Prioritising children’s rights in the COVID-19 response

The Lancet Child & Adolescent Health
Jul 2020 Volume 4 Number 7 p479-554, e17-e25
https://www.thelancet.com/journals/lanchi/issue/current

 

Editorial
Prioritising children’s rights in the COVID-19 response
The Lancet Child & Adolescent Health
Although substantial progress has been made in many aspects of child health in the past two decades, the COVID-19 pandemic and its wide-ranging effects are threatening some of these hard-won gains. Public health measures such as lockdown, school closures, and restrictions in population movement—while necessary to halt virus transmission—are causing prolonged disruption to societal functioning and exacerbating inequalities worldwide. The global Human Development Index (HDI) is projected to decline this year for the first time since 1990, effectively erasing all progress in human development made in the past 6 years…

 

The European artificial intelligence strategy: implications and challenges for digital health

Lancet Digital Health
Jul 2020 Volume 2 Number 7 e331-e379
https://www.thelancet.com/journals/landig/issue/current

 

Viewpoint
The European artificial intelligence strategy: implications and challenges for digital health
I Glenn Cohen, Theodoros Evgeniou, Sara Gerke, Timo Minssen
Summary
In February, 2020, the European Commission published a white paper on artificial intelligence (AI) as well as an accompanying communication and report. The paper sets out policy options to facilitate a secure and trustworthy development of AI and considers health to be one of its most important areas of application. We illustrate that the European Commission’s approach, as applied to medical AI, presents some challenges that can be detrimental if not addressed. In particular, we discuss the issues of European values and European data, the update problem of AI systems, and the challenges of new trade-offs such as privacy, cybersecurity, accuracy, and intellectual property rights. We also outline what we view as the most important next steps in the Commission’s iterative process. Although the European Commission has done good work in setting out a European approach for AI, we conclude that this approach will be more difficult to implement in health care. It will require careful balancing of core values, detailed consideration of nuances of health and AI technologies, and a keen eye on the political winds and global competition.

 

A wake-up call: COVID-19 and its impact on children’s health and wellbeing

Lancet Global Health
Jul 2020 Volume 8 Number 7 e860-e972
http://www.thelancet.com/journals/langlo/issue/current

 

Comment
A wake-up call: COVID-19 and its impact on children’s health and wellbeing
Henrietta H Fore, Executive Director, UNICEF
As cases of COVID-19 surge worldwide and threaten to overwhelm life-saving health services, the survival of mothers and children is at great risk.

In The Lancet Global Health, Timothy Roberton and colleagues1 present startling new evidence on the potential rise in maternal and child mortality in low-income and middle-income countries if essential health services are disrupted as a result of COVID-19. Building on lessons learned from previous outbreaks of Ebola virus disease and severe acute respiratory syndrome (SARS), the authors estimate a devastating increase in the numbers of maternal and child deaths resulting from reductions in routine health service coverage.

Left unchecked, these reductions (due to, for example, disruptions in medical supply chains or the availability of human and financial resources) along with declines in the uptake of health services by communities fearful of infection will be more catastrophic for mothers and children than COVID-19 itself. The projection of an additional 1·2 million child deaths and 56 700 maternal deaths in 118 countries if coverage of essential services drops by around 45% for 6 months is alarming. It is also avoidable if we act now.

These findings reinforce the multi-part approach that UNICEF has adopted from the start of the outbreak.2 First, we are working to prevent COVID-19 transmission and treat those who fall sick. Second, we are working to address the effects of the policy responses aimed at containing the spread, including maintaining routine health services for all children and mothers, ensuring continuity of learning, keeping mothers and children safe and protected from violence, and scaling up social protections to keep children and their families afloat. Third, we are working to strengthen the systems that underpin all of these services…

Continue reading

Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study

Lancet Global Health
Jul 2020 Volume 8 Number 7 e860-e972
http://www.thelancet.com/journals/langlo/issue/current

 

Articles
Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study
While the COVID-19 pandemic will increase mortality due to the virus, it is also likely to increase mortality indirectly. In this study, we estimate the additional maternal and under-5 child deaths resulting from the potential disruption of health systems and decreased access to food…Our estimates are based on tentative assumptions and represent a wide range of outcomes. Nonetheless, they show that, if routine health care is disrupted and access to food is decreased (as a result of unavoidable shocks, health system collapse, or intentional choices made in responding to the pandemic), the increase in child and maternal deaths will be devastating. We hope these numbers add context as policy makers establish guidelines and allocate resources in the days and months to come.
Timothy Roberton, Emily D Carter, Victoria B Chou, Angela R Stegmuller, Bianca D Jackson, Yvonne Tam, Talata Sawadogo-Lewis, Neff Walker

 

Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial

Lancet Infectious Diseases
Jul 2020 Volume 20 Number 7 p755-874, e148-e179
http://www.thelancet.com/journals/laninf/issue/current

 

Articles
Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial
Pedro M Folegatti, et al

 

Safety and immunogenicity of a modified vaccinia virus Ankara vector vaccine candidate for Middle East respiratory syndrome: an open-label, phase 1 trial

Lancet Infectious Diseases
Jul 2020 Volume 20 Number 7 p755-874, e148-e179
http://www.thelancet.com/journals/laninf/issue/current

 

Safety and immunogenicity of a modified vaccinia virus Ankara vector vaccine candidate for Middle East respiratory syndrome: an open-label, phase 1 trial
Till Koch, et al

 

