well as the potential for translating these approaches to the clinic.
Pedro Silva-Pinheiro, Michal Minczuk

Lessons from Long COVID: working with patients to design better research

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Nature Reviews Immunology
Volume 22 Issue 4, April 2022
https://www.nature.com/nri/volumes/22/issues/4

 

Comment | 15 February 2022
Lessons from Long COVID: working with patients to design better research
In this Comment article, Nisreen Alwan discusses what her experience as both a public health academic and a person living with Long COVID has taught her about the importance of including those with lived experience of a condition in setting the research agenda.
Nisreen A. Alwan

Vaccine safety in an era of novel vaccines: a proposed research agenda

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Nature Reviews Immunology
Volume 22 Issue 4, April 2022
https://www.nature.com/nri/volumes/22/issues/4

 

Collection: COVID-19 Watch
Comment | 23 February 2022
Vaccine safety in an era of novel vaccines: a proposed research agenda
In this Comment article, Gregory Poland and Richard Kennedy outline the importance of continued funding and infrastructure support for research into vaccine safety to inform public health decisions and increase public trust in new vaccine technologies.
Gregory A. Poland
Richard B. Kennedy

Mucosal vaccines — fortifying the frontiers

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Nature Reviews Immunology
Volume 22 Issue 4, April 2022
https://www.nature.com/nri/volumes/22/issues/4

 

Review Article | 26 July 2021
Mucosal vaccines — fortifying the frontiers
Here, Ed Lavelle and Ross Ward discuss the unique aspects of mucosal immunity that must be considered when developing effective mucosal vaccines. The authors highlight the key immune cell populations that are targeted by mucosal vaccination strategies and explain how innovative adjuvant and delivery approaches should lead to new vaccines for infectious diseases and cancers.
Ed C. Lavelle
Ross W. Ward

Identification of neoantigens for individualized therapeutic cancer vaccines

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Nature Reviews Drug Discovery
Volume 21 Issue 4, April 2022
https://www.nature.com/nrd/volumes/21/issues/4

 

Review Article | 01 February 2022
Identification of neoantigens for individualized therapeutic cancer vaccines
Mutations in cancer cells can generate tumour-specific neoepitopes, which are attractive targets for anticancer vaccines. This Review discusses the mechanisms of neoantigen T cell recognition and computational approaches to predict which neoantigens might confer proficient antitumour immunity in a given clinical context.
Franziska Lang, Barbara Schrörs, Ugur Sahin

Population Immunity and Covid-19 Severity with Omicron Variant in South Africa

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New England Journal of Medicine
April 7, 2022 Vol. 386 No. 14
https://www.nejm.org/toc/nejm/medical-journal

 

Original Articles
Population Immunity and Covid-19 Severity with Omicron Variant in South Africa S.A. Madhi and Others
Widespread underlying SARS-CoV-2 seropositivity was observed in Gauteng before the omicron-dominant wave of Covid-19. Epidemiologic data showed a decoupling of hospitalizations and deaths from infections while omicron was circulating.

Prenatal influenza vaccination and allergic and autoimmune diseases in childhood: A longitudinal, population-based linked cohort study

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PLoS Medicine
http://www.plosmedicine.org/
(Accessed 09 Apr 2022)

 

Prenatal influenza vaccination and allergic and autoimmune diseases in childhood: A longitudinal, population-based linked cohort study
Damien Foo, Mohinder Sarna, Gavin Pereira, Hannah C. Moore, Annette K. Regan
Research Article | published 05 Apr 2022 PLOS Medicine
https://doi.org/10.1371/journal.pmed.1003963

Awareness, attitudes and acceptability of the HPV vaccine among female university students in Morocco

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PLoS One
http://www.plosone.org/
[Accessed 09 Apr 2022]

 

Awareness, attitudes and acceptability of the HPV vaccine among female university students in Morocco
A. Yacouti, N. Elkhoudri, A. El got, A. Benider, F. Hadrya, R. Baddou, A. Forster, M. Mouallif
Research Article | published 08 Apr 2022 PLOS ONE
https://doi.org/10.1371/journal.pone.0266081

COVID-19 vaccine acceptance, hesitancy, and associated factors among medical students in Sudan

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PLoS One
http://www.plosone.org/
[Accessed 09 Apr 2022]

 

COVID-19 vaccine acceptance, hesitancy, and associated factors among medical students in Sudan
Saud Mohammed Raja, Murwan Eissa Osman, Abdelmageed Osman Musa, Asim Abdelmoneim Hussien, Kabirat Yusuf
Research Article | published 07 Apr 2022 PLOS ONE
https://doi.org/10.1371/journal.pone.0266670

The COVID-19 Vaccine: Trust, doubt, and hope for a future beyond the pandemic in Germany

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PLoS One
http://www.plosone.org/
[Accessed 09 Apr 2022]

 

The COVID-19 Vaccine: Trust, doubt, and hope for a future beyond the pandemic in Germany
Amelia Fiske, Franziska Schönweitz, Johanna Eichinger, Bettina Zimmermann, Nora Hangel, Anna Sierawska, Stuart McLennan, Alena Buyx
Research Article | published 07 Apr 2022 PLOS ONE
https://doi.org/10.1371/journal.pone.0266659

Knowledge, attitude, and practice of seasonal influenza and influenza vaccine immunization among people visiting primary healthcare centers in Riyadh, Saudi Arabia

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PLoS One
http://www.plosone.org/
[Accessed 09 Apr 2022]

 

Knowledge, attitude, and practice of seasonal influenza and influenza vaccine immunization among people visiting primary healthcare centers in Riyadh, Saudi Arabia
Norah Alhatim, Ahmad M. Al-Bashaireh, Ola Alqudah
Research Article | published 04 Apr 2022 PLOS ONE
https://doi.org/10.1371/journal.pone.0266440

A single-shot vaccine approach for the universal influenza A vaccine candidate M2e

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PNAS – Proceedings of the National Academy of Sciences of the United States
March 29, 2022 | vol. 119 | no. 13
https://www.pnas.org/toc/pnas/119/13

 

Research Article
March 23, 2022
A single-shot vaccine approach for the universal influenza A vaccine candidate M2e
Influenza, commonly referred to as “flu,” is a major global public health concern and a huge economic burden to societies. Current influenza vaccines need to be updated annually to match circulating strains, resulting in low take-up rates and poor …
Ranmali Kavishna, Tha Yang Kang, […] Sylvie Alonso