Safety and immunogenicity of the tetravalent, live-attenuated dengue vaccine Butantan-DV in adults in Brazil: a two-step, double-blind, randomised placebo-controlled phase 2 trial

Lancet Infectious Diseases
Jul 2020 Volume 20 Number 7 p755-874, e148-e179
http://www.thelancet.com/journals/laninf/issue/current

 

Safety and immunogenicity of the tetravalent, live-attenuated dengue vaccine Butantan-DV in adults in Brazil: a two-step, double-blind, randomised placebo-controlled phase 2 trial
Esper G Kallas, et al

 

Safety and immunogenicity of a parenteral trivalent P2-VP8 subunit rotavirus vaccine: a multisite, randomised, double-blind, placebo-controlled trial

Lancet Infectious Diseases
Jul 2020 Volume 20 Number 7 p755-874, e148-e179
http://www.thelancet.com/journals/laninf/issue/current

 

Safety and immunogenicity of a parenteral trivalent P2-VP8 subunit rotavirus vaccine: a multisite, randomised, double-blind, placebo-controlled trial
Michelle J Groome, et al

 

Education and wealth inequalities in healthy ageing in eight harmonised cohorts in the ATHLOS consortium: a population-based study

Lancet Public Health
Jul 2020 Volume 5 Number 7 e361-e413
https://www.thelancet.com/journals/lanpub/issue/current

 

Articles
Education and wealth inequalities in healthy ageing in eight harmonised cohorts in the ATHLOS consortium: a population-based study
Yu-Tzu Wu, et al on behalf of the ATHLOS consortium
Background
The rapid growth of the size of the older population is having a substantial effect on health and social care services in many societies across the world. Maintaining health and functioning in older age is a key public health issue but few studies have examined factors associated with inequalities in trajectories of health and functioning across countries. The aim of this study was to investigate trajectories of healthy ageing in older men and women (aged ≥45 years) and the effect of education and wealth on these trajectories.
Interpretation
The apparent difference in baseline healthy ageing scores between those with high versus low education levels and wealth suggests that cumulative disadvantage due to low education and wealth might have largely deteriorated health conditions in early life stages, leading to persistent differences throughout older age, but no further increase in ageing disparity after age 70 years. Future research should adopt a lifecourse approach to investigate mechanisms of health inequalities across education and wealth in different societies.

 

Mapping and characterization of structural variation in 17,795 human genomes

Nature
Volume 583 Issue 7814, 2 July 2020
http://www.nature.com/nature/current_issue.html

 

Article | 27 May 2020
Mapping and characterization of structural variation in 17,795 human genomes
Structural variants in more than 17,000 human genomes are mapped and characterized using whole-genome sequencing, showing how this type of variation contributes to rare deleterious coding and noncoding alleles.
Haley J. Abel, David E. Larson[…] & Ira M. Hall

 

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Nature
Volume 583 Issue 7814, 2 July 2020
http://www.nature.com/nature/current_issue.html

 

Article | 06 May 2020
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.
James E. D. Thaventhiran, Hana Lango Allen[…] & Kenneth G. C. Smith

Continue reading

Whole-genome sequencing of patients with rare diseases in a national health system

Nature
Volume 583 Issue 7814, 2 July 2020
http://www.nature.com/nature/current_issue.html

 

Article | 24 June 2020
Whole-genome sequencing of patients with rare diseases in a national health system
Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.
Ernest Turro, William J. Astle[…] & Willem H. Ouwehand

 

Effective study design for comparative functional genomics

Nature Reviews Genetics
Volume 21 Issue 7, July 2020
https://www.nature.com/nrg/volumes/21/issues/7

 

Comment | 24 April 2020
Effective study design for comparative functional genomics
Comparative studies struggle to balance technical properties with the need to obtain samples from multiple species. The authors argue for extensive record keeping and reporting of metadata to minimize the effect of confounders and increase the robustness of inferences from these studies.
Joanna L. Kelley  & Yoav Gilad

 

COVID-19 vaccines: neutralizing antibodies and the alum advantage

Nature Reviews Immunology
Volume 20 Issue 7, July 2020
https://www.nature.com/nri/volumes/20/issues/7

 

Comment | 04 June 2020
COVID-19 vaccines: neutralizing antibodies and the alum advantage
Here, Peter Hotez and colleagues discuss the advantages of using an aluminium-based adjuvant in candidate COVID-19 vaccines.
Peter J. Hotez, David B. Corry[…] & Maria Elena Bottazzi

 

 

Next-generation stem cells — ushering in a new era of cell-based therapies

Nature Reviews Drug Discovery
Volume 19 Issue 7, July 2020
https://www.nature.com/nrd/volumes/19/issues/7

 

Review Article | 06 April 2020
Next-generation stem cells — ushering in a new era of cell-based therapies
Primary stem cells have long been used therapeutically for applications such as bone marrow transplantation. This Review discusses how cell-engineering approaches are enabling the development of next-generation stem cell therapies with improved function, specificity and responsiveness, thereby expanding their applications into areas such as delivering drugs and oncolytic viruses to tumours and promoting tissue repair in various diseases.
Erin A. Kimbrel  & Robert Lanza

 

A Half-Century of Progress in Health: The National Academy of Medicine at 50: Four Decades of HIV/AIDS — Much Accomplished, Much to Do

New England Journal of Medicine
July 2, 2020 Vol. 383 No. 1
http://www.nejm.org/toc/nejm/medical-journal

 

Perspective
A Half-Century of Progress in Health: The National Academy of Medicine at 50: Four Decades of HIV/AIDS — Much Accomplished, Much to Do
Anthony S. Fauci, M.D., and H. Clifford Lane, M.D.

 

Parental Hesitancy About Routine Childhood and Influenza Vaccinations: A National Survey

Pediatrics
Vol. 146, Issue 1 1 Jul 2020
https://pediatrics.aappublications.org/

 

Articles
Parental Hesitancy About Routine Childhood and Influenza Vaccinations: A National Survey
Allison Kempe, Alison W. Saville, Christina Albertin, Gregory Zimet, Abigail Breck, Laura Helmkamp, Sitaram Vangala, L. Miriam Dickinson, Cindy Rand, Sharon Humiston, Peter G. Szilagyi
Pediatrics, Jul 2020, 146 (1) e20193852

 

Improving HPV Vaccination Rates: A Stepped-Wedge Randomized Trial

Pediatrics
Vol. 146, Issue 1 1 Jul 2020
https://pediatrics.aappublications.org/

 

Improving HPV Vaccination Rates: A Stepped-Wedge Randomized Trial
Rebecca B. Perkins, Aaron Legler, Emily Jansen, Judith Bernstein, Natalie Pierre-Joseph, Terresa J. Eun, Dea L. Biancarelli, Thomas J. Schuch, Karin Leschly, Anny T.H.R. Fenton, William G. Adams, Jack A. Clark, Mari-Lynn Drainoni, Amresh Hanchate
Pediatrics, Jul 2020, 146 (1) e20192737

 

The Ethics of Creating a Resource Allocation Strategy During the COVID-19 Pandemic

Pediatrics
Vol. 146, Issue 1 1 Jul 2020
https://pediatrics.aappublications.org/

 

Special Articles
The Ethics of Creating a Resource Allocation Strategy During the COVID-19 Pandemic
Naomi Laventhal, Ratna Basak, Mary Lynn Dell, Douglas Diekema, Nanette Elster, Gina Geis, Mark Mercurio, Douglas Opel, David Shalowitz, Mindy Statter, Robert Macauley
Pediatrics, Jul 2020, 146 (1) e20201243
The coronavirus disease 2019 pandemic has affected nearly every aspect of medicine and raises numerous moral dilemmas for clinicians. Foremost of these quandaries is how to delineate and implement crisis standards of care and, specifically, how to consider how health care resources should be distributed in times of shortage. We review basic principles of disaster planning and resource stewardship with ethical relevance for this and future public health crises, explore the role of illness severity scoring systems and their limitations and potential contribution to health disparities, and consider the role for exceptionally resource-intensive interventions. We also review the philosophical and practical underpinnings of crisis standards of care and describe historical approaches to scarce resource allocation to offer analysis and guidance for pediatric clinicians. Particular attention is given to the impact on children of this endeavor. Although few children have required hospitalization for symptomatic infection, children nonetheless have the potential to be profoundly affected by the strain on the health care system imposed by the pandemic and should be considered prospectively in resource allocation frameworks.

 

The challenges of modeling and forecasting the spread of COVID-19

PNAS – Proceedings of the National Academy of Sciences of the United States of America
http://www.pnas.org/content/early/

 

Inaugural Article
The challenges of modeling and forecasting the spread of COVID-19
Andrea L. Bertozzi, Elisa Franco, George Mohler, Martin B. Short, and Daniel Sledge
PNAS first published July 2, 2020. https://doi.org/10.1073/pnas.2006520117
Significance
The coronavirus disease 2019 (COVID-19) pandemic has placed epidemic modeling at the forefront of worldwide public policy making. Nonetheless, modeling and forecasting the spread of COVID-19 remain a challenge. Here, we present and detail three regional-scale models for forecasting and assessing the course of the pandemic. This work is intended to demonstrate the utility of parsimonious models for understanding the pandemic and to provide an accessible framework for generating policy-relevant insights into its course. We show how these models can be connected to each other and to time series data for a particular region. Capable of measuring and forecasting the impacts of social distancing, these models highlight the dangers of relaxing nonpharmaceutical public health interventions in the absence of a vaccine or antiviral therapies.

 

Officials gird for a war on vaccine misinformation

Science
03 July 2020 Vol 369, Issue 6499
http://www.sciencemag.org/current.dtl

 

In Depth
Officials gird for a war on vaccine misinformation
By Warren Cornwall
Science03 Jul 2020 : 14-15 Full Access
Summary
As scientists rush to develop a vaccine for the new coronavirus, experts warn that public health agencies need new strategies to persuade people to accept a vaccine. Antivaccine activists have helped stoke rising levels of “vaccine hesitancy” in the United States and elsewhere. Now, those groups are turning their attention to the coronavirus. Polls have found as few as half of Americans are committed to taking the coronavirus vaccine. Now, researchers who study health behavior are urging adoption of some of the tactics used by vaccine critics: telling compelling, personal stories; spreading messages quickly and creatively through social media; offering more individualized responses to the concerns of different groups; and recruiting volunteers to act as a pro-vaccine counterweight

 

Improve alignment of research policy and societal values

Science
03 July 2020 Vol 369, Issue 6499
http://www.sciencemag.org/current.dtl

 

Policy Forum
Improve alignment of research policy and societal values
By Peter Novitzky, Michael J. Bernstein, Vincent Blok, Robert Braun, Tung Tung Chan, Wout Lamers, Anne Loeber, Ingeborg Meijer, Ralf Lindner, Erich Griessler
Science03 Jul 2020 : 39-41 Restricted Access
Summary
Historically, scientific and engineering expertise has been key in shaping research and innovation (R&I) policies, with benefits presumed to accrue to society more broadly over time (1). But there is persistent and growing concern about whether and how ethical and societal values are integrated into R&I policies and governance, as we confront public disbelief in science and political suspicion toward evidence-based policy-making (2). Erosion of such a social contract with science limits the ability of democratic societies to deal with challenges presented by new, disruptive technologies, such as synthetic biology, nanotechnology, genetic engineering, automation and robotics, and artificial intelligence. Many policy efforts have emerged in response to such concerns, one prominent example being Europe’s Eighth Framework Programme, Horizon 2020 (H2020), whose focus on “Responsible Research and Innovation” (RRI) provides a case study for the translation of such normative perspectives into concrete policy action and implementation. Our analysis of this H2020 RRI approach suggests a lack of consistent integration of elements such as ethics, open access, open innovation, and public engagement. On the basis of our evaluation, we suggest possible pathways for strengthening efforts to deliver R&I policies that deepen mutually beneficial science and society relationships.

 

Factors limiting data quality in the expanded programme on immunization in low and middle-income countries: A scoping review

Vaccine
Volume 38, Issue 30 Pages 4651-4782 (19 June 2020)
https://www.sciencedirect.com/journal/vaccine/vol/38/issue/30

 

Review article Open access
Factors limiting data quality in the expanded programme on immunization in low and middle-income countries: A scoping review
Katherine Harrison, Nargis Rahimi, M. Carolina Danovaro-Holliday
Pages 4652-4663

 

Cost-effectiveness analysis of a gender-neutral human papillomavirus vaccination program in the Netherlands

Vaccine
Volume 38, Issue 30 Pages 4651-4782 (19 June 2020)
https://www.sciencedirect.com/journal/vaccine/vol/38/issue/30

 

Research article Open access
Cost-effectiveness analysis of a gender-neutral human papillomavirus vaccination program in the Netherlands
Joost J.M. Simons, Nora Vida, Tjalke A. Westra, Maarten J. Postma

 

Acceptability of vaccination against human papillomavirus among women aged 20 to 45 in rural Hunan Province, China: A cross-sectional study

Vaccine
Volume 38, Issue 30 Pages 4651-4782 (19 June 2020)
https://www.sciencedirect.com/journal/vaccine/vol/38/issue/30

 

Research article Abstract only
Acceptability of vaccination against human papillomavirus among women aged 20 to 45 in rural Hunan Province, China: A cross-sectional study
Si Qin, Jing-Xia Fu, Ming-Zhu Chen, Yan-Ting Meng, … Yang Luo
Pages 4732-4739

 

Early smallpox vaccine manufacturing in the United States: Introduction of the “animal vaccine” in 1870, establishment of “vaccine farms”, and the beginnings of the vaccine industry

Vaccine
Volume 38, Issue 30 Pages 4651-4782 (19 June 2020)
https://www.sciencedirect.com/journal/vaccine/vol/38/issue/30

 

History of Vaccinology paper
Research article Open access
Early smallpox vaccine manufacturing in the United States: Introduction of the “animal vaccine” in 1870, establishment of “vaccine farms”, and the beginnings of the vaccine industry
José Esparza, Seth Lederman, Andreas Nitsche, Clarissa R. Damaso
Pages 4773-4779

 

Strategies to Improve Vaccination among At-Risk Adults and the Elderly in Italy

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines
(Accessed 4 July 2020)

 

Open Access Article
Strategies to Improve Vaccination among At-Risk Adults and the Elderly in Italy
by Giovanna Elisa Calabrò , Alessia Tognetto , Elettra Carini , Silvia Mancinelli , Laura Sarnari , Vittoria Colamesta , Walter Ricciardi and Chiara de Waure
Vaccines 2020, 8(3), 358; https://doi.org/10.3390/vaccines8030358 (registering DOI) – 04 Jul 2020
Abstract
The World Health Organization (WHO), the United States (US) Centers for Disease Control and Prevention (CDC), the European Center for Disease Control (ECDC), and the immunization guidelines of many countries issue vaccination recommendations for adults and the elderly. However, the uptake of vaccination

 

Strategies to Improve Vaccination among At-Risk Adults and the Elderly in Italy

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines
(Accessed 4 July 2020)

 

Open Access Article
Strategies to Improve Vaccination among At-Risk Adults and the Elderly in Italy
by Giovanna Elisa Calabrò , Alessia Tognetto , Elettra Carini , Silvia Mancinelli , Laura Sarnari , Vittoria Colamesta , Walter Ricciardi and Chiara de Waure
Vaccines 2020, 8(3), 358; https://doi.org/10.3390/vaccines8030358 (registering DOI) – 04 Jul 2020
Abstract
The World Health Organization (WHO), the United States (US) Centers for Disease Control and Prevention (CDC), the European Center for Disease Control (ECDC), and the immunization guidelines of many countries issue vaccination recommendations for adults and the elderly. However, the uptake of vaccination

 

HPV Vaccination: The Position Paper of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines
(Accessed 4 July 2020)

 

Open Access Review
HPV Vaccination: The Position Paper of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)
by Andrea Ciavattini , Luca Giannella , Rosa De Vincenzo , Jacopo Di Giuseppe , Maria Papiccio , Ankica Lukic , Giovanni Delli Carpini , Antonio Perino , Antonio Frega , Francesco Sopracordevole , Maggiorino Barbero and Murat Gultekin
Vaccines 2020, 8(3), 354; https://doi.org/10.3390/vaccines8030354 – 02 Jul 2020

 

Media/Policy Watch

Media/Policy Watch
This watch section is intended to alert readers to substantive news, analysis and opinion from the general media and selected think tanks and similar organizations on vaccines, immunization, global public health and related themes. Media Watch is not intended to be exhaustive, but indicative of themes and issues CVEP is actively tracking. This section will grow from an initial base of newspapers, magazines and blog sources, and is segregated from Journal Watch above which scans the peer-reviewed journal ecology.
We acknowledge the Western/Northern bias in this initial selection of titles and invite suggestions for expanded coverage. We are conservative in our outlook in adding news sources which largely report on primary content we are already covering above. Many electronic media sources have tiered, fee-based subscription models for access. We will provide full-text where content is published without restriction, but most publications require registration and some subscription level.

 

The Atlantic
http://www.theatlantic.com/magazine/
Accessed 4 July 2020
[No new, unique, relevant content]

 

BBC
http://www.bbc.co.uk/
Accessed 4 July 2020
Health
Covaxin: India to hold human trial of coronavirus vaccine in July
30 June 2020

 

The Economist
http://www.economist.com/
Accessed 4 July 2020
Leaders
Jul 4th 2020 edition
The way we live now
Covid-19 is here to stay. People will have to adapt
The world is not experiencing a second wave: it never got over the first

Britain
Jul 2nd 2020 edition
Covid-19 – Oxford University is leading in the vaccine race
Governments are pouring money into a more urgent version of the space race

 

Financial Times
http://www.ft.com/home/uk
Accessed 4 July 2020
[No new, unique, relevant content]

 

Forbes
http://www.forbes.com/
Accessed 4 July 2020
Jul 2, 2020
Fauci: Covid-19 Vaccine Safety And Effectiveness Should Be Known ‘By Early Winter’
Dr. Anthony Fauci said the safety and effectiveness of a vaccine for the coronavirus strain Covid-19 should be known by “early winter” with 200 million doses available for U.S. use by early 2021.
By Bruce Japsen Senior Contributor

 

Foreign Affairs
http://www.foreignaffairs.com/
Accessed 4 July 2020
[No new, unique, relevant content]

 

Foreign Policy
http://foreignpolicy.com/
Accessed 4 July 2020 | [No new, unique, relevant content]
[No new, unique, relevant content]

 

The Guardian
http://www.guardiannews.com/
[No new, unique, relevant content]

 

New Yorker
http://www.newyorker.com/
Accessed 4 July 2020
[No new, unique, relevant content]

 

New York Times
http://www.nytimes.com/
Accessed 4 July 2020
Asia Pacific
India’s Clinical Research Body Defends Timeline for Coronavirus Vaccine Trials
India’s leading clinical research agency said Saturday its decision to fast-track development of a potential coronavirus vaccine was in line with international standards, after health experts raised concerns about the schedule for clinical trials.
By Reuters July 4, 2020

Americas
Brazil Health Regulator Anvisa Allows Chinese COVID-19 Vaccine Trial
Brazilian health regulator Anvisa on Friday approved clinical trials of a potential coronavirus vaccine developed by China’s Sinovac, according to an official gazette publication.
By Reuters July 4, 2020

Asia Pacific
WHO Sees First Results From COVID Drug Trials Within Two Weeks
The World Health Organization (WHO) should soon get results from clinical trials it is conducting of drugs that might be effective in treating COVID-19 patients, its Director General Tedros Adhanom Ghebreyesus said on Friday.
By Reuters July 3, 2020

Asia Pacific
Health Experts Cast Doubt on India’s Timeline for COVID Vaccine
The chief of India’s top clinical research agency said in a leaked letter circulated on Friday it envisaged launching a novel coronavirus vaccine by Aug. 15, prompting scepticism from some health experts who questioned the short timeline.
By Reuters July 3, 2020

U.S.
COVID-19 Vaccines to Enter Late-Stage Trial by End of July, Fauci Says
COVID-19 vaccine candidates will enter late-stage clinical studies by the end of the month, with others beginning in August, September and October, the U.S. government’s top infectious diseases expert said on Thursday.
By Reuters July 3, 2020

U.S.
NIH Director Collins Optimistic on COVID-19 Vaccine by Year End
The U.
By Reuters

 

Washington Post
https://www.washingtonpost.com/
Accessed 4 July 2020
Prospect of a coronavirus vaccine unites anti-vaxxers, conspiracy theorists and hippie moms in
Loveday Morris · Jul 3, 2020

 

Think Tanks et al

Think Tanks et al

Brookings
http://www.brookings.edu/
Accessed 4 July 2020
[No new relevant content]

Center for Global Development [to 4 July 2020]
http://www.cgdev.org/page/press-center
Accessed 4 July 2020
[No new relevant content]

Chatham House [to 4 July 2020]
https://www.chathamhouse.org/
[No new relevant content]

 

CSIS
https://www.csis.org/
Accessed 4 July 2020
[No new relevant content]

 

Council on Foreign Relations
http://www.cfr.org/
Accessed 4 July 2020
June 30, 2020
Pharmaceuticals and Vaccines
What Is the World Doing to Create a COVID-19 Vaccine?
Backgrounder by Claire Felter

 

Kaiser Family Foundation
https://www.kff.org/search/?post_type=press-release
Accessed 4 July 2020
July 1, 2020 News Release
KFF’s Kaiser Health News (KHN), AP Investigate the State of the Nation’s Public Health Infrastructure as It Confronts the Challenge of the COVID-19 Pandemic
A new investigation from KHN and The Associated Press examines the troubling state of the public health infrastructure the nation is relying on to navigate the health and economic threats presented by the COVID-19 pandemic.

 

Vaccines and Global Health: The Week in Review :: 27 June 2020

Act-Accelerator update

Milestones :: Perspectives :: Research

 

COVID-19

Act-Accelerator update
Publication of investment cases
26 June 2020 News release
:: The tools developed will benefit the whole world, and by saving lives and reducing severe COVID-19 disease, contribute to the goal of protecting health systems and restoring full societal and economic activity globally in the near term, and facilitating high-level control of COVID-19 disease in the medium term.

:: The consolidated investment case calls for US$31.3 billion over the next 12 months[1]. US$3.4 billion has been contributed to date, resulting in a funding gap of US$27.9 billion, of which $13.7 billion is urgently needed.

 

:: Pillar plans published today show a path to the accelerated development, equitable allocation, and scaled up delivery of 500 million tests to LMIC’s by mid-2021, 245 million courses of treatments to LMICs by mid-2021, and 2 billion vaccine doses, of which 1 billion will be purchased for LMICs, by the end of 2021.

Today, the Access to COVID-19 Tools Accelerator (ACT-Accelerator) published its consolidated investment case, alongside the costed plans of the member organizations.

Launched at the end of April 2020, at an event co-hosted by the Director-General of the World Health Organization, the President of France, the President of the European Commission, and The Bill & Melinda Gates Foundation, the ACT-Accelerator brings together governments, health organizations, scientists, businesses, civil society, and philanthropists who have joined forces to speed up an end to the pandemic.

Since the ACT-Accelerator was launched, the partner organizations have moved fast to develop costed and implementable plans designed to contribute to the end of the pandemic through the accelerated development, equitable allocation, and scaled up delivery of new tools to reduce rapidly mortality and severe disease, protecting health systems and restoring full societal and economic activity globally in the near term, and facilitating high-level control of COVID-19 disease in the medium term.

ACT-Accelerator investment case and costed plans
The ACT-Accelerator’s investment case and the plans published by the organizations leading each of the ‘pillars’  show a path to the accelerated development, equitable allocation, and scaled up delivery of 500 million diagnostic tests to LMIC’s by mid-2021, 245 million courses of treatments to LMICs by mid-2021, and 2 billion vaccine doses, of which 50% will go to LMICs by the end of 2021.

To achieve this, the costed plans presented today call for US $31.3 billion in funding for diagnostics, therapeutics and vaccines, of which US$3.4 billion has so far been pledged[2]. An additional US$27.9 billion is therefore needed, including US$13.7 billion to cover immediate needs (i.e. US$17.1 billion is immediately required, of which US$3.4 billion has been pledged).

The investment required is significant, but it pales in significance when compared to the cost of COVID-19: the total cost of the ACT-Accelerator’s work is less than a tenth of what the IMF estimates the global economy is losing every month due to the pandemic.  468,000 thousand people have already lost their lives.

The tools developed will benefit the whole world; the ACT-Accelerator pillars will also buy and deliver tools to ensure that LMIC’s have access.

The ACT-Accelerator’s investment case is available here.

COVID-19 Therapeutics Accelerator Donors Launch International Alliance to Connect Research Data Sources and Enable Collaboration

Milestones :: Perspectives :: Research

COVID-19 Therapeutics Accelerator Donors Launch International Alliance to Connect Research Data Sources and Enable Collaboration
International COVID-19 Data Research Alliance and Workbench will bring together data to
accelerate the search for new therapies to fight the pandemic and save lives

SEATTLE, JUNE 26, 2020 – The COVID-19 Therapeutics Accelerator donors and partners today announced the formation of the International COVID-19 Data Research Alliance to accelerate clinical research on COVID-19. Composed of academic institutions, research organizations, life sciences and technology companies, and philanthropies, the International Alliance was created to fight the COVID-19 pandemic, but with the promise for use across other health conditions, including readiness for future pandemics.

Accelerator donors, including the Bill & Melinda Gates Foundation, Chan Zuckerberg Initiative, Mastercard, Minderoo Foundation, and Wellcome, will be founding members of the International Alliance. It will be managed by Health Data Research UK, a national institute for health data science with expertise in harnessing data at scale to improve people’s lives, working in partnership with alliance partners from life science companies, academic institutions and clinical research organizations from around the world.

The current pandemic has prompted a great deal of research, but there are few environments where data sets generated by previous studies and trials can be accessed to inform research and development efforts. These data sets could address key questions about the course of COVID-19, how it impacts the body, and what treatments might be effective. In many cases, relevant data sets exist, but researchers cannot easily access or link them for integrated analysis. The International Alliance will provide a variety of ways for researchers to collaborate on data—from pooled to federated analyses—for trustworthy, privacy-protected, and ethical research as determined by a governance board of global specialists in the field.

“In a pandemic, the pathogen has the upper hand. We know very little about it, so access to information becomes an important commodity,” said Trevor Mundel, president of global health at the Gates Foundation. “By entering into agreements on data sharing up front, we can avoid wasting time going down blind alleys, ultimately saving lives by getting definitive answers to key questions more quickly. This grant to form an international data alliance will accelerate efforts and provide a legacy for future collaboration on pandemics. We encourage others to join us and the other founding partners in this important initiative.”…

An Analytical Workbench for Scientific Inquiry
The Workbench will connect to regional and national data infrastructures used by International Alliance members, such as data generated by Therapeutics Accelerator-funded trials, pharmaceutical industry partners, the national BREATHE health data research hub in the United Kingdom, SAIL Databank and others to be confirmed in the coming months. The Workbench, developed by Aridhia Informatics, will enable the discovery of data relevant for answering priority questions from its own repository and federated repositories, and will provide a secure location where analysts can work collectively on a target research hypothesis. Data access and use will be conducted in accordance with the governance requirements of individual data controllers from countries around the world, in a transparent and ethical manner. Authorized users will be able to bring their data to the Workbench and collaborate with others in a secure environment. The Workbench will be designed to encourage and enable responsible data use, including transparency, ethical review, privacy, and data protection…

COVAX: ensuring fair allocation of a COVID-19 vaccine

Milestones :: Perspectives :: Research

 

COVAX: ensuring fair allocation of a COVID-19 vaccine
A global initiative to ensure equitable access to COVID-19 vaccines for all countries
26 June 2020
When a vaccine against COVID-19 becomes available, there will be intense and global demand. Therefore, an ambitious solution is needed to ensure fair allocation of vaccine supply and to make sure no one is left behind. If we are to end this pandemic, we need to stamp out the coronavirus everywhere, not just in the countries that can afford to procure large volumes of a vaccine.

To meet this challenge the COVID-19 Vaccine Global Access Facility (COVAX), part of the ACT Accelerator, has been launched. This initiative, of which CEPI is a proud partner, aims to ensure equitable access to COVID-19 vaccines for all countries, at all levels of development, that wish to participate.

COVAX is our best hope of ending the pandemic
COVAX is radical in its ambition but practical in its approach, harnessing the strengths of existing organisations: CEPI will continue to develop, at speed, one of the largest and most advanced COVID-19 vaccine portfolios in the world and will ensure, in collaboration with its industry partners, candidates are ready to be produced at scale. Simultaneously, GAVI will procure and finance (licensed) vaccine and help deploy it to the world, ensuring supply to low-income and middle-income countries and other countries through domestic government budgets.

Ultimately, governments that decide to go it alone risk concentrating their resources in a few potentially unsuccessful vaccine candidates, but by participating in COVAX they will be able to hedge that risk and increase their chances of success by contributing to a large and diverse portfolio of vaccines. At the same time, through COVAX, governments with limited or no ability to finance their own bilateral procurement can be assured access to life-saving vaccines that would otherwise have been beyond their reach.

Funding COVAX
$18.1 billion will be required to get 2 billion doses of vaccine in 2021. The funding is required immediately, so that we can ensure that accelerated development, manufacturing, procurement, stockpiling, and fair allocation of a vaccine can be achieved. These vital elements must be put in place now, otherwise we could face a delay of up to a year in getting a vaccine to the people who need it most.

Such a delay would be unacceptable, especially against a backdrop of rising coronavirus infections and deaths and an estimated US$375 billion impact on the global economy for every month this pandemic rages on.

Fair allocation of a vaccine
COVAX partners will work together to setup the framework and mechanism required to ensure fair allocation. A methodology is required to fairly allocate a COVID-19 vaccine and it will need to prioritise vaccine supply according to risk groups to reduce the spread of virus and its impact as quickly as possible. Priority populations for the first round of vaccinations will likely include healthcare workers, adults over the age of 65 years, and other high-risk adults with underlying health conditions.

Why we need to act now
Mitigate economic damage – for every month that this pandemic continues, $375 billion is lost from the global economy. Acting now to accelerate development, manufacture, and distribution of a COVID-19 vaccine will save hundreds of thousands of lives and protect the livelihoods of millions more.

Accelerate availability of vaccine – if we follow the traditional course of vaccine development, we could face years of delay. Such a delay will cost lives and trillions of dollars in economic damage. COVAX will enable at-risk investments in production capacity across several candidates now – to ensure that, upon regulatory approval, doses can be made immediately available at scale.

Ensure globally fair allocation and access for low and middle income countries –nobody is safe from COVID-19 until everybody is safe. COVAX not only represents the best solution to end this pandemic, it is also the fairest way to allocate vaccine for all countries to ensure that access can be provided for every country.

 

With the launch of COVAX, we have a real chance to end this pandemic, but only if governments take a global approach to how they allocate funds for vaccine development, manufacturing, and distribution.

Dr. Richard Hatchett
Chief Executive Officer, CEPI

“What Worries Me Is That People Do Trust Vaccines”

Milestones :: Perspectives :: Research

 

Human Vaccines Project [to 27 June 2020]
http://www.humanvaccinesproject.org/media/press-releases/
COVID Report
“What Worries Me Is That People Do Trust Vaccines”
Interview with Paul A. Offit, M.D.
We asked for his thoughts on the clinical trials of COVID-19 vaccine candidates prioritized
by Operation Warp Speed. A slightly edited version of our conversation appears below.

 

Are the vaccines that are being prioritized by Operation Warp Speed in the US the most likely to work or just the fastest to produce?
I think they’re just the fastest to be produced because for the most part they are all genetic vaccines; mRNA or replication-defective simian or human adenoviruses where you can just sort of plug and play. You know the gene you’re interested in—it’s the gene that codes for the SARS-CoV-2 surface protein, the Spike protein—so you just plug it in. It’s much easier to make than an inactivated viral vaccine, a live attenuated viral vaccine, or a purified protein vaccine. There is nothing that says these vaccines will be more likely to be safe or effective than existing vaccine strategies.
I don’t know how the decision was made to prioritize these candidates. I’m on the NIH ACTIV group but we weren’t involved in picking those vaccines.

 

Is there a potential trade-off between speed and safety/efficacy in the race to develop vaccines for SARS-CoV-2?
I’ll tell you eight months from now. The Phase III trials will tell all, assuming that we do the Phase III trials that we’ve been asking to do, which will involve at least 20,000 vaccine recipients and 10,000 placebo recipients. If we at least do that, we’ll see.
We have no experience with those strategies. There are no mRNA vaccines or replication-defective simian or human adenovirus vaccines on the market. They don’t exist. With messenger RNA, the mRNA itself is a very labile molecule that is rapidly degraded, so that doesn’t worry me. But do you know how many particles are given when you give a replication defective virus vaccine? Roughly 100 billion particles. Might that invoke some aberrant immune response? It’s possible. That’s why you have to enroll at least 20,000 volunteers in the vaccine arm to rule out an uncommon side effect. You’re not going to be able to rule out rare side effects until you put the vaccine in 20 million people.

 

Are there plans now to test any of these COVID-19 vaccine candidates in children?
Not initially. When the vaccine rolls out, then children will be part of those studies. For children, you have to hold this vaccine to an especially high standard of safety because although there is this post-infection Kawasaki-like disease, it’s still the rare child that dies of this virus. When you consider that there 114,000 people who have died in the US from COVID-19, how many have been children? It has to be fewer than 20, whereas 160 children died from flu this year.

 

Does releasing a vaccine so quickly risk increasing the distrust of vaccines, particularly among certain groups?
The true anti-vaccine activists, which is to say the conspiracy theorists, will still find some reason to hate this vaccine no matter how safe or effective it is, even though those reasons won’t be valid.
I think the focus by the media has been wrong to some extent. When people say there’s a distrust of vaccines, I don’t think that’s true. What worries me is that people do trust vaccines. Very much so. Parents in this country are asked to give children 14 different vaccines in the first years of life—that can be as many as 27 inoculations during that time period and as many as five shots at one time—to prevent diseases most parents have never seen, using biological fluids most parents don’t understand. They do trust us. I think we risk that trust if we rush this
along and don’t do the type of Phase III testing that we need to do for this vaccine.
We also need to manage expectations when we do release a vaccine to say that we don’t know if it causes rare side effects, but we’re looking, and we don’t know how long the duration of immunity will be because we’ll learn as we go. You will never, ever convince the anti-vaccine people because data doesn’t convince them.

 

When vaccines are available, what percentage of the population will likely need to be vaccinated to establish herd immunity?
It’s a guess. It is a combination of two factors: the contagiousness of the virus and the effectiveness of the vaccine. With measles, for example, you have a very, very contagious virus—the most contagious of the vaccine-preventable diseases—but you have an extraordinarily effective vaccine, so you need to have just over 90 percent of the population vaccinated. With polio, we started to see a decrease in the spread of polio when we started to get to 40-50 percent immunization rates. With rotavirus, by the time you got to 60-70 percent immunization rates, the disease dramatically declined. I think if you get to 70-80 percent with a COVID-19 vaccine you’ll see a dramatic reduction in the incidence of this disease, as a guess.

 

What keeps you up at night given all of this?
There is a system, which I trust, that has been in place since the 1950s to make sure that the vaccines that are brought into this country are tested as much as is reasonable to mitigate risks regarding safety and efficacy. This system involves the NIH, the CDC [US Centers for Disease Control and Prevention], and the FDA [US Food and Drug Administration]. As long as that system stays in place, I’m good. What worries me is that this system could be perturbed by an administration that perturbs the science. This is an administration that took the words climate change off the EPA’s [US Environmental Protection Agency’s] website. This is an administration that pushed hydroxychloroquine [as a COVID-19 treatment] and got the FDA to approve it—a product that had never been shown to work, was known to have a certain level of toxicity, and that ended up doing more harm than good. That was the FDA at its worst. They let themselves be pushed around and if that happens here, that would be a problem.

Coronavirus [COVID-19]

EMERGENCIES

Coronavirus [COVID-19]
Public Health Emergency of International Concern (PHEIC)

WHO – Situation report – 158
Coronavirus disease 2019 (COVID-19)
26 June 2020
Confirmed cases :: 9 653 048
Confirmed deaths :: 491 128
Countries, areas or territories with cases :: 216

Highlights
:: On 25 June, Health Minister Jens Spahn of Germany, and Solidarity and Health Minister Olivier Veran of France, visited WHO headquarters. During a press briefing they expressed their solidarity and additional support to both COVID-19 response and WHO’s core programmes.

Yesterday the Ebola virus disease outbreak in the northeast of the Democratic Republic of the Congo was declared over after nearly two years. The WHO Regional Office for Africa and partners are now building on the Ebola response to tackle COVID-19 in the country. Additionally, WHO is supporting other countries in Africa as the COVID-19 pandemic accelerates in the region.

:: In a press briefing yesterday, Dr Hans Henri P. Kluge, WHO Regional Director for Europe, spoke about COVID-19 in the region and how digital technology and artificial intelligence can empower people and play a leading role in optimizing efforts to control transmission of the disease.

